+

WO2000047247A1 - Technique d'utilisation detournee d'un dispositif dans un but de prevention du cancer canalaire du sein - Google Patents

Technique d'utilisation detournee d'un dispositif dans un but de prevention du cancer canalaire du sein Download PDF

Info

Publication number
WO2000047247A1
WO2000047247A1 PCT/US2000/003661 US0003661W WO0047247A1 WO 2000047247 A1 WO2000047247 A1 WO 2000047247A1 US 0003661 W US0003661 W US 0003661W WO 0047247 A1 WO0047247 A1 WO 0047247A1
Authority
WO
WIPO (PCT)
Prior art keywords
wall
mammary
mammary gland
breast pad
breast
Prior art date
Application number
PCT/US2000/003661
Other languages
English (en)
Inventor
Elena T. Medo
Original Assignee
Medo Elena T
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medo Elena T filed Critical Medo Elena T
Priority to AU32303/00A priority Critical patent/AU3230300A/en
Publication of WO2000047247A1 publication Critical patent/WO2000047247A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/06—Milking pumps
    • A61M1/062—Pump accessories
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/06—Milking pumps
    • A61M1/062—Pump accessories
    • A61M1/064—Suction cups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/06—Milking pumps
    • A61M1/062—Pump accessories
    • A61M1/064—Suction cups
    • A61M1/066—Inserts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/06—Milking pumps
    • A61M1/069—Means for improving milking yield
    • A61M1/0697—Means for improving milking yield having means for massaging the breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/366—General characteristics of the apparatus related to heating or cooling by liquid heat exchangers

