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WO1999037774A8 - Differentiation-associated sequences and methods of use therefor - Google Patents

Differentiation-associated sequences and methods of use therefor

Info

Publication number
WO1999037774A8
WO1999037774A8 PCT/US1999/001549 US9901549W WO9937774A8 WO 1999037774 A8 WO1999037774 A8 WO 1999037774A8 US 9901549 W US9901549 W US 9901549W WO 9937774 A8 WO9937774 A8 WO 9937774A8
Authority
WO
WIPO (PCT)
Prior art keywords
methods
differentiation
polypeptides
polynucleotides
cancer therapy
Prior art date
Application number
PCT/US1999/001549
Other languages
French (fr)
Other versions
WO1999037774A3 (en
WO1999037774A2 (en
Inventor
Fei Huang
Paul B Fisher
Original Assignee
Genquest Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genquest Inc filed Critical Genquest Inc
Priority to AU24697/99A priority Critical patent/AU2469799A/en
Publication of WO1999037774A2 publication Critical patent/WO1999037774A2/en
Publication of WO1999037774A8 publication Critical patent/WO1999037774A8/en
Publication of WO1999037774A3 publication Critical patent/WO1999037774A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compositions and methods are provided for inhibiting cell growth, inducing terminal differentiation and cancer therapy. The compounds provided are polypeptides and polynucleotides associated with terminal differentiation and growth arrest, as well as polynucleotides that encode such polypeptides. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for cancer therapy. Such molecules may also be used, for example, to identify agents that may be used in vaccines and pharmaceutical compositions for cancer therapy. The polypeptides and polynucleotides provided herein may also be used as markers for diagnosing and monitoring the progression of a cancer in a patient.
PCT/US1999/001549 1998-01-26 1999-01-25 Differentiation-associated sequences and methods of use therefor WO1999037774A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU24697/99A AU2469799A (en) 1998-01-26 1999-01-25 Differentiation-associated sequences and methods of use therefor

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US7329898P 1998-01-26 1998-01-26
US60/073,298 1998-01-26
US7444198P 1998-02-11 1998-02-11
US60/074,441 1998-02-11
US7780498P 1998-03-12 1998-03-12
US60/077,804 1998-03-12
US7932698P 1998-03-25 1998-03-25
US60/079,326 1998-03-25
US8319598P 1998-04-28 1998-04-28
US60/083,195 1998-04-28
US8560998P 1998-05-15 1998-05-15
US60/085,609 1998-05-15
US8682998P 1998-05-26 1998-05-26
US60/086,829 1998-05-26
US8716798P 1998-05-29 1998-05-29
US60/087,167 1998-05-29

Publications (3)

Publication Number Publication Date
WO1999037774A2 WO1999037774A2 (en) 1999-07-29
WO1999037774A8 true WO1999037774A8 (en) 1999-09-23
WO1999037774A3 WO1999037774A3 (en) 2000-01-13

Family

ID=27574528

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/001549 WO1999037774A2 (en) 1998-01-26 1999-01-25 Differentiation-associated sequences and methods of use therefor

Country Status (2)

Country Link
AU (1) AU2469799A (en)
WO (1) WO1999037774A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706867B1 (en) 2000-12-19 2004-03-16 The United States Of America As Represented By The Department Of Health And Human Services DNA array sequence selection

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1650303B1 (en) * 1993-10-27 2008-05-28 The Trustees of Columbia University of the City of New York Method for generating a substracted cDNA library and uses of the generated library
EP0679716A4 (en) * 1993-11-12 1999-06-09 Kenichi Matsubara Gene signature.
US5710137A (en) * 1996-08-16 1998-01-20 The Trustees Of Columbia University In The City Of New York Use of a melanoma differentiation associated gene (mda 7) for reversing a cancerous phenotype

Also Published As

Publication number Publication date
WO1999037774A3 (en) 2000-01-13
WO1999037774A2 (en) 1999-07-29
AU2469799A (en) 1999-08-09

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