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WO1999039743A3 - Method of promoting hepatic cell proliferation - Google Patents

Method of promoting hepatic cell proliferation Download PDF

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Publication number
WO1999039743A3
WO1999039743A3 PCT/US1999/002618 US9902618W WO9939743A3 WO 1999039743 A3 WO1999039743 A3 WO 1999039743A3 US 9902618 W US9902618 W US 9902618W WO 9939743 A3 WO9939743 A3 WO 9939743A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell proliferation
hepatic cell
analogues
aii
promoting hepatic
Prior art date
Application number
PCT/US1999/002618
Other languages
French (fr)
Other versions
WO1999039743A2 (en
Inventor
Kathleen E Rodgers
Gere Dizerega
Original Assignee
Univ Southern California
Kathleen E Rodgers
Gere Dizerega
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Southern California, Kathleen E Rodgers, Gere Dizerega filed Critical Univ Southern California
Priority to AU25903/99A priority Critical patent/AU2590399A/en
Publication of WO1999039743A2 publication Critical patent/WO1999039743A2/en
Publication of WO1999039743A3 publication Critical patent/WO1999039743A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/085—Angiotensins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/32—Angiotensins [AT], angiotensinogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention provides methods, improved cell culture medium and kits for promoting hepatic cell proliferation and differentiation by growth in the presence of angiotensinogen, AI, AI anoalogues, and/or AI fragments and analogues thereof, AII analogues, AII fragments or analogues thereof, and/or AII AT2 type 2 receptor agonists, either alone or in combination with other growth factors and cytokines.
PCT/US1999/002618 1998-02-09 1999-02-08 Method of promoting hepatic cell proliferation WO1999039743A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU25903/99A AU2590399A (en) 1998-02-09 1999-02-08 Method of promoting hepatic cell proliferation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7410498P 1998-02-09 1998-02-09
US60/074,104 1998-02-09
US10841298P 1998-11-13 1998-11-13
US60/108,412 1998-11-13

Publications (2)

Publication Number Publication Date
WO1999039743A2 WO1999039743A2 (en) 1999-08-12
WO1999039743A3 true WO1999039743A3 (en) 1999-09-30

Family

ID=26755260

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/002618 WO1999039743A2 (en) 1998-02-09 1999-02-08 Method of promoting hepatic cell proliferation

Country Status (2)

Country Link
AU (1) AU2590399A (en)
WO (1) WO1999039743A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3376300A (en) * 1999-02-26 2000-09-14 University Of Pittsburgh Bone marrow transplantation for hepatic regeneration and repair
US6730775B1 (en) 1999-03-23 2004-05-04 University Of Southern California Methods for limiting scar and adhesion formation
DK1395566T3 (en) 2001-05-31 2008-01-07 Vicore Pharma Ab Tricyclic compounds useful as angiotensin II agonists
EP2455388A1 (en) 2010-11-23 2012-05-23 LanthioPep B.V. Novel angiotensin type 2 (AT2) receptor agonists and uses thereof.
JP2022542437A (en) 2019-08-02 2022-10-03 ランティオペプ ベスローテン ヴェンノーツハップ Angiotensin type 2 (AT2) receptor agonists for treating cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014858A1 (en) * 1994-11-14 1996-05-23 University Of Southern California Use of angiotensin ii fragments and analogs thereof in tissue repair
WO1996039164A1 (en) * 1995-06-06 1996-12-12 The University Of Southern California Use of angiotensin ii type 2 receptor agonists in tissue repair
WO1998032457A2 (en) * 1997-01-28 1998-07-30 University Of Southern California Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014858A1 (en) * 1994-11-14 1996-05-23 University Of Southern California Use of angiotensin ii fragments and analogs thereof in tissue repair
WO1996039164A1 (en) * 1995-06-06 1996-12-12 The University Of Southern California Use of angiotensin ii type 2 receptor agonists in tissue repair
WO1998032457A2 (en) * 1997-01-28 1998-07-30 University Of Southern California Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DAJANI, OLAV F. ET AL: "Growth-promoting effects of Ca2+-mobilizing agents in hepatocytes: lack of correlation between the acute activation of phosphoinositide-specific phospholipase C and the stimulation of DNA synthesis by angiotensin II, vasopressin, norepinephrine, and prostaglandin F2.alpha.", XP002111087, retrieved from STN Database accession no. 125:213302 HCA *
J. CELL. PHYSIOL. (1996), 168(3), 608-617 *

Also Published As

Publication number Publication date
AU2590399A (en) 1999-08-23
WO1999039743A2 (en) 1999-08-12

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