+

WO1999037299B1 - Utilisation d'inhibiteurs pour le traitement de troubles lies a une hyperfonction de recepteurs presentant une activite de tyrosine kinase (rtk), notamment le cancer - Google Patents

Utilisation d'inhibiteurs pour le traitement de troubles lies a une hyperfonction de recepteurs presentant une activite de tyrosine kinase (rtk), notamment le cancer

Info

Publication number
WO1999037299B1
WO1999037299B1 PCT/EP1999/000405 EP9900405W WO9937299B1 WO 1999037299 B1 WO1999037299 B1 WO 1999037299B1 EP 9900405 W EP9900405 W EP 9900405W WO 9937299 B1 WO9937299 B1 WO 9937299B1
Authority
WO
WIPO (PCT)
Prior art keywords
fgfr
use according
mutation
treatment
cancer
Prior art date
Application number
PCT/EP1999/000405
Other languages
German (de)
English (en)
Other versions
WO1999037299A1 (fr
Inventor
Axel Ullrich
Johannes Bange
Pjotr Knyazev
Original Assignee
Max Planck Gesellschaft
Axel Ullrich
Johannes Bange
Pjotr Knyazev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7855380&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1999037299(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to JP2000528281A priority Critical patent/JP2002518292A/ja
Priority to DE59913907T priority patent/DE59913907D1/de
Priority to CA002319121A priority patent/CA2319121A1/fr
Priority to DK99903669T priority patent/DK1049465T3/da
Priority to AU24239/99A priority patent/AU756378B2/en
Application filed by Max Planck Gesellschaft, Axel Ullrich, Johannes Bange, Pjotr Knyazev filed Critical Max Planck Gesellschaft
Priority to EP99903669A priority patent/EP1049465B1/fr
Priority to US09/600,826 priority patent/US6770742B1/en
Publication of WO1999037299A1 publication Critical patent/WO1999037299A1/fr
Publication of WO1999037299B1 publication Critical patent/WO1999037299B1/fr
Priority to US10/649,413 priority patent/US7678372B2/en
Priority to US10/863,880 priority patent/US7297774B2/en
Priority to US12/689,672 priority patent/US8043806B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne l'utilisation d'inhibiteurs pour le traitement et/ou la prophylaxie de maladies provoquées par une hyperactivité de récepteurs présentant une activité de tyrosine kinase (RTK), notamment le cancer. Ils sont utilisés en particulier pour inhiber ou réduire l'hyperexpression et/ou la modification d'activité des RTK. Cette modification d'activité des RTK peut en particulier être déclenchée par une mutation du FGFR-4. Cette mutation est en particulier une mutation ponctuelle dans le domaine transmembranaire du FGFR-4 et entraîne l'échange d'un acide aminé hydrophobe contre un acide aminé hydrophile. L'invention concerne en outre l'utilisation d'un inhibiteur dirigé contre le FGFR-4 pour le traitement et/ou la prophylaxie du cancer. De plus, l'invention concerne un FGFR-4 ayant subi une mutation entraînant une hyperexpression et/ou une modification d'activité dans les cellules. Enfin, l'invention concerne une séquence d'ADN ou d'ARN d'une molécule de FGFR-4 ayant subi une mutation, une composition pharmaceutique, contenant ledit inhibiteur, ainsi qu'une méthode de diagnostic et de criblage.
PCT/EP1999/000405 1998-01-22 1999-01-22 Utilisation d'inhibiteurs pour le traitement de troubles lies a une hyperfonction de recepteurs presentant une activite de tyrosine kinase (rtk), notamment le cancer WO1999037299A1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
US09/600,826 US6770742B1 (en) 1998-01-22 1999-01-22 Use of inhibitors for the treatment of disorders related to RTK hyperfunction, especially cancer
DE59913907T DE59913907D1 (de) 1998-01-22 1999-01-22 Verwendung von inhibitoren für die behandlung von rtk-überfunktions-bedingten störungen, insbesondere von krebs
CA002319121A CA2319121A1 (fr) 1998-01-22 1999-01-22 Utilisation d'inhibiteurs pour le traitement de troubles lies a une hyperfonction de recepteurs presentant une activite de tyrosine kinase (rtk), notamment le cancer
DK99903669T DK1049465T3 (da) 1998-01-22 1999-01-22 Anvendelse af inhibitorer til behandling af RTK-hyperfunktionsbetingede forstyrrelser, især af kræft
AU24239/99A AU756378B2 (en) 1998-01-22 1999-01-22 Use of inhibitors for the treatment of disorders related to RTK hyperfunction, especially cancer
JP2000528281A JP2002518292A (ja) 1998-01-22 1999-01-22 Ｒｔｋ−過剰機能−誘導障害、特に癌の治療のための阻害剤の使用
EP99903669A EP1049465B1 (fr) 1998-01-22 1999-01-22 Utilisation d'inhibiteurs pour le traitement de troubles lies a une hyperfonction de recepteurs presentant une activite de tyrosine kinase (rtk), notamment le cancer
US10/649,413 US7678372B2 (en) 1998-01-22 2003-08-27 Use of inhibitors for the treatment of RTK-hyperfunction-induced disorders, particularly cancer
US10/863,880 US7297774B2 (en) 1998-01-22 2004-06-08 Use of inhibitors for the treatment of RTK-hyperfunction-induced disorders, particularly cancer
US12/689,672 US8043806B2 (en) 1998-01-22 2010-01-19 Method of diagnosing an RTK-hyperfunction induced disorder