Definitions

  • the present invention generally relates to breast pumps but more particularly to breast pump technology designed to obtain breast fluids from non-lactating breasts while stimulating elevated levels of prolactin in the blood.
  • Breast cancer is one of the leading causes of disease and death in women, with greater than 90% of breast cancer originating in the epithelial cells of the ducts of the breast.
  • Early detection and treatment of breast cancer has focused on improving prognosis and increasing the survival rates. Renewed focus on prevention and detection of breast cancer has lead to the use of numerous biological indicators in mammary fluid and methods of early detection of breast cancer risk.
  • Such indicators include numerous oncogenic determinants, cytokines, angiogenic factors, proteins and nucleic acids, as well as biochemical products and lipids.
  • breast pumps have been used to remove milk from a lactating mother's breasts. These breast pumps include both powered and manual versions.
  • a breast pump applies suction to the breast tissue with the intended result being the flow and capture of a quantity of milk for use in feeding a baby.
  • the shape of the breast funnel and performance of the suction unit vary in different models, some being more efficient in pumping than others due to the differences in design and individual breast physiology.
  • the pumps designed for obtaining mammary fluid from lactating subjects do not generally draw fluids from non-lactating subject.
  • a more routine method of obtaining ductal fluid has been the performance of fine needle aspiration methods, as described in U.S. Patent No. 4,697,600 issued to Cardenas et al. on October 6, 1987. Because the needle asporation methods aare painful, women are understandably reluctant to consent to those processes to obtain a ductal fluid sample from their breasts unless they have already been diagnosed with breast cancer or believe to be at very high risk for the disease.
  • breast ductal fluid content can be altered to improve health by systematically removing the existing fluid from the ducts on a regular basis, thus increasing fluid turnover in the breast.
  • Such fluid turnover is thought to increase blood flow, hormones, and biological factors which are effective in reducing the risk of breast cancer. Examples of biological factors include carotenoids.
  • the invention provides compositions, systems and devices useful in obtaining fluid from the mammary gland of a female subject.
  • the subject can be any mammal including humans.
  • the female will typically be a non-lactating female.
  • the methods systems and devices are useful in removing keratin plugs found in the ducts of the mammary gland and in obtaining fluids from the mammary gland by warming and providing compression or vibration stimuli to the mammary gland.
  • a mammary gland pad is provided containing a detergent solution or a detergent solution combined with other active ingredients, which is useful in removing keratin plugs from the ductal glands of mammary tissue. This pad can be used alone or in combination with the mammary funnel system of the invention.
  • a mammary funnel system which is capable of heating the mammary gland to increase blood flow and reduce viscosity of the mammary fluid.
  • the mammary funnel system is capable of providing additional compression stimuli to the mammary gland to further promote fluid secretion.
  • the mammary funnel system is further capable of providing vibrational stimulation to promote expression of viscous mammary fluid from the breast.
  • the system, methods and devices of the invention are useful in promoting expression of mammary gland fluids, thereby increasing fluid turnover, reducing accumulation of carcinogenic agents in the breast tissue fluid, stimulating the rise of hormonal levels associated with lactation, and increasing the presence of beneficial biological agents in the mammary gland fluids.
  • FIG. 1 is a depiction of the mammary funnel system of the invention having a substantially rigid tubular portion 15 and a pliable tubular structure 40 in contact with a mammary gland 12.
  • FIG. 2 shows the substantially rigid tubular portion 15 in further detail including the stimuli elements 30 and 35, sampling opening 32, and connector regions 60, 65, and 70.
  • FIG. 3 shows the pliable tubular structure 40 in more detail, including openings 45 and 50 and regions of varying thickness 55.
  • FIG. 4 shows the mammary funnel 10 in use with a mammary gland 12.
  • A. shows the funnel as it is being pressed against the mammary gland.
  • the substantially rigid portion 15 provides resilience as the funnel is pressed against the mammary gland.
  • B. shows the mammary funnel 10 in use with the mammary gland.
  • a vacuum 65 causes the regions of varying thickness 55 to collapse and exert pressure on the nipple of the mammary gland 12. Fluid is expressed 34, which can be collected through sampling opening 32.
  • FIG. 5 A shows a mammary gland pad 80.
  • FIG. 5B shows a mammary gland pad 80 in contact with a mammary gland 12.
  • prolactin plays a significant role in the integrity and health of the epithelial lining of the breast duct system and the digestive system.
  • prolactin triggers the production of breast milk.
  • Prolactin levels are elevated during suckling and, depending upon the frequency of the suckling activity, can either reach lactation levels or remain elevated but below the level needed to trigger lactation.
  • Research indicates that elevated blood serum prolactin levels are consistent with positive changes in the epithelial lining of the breast duct and intestines, possibly rendering them more resistant to disease such as cancer and infection.
  • the ability to manipulate hormone levels though a pre-defined process of nipple stimulation using the devices of the invention may prove to be a useful intervention in breast ductal cancer, and other hormone related diseases.
  • the nipples of the breast serve as somewhat of a "control panel" to the pituitary gland where prolactin, oxytocin and other hormones are manufactured. Since oxytocin and prolactin are both reproductive hormones, the presence of these hormones in high levels indicates the individual's membership in the reproductive population. There is some rationale for health related defensive mechanism that would protect the members of the reproductive population from illness or death in order to increase the chance of survival for offspring.
