+

WO1999039740A8 - Sensibilisation de cellules a des composes utilisant un apport de gene et de compose induit par lipides - Google Patents

Sensibilisation de cellules a des composes utilisant un apport de gene et de compose induit par lipides

Info

Publication number
WO1999039740A8
WO1999039740A8 PCT/CA1999/000089 CA9900089W WO9939740A8 WO 1999039740 A8 WO1999039740 A8 WO 1999039740A8 CA 9900089 W CA9900089 W CA 9900089W WO 9939740 A8 WO9939740 A8 WO 9939740A8
Authority
WO
WIPO (PCT)
Prior art keywords
lipid
compounds
mediated gene
compound delivery
sensitizing cells
Prior art date
Application number
PCT/CA1999/000089
Other languages
English (en)
Other versions
WO1999039740A9 (fr
WO1999039740A2 (fr
WO1999039740A3 (fr
Inventor
Ian Maclachlan
Roger W Graham
Susan S Buchkowsky
Original Assignee
Inex Pharmaceuticals Corp
Ian Maclachlan
Roger W Graham
Susan S Buchkowsky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27535971&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1999039740(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Inex Pharmaceuticals Corp, Ian Maclachlan, Roger W Graham, Susan S Buchkowsky filed Critical Inex Pharmaceuticals Corp
Priority to JP2000530237A priority Critical patent/JP2002528381A/ja
Priority to AU24056/99A priority patent/AU754611B2/en
Priority to EP99903556A priority patent/EP1053022A2/fr
Priority to CA002319468A priority patent/CA2319468A1/fr
Publication of WO1999039740A2 publication Critical patent/WO1999039740A2/fr
Publication of WO1999039740A8 publication Critical patent/WO1999039740A8/fr
Publication of WO1999039740A3 publication Critical patent/WO1999039740A3/fr
Publication of WO1999039740A9 publication Critical patent/WO1999039740A9/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention a trait à des méthodes et des compositions de sensibilisation d'une cellule à un composé tel qu'un promédicament.
PCT/CA1999/000089 1998-02-03 1999-02-03 Sensibilisation de cellules a des composes utilisant un apport de gene et de compose induit par lipides WO1999039740A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000530237A JP2002528381A (ja) 1998-02-03 1999-02-03 脂質媒介式の遺伝子及び化合物導入を利用する化合物に対する細胞の感作
AU24056/99A AU754611B2 (en) 1998-02-03 1999-02-03 Sensitizing cells to compounds using lipid-mediated gene and compound delivery
EP99903556A EP1053022A2 (fr) 1998-02-03 1999-02-03 Sensibilisation de cellules a des composes utilisant un apport de gene et de compose induit par lipides
CA002319468A CA2319468A1 (fr) 1998-02-03 1999-02-03 Sensibilisation de cellules a des composes utilisant un apport de gene et de compose induit par lipides

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US7359898P 1998-02-03 1998-02-03
US8691798P 1998-05-27 1998-05-27
US10142998P 1998-09-22 1998-09-22
US11238498P 1998-12-14 1998-12-14
US24310299A 1999-02-02 1999-02-02
US60/101,429 1999-02-02
US60/112,384 1999-02-02
US09/243,102 1999-02-02
US60/086,917 1999-02-02
US60/073,598 1999-02-02

Publications (4)

Publication Number Publication Date
WO1999039740A2 WO1999039740A2 (fr) 1999-08-12
WO1999039740A8 true WO1999039740A8 (fr) 1999-09-23
WO1999039740A3 WO1999039740A3 (fr) 1999-10-28
WO1999039740A9 WO1999039740A9 (fr) 1999-11-25

Family

ID=27535971

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/CA1999/000089 WO1999039740A2 (fr) 1998-02-03 1999-02-03 Sensibilisation de cellules a des composes utilisant un apport de gene et de compose induit par lipides
PCT/CA1999/000090 WO1999039741A2 (fr) 1998-02-03 1999-02-03 Administration systemique de particules lipidiques du plasmide stables dans le serum en cancerotherapie

