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WO1999038185A3 - Spectrometre a source ionique a impulsions et appareil de transmission visant a amortir la mobilite ionique, et procede d'utilisation - Google Patents

Spectrometre a source ionique a impulsions et appareil de transmission visant a amortir la mobilite ionique, et procede d'utilisation Download PDF

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Publication number
WO1999038185A3
WO1999038185A3 PCT/CA1999/000034 CA9900034W WO9938185A3 WO 1999038185 A3 WO1999038185 A3 WO 1999038185A3 CA 9900034 W CA9900034 W CA 9900034W WO 9938185 A3 WO9938185 A3 WO 9938185A3
Authority
WO
WIPO (PCT)
Prior art keywords
ion
ions
transmission device
source
spectrometer
Prior art date
Application number
PCT/CA1999/000034
Other languages
English (en)
Other versions
WO1999038185A2 (fr
Inventor
Andrew N Krutchinsky
Alexandre V Loboda
Victor L Spicer
Erich W Ens
Kenneth G Standing
Original Assignee
Univ Manitoba
Andrew N Krutchinsky
Alexandre V Loboda
Victor L Spicer
Erich W Ens
Kenneth G Standing
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4162020&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1999038185(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Manitoba, Andrew N Krutchinsky, Alexandre V Loboda, Victor L Spicer, Erich W Ens, Kenneth G Standing filed Critical Univ Manitoba
Priority to AT99900849T priority Critical patent/ATE273561T2/de
Priority to DK99900849.3T priority patent/DK1050061T4/en
Priority to DE69919325.7T priority patent/DE69919325T3/de
Priority to DE1050061T priority patent/DE1050061T1/de
Priority to EP99900849.3A priority patent/EP1050061B2/fr
Priority to JP2000528992A priority patent/JP4331398B2/ja
Priority to AU20428/99A priority patent/AU745866B2/en
Publication of WO1999038185A2 publication Critical patent/WO1999038185A2/fr
Publication of WO1999038185A3 publication Critical patent/WO1999038185A3/fr

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Electron Sources, Ion Sources (AREA)

Abstract

L'invention concerne un procédé et un dispositif permettant d'utiliser un appareil ou une interface de transmission ionique entre une source ionique et un spectromètre. L'appareil de transmission ionique peut comprendre un ensemble de tiges multipolaires, et il comporte un gaz d'amortissement permettant d'amortir l'étalement spatial et énergétique d'ions émanant d'une source ionique à impulsions. L'ensemble de tiges multipolaires guide les ions le long d'un trajet ionique, de manière à diriger ces ions vers l'entrée d'un spectromètre de masse. L'invention s'applique en particulier aux sources ioniques de type MALDI (à désorption/ionisation laser de type matriciel), qui produisent un petit jet supersonique d'ions et de molécules de type matriciel. Ce jet, sensiblement non directionnel, peut comporter des ions évoluant dans toutes les directions disponibles depuis la source et ayant une large gamme d'étalement énergétique. L'appareil de transmission ionique peut engendrer différents effets, à savoir entre autres : étalement sensible des ions produits, le long d'un axe ionique, pour engendrer un faisceau quasi-continu; réduction de l'étalement énergétique des ions émis depuis la source; et suppression au moins partielle de la fragmentation non désirée des ions d'analysat. En conséquence, un certain nombre d'impulsions ioniques peuvent être fournies à l'analyseur de temps de vol ou autre spectromètre, pour chaque cycle de la production ionique.
PCT/CA1999/000034 1998-01-23 1999-01-25 Spectrometre a source ionique a impulsions et appareil de transmission visant a amortir la mobilite ionique, et procede d'utilisation WO1999038185A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AT99900849T ATE273561T2 (de) 1998-01-23 1999-01-25 Spektrometer mit gepulster ionenquelle, kopplungsvorrichtung zur dämpfung der ionenbewegung, und methode zur verwendung derselben
DK99900849.3T DK1050061T4 (en) 1998-01-23 1999-01-25 Spectrometer equipped with pulsed ion source and transmission device for attenuation of ion movement and method of use thereof
DE69919325.7T DE69919325T3 (de) 1998-01-23 1999-01-25 Spektrometer mit gepulster Ionenquelle, Kopplungsvorrichtung zur Dämpfung der Ionenbewegung, und Methode zur Verwendung derselben
DE1050061T DE1050061T1 (de) 1998-01-23 1999-01-25 Spektrometer mit gepulster ionenquelle, kopplungsvorrichting zur dämpfung der ionenbewegung, und methode zur verwendung derselben
EP99900849.3A EP1050061B2 (fr) 1998-01-23 1999-01-25 Spectromètre à source ionique à impulsions et appareil de transmission visant à amortir la mobilité ionique, et procédé d'utilisation
JP2000528992A JP4331398B2 (ja) 1998-01-23 1999-01-25 パルスイオン源及びイオン運動を制動するための輸送デバイスを備えた分析計並びにその使用方法
AU20428/99A AU745866B2 (en) 1998-01-23 1999-01-25 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA2,227,806 1998-01-23
CA002227806A CA2227806C (fr) 1998-01-23 1998-01-23 Spectrometre muni d'une source d'ions pulsee et dispositif de transmission pour amortir la vitesse des ions, et methode d'utilisation