  • the keratin plugs effectively seal the breast contents behind them, making it difficult or impossible for the breast to drain naturally as well as impossible to remove ductal fluid using suction only.
  • the keratin plugs are comprised of basically the same material as earwax, with the same tendency to harden into a solid plug.
  • the ductal fluid is typically thick in non-lactating females. It moves very slowly through the duct to the nipple, further necessitating a system that differs greatly in design from conventional breast milk pumps. Because of the thickness of the fluid and its inability to form a stream, it becomes necessary to capture the fluid in something other than a container.
  • the methods, systems, and devices envisioned by the inventor include multiple steps or device elements. In some females, not all steps in the process are necessary to achieve the desired results of cleansing the ducts, obtaining ductal fluid and/or elevating prolactin. The inventor believes that the process may be effective on some individuals without utilizing all steps or all elements present in the devices of the invention.
  • the mammary gland funnel of the invention is applicable to all mammalian females, including for example, humans, exotic mammals, such as rhinos and tigers, as well as to domestic animals including cattle, cats, and dogs.
  • the mammary gland funnel of the invention provides heat, compression stimuli, and suction simultaneously to the breast. In one embodiment, a further stimuli of vibration is added to assist in obtaining breast ductal fluids.
  • the invention provides a mammary gland funnel system (10) for obtaining breast ductal fluid from the mammary gland (12) of non-lactating females.
  • the pump has a number of features that overcome the deficiencies of the standard breast pump systems used for lactating females.
  • FIG. 1 shows one embodiment of the invention.
  • the pump has a substantially-rigid tubular structure (15) having a first opening (20) and a second opening (25).
  • the substantially-rigid tubular structure has at least one stimuli element (30 or 35) for delivering a stimulus to mammary gland (12).
  • One or more connector ports (60, 65, or 70) are present at the second end of the substantially-rigid tubular structure.
  • a pliable tubular structure (40) Nested within the substantially-rigid tubular structure (15) is a pliable tubular structure (40) having a first end (45) and a second end (50).
  • the pliable tubular structure (40) has areas of varying thickness (55) in the structure.
  • the pliable tubular structure (40) is attached at its first end (45) and its second end (25) to the wall (18) of the substantially-rigid tubular structure (15) to form a seal (e.g., a vacuum seal).
  • FIG. 2 shows the substantially-rigid tubular structure (15) in more detail.
  • the substantially-rigid tubular structure (15) has at least one wall (18) defining a first opening (20) and a second opening (25).
  • the substantially-rigid tubular structure has at least one stimuli element (30 or 35) coupled to the tubular structure (15) for delivering a stimulus to mammary gland (12).
  • One or more connector ports (60, 65, or 70) are present proximate the second opening of the substantially-rigid tubular structure (15).
  • substantially-rigid is meant that the material from which the structure is made is resistant to collapsing under pressure, such materials include, for example, polypropylene, polystyrene and others known to those of skill in the art or easily identified by those of skill in the art.
  • the substantially-rigid tubular structure (15) is tapered somewhat like a funnel, where the first opening (20) is broader and receives the mammary gland (12).
  • the second opening (25) may have at least one connector for connection to a vacuum (65), and connectors (60 or 70) for connection to stimuli element leads.
  • Stimuli elements (30 or 35) include for example, heating elements (30) and vibrating elements (35).
  • Such elements are useful in providing stimulus to the mammary gland of the female during the process of obtaining breast fluid.
  • the design of such elements include inner pouches molded in the funnel material filled with a liquid that is able to hold a heated temperature for a given period of time. In such instances the funnel can be warmed by preparation in a microwave oven, conventional oven, warm water bath, boiling water, solar power or other methods known in the art.
  • small heat elements may be coupled to the funnel or clipped on to the funnel.
  • Such elements include those used in heating blankets and similar devices.
  • the stimuli elements (30 or 35) can be coupled to the wall of the tubular structure (15) in any number of ways. For example, the elements (30 or 35) can be attached to the surface of the wall (18), embedded in the wall (18) or integrally formed within the wall (18) of the tubular structure (15).
  • FIG. 3 shows the pliable tubular structure (40) in more detail.
  • the pliable tubular structure has at least one wall (42) defining a first end (45) and a second end (50).
  • the wall (42) of the tubular structure (40) is capable of collapsing under pressure (e.g., vacuum pressure).
  • the tubular structure (40) typically will be larger at one end and tapered to the opposite end more or less in the shape of a funnel.
  • the wall (42) has a plurality of regions of varying thickness (55). These regions of varying thickness (55) are typically integral with the wall (42).
  • the regions of varying thickness (55) can be formed in any number of ways and include varying the thickness of the polymer material from which the wall (42) is made, by providing liquid filled regions within the wall (42), or by providing air filled regions within the wall (42). Other methods for creating regions of varying thickness (55) will be recognized by those of skill in the art.
  • the regions of varying thickness (55) are designed to collapse at a different pressure than the remainder of the wall (42). By varying the degree of collapse the degree of compression on the mammary gland can be modulated.
  • the second end (50) can be designed to be in vacuum communication with vacuum source, such as, for example, a hand held pump or portable pump or a wall vacuum with a regulator.
  • FIG. 4 diagrammatically shows the mammary gland funnel system (10) in use.