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19802377.4 1998-01-22
DE19802377A DE19802377A1 (de) 1998-01-22 1998-01-22 Verwendung von Inhibitoren für die Behandlung von RTK-Überfunktions-bedingten Störungen, insbesondere von Krebs

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US09600826 A-371-Of-International 1999-01-22
US09/600,826 A-371-Of-International US6770742B1 (en) 1998-01-22 1999-01-22 Use of inhibitors for the treatment of disorders related to RTK hyperfunction, especially cancer
US10/649,413 Division US7678372B2 (en) 1998-01-22 2003-08-27 Use of inhibitors for the treatment of RTK-hyperfunction-induced disorders, particularly cancer
US10/863,880 Continuation US7297774B2 (en) 1998-01-22 2004-06-08 Use of inhibitors for the treatment of RTK-hyperfunction-induced disorders, particularly cancer

Publications (2)

Publication Number Publication Date
WO1999037299A1 WO1999037299A1 (fr) 1999-07-29
WO1999037299B1 true WO1999037299B1 (fr) 1999-10-28

Family

ID=7855380

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/000405 WO1999037299A1 (fr) 1998-01-22 1999-01-22 Utilisation d'inhibiteurs pour le traitement de troubles lies a une hyperfonction de recepteurs presentant une activite de tyrosine kinase (rtk), notamment le cancer

Country Status (11)