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/CA1999/000090 WO1999039741A2 (fr) 1998-02-03 1999-02-03 Administration systemique de particules lipidiques du plasmide stables dans le serum en cancerotherapie

Country Status (7)

Country Link
EP (1) EP1053023B2 (fr)
JP (1) JP2002502831A (fr)
AT (1) ATE366121T1 (fr)
AU (1) AU749881B2 (fr)
CA (2) CA2319468A1 (fr)
DE (1) DE69936444T3 (fr)
WO (2) WO1999039740A2 (fr)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002500201A (ja) 1998-01-05 2002-01-08 ユニバーシティ オブ ワシントン 膜破壊剤を使用する増強された輸送
EP1459761A4 (fr) * 2001-06-08 2005-04-13 Fourth Military Medical Univ Kit pharmaceutique comprenant une proteine de fusion carboxypeptidase humaine dirigee contre un anticorps a chaine simple de proteine plasmatique seminale et promedicament
WO2003049764A1 (fr) 2001-12-12 2003-06-19 Fh Faulding & Co Limited Composition de preservation virale
US7893033B2 (en) 2002-05-06 2011-02-22 Board Of Regents, The University Of Texas System Targeting proteins to deliver therapeutic or diagnostic reagents
WO2018081480A1 (fr) 2016-10-26 2018-05-03 Acuitas Therapeutics, Inc. Formulations de nanoparticules lipidiques
JP7162021B2 (ja) 2017-03-17 2022-10-27 ニューカッスル ユニバーシティ 筋ジストロフィーを治療するためのマイクロジストロフィン断片のアデノ随伴ウイルスベクター送達
WO2018191719A1 (fr) 2017-04-13 2018-10-18 Acuitas Therapeutics, Inc. Administration lipidique d'agents thérapeutiques au tissu adipeux
WO2019089828A1 (fr) 2017-10-31 2019-05-09 Acuitas Therapeutics, Inc. Nanoparticules lipidiques lamellaires
US12329857B2 (en) 2018-09-21 2025-06-17 Acuitas Therapeutics, Inc. Systems and methods for manufacturing lipid nanoparticles and liposomes
PL4013385T3 (pl) 2019-08-14 2024-11-18 Acuitas Therapeutics, Inc. Ulepszone nanocząstki lipidowe do dostarczania kwasów nukleinowych
US20240043527A1 (en) 2020-03-30 2024-02-08 BioNTech SE Rna compositions targeting claudin-18.2
TW202208630A (zh) 2020-06-15 2022-03-01 美國全美兒童醫院之研究學會 針對肌肉營養不良症的腺相關病毒載體遞送
EP4319803A1 (fr) 2021-04-08 2024-02-14 Vaxthera SAS Vaccin à coronavirus comprenant une protéine mosaïque
WO2023023055A1 (fr) 2021-08-16 2023-02-23 Renagade Therapeutics Management Inc. Compositions et procédés d'optimisation du tropisme de systèmes d'administration d'arn
EP4402123A1 (fr) 2021-09-14 2024-07-24 Renagade Therapeutics Management Inc. Lipides cycliques et leurs procédés d'utilisation
CN118317944A (zh) 2021-09-14 2024-07-09 雷纳嘉德医疗管理公司 非环状脂质及其使用方法
EP4426832A1 (fr) 2021-11-03 2024-09-11 The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone Édition précise du génome à l'aide de rétrons
MX2024005970A (es) 2021-11-16 2024-08-09 Sail Biomedicines Inc Lípidos ionizables y nanopartículas lipídicas novedosos ymétodos para usarlos.
KR20240128683A (ko) 2021-11-22 2024-08-26 세일 바이오메디슨스, 인크. 신규한 이온화 가능 지질 및 지질 나노입자, 및 이를 사용하는 방법
WO2023122752A1 (fr) 2021-12-23 2023-06-29 Renagade Therapeutics Management Inc. Lipides contraints et procédés d'utilisation associés
WO2023141602A2 (fr) 2022-01-21 2023-07-27 Renagade Therapeutics Management Inc. Rétrons modifiés et méthodes d'utilisation
WO2023147090A1 (fr) 2022-01-27 2023-08-03 BioNTech SE Compositions pharmaceutiques pour administration d'antigènes du virus herpès simplex et méthodes associées
KR20240166554A (ko) 2022-03-25 2024-11-26 세일 바이오메디슨스, 인크. 신규한 이온화 가능 지질 및 지질 나노입자, 및 이를 사용하는 방법
WO2023196931A1 (fr) 2022-04-07 2023-10-12 Renagade Therapeutics Management Inc. Lipides cycliques et nanoparticules lipidiques (npl) pour l'apport d'acides nucléiques ou de peptides destinés à être utilisés dans la vaccination contre des agents infectieux
WO2023218431A1 (fr) 2022-05-13 2023-11-16 BioNTech SE Compositions d'arn ciblant le vih