  • the funnel system (10) is aligned with the nipple and mammary gland (12) and is forcibly pressed inwardly towards the mammary gland (12) sufficient to cause the nipple to be inserted into the opening (45) of the pliable tubular structure (40).
  • the substantially-rigid tubular structure (15) provides sufficient resilience to prevent collapse under the pressure of forcing the funnel onto the mammary gland.
  • the pliable tubular structure (40) receives the nipple of the mammary gland (12) through opening (45).
  • the stimuli elements (30 or 35) may be activated prior to contact with the mammary gland (e.g., the funnel system (10) may be pre-warmed by a heating element (30)) or may be warmed after the funnel system (10) is contacted with the mammary gland (12).
  • the mammary gland e.g., the funnel system (10) may be pre-warmed by a heating element (30)
  • a heating element (30) may be warmed after the funnel system (10) is contacted with the mammary gland (12).
  • the ductal fluids (34) can be sampled through sampling port (32) using a capillary pipette, filter paper or other devices useful in obtaining or measuring a biological fluid sample.
  • the invention provides a mammary gland pad useful in removing keratin plugs present in the ducts of the mammary gland.
  • the pad can be of any shape, but typically will be of a shape that fits comfortably over the breast of a female. For example, where the female is human, the pad can be designed to fit within the brassier.
  • the pad has disposed within it a detergent solution, which may include other active ingredients (e.g., capsicum or other vasodilators), useful in removing keratin plugs and dilating nipple ducts.
  • a typical solution ratio will be about 1/8 teaspoon of baking soda per 1/2 cup of water.
  • Other detergent solutions will be readily identifiable in the art (e.g., liquid detergents such as IVORY).
  • the solution can be disposed in a pocket of the pad (as described more fully below) or integral to one or more layers of the pad.
  • the pad will typically be applied to the mammary gland, particularly the nipple of the mammary gland for about 10 minutes to 24 hours or for a sufficient time to assist in dissolving or removal of keratin plugs.
  • FIG. 5 is a diagram showing the mammary gland pad of the invention.
  • FIG 5 A shows a typical pad (80) comprising at least two walls. A first wall (100) and a second wall (200) are fixedly connected. The walls can be connected at their periphery or throughout the area of each wall. Where walls (100 and 200) are connected only at the periphery a pocket or pouch (230) is formed between the two walls. This pouch or pocket can be used to hold a detergent solution useful to remove keratin plugs. Alternatively, a detergent based solution can be integrally applied to the fibers or composite material (250) of at least one wall (200).
  • FIG. 5B shows the pad of the present invention during use.
  • Wall (200) is in contact with the mammary gland (12).
  • Wall (200) will typically contain or be permeable to liquids, and in particular permeable to a detergent solution, present within the pad.
  • Wall (100) may be impermeable to liquids to avoid staining or wetting of clothing or garments that may be in contact with the pad (80).
  • the walls of the pad (80) can be formed of any number of materials.
  • wall (100) will typically be formed of a thin thermoplastic film, such as polyethylene film, which is substantially impermeable to liquid. This functions to prevent the detergent solution contained in the pad from wetting or soiling the wearer's clothing, bedding, or other materials contacting pad.
  • the wall may be, for example, a polyethylene film having an initial thickness of from about 0.5 mil (0.012 millimeter) to about 5.0 mil (0.12 millimeter).
  • Other alternative constructions for the pad wall include woven or nonwoven fibrous webs that have been constructed or treated to impart the desired level of liquid impermeability, or laminates formed of a woven or nonwoven fabric and thermoplastic film.
  • the walls may optionally be composed of a vapor or gas permeable, microporous "breathable" material that is permeable to vapors or gas yet substantially impermeable to liquid.
  • Breathability can be imparted to polymer films by, for example, using fillers in the film polymer formulation, extruding the filler/polymer formulation into a film and then stretching the film sufficiently to create voids around the filler particles, thereby making the film breathable.
  • the more filler used and the higher the degree of stretching the greater the degree of breathability.
  • kits are provided, containing the mammary gland pad of the invention.
  • the pad of the invention is ideally suited for a kit for assisting in the removal of keratin plugs from the mammary gland.
  • a kit comprises a container containing a mammary gland pad containing a detergent based solution for application to the mammary gland of a female.
  • a kit of the invention contains one or more containers compartmentalized to hold a mammary gland pad and a mammary gland funnel system. The kit may further include instructions for use in obtaining mammary gland fluid from non-lactating females.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Pediatric Medicine (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne un entonnoir (10) de pompe mammaire, comprenant une structure tubulaire (40) pliable pourvue d'une pluralité de régions d'épaisseur (55) variable disposées dans ladite structure (40), de façon à produire une pression variable sur une glande mammaire (12) pendant son utilisation, et une structure tubulaire (15) sensiblement rigide, ladite structure (15) étant fixée de manière étanche à la structure tubulaire (40) pliable, et au moins un élément de stimulus (30, 35) couplé à au moins une paroi (18) de façon à produire sélectivement un stimulus sur une glande mammaire (12). L'invention concerne également un tampon (80) pour glande mammaire contenant une solution à base de détersif utile pour retirer les bouchons de kératine des canaux de glande mammaire et un dilatateur de canal tel qu'un capsicum.
PCT/US2000/003661 1999-02-12 2000-02-11 Technique d'utilisation detournee d'un dispositif dans un but de prevention du cancer canalaire du sein WO2000047247A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU32303/00A AU3230300A (en) 1999-02-12 2000-02-11 Bifurcated method for preventing breast ductal cancer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12021299P 1999-02-12 1999-02-12
US12041199P 1999-02-12 1999-02-12
US60/120,212 1999-02-12
US60/120,411 1999-02-12