Publications (2)

Publication Number Publication Date
WO1999038185A2 WO1999038185A2 (fr) 1999-07-29
WO1999038185A3 true WO1999038185A3 (fr) 1999-10-21

Family

ID=4162020

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1999/000034 WO1999038185A2 (fr) 1998-01-23 1999-01-25 Spectrometre a source ionique a impulsions et appareil de transmission visant a amortir la mobilite ionique, et procede d'utilisation

Country Status (8)

Country Link
EP (1) EP1050061B2 (fr)
JP (1) JP4331398B2 (fr)
AT (1) ATE273561T2 (fr)
AU (1) AU745866B2 (fr)
CA (1) CA2227806C (fr)
DE (2) DE69919325T3 (fr)
DK (1) DK1050061T4 (fr)
WO (1) WO1999038185A2 (fr)

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US9196466B2 (en) 2002-07-24 2015-11-24 Micromass Uk Limited Mass spectrometer with bypass of a fragmentation device

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US5965884A (en) * 1998-06-04 1999-10-12 The Regents Of The University Of California Atmospheric pressure matrix assisted laser desorption
US6849847B1 (en) 1998-06-12 2005-02-01 Agilent Technologies, Inc. Ambient pressure matrix-assisted laser desorption ionization (MALDI) apparatus and method of analysis
GB9820210D0 (en) 1998-09-16 1998-11-11 Vg Elemental Limited Means for removing unwanted ions from an ion transport system and mass spectrometer
DE60044899D1 (de) 1999-06-11 2010-10-14 Applied Biosystems Llc Maldi ionenquelle mit gasimpuls, vorrichtung und verfahren zur ermittlung des molekulargewichtes labilen moleküle
DE10010204A1 (de) 2000-03-02 2001-09-13 Bruker Daltonik Gmbh Konditionierung eines Ionenstrahls für den Einschuss in ein Flugzeitmassenspektrometer
DE10010902A1 (de) 2000-03-07 2001-09-20 Bruker Daltonik Gmbh Tandem-Massenspektrometer aus zwei Quadrupolfiltern
CA2340150C (fr) * 2000-06-09 2005-11-22 Micromass Limited Methodes et appareil pour la spectrometrie de masse
US6586727B2 (en) * 2000-06-09 2003-07-01 Micromass Limited Methods and apparatus for mass spectrometry
EP1215712B1 (fr) 2000-11-29 2010-09-08 Micromass UK Limited Spectromètre de masse et méthodes associées
GB2370685B (en) 2000-11-29 2003-01-22 Micromass Ltd Mass spectrometers and methods of mass spectrometry
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US6617577B2 (en) 2001-04-16 2003-09-09 The Rockefeller University Method and system for mass spectroscopy
WO2003025973A1 (fr) * 2001-09-17 2003-03-27 Mds Inc. Doing Business As Mds Sciex Procede et dispositif pour le refroidissement et la concentration d'ions
AU2002349241A1 (en) 2001-12-14 2003-06-30 Mds Inc., D.B.A. Mds Sciex Method of chemical of ionization at reduced pressures
EP1492613A4 (fr) 2002-03-21 2009-12-16 Thermo Finnigan Llc Appareil d'ionisation et procede pour un systeme de spectrometre de masse
US7388194B2 (en) 2002-03-28 2008-06-17 Mds Sciex Inc. Method and system for high-throughput quantitation using laser desorption and multiple-reaction-monitoring
CA2477835C (fr) * 2002-03-28 2011-11-22 Mds Sciex Procede et systeme de quantification a haut rendement de petites molecules recourant a la desorption laser et au suivi de reactions multiples
