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WO1999037774A3 - Sequences associees a la differenciation cellulaire et procedes d'utilisation de ces sequences - Google Patents

Sequences associees a la differenciation cellulaire et procedes d'utilisation de ces sequences Download PDF

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Publication number
WO1999037774A3
WO1999037774A3 PCT/US1999/001549 US9901549W WO9937774A3 WO 1999037774 A3 WO1999037774 A3 WO 1999037774A3 US 9901549 W US9901549 W US 9901549W WO 9937774 A3 WO9937774 A3 WO 9937774A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
differentiation
polypeptides
polynucleotides
cancer therapy
Prior art date
Application number
PCT/US1999/001549
Other languages
English (en)
Other versions
WO1999037774A8 (fr
WO1999037774A2 (fr
Inventor
Fei Huang
Paul B Fisher
Original Assignee
Genquest Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genquest Inc filed Critical Genquest Inc
Priority to AU24697/99A priority Critical patent/AU2469799A/en
Publication of WO1999037774A2 publication Critical patent/WO1999037774A2/fr
Publication of WO1999037774A8 publication Critical patent/WO1999037774A8/fr
Publication of WO1999037774A3 publication Critical patent/WO1999037774A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cette invention se rapporte à des compositions et à des procédés servant à inhiber la croissance cellulaire, tout en induisant la différenciation cellulaire terminale et en offrant ainsi une thérapie contre le cancer. Ces composés sont des polypeptides et des polynucléotides associés à la différenciation cellulaire terminale et à l'interruption de la croissance cellulaire, ainsi que des polynucléotides qui codent ces polypeptides. Des vaccins et des compositions pharmaceutiques contenant ces composés sont également présentés et peuvent servir notamment dans les thérapies contre le cancer. De telles molécules peuvent également être utilisées, par exemple, pour identifier des agents pouvant servir dans des vaccins et des compositions pharmaceutiques de traitement du cancer. Les polypeptides et les polynucléotides présentés ici peuvent également servir de marqueurs pour le diagnostic et la surveillance du développement d'un cancer chez un patient.
PCT/US1999/001549 1998-01-26 1999-01-25 Sequences associees a la differenciation cellulaire et procedes d'utilisation de ces sequences WO1999037774A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU24697/99A AU2469799A (en) 1998-01-26 1999-01-25 Differentiation-associated sequences and methods of use therefor

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US7329898P 1998-01-26 1998-01-26
US60/073,298 1998-01-26
US7444198P 1998-02-11 1998-02-11
US60/074,441 1998-02-11
US7780498P 1998-03-12 1998-03-12
US60/077,804 1998-03-12
US7932698P 1998-03-25 1998-03-25
US60/079,326 1998-03-25
US8319598P 1998-04-28 1998-04-28
US60/083,195 1998-04-28
US8560998P 1998-05-15 1998-05-15
US60/085,609 1998-05-15
US8682998P 1998-05-26 1998-05-26
US60/086,829 1998-05-26
US8716798P 1998-05-29 1998-05-29
US60/087,167 1998-05-29

Publications (3)

Publication Number Publication Date
WO1999037774A2 WO1999037774A2 (fr) 1999-07-29
WO1999037774A8 WO1999037774A8 (fr) 1999-09-23
WO1999037774A3 true WO1999037774A3 (fr) 2000-01-13

Family

ID=27574528

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/001549 WO1999037774A2 (fr) 1998-01-26 1999-01-25 Sequences associees a la differenciation cellulaire et procedes d'utilisation de ces sequences

Country Status (2)

Country Link
AU (1) AU2469799A (fr)
WO (1) WO1999037774A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706867B1 (en) 2000-12-19 2004-03-16 The United States Of America As Represented By The Department Of Health And Human Services DNA array sequence selection

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011986A1 (fr) * 1993-10-27 1995-05-04 The Trustees Of Columbia University In The City Of New York PROCEDE DE CONSTITUTION D'UNE BANQUE D'ADNc A SOUSTRACTION ET UTILISATION DE LADITE BANQUE
WO1995014772A1 (fr) * 1993-11-12 1995-06-01 Kenichi Matsubara Signature genique
US5710137A (en) * 1996-08-16 1998-01-20 The Trustees Of Columbia University In The City Of New York Use of a melanoma differentiation associated gene (mda 7) for reversing a cancerous phenotype

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011986A1 (fr) * 1993-10-27 1995-05-04 The Trustees Of Columbia University In The City Of New York PROCEDE DE CONSTITUTION D'UNE BANQUE D'ADNc A SOUSTRACTION ET UTILISATION DE LADITE BANQUE
WO1995014772A1 (fr) * 1993-11-12 1995-06-01 Kenichi Matsubara Signature genique
US5710137A (en) * 1996-08-16 1998-01-20 The Trustees Of Columbia University In The City Of New York Use of a melanoma differentiation associated gene (mda 7) for reversing a cancerous phenotype

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMEST 2 E.M.B.L. Databases; 19 January 1998 (1998-01-19), NCI-CGAP: "Homo sapiens cDNA clone IMAGE:1257352 similar to TR:O00605 O00605 PUTATIVE RAB5-INTERACTING PROTEIN", XP002108010 *
DATABASE EMEST10 E.M.B.L. Databases; 18 November 1992 (1992-11-18), OKUBO K ET AL: "Human HepG2 3'-directed MboI cDNA, clone a-21", XP002108009 *
DATABASE GENESEQ 20 June 1996 (1996-06-20), MATSUBARA K ET AL: "Gene signature", XP002108011 *
OKUBO K ET AL: "Large scale cDNA sequencing for analysis of quantitative and qualitative aspects of gene expression", NATURE GENETICS, vol. 2, 1992, pages 173 - 179, XP000573852 *
VIELKIND U: "GENETIC CONTROL OF CELL DIFFERENTIATION IN PLATYFISH-SWORDTAIL MELANOMAS", JOURNAL OF EXPERIMENTAL ZOOLOGY, vol. 196, no. 2, 1 May 1976 (1976-05-01), pages 197 - 203, XP002048879 *

Also Published As

Publication number Publication date
WO1999037774A8 (fr) 1999-09-23
WO1999037774A2 (fr) 1999-07-29
AU2469799A (en) 1999-08-09

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