Publications (1)

Publication Number Publication Date
WO2000047247A1 true WO2000047247A1 (fr) 2000-08-17

Family

ID=26818161

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/003661 WO2000047247A1 (fr) 1999-02-12 2000-02-11 Technique d'utilisation detournee d'un dispositif dans un but de prevention du cancer canalaire du sein

Country Status (2)

Country Link
AU (1) AU3230300A (fr)
WO (1) WO2000047247A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6328709B1 (en) 1998-11-13 2001-12-11 Pro Duct Health, Inc. Devices and methods to identify ductal orifices during nipple aspiration
WO2003066133A1 (fr) * 2002-02-07 2003-08-14 Medela Ag Cloche de tire-lait
EP1402056A2 (fr) * 2001-05-30 2004-03-31 Neomatrix, LLC. Criblage diagnostic a l'aide d'un fluide intracanalaire non-invasif
WO2007071093A1 (fr) * 2005-12-22 2007-06-28 Medela Holding Ag Bonnet pour sein
EP2130558A1 (fr) * 2000-11-13 2009-12-09 Ensisheim Partners LLC Procédés et dispositifs pour la collecte, la manipulation et le traitement d'échantillons liquides de mamelles pour évaluer les maladies mammaires y compris le cancer
WO2013066919A3 (fr) * 2011-10-31 2013-07-25 Zhang Henian Systèmes et procédés de protection de la santé des seins ou des mamelles
US8715225B2 (en) 2010-06-07 2014-05-06 Koninklijke Philips N.V. Breast pump

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3822703A (en) * 1973-02-13 1974-07-09 P Davisson Breast pump
US5476492A (en) * 1994-02-23 1995-12-19 Unrug; Sophia Body warmer for therapeutic purposes containing whole herb seed
US5576329A (en) * 1992-07-24 1996-11-19 Hennessey; Richard K. Method for treating tendon or joint inflammation with papaverine HCL
US5664984A (en) * 1996-05-08 1997-09-09 Laughridge; Nancy E. Brassiere having frontal moisture control
US5776177A (en) * 1992-12-21 1998-07-07 Macwhinnie; Virginia C-shaped heat pack for thermal treatment of breast
US5810796A (en) * 1996-01-10 1998-09-22 Kao Corporation Absorbent article
US5885246A (en) * 1995-02-16 1999-03-23 Cannon Rubber Limited Breast pump insert