AU2023277551A1 (en) 2022-05-25 2024-12-05 BioNTech SE Rna compositions for delivery of monkeypox antigens and related methods
EP4518845A1 (fr) 2022-05-30 2025-03-12 BioNTech SE Complexes pour l'administration d'acides nucléiques
AU2023334610A1 (en) 2022-08-31 2025-03-13 Sail Biomedicines, Inc. Novel ionizable lipids and lipid nanoparticles and methods of using the same
WO2024063788A1 (fr) 2022-09-23 2024-03-28 BioNTech SE Compositions pour l'administration d'antigènes du paludisme et méthodes associées
IL319414A (en) 2022-09-23 2025-05-01 BioNTech SE Compositions for delivering antigens at the liver level and related methods
CN120152736A (zh) 2022-09-23 2025-06-13 生物技术欧洲股份公司 用于递送疟原虫csp抗原的组合物及相关方法
WO2024063789A1 (fr) 2022-09-23 2024-03-28 BioNTech SE Compositions pour l'administration d'antigènes du paludisme et méthodes associées
WO2024074634A1 (fr) 2022-10-06 2024-04-11 BioNTech SE Compositions d'arn ciblant la claudine 18.2
WO2024074211A1 (fr) 2022-10-06 2024-04-11 BioNTech SE Compositions d'arn ciblant la claudine-18.2
WO2024141955A1 (fr) 2022-12-28 2024-07-04 BioNTech SE Compositions d'arn ciblant le vih
WO2024229309A2 (fr) 2023-05-03 2024-11-07 Manifold Biotechnologies, Inc. Procedes et compositions pour la distribution, le criblage et la detection de proteines a haut rendement
WO2024228044A1 (fr) 2023-05-03 2024-11-07 BioNTech SE Variants de csp optimisés et méthodes associées
WO2024228150A1 (fr) 2023-05-03 2024-11-07 BioNTech SE Variants de csp optimisés et méthodes associées
WO2025024324A1 (fr) 2023-07-21 2025-01-30 BioNTech SE Compositions d'administration d'antigènes de plasmodium et méthodes associées
WO2025024335A2 (fr) 2023-07-21 2025-01-30 BioNTech SE Compositions pour l'administration d'antigènes de plasmodium et méthodes associées
WO2025024337A1 (fr) 2023-07-24 2025-01-30 BioNTech SE Compositions pour l'administration d'antigènes de plasmodium et méthodes associées
WO2025027089A1 (fr) 2023-08-01 2025-02-06 BioNTech SE Thioplipides ionisables et leurs utilisations
WO2025026545A1 (fr) 2023-08-01 2025-02-06 BioNTech SE Thioplipides ionisables et utilisations associées
WO2025027576A2 (fr) 2023-08-03 2025-02-06 BioNTech SE Compositions d'arn ciblant le vih
WO2025027579A2 (fr) 2023-08-03 2025-02-06 BioNTech SE Compositions d'arn ciblant le vih
WO2025030154A1 (fr) 2023-08-03 2025-02-06 The Trustees Of The University Of Pennsylvania Compositions pharmaceutiques pour l'administration d'antigènes de glycoprotéine b du virus herpès simplex et méthodes associées
WO2025030097A2 (fr) 2023-08-03 2025-02-06 BioNTech SE Compositions pharmaceutiques pour l'administration d'antigènes du virus de l'herpès simplex et méthodes associées
WO2025054556A1 (fr) 2023-09-07 2025-03-13 BioNTech SE Compositions d'arn pour l'administration d'antigènes de mpox et méthodes associées
WO2025056938A1 (fr) 2023-09-11 2025-03-20 BioNTech SE Compositions d'arn pour l'administration d'agents d'incrétine
WO2025057088A1 (fr) 2023-09-11 2025-03-20 BioNTech SE Compositions d'arn pour administration d'agents d'incrétine
WO2025064850A1 (fr) 2023-09-22 2025-03-27 BioNTech SE Constructions d'arn avec des dégrons n-terminaux pour améliorer une réponse immunitaire
WO2025081042A1 (fr) 2023-10-12 2025-04-17 Renagade Therapeutics Management Inc. Système d'édition de précision basé sur un modèle de nickase-rétron et méthodes d'utilisation
KR20250071877A (ko) 2023-11-15 2025-05-22 바이오엔테크 에스이 Sars-cov-2 면역원성 조성물
WO2025106754A1 (fr) 2023-11-15 2025-05-22 BioNTech SE Vaccin anti-coronavirus
WO2025124711A1 (fr) 2023-12-13 2025-06-19 BioNTech SE Compositions de glycolipides