Country Link
US (4) US6770742B1 (fr)
EP (1) EP1049465B1 (fr)
JP (3) JP2002518292A (fr)
CN (2) CN100444838C (fr)
AT (1) ATE342056T1 (fr)
AU (1) AU756378B2 (fr)
CA (1) CA2319121A1 (fr)
DE (2) DE19802377A1 (fr)
DK (1) DK1049465T3 (fr)
ES (1) ES2274616T3 (fr)
WO (1) WO1999037299A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19802377A1 (de) * 1998-01-22 1999-08-19 Max Planck Gesellschaft Verwendung von Inhibitoren für die Behandlung von RTK-Überfunktions-bedingten Störungen, insbesondere von Krebs
US6306119B1 (en) * 1999-01-20 2001-10-23 Pearl Technology Holdings, Llc Skin resurfacing and treatment using biocompatible materials
EP1332761A1 (fr) * 2002-01-31 2003-08-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Agonistes des récepteurs du facteur de croissance des fibroblastes
EP1469878B1 (fr) * 2002-01-31 2011-03-23 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Agonistes du fgfr
JP4822371B1 (ja) 2005-07-22 2011-11-24 ファイブ プライム セラピューティクス， インコーポレイテッド Ｆｇｆｒ融合タンパク質によって疾患を治療するための組成物および方法
EP1918376A1 (fr) * 2006-11-03 2008-05-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. FGFR4 favorise la résistance des cellules cancéreuses en réponse aux agents chimiothérapeutiques
CA2668295A1 (fr) 2006-11-03 2008-05-08 U3 Pharma Gmbh Anticorps anti-fgfr4
US8216783B2 (en) * 2008-04-14 2012-07-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Over-expression and mutation of a tyrosine kinase receptor FGFR4 in tumors
AU2009279806B2 (en) 2008-08-04 2015-04-30 Five Prime Therapeutics, Inc. FGFR extracellular domain acidic region muteins
US8278105B2 (en) * 2008-09-09 2012-10-02 University Of Southern California Induction, propagation and isolation of liver progenitor cells
WO2011034940A1 (fr) 2009-09-15 2011-03-24 Five Prime Therapeutics, Inc. Méthodes de croissance des cheveux utilisant les domaines extracellulaires de fgfr4
PT2498799T (pt) 2009-11-13 2016-11-04 Five Prime Therapeutics Inc Utilização de proteínas do domínio extracelular rfcf1 para tratar cancros caracterizados por mutações ativadoras dependentes de ligando em rfcf2
US8685931B2 (en) 2009-12-17 2014-04-01 Five Prime Therapeutics, Inc. Hair growth methods using FGFR3 extracellular domains
US8481038B2 (en) 2010-11-15 2013-07-09 Five Prime Therapeutics, Inc. Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins
US8951972B2 (en) 2010-12-09 2015-02-10 Five Prime Therapeutics, Inc. FGFR1 extracellular domain combination therapies for lung cancer
US10016484B2 (en) 2011-11-14 2018-07-10 Five Prime Therapeutics, Inc. Methods of treating lung cancer
BR112015022191A8 (pt) 2013-03-15 2018-01-23 Celgene Avilomics Res Inc compostos heteroarila e usos dos mesmos
NZ711376A (en) 2013-03-15 2020-01-31 Sanofi Sa Heteroaryl compounds and uses thereof
AR095464A1 (es) 2013-03-15 2015-10-21 Celgene Avilomics Res Inc Compuestos de heteroarilo y usos de los mismos
US9890187B2 (en) 2015-06-26 2018-02-13 Epos-Iasis Research And Development, Ltd. Prototype systems of theranostic biomarkers for in vivo molecular management of cancer
JP2020530467A (ja) * 2017-08-11 2020-10-22 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 癌転移を処置するためにキナーゼを標的とする方法
EP3852756A1 (fr) * 2018-09-21 2021-07-28 Janssen Pharmaceutica NV Traitement du cholangiocarcinome

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4988617A (en) * 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
JPH03297390A (ja) * 1990-04-13 1991-12-27 Fujisawa Pharmaceut Co Ltd Ｆｒ９０１３６２物質、その製法及び用途
DE4104240A1 (de) * 1991-02-12 1992-08-13 Speyer Georg Haus Chemo Klonierung eines neuen mitgliedes der familie der fibroblasten-wachstumsfaktoren (fgf)-rezeptoren
ATE206765T1 (de) 1994-02-14 2001-10-15 Univ Leiden Verfahren zum nachweis eines genetischen defektes,assoziert mit thrombose und/oder mangelhafter anticoagulanz-reaktion auf aktiviertes protein c
US5866323A (en) 1995-04-07 1999-02-02 Case Western Reserve University Cancer diagnosis prognosis and therapy based on mutation of receptors for transforming growth factor β and homologous growth controlling factors
US5766851A (en) 1995-05-19 1998-06-16 The Johns Hopkins University School Of Medicine Susceptibility gene for obesity and type II diabetes mellitus
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
WO1998024432A2 (fr) 1996-12-05 1998-06-11 Sugen, Inc. Utilisation de composes a base d'indolinone en tant que modulateurs de proteine kinases
JP2002511852A (ja) * 1997-05-07 2002-04-16 スージェン・インコーポレーテッド 蛋白質キナーゼ活性の調節剤としての２−インドリノン誘導体
DE19802377A1 (de) * 1998-01-22 1999-08-19 Max Planck Gesellschaft Verwendung von Inhibitoren für die Behandlung von RTK-Überfunktions-bedingten Störungen, insbesondere von Krebs

