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WO2000040711A3 - Polycystic kidney disease gene homologs required for male mating behavior in nematodes and assays based thereon - Google Patents

Polycystic kidney disease gene homologs required for male mating behavior in nematodes and assays based thereon Download PDF

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Publication number
WO2000040711A3
WO2000040711A3 PCT/US2000/000521 US0000521W WO0040711A3 WO 2000040711 A3 WO2000040711 A3 WO 2000040711A3 US 0000521 W US0000521 W US 0000521W WO 0040711 A3 WO0040711 A3 WO 0040711A3
Authority
WO
WIPO (PCT)
Prior art keywords
genes
polycystic kidney
nematodes
involved
diseases
Prior art date
Application number
PCT/US2000/000521
Other languages
French (fr)
Other versions
WO2000040711A8 (en
WO2000040711A2 (en
Inventor
Paul W Sternberg
Maureen M Barr
Original Assignee
California Inst Of Techn
Paul W Sternberg
Maureen M Barr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn, Paul W Sternberg, Maureen M Barr filed Critical California Inst Of Techn
Priority to AU24974/00A priority Critical patent/AU2497400A/en
Publication of WO2000040711A2 publication Critical patent/WO2000040711A2/en
Publication of WO2000040711A3 publication Critical patent/WO2000040711A3/en
Publication of WO2000040711A8 publication Critical patent/WO2000040711A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/60—New or modified breeds of invertebrates
    • A01K67/61—Genetically modified invertebrates, e.g. transgenic or polyploid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • C07K14/4354—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes
    • C07K14/43545—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes from Caenorhabditis
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Nematodes, such as Caenorhabditis elegans, that express mutant and wild-type orthologs of human genes involved in polycystic kidney diseases (PKDs), are used to study the functions of the proteins encoded by the genes, to screen for other genes involved in the diseases, to identify mutations involved in the diseases, and to screen for drugs that affect PKD. Behaviors controlled by the action of the genes or gene products are identified and used in the assays. Hence an animal model is provided that permits study of the etiology of polycystic kidney disease and provides a tool to identify the genes involved in the disease pathway, and to identify compounds that may be used to treat or alter the disease progression, lessen its severity or ameliorate symptoms. The nematode genes that encode protein products, mutants of the genes, vectors contain the genes and mutant genes and nematode strains that contain the vectors are also provided.
PCT/US2000/000521 1999-01-06 2000-01-06 Polycystic kidney disease gene homologs required for male mating behavior in nematodes and assays based thereon WO2000040711A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU24974/00A AU2497400A (en) 1999-01-06 2000-01-06 Polycystic kidney disease gene homologs required for male mating behavior in nematodes and assays based thereon

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11512799P 1999-01-06 1999-01-06
US60/115,127 1999-01-06

Publications (3)

Publication Number Publication Date
WO2000040711A2 WO2000040711A2 (en) 2000-07-13
WO2000040711A3 true WO2000040711A3 (en) 2000-09-21
WO2000040711A8 WO2000040711A8 (en) 2000-11-23

Family

ID=22359444

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/000521 WO2000040711A2 (en) 1999-01-06 2000-01-06 Polycystic kidney disease gene homologs required for male mating behavior in nematodes and assays based thereon

Country Status (2)

Country Link
AU (1) AU2497400A (en)
WO (1) WO2000040711A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063427A2 (en) * 1999-04-15 2000-10-26 Devgen Nv Compound screening method
GB9912748D0 (en) * 1999-06-01 1999-08-04 Devgen Nv PKD constructs and screening methods
EP1283271A1 (en) * 2001-08-10 2003-02-12 Elegene AG Method of screening compounds using nematode worms

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995034573A1 (en) * 1994-06-03 1995-12-21 Brigham And Women's Hospital Identification of polycystic kidney disease gene, diagnostics and treatment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995034573A1 (en) * 1994-06-03 1995-12-21 Brigham And Women's Hospital Identification of polycystic kidney disease gene, diagnostics and treatment
US5891628A (en) * 1994-06-03 1999-04-06 Brigham And Women's Hospital Identification of polycystic kidney disease gene, diagnostics and treatment

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BARR MAUREEN M ET AL: "A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans.", NATURE (LONDON) SEPT. 23, 1999, vol. 401, no. 6751, pages 386 - 389, XP000913751, ISSN: 0028-0836 *
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 1 March 1995 (1995-03-01), HINXTON, GB, XP002140194 *
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 1 November 1996 (1996-11-01), HINXTON, GB, XP002140195 *
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 9 November 1999 (1999-11-09), HINXTON, GB, XP002140196 *
LIU KATHARINE S AND STERNBERG PAUL W: "Sensory regulation of male mating behaviour in Caenorhabditis elegans", NEURON, vol. 14, 1995, pages 79 - 89, XP000913892 *
MOCHIZUKI T ET AL: "PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, vol. 272, 31 May 1996 (1996-05-31), pages 1339 - 1342, XP002120869, ISSN: 0036-8075 *

Also Published As

Publication number Publication date
AU2497400A (en) 2000-07-24
WO2000040711A8 (en) 2000-11-23
WO2000040711A2 (en) 2000-07-13

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