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
ATE157012T1 (de) * 1989-11-03 1997-09-15 Univ Vanderbilt Verfahren zur in vivo-verabreichung von funktionsfähigen fremden genen
US5676954A (en) 1989-11-03 1997-10-14 Vanderbilt University Method of in vivo delivery of functioning foreign genes
US6001644A (en) 1991-12-17 1999-12-14 The Regents Of The University Of California Mammalian transformation complex comprising a lipid carrier and DNA encoding CFTR
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
WO1993024640A2 (fr) 1992-06-04 1993-12-09 The Regents Of The University Of California PROCEDES ET COMPOSITIONS UTILISES DANS UNE THERAPIE GENIQUE $i(IN VIVO)
CA2169635C (fr) * 1993-08-26 2002-11-12 Dennis A. Carson Methode, compositions et dispositifs pour administrer des polynucleotides nus codant des peptides biologiquement actifs
US5631236A (en) * 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
AU692865B2 (en) 1994-04-26 1998-06-18 Children's Medical Center Corporation Angiostatin and method of use for inhibition of angiogenesis
GB9415167D0 (en) 1994-07-27 1994-09-14 Springer Caroline J Improvements relating to cancer therapy
GB9501052D0 (en) 1995-01-19 1995-03-08 Cancer Res Campaign Tech Improvements relating to prodrugs
US7517858B1 (en) * 1995-06-07 2009-04-14 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability
US5705385A (en) 1995-06-07 1998-01-06 Inex Pharmaceuticals Corporation Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
ATE285477T1 (de) * 1995-06-07 2005-01-15 Inex Pharmaceutical Corp Herstellung von lipid-nukleinsäure partikeln duch ein hydrophobische lipid-nukleinsäuree komplexe zwischenprodukt und zur verwendung in der gentransfer
GB9517001D0 (en) 1995-08-18 1995-10-18 Denny William Enediyne compounds
DE69629826T2 (de) 1995-10-23 2004-07-01 Children's Medical Center Corp., Boston Therapeutische antiangiogenische zusammensetzungen und verfahren
GB9523703D0 (en) 1995-11-20 1996-01-24 Wellcome Found Enzyme prodrug thearapy
US6347397B1 (en) 1999-03-29 2002-02-12 International Business Machines Corporation System, method, and program for providing an object-oriented install architecture
US8266598B2 (en) 2008-05-05 2012-09-11 Microsoft Corporation Bounding resource consumption using abstract interpretation