Also Published As

Publication number Publication date
EP1049465B1 (fr) 2006-10-11
US20100184686A1 (en) 2010-07-22
DE19802377A1 (de) 1999-08-19
JP5732109B2 (ja) 2015-06-10
ES2274616T3 (es) 2007-05-16
JP5512935B2 (ja) 2014-06-04
DK1049465T3 (da) 2007-02-05
CN101474398A (zh) 2009-07-08
EP1049465A1 (fr) 2000-11-08
DE59913907D1 (de) 2006-11-23
US7297774B2 (en) 2007-11-20
JP2009001549A (ja) 2009-01-08
US20040235776A1 (en) 2004-11-25
WO1999037299A1 (fr) 1999-07-29
JP2002518292A (ja) 2002-06-25
AU756378B2 (en) 2003-01-09
US20040067885A1 (en) 2004-04-08
AU2423999A (en) 1999-08-09
CN100444838C (zh) 2008-12-24
CN1291096A (zh) 2001-04-11
US6770742B1 (en) 2004-08-03
CA2319121A1 (fr) 1999-07-29
US8043806B2 (en) 2011-10-25
ATE342056T1 (de) 2006-11-15
JP2013231048A (ja) 2013-11-14
US7678372B2 (en) 2010-03-16

Similar Documents

Publication Publication Date Title
WO1999037299B1 (fr) Utilisation d'inhibiteurs pour le traitement de troubles lies a une hyperfonction de recepteurs presentant une activite de tyrosine kinase (rtk), notamment le cancer
Olds et al. Complete nucleotide sequence of the antithrombin gene: evidence for homologous recombination causing thrombophilia
Edgeworth et al. lonomycin-regulated phosphorylation of the myeloid calcium-binding protein p14
US8410054B2 (en) Methods for treating pain by inhibition of the SCN9A channel
EP0393438B1 (fr) Récepteur du TNF, protéine liant le TNF at ADN codant pour ceux-ci
JP5602015B2 (ja) ブレオマイシン水解酵素の活性を指標とした天然保湿因子による皮膚バリアー機能状態の評価方法
DE696325T1 (de) Verfahren zum nachweis eines genetischen defektes, assoziert mit thrombose und/oder mangelhafter anticoagulanz-reaktion auf aktiviertem protein c
DE60032784T2 (de) Markerproteine für prostatakrebs
DE60214867T2 (de) Histonedeacetylase 9
DE69835509T2 (de) Verfahren zur bestimmung des kardiovasculären status und zusammensetzungen zu deren verwendung
EP0936270A2 (fr) Sérine protéase de la prostate
CA2263895A1 (fr) Applications therapeutiques et diagnostiques d'alleles produits par epissure dans le domaine i du perlecan
DE60032910T3 (de) Mittel zum nachweis und zur behandlung von krankheiten die in verbindung stehen mit fgfr3
EP1182258B1 (fr) Mutants de la protéase pour l'activation du facteur de coagulation VII
EP1284297A3 (fr) Identification et utilisation des molécules impliquées dans la douleur
Stapleton et al. Gene expression of prothrombin in the human kidney and its potential relevance to kidney stone disease
DE60126659T2 (de) Neue protease
DE69033810T2 (de) Herstellung und verwendung des menschlichen nm23-h2-proteins und dagegen gerichtete antikörper
Yamamoto et al. Primary structure of human amphiphysin, the dominant autoantigen of paraneoplastic Stiff—Man syndrome, and mapping of its gene (AMPH) to chromosome 7p13–p14
DE3686786T2 (de) Menschliche proteine des chinolinesterase-typs und ihre herstellung.
WO2003048384A3 (fr) Procedes d'identification de risque genetique et d'evaluation de traitement de la maladie d'alzheimer par la determination de polymorphismes d'un seul nucleotide
EP0198259B1 (fr) Procédé de détermination immunologique de sulfate d'héparane protéoglycane, procédé de production et de purification de sulfate d'héparane protéoglycane approprié à partir de tissus contenant les membranes basales
Kang et al. The effect of MDR1 G2677T/A polymorphism on pharmacokinetics of gabapentin in healthy Korean subjects
EP0943685A2 (fr) Récepteur couplé à la protein G provenant du cerveau human
EP0825443A1 (fr) Procédure pour la détermination quantitative de glycosaminoglycan dans une solution contenant de l'antithrombine III

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 99803223.9

Country of ref document: CN

AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: B1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: B1

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref document number: 2319121

Country of ref document: CA

Ref document number: 2319121

Country of ref document: CA

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: KR

WWE Wipo information: entry into national phase

Ref document number: 1999903669

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 24239/99

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 09600826

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1999903669

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 24239/99

Country of ref document: AU

WWG Wipo information: grant in national office

Ref document number: 1999903669

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载