WO2000042995A3 - Derives anticonvulsivants utiles dans le traitement de la migraine dite transformee - Google Patents
Derives anticonvulsivants utiles dans le traitement de la migraine dite transformee Download PDFInfo
- Publication number
- WO2000042995A3 WO2000042995A3 PCT/US2000/001382 US0001382W WO0042995A3 WO 2000042995 A3 WO2000042995 A3 WO 2000042995A3 US 0001382 W US0001382 W US 0001382W WO 0042995 A3 WO0042995 A3 WO 0042995A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- anticonvulsant derivatives
- transformed migraine
- hydrogen
- treating transformed
- Prior art date
Links
- 208000019695 Migraine disease Diseases 0.000 title abstract 2
- 230000001773 anti-convulsant effect Effects 0.000 title abstract 2
- 239000001961 anticonvulsive agent Substances 0.000 title abstract 2
- 229960003965 antiepileptics Drugs 0.000 title abstract 2
- 206010027599 migraine Diseases 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052760 oxygen Chemical group 0.000 abstract 2
- 239000001301 oxygen Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002009 alkene group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 methylenedioxy group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'invention concerne des dérivés anticonvulsivants, utiles dans le traitement de la migraine dite transformée.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU35826/00A AU3582600A (en) | 1999-01-21 | 2000-01-20 | Anticonvulsant derivatives useful in treating transformed migraine |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11654499P | 1999-01-21 | 1999-01-21 | |
| US60/116,544 | 1999-01-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2000042995A2 WO2000042995A2 (fr) | 2000-07-27 |
| WO2000042995A3 true WO2000042995A3 (fr) | 2000-11-30 |
Family
ID=22367829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2000/001382 WO2000042995A2 (fr) | 1999-01-21 | 2000-01-20 | Derives anticonvulsivants utiles dans le traitement de la migraine dite transformee |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR022321A1 (fr) |
| AU (1) | AU3582600A (fr) |
| WO (1) | WO2000042995A2 (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY147767A (en) | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| EA200702558A1 (ru) | 2005-05-20 | 2008-06-30 | Янссен Фармацевтика Н. В. | Способ получения производных сульфамида |
| US8492431B2 (en) | 2005-12-19 | 2013-07-23 | Janssen Pharmaceutica, N.V. | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity |
| US8691867B2 (en) | 2005-12-19 | 2014-04-08 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction |
| US8716231B2 (en) | 2005-12-19 | 2014-05-06 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain |
| US8497298B2 (en) | 2005-12-19 | 2013-07-30 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels |
| US8937096B2 (en) | 2005-12-19 | 2015-01-20 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder |
| JP2009537635A (ja) | 2006-05-19 | 2009-10-29 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 癲癇の処置のための共同−療法 |
| MX2011000090A (es) | 2008-06-23 | 2011-03-02 | Janssen Pharmaceutica Nv | Forma cristalina de (2s)-(-)-n-(6-cloro-2,3-dihidro-benzo[1,4]diox in-2-ilmetil)sulfamida. |
| US8815939B2 (en) | 2008-07-22 | 2014-08-26 | Janssen Pharmaceutica Nv | Substituted sulfamide derivatives |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| CN110346004B (zh) * | 2019-08-16 | 2020-08-21 | 杭州山科智能科技股份有限公司 | 一种双声道超声时差法的流量测量数据融合方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4513006A (en) * | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| WO1997013510A1 (fr) * | 1995-10-13 | 1997-04-17 | New England Medical Center Hospitals, Inc. | Traitement de la migraine |
| WO1998015270A1 (fr) * | 1996-10-08 | 1998-04-16 | Ortho Pharmaceutical Corporation | Derives d'anticonvulsifs utiles dans le traitement de la douleur neuropathique |
-
2000
- 2000-01-20 AU AU35826/00A patent/AU3582600A/en not_active Abandoned
- 2000-01-20 WO PCT/US2000/001382 patent/WO2000042995A2/fr active Application Filing
- 2000-01-20 AR ARP000100250A patent/AR022321A1/es unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4513006A (en) * | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| WO1997013510A1 (fr) * | 1995-10-13 | 1997-04-17 | New England Medical Center Hospitals, Inc. | Traitement de la migraine |
| WO1998015270A1 (fr) * | 1996-10-08 | 1998-04-16 | Ortho Pharmaceutical Corporation | Derives d'anticonvulsifs utiles dans le traitement de la douleur neuropathique |
Non-Patent Citations (5)
| Title |
|---|
| KUZNIECKY R ET AL: "Topiramate increases cerebral GABA in healthy humans.", NEUROLOGY, (1998 AUG) 51 (2) 627-9., XP000923467 * |
| ROTHROCK, J. F. (1) ET AL: "A differential response to treatment with divalproex sodium in patients with intractable headache.", CEPHALALGIA, (1994) VOL. 14, NO. 3, PP. 241-244., XP000924812 * |
| SHUAIB A (REPRINT) ET AL: "Topiramate in migraine prophylaxis: a pilot study.", CEPHALALGIA, (MAY 1999) VOL. 19, NO. 4, PP. 379-380. PUBLISHER: SCANDINAVIAN UNIVERSITY PRESS, PO BOX 2959 TOYEN, JOURNAL DIVISION CUSTOMER SERVICE, N-0608 OSLO, NORWAY. ISSN: 0333-1024., UNIV ALBERTA, EDMONTON, AB T6G 2M7, CANADA, XP000923377 * |
| STOREY, JAMES R. (1) ET AL: "Potential role of topiramate (TPM) in the treatment of intractable daily headache: A retrospective pilot study.", NEUROLOGY, (APRIL 12, 1999) VOL. 52, NO. 6 SUPPL. 2, PP. A211. MEETING INFO.: 51ST ANNUAL MEETING OF THE AMERICAN ACADEMY OF NEUROLOGY TORONTO, ONTARIO, CANADA APRIL 17-24, 1999 AMERICAN ACADEMY OF NEUROLOGY., XP000921300 * |
| TRAN, BIHN N. (1) ET AL: "Can valproate prevent migraine headaches.", JOURNAL OF PHARMACY TECHNOLOGY, (1997) VOL. 13, NO. 4, PP. 163-168., XP000925386 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000042995A2 (fr) | 2000-07-27 |
| AU3582600A (en) | 2000-08-07 |
| AR022321A1 (es) | 2002-09-04 |
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