Also Published As

Publication number Publication date
AU2405799A (en) 1999-08-23
ATE366121T1 (de) 2007-07-15
WO1999039741A2 (fr) 1999-08-12
EP1053023A2 (fr) 2000-11-22
WO1999039740A9 (fr) 1999-11-25
EP1053023B2 (fr) 2011-03-30
CA2321837C (fr) 2011-08-16
WO1999039741A3 (fr) 1999-09-30
DE69936444T2 (de) 2008-03-20
DE69936444T3 (de) 2012-05-10
CA2319468A1 (fr) 1999-08-12
CA2321837A1 (fr) 1999-08-12
AU749881B2 (en) 2002-07-04
JP2002502831A (ja) 2002-01-29
WO1999039740A2 (fr) 1999-08-12
WO1999039740A3 (fr) 1999-10-28
DE69936444D1 (de) 2007-08-16
EP1053023B1 (fr) 2007-07-04

Similar Documents

Publication Publication Date Title
WO1999039740A3 (fr) Sensibilisation de cellules a des composes utilisant un apport de gene et de compose induit par lipides
AU5420699A (en) Compositions suitable for electrochemical cells
AU3826999A (en) Compositions suitable for electrochemical cells
BG106440A (en) Nitrogen-heterocyclic derivatives as nos inhibitors
AU2002360320A1 (en) Active material for fuel cell anodes incorporating an additive for precharging/activation thereof
AU2001245972A1 (en) N-heterocyclic derivatives as nos inhibitors
MY142109A (en) Pyrimidine derivatives for the treatment of abnormal cell growth
AU3369499A (en) Phosphorus compounds as corrosion inhibitors for perfluoropolyethers
TW200607801A (en) Pyrimidine derivatives for the treatment of abnormal cell growth
AU6864600A (en) Fuel cell
AU2003228678A1 (en) 1-substituted imidazole derivatives as nos inhibitors
AU751122C (en) Fuel compositions containing propoxilate
AUPP818099A0 (en) New n-containing heterocyclic compounds
AU2002334658A1 (en) Fuel additives for fuel cell
WO1999059572A8 (fr) Compositions solides contenant des derives de l'acide gamma-aminobutyrique, et procede de preparation associe
AU2003235340A1 (en) Separator for fuel cell
AU2002335219A1 (en) Coating material for fuel cell separator
AU2003281013A1 (en) Composition for antireflection film formation
AU2003291869A1 (en) Fuel compositions
AU2251901A (en) Methods and compounds for inhibiting MRP1
WO2002020017A3 (fr) Utilisation de l'ectoine ou de derives de l'ectoine pour la stabilisation du p53
AU2001261732A1 (en) Composition for delivery of compounds to cells
AU5064900A (en) Herbicidal compositions for paddy fields
AU4800800A (en) Fuel compositions
WO2003080631A8 (fr) Inhibiteurs de plasma carboxypeptidase b

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: C1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: PAT. BUL. 32/99 UNDER (30) REPLACE "09/243104" BY "09/243102"

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: C2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: C2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

COP Corrected version of pamphlet

Free format text: PAGES 1/19-19/19, DRAWINGS, REPLACED BY NEW PAGES 1/18-18/18; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref document number: 2319468

Country of ref document: CA

Kind code of ref document: A

Ref document number: 2319468

WWE Wipo information: entry into national phase

Ref document number: 1999903556

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 24056/99

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 1999903556

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 24056/99

Country of ref document: AU

WWW Wipo information: withdrawn in national office

Ref document number: 1999903556

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载