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3822703A (en) * 1973-02-13 1974-07-09 P Davisson Breast pump
US5576329A (en) * 1992-07-24 1996-11-19 Hennessey; Richard K. Method for treating tendon or joint inflammation with papaverine HCL
US5776177A (en) * 1992-12-21 1998-07-07 Macwhinnie; Virginia C-shaped heat pack for thermal treatment of breast
US5476492A (en) * 1994-02-23 1995-12-19 Unrug; Sophia Body warmer for therapeutic purposes containing whole herb seed
US5885246A (en) * 1995-02-16 1999-03-23 Cannon Rubber Limited Breast pump insert
US5810796A (en) * 1996-01-10 1998-09-22 Kao Corporation Absorbent article
US5664984A (en) * 1996-05-08 1997-09-09 Laughridge; Nancy E. Brassiere having frontal moisture control

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6328709B1 (en) 1998-11-13 2001-12-11 Pro Duct Health, Inc. Devices and methods to identify ductal orifices during nipple aspiration
EP2130558A1 (fr) * 2000-11-13 2009-12-09 Ensisheim Partners LLC Procédés et dispositifs pour la collecte, la manipulation et le traitement d'échantillons liquides de mamelles pour évaluer les maladies mammaires y compris le cancer
EP1402056A2 (fr) * 2001-05-30 2004-03-31 Neomatrix, LLC. Criblage diagnostic a l'aide d'un fluide intracanalaire non-invasif
EP1402056A4 (fr) * 2001-05-30 2009-04-08 Neomatrix Llc Criblage diagnostic a l'aide d'un fluide intracanalaire non-invasif
WO2003066133A1 (fr) * 2002-02-07 2003-08-14 Medela Ag Cloche de tire-lait
WO2003066132A1 (fr) * 2002-02-07 2003-08-14 Medela Ag Embout tire-lait
US8597234B2 (en) 2002-02-07 2013-12-03 Medela Ag Breast shield with sensor
WO2007071093A1 (fr) * 2005-12-22 2007-06-28 Medela Holding Ag Bonnet pour sein
US8052634B2 (en) 2005-12-22 2011-11-08 Medela Holding Ag Breast shield
US8715225B2 (en) 2010-06-07 2014-05-06 Koninklijke Philips N.V. Breast pump
WO2013066919A3 (fr) * 2011-10-31 2013-07-25 Zhang Henian Systèmes et procédés de protection de la santé des seins ou des mamelles

Also Published As

Publication number Publication date
AU3230300A (en) 2000-08-29

Similar Documents

Publication Publication Date Title
JP6832845B2 (ja) 点滴を伴う動的陰圧療法
US7108683B2 (en) Wound therapy and tissue management system and method with fluid differentiation
JP5267962B2 (ja) 負圧創傷療法において連続的排出を提供するシステム
CA1313804C (fr) Tire-lait
US10016566B2 (en) Systems and methods for maintaining breast or udder health
US9125770B2 (en) Portable, adjustable disposable medical suction system and method of use
CN106176188B (zh) 一种多功能中药熏蒸治疗仪
WO2000047247A1 (fr) Technique d'utilisation detournee d'un dispositif dans un but de prevention du cancer canalaire du sein
US20220296271A1 (en) Micro-lipo needle devices and use thereof
JP7618180B2 (ja) 液体用収集器
US3281864A (en) Portable bathing appliance for therapeutic use
CN204219476U (zh) 一体式一次性多功能吸痰装置
WO2022029509A1 (fr) Collecteur pour liquides
CN104644333B (zh) 一种用于贮存伤口渗出液的集液装置及负压治疗设备
CN107296729A (zh) 女性阴道按摩手套
CN217067182U (zh) 一种全密闭式吸脂罐
CN206700383U (zh) 一种妇科护理清洗器
CN208319699U (zh) 中药湿敷药袋
CN211024392U (zh) 一种树鼩自动吸奶器
CN112220654A (zh) 中医理疗仪主机
WO1999021521A1 (fr) Systeme de prelevements dans la cavite vaginale
CN212327086U (zh) 一种消化内科用灌肠器
CN220158720U (zh) 一种中药熏蒸治疗器
CN215230332U (zh) 注射富血小板血浆来源性外泌体的给药设备
CN201295421Y (zh) 一次性灌肠包

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载