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WO1999038975A3 - Polynucleotide and polypeptide sequences associated with cns depressant sensitivity and methods of use thereof - Google Patents

Polynucleotide and polypeptide sequences associated with cns depressant sensitivity and methods of use thereof Download PDF

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Publication number
WO1999038975A3
WO1999038975A3 PCT/US1999/002033 US9902033W WO9938975A3 WO 1999038975 A3 WO1999038975 A3 WO 1999038975A3 US 9902033 W US9902033 W US 9902033W WO 9938975 A3 WO9938975 A3 WO 9938975A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
polynucleotide
polypeptide sequences
sensitivity
sequences associated
Prior art date
Application number
PCT/US1999/002033
Other languages
French (fr)
Other versions
WO1999038975A2 (en
Inventor
Thomas E Johnson
James M Sikela
Victoria J Simpson
Brad A Rikke
Original Assignee
Univ Technology Corp
Thomas E Johnson
James M Sikela
Victoria J Simpson
Brad A Rikke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Technology Corp, Thomas E Johnson, James M Sikela, Victoria J Simpson, Brad A Rikke filed Critical Univ Technology Corp
Priority to AU24869/99A priority Critical patent/AU2486999A/en
Publication of WO1999038975A2 publication Critical patent/WO1999038975A2/en
Publication of WO1999038975A3 publication Critical patent/WO1999038975A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides polynucleotide and polypeptide sequences associated with CNS depressant sensitivity, and methods for identifying and classifying candidate CNS depressants as well as methods to identify agents which may modulate CNS depressant action. The invention also provides mouse mGluR5 polynucleotide and polypeptide sequences.
PCT/US1999/002033 1998-01-30 1999-01-29 Polynucleotide and polypeptide sequences associated with cns depressant sensitivity and methods of use thereof WO1999038975A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU24869/99A AU2486999A (en) 1998-01-30 1999-01-29 Polynucleotide and polypeptide sequences associated with cns depressant sensitivity and methods of use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7319098P 1998-01-30 1998-01-30
US60/073,190 1998-01-30

Publications (2)

Publication Number Publication Date
WO1999038975A2 WO1999038975A2 (en) 1999-08-05
WO1999038975A3 true WO1999038975A3 (en) 1999-09-23

Family

ID=22112282

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/002033 WO1999038975A2 (en) 1998-01-30 1999-01-29 Polynucleotide and polypeptide sequences associated with cns depressant sensitivity and methods of use thereof

Country Status (2)

Country Link
AU (1) AU2486999A (en)
WO (1) WO1999038975A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5897500A (en) * 1999-07-02 2001-01-22 Neurocrine Biosciences, Inc. Metabotropic glutamate receptors and methods of use therefor
US6534287B1 (en) * 1999-10-25 2003-03-18 Nps Pharmaceuticals, Inc. Human metabotropic glutamate receptor
WO2002070708A2 (en) * 2000-12-22 2002-09-12 Wyeth Glutamate receptor modulatory proteins and nucleic acids encoding them
CN101947223B (en) * 2010-08-25 2013-05-22 新疆医科大学第一附属医院 Compound anesthetic and its preparation method and application in animal model of myocardial infarction

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994029449A1 (en) * 1993-06-04 1994-12-22 The Salk Institute Biotechnology/Industrial Associates, Inc. Human metabotropic glutamate receptors, nucleic acids encoding same and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994029449A1 (en) * 1993-06-04 1994-12-22 The Salk Institute Biotechnology/Industrial Associates, Inc. Human metabotropic glutamate receptors, nucleic acids encoding same and uses thereof

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ABE T ET AL: "MOLECULAR CHARACTERIZATION OF A NOVEL METABOTROPIC GLUTAMATE RECEPTOR MGLUR5 COUPLED TO INOSITOL PHOSPHATE/CA2+ SIGNAL TRANSDUCTION", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 19, 5 July 1992 (1992-07-05), pages 13361 - 13368, XP000605387 *
DORRI, F. ET AL.: "Down-regulation of mGluR5 by antisense deoxynucleotides alters pharmacological responses to application of ACPD in the rat hippocampus.", EXPERIMENTAL NEUROLOGY, vol. 147, no. 1, September 1997 (1997-09-01), pages 48 - 54, XP002108293 *
MINAKAMI, R. ET AL.: "The expression of two splice variants of metabotropic glutamate receptor subtype 5 in the rat brain and neural cells during development.", JOURNAL OF NEUROCHEMISTRY, vol. 65, no. 4, October 1995 (1995-10-01), pages 1536 - 42, XP002108290 *
MINAMI, K. ET AL.: "Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes.", MOLECULAR PHARMACOLOGY, vol. 53, no. 1, 1 January 1998 (1998-01-01), pages 148 - 156, XP002108294 *
PROCTER, M. ET AL.: "Possible role of GluR5 glutamate receptors in spinal nociceptive processing in the anaesthetized rat.", JOURNAL OF PHYSIOLOGY, vol. 504P, November 1997 (1997-11-01), pages 101P - 102P, XP002108296 *
SCHEDL A ET AL: "A YEAST ARTIFICIAL CHROMOSOME COVERING THE TYROSINASE GENE CONFERS COPY NUMBER-DEPENDENT EXPRESSION IN TRANSGENIC MICE", NATURE, vol. 362, no. 6417, 18 March 1993 (1993-03-18), pages 258 - 261, XP000563891 *
SIMPSON, V.J. ET AL.: "Ketamine exerts differential hypnotic effects in long sleep and short sleep mice.", ANESTHESIOLOGY, vol. 89, no. 3a, September 1998 (1998-09-01), pages A128, XP002108299 *
SIMPSON, V.J. ET AL.: "Mapping a major QTL for propofol neurosensitivity in F2 mice from an LS by SS cross.", ANESTHESIOLOGY, vol. 65, no. 3a, September 1996 (1996-09-01), pages a627, XP002108295 *
SOMMER, B. ET AL.: "RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.", CELL, vol. 67, 4 October 1991 (1991-10-04), pages 11 - 9, XP002108292 *

Also Published As

Publication number Publication date
WO1999038975A2 (en) 1999-08-05
AU2486999A (en) 1999-08-16

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