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WO1999038866A8 - 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled form and use of 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled and unlabelled form - Google Patents

8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled form and use of 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled and unlabelled form

Info

Publication number
WO1999038866A8
WO1999038866A8 PCT/DK1999/000044 DK9900044W WO9938866A8 WO 1999038866 A8 WO1999038866 A8 WO 1999038866A8 DK 9900044 W DK9900044 W DK 9900044W WO 9938866 A8 WO9938866 A8 WO 9938866A8
Authority
WO
WIPO (PCT)
Prior art keywords
labelled
azabicyclo
oct
ene derivatives
derivatives
Prior art date
Application number
PCT/DK1999/000044
Other languages
French (fr)
Other versions
WO1999038866A1 (en
Inventor
Peter Moldt
Joergen Scheel-Krueger
Elsebet Oestergaard Nielsen
Original Assignee
Neurosearch As
Peter Moldt
Scheel Krueger Joergen
Elsebet Oestergaard Nielsen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As, Peter Moldt, Scheel Krueger Joergen, Elsebet Oestergaard Nielsen filed Critical Neurosearch As
Priority to EP99906069A priority Critical patent/EP1068204A1/en
Priority to JP2000529334A priority patent/JP2002501921A/en
Priority to AU26099/99A priority patent/AU2609999A/en
Publication of WO1999038866A1 publication Critical patent/WO1999038866A1/en
Publication of WO1999038866A8 publication Critical patent/WO1999038866A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to 8-azabicyclo[3.2.1]oct-2-ene derivatives in their labelled form. Furthermore, the present invention relates to the use of said derivatives in their labelled or unlabelled form in diganostic methods, in particular for in vivo receptor imaging (neuroimaging).
PCT/DK1999/000044 1998-01-28 1999-01-28 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled form and use of 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled and unlabelled form WO1999038866A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP99906069A EP1068204A1 (en) 1998-01-28 1999-01-28 8-azabicyclo 3.2.1]oct-2-ene derivatives in labelled and use of 8-azabicyclo 3.2.1]oct-2-ene derivatives in labelled and unlabelled form
JP2000529334A JP2002501921A (en) 1998-01-28 1999-01-28 8-Azabicyclo [3.2.1] oct-2-ene derivatives in labeled form and 8-azabicyclo [3.2.1] oct-2-ene derivatives in labeled and unlabeled form How to use
AU26099/99A AU2609999A (en) 1998-01-28 1999-01-28 8-azabicyclo(3.2.1)oct-2-ene derivatives in labelled and use of 8-azabicyclo(3.2.1)oct-2-ene derivatives in labelled and unlabelled form

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK0125/98 1998-01-28
DK12598 1998-01-28

Publications (2)

Publication Number Publication Date
WO1999038866A1 WO1999038866A1 (en) 1999-08-05
WO1999038866A8 true WO1999038866A8 (en) 1999-10-28

Family

ID=8090037

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1999/000044 WO1999038866A1 (en) 1998-01-28 1999-01-28 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled form and use of 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled and unlabelled form

Country Status (5)

Country Link
EP (1) EP1068204A1 (en)
JP (1) JP2002501921A (en)
AU (1) AU2609999A (en)
WO (1) WO1999038866A1 (en)
ZA (1) ZA99681B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60007841T2 (en) 1999-01-28 2004-07-08 Neurosearch A/S NEW AZABICYCLO DERIVATIVES AND THEIR USE
AU9543601A (en) * 2000-10-13 2002-04-22 Neurosearch As Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
GB9019973D0 (en) * 1990-09-12 1990-10-24 Wyeth John & Brother Ltd Azabicyclic derivatives
DE69233656D1 (en) * 1991-11-15 2006-10-19 Res Triangle Inst Cocaine receptor binding ligands
AU672052B2 (en) * 1992-12-23 1996-09-19 Neurosearch A/S Antidepressant and antiparkinsonian compounds
FI96603C (en) * 1994-12-30 1996-07-25 Joergen Bergman A new radiolabeled compound, a mixture containing the compound and a process for their preparation
HUP9802433A3 (en) * 1995-10-13 2000-03-28 Neurosearch As 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use
US5726189A (en) * 1996-05-03 1998-03-10 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Method for imaging nicotinic acetylcholinergic receptors in the brain using radiolabeled pyridyl-7-azabicyclo 2.2.1!heptanes
GB9706222D0 (en) * 1997-03-26 1997-05-14 Zeneca Ltd Bicyclic amine derivatives

Also Published As

Publication number Publication date
ZA99681B (en) 1999-09-27
WO1999038866A1 (en) 1999-08-05
AU2609999A (en) 1999-08-16
EP1068204A1 (en) 2001-01-17
JP2002501921A (en) 2002-01-22

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Free format text: PAT. BUL. 31/99 UNDER (54) THE TITLE IN ENGLISH SHOULD READ "8-AZABICYCLO (3.2.1) OCT-2-ENE DERIVATIVES IN LABELLED FORM AND USE OF 8-AZABICYCLO (3.2.1) OCT-2-ENE DERIVATIVES IN LABELLED AND UNLABELLED FORM"

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