US7405397B2 (en) * 2002-03-28 2008-07-29 Mds Sciex Inc. Laser desorption ion source with ion guide coupling for ion mass spectroscopy
GB0210930D0 (en) 2002-05-13 2002-06-19 Thermo Electron Corp Improved mass spectrometer and mass filters therefor
US6977371B2 (en) 2003-06-10 2005-12-20 Micromass Uk Limited Mass spectrometer
DE102004025841B4 (de) * 2004-05-24 2015-07-09 Bruker Daltonik Gmbh Verfahren und Vorrichtung zur massenspektroskopischen Untersuchung von Analyten
GB0420408D0 (en) * 2004-09-14 2004-10-20 Micromass Ltd Mass spectrometer
DE102004051785B4 (de) 2004-10-25 2008-04-24 Bruker Daltonik Gmbh Proteinprofile mit Luft-MALDI
EP1955077B1 (fr) 2005-12-02 2012-06-13 Sirtris Pharmaceuticals, Inc. Dosages biologiques par spectrometrie de masse destines a determiner une activite d'acetyltransferase/desacetylase
US8097425B2 (en) 2006-03-10 2012-01-17 Tethys Bioscience, Inc. Multiplex protein fractionation
DE102007043456B4 (de) 2007-07-31 2012-02-09 Bruker Daltonik Gmbh Matrixunterstützte Laserdesorption hoher Ionisierungsausbeute
CN111801574B (zh) * 2018-02-13 2024-02-09 生物梅里埃有限公司 用于确认仪器中带电粒子产生的方法及相关的仪器
US12205807B2 (en) 2020-04-01 2025-01-21 Mstm, Llc Multi-mode ionization apparatus and uses thereof

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US5689111A (en) * 1995-08-10 1997-11-18 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
WO1999030350A1 (fr) * 1997-12-05 1999-06-17 University Of British Columbia Procede d'analyse d'ions dans un appareil comprenant un spectrometre de masse a temps de vol et un piege a ions lineaire

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WO1999030350A1 (fr) * 1997-12-05 1999-06-17 University Of British Columbia Procede d'analyse d'ions dans un appareil comprenant un spectrometre de masse a temps de vol et un piege a ions lineaire

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KRUTCHINSKY A N ET AL: "Collisional Damping Interface for an Electrospray Ionization Time -of-Flight Mass Spectrometer", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, vol. 9, no. 6, 1 June 1998 (1998-06-01), pages 569-579, XP004122896, ISSN: 1044-0305 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9196466B2 (en) 2002-07-24 2015-11-24 Micromass Uk Limited Mass spectrometer with bypass of a fragmentation device
US9384951B2 (en) 2002-07-24 2016-07-05 Micromass Uk Limited Mass analysis using alternating fragmentation modes

Also Published As

Publication number Publication date
DK1050061T4 (en) 2017-01-23
DE1050061T1 (de) 2001-06-07
CA2227806C (fr) 2006-07-18
AU2042899A (en) 1999-08-09
AU745866B2 (en) 2002-04-11
DK1050061T3 (da) 2004-11-22
EP1050061A2 (fr) 2000-11-08
JP4331398B2 (ja) 2009-09-16
DE69919325T3 (de) 2017-03-02
DE69919325D1 (de) 2004-09-16
ATE273561T2 (de) 2004-08-15
DE69919325T2 (de) 2005-02-17
JP2002502084A (ja) 2002-01-22
CA2227806A1 (fr) 1999-07-23
WO1999038185A2 (fr) 1999-07-29
EP1050061B1 (fr) 2004-08-11
EP1050061B2 (fr) 2016-10-19

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