WO1999037260A1 - Obturateur de conduit lacrymal - Google Patents
Obturateur de conduit lacrymal Download PDFInfo
- Publication number
- WO1999037260A1 WO1999037260A1 PCT/NL1999/000023 NL9900023W WO9937260A1 WO 1999037260 A1 WO1999037260 A1 WO 1999037260A1 NL 9900023 W NL9900023 W NL 9900023W WO 9937260 A1 WO9937260 A1 WO 9937260A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- plug
- tear
- broadened
- duct
- head
- Prior art date
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical class CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000011358 absorbing material Substances 0.000 claims abstract description 4
- 238000010521 absorption reaction Methods 0.000 claims abstract description 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims abstract description 3
- 206010061218 Inflammation Diseases 0.000 claims abstract description 3
- 229960002897 heparin Drugs 0.000 claims abstract description 3
- 229920000669 heparin Polymers 0.000 claims abstract description 3
- 230000004054 inflammatory process Effects 0.000 claims abstract description 3
- 239000003112 inhibitor Substances 0.000 claims abstract description 3
- 239000000126 substance Substances 0.000 claims abstract description 3
- 102100026735 Coagulation factor VIII Human genes 0.000 claims description 5
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 2
- 210000003128 head Anatomy 0.000 description 16
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 4
- 206010013774 Dry eye Diseases 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 230000037431 insertion Effects 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 241000083513 Punctum Species 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 210000003928 nasal cavity Anatomy 0.000 description 2
- 0 CC[C@]([C@@](C)C*(C)C[C@@](C)**)N Chemical compound CC[C@]([C@@](C)C*(C)C[C@@](C)**)N 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
- A61B17/1219—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices expandable in contact with liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12159—Solid plugs; being solid before insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00772—Apparatus for restoration of tear ducts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
Definitions
- the invention relates to a plug for closing off a tear-duct, which plug is provided with two extremities, with a shaft which at one of the two extremities is provided with a broadened head with a lower surface and an edge, the lower surface having at least a partially bent shape, the shaft having a broadened part which slopes in the direction of both extremities.
- Tear-ducts serve to discharge tear-water from an eye to the nasal cavity.
- Two tear-ducts end near each eye which ducts usually have a diameter of about 0.3 mm and are surrounded by a ring of connective tissue. Via the tear-duct opening or punctum and the tear-ducts or canaliculi tear-water is discharged to the tear- bag and from there to the nasal cavity.
- Tear-water among others serves to discharge dust and dirt and to keep the eye clean and moist. Tear-water also contains among other the enzyme lysozyme which acts as a kind of antibiotic and which protects the eye from infections. Per day a normal eye produces about 400 drops of tear water. During sleeping the tear-water production is lower.
- a shortage of tear-water may for instance occur as a result of excessive discharge via the tear-ducts.
- An unfavourable composition of the tear-water may also cause these problems, for instance when too little sebaceous matter is produced and the tear-water is too watery as a result of which it evaporates more quickly.
- Cir- cumstances which may aggravate the symptoms of dry eyes are for instance working in dry environments with a low air humidity, such as air-conditioned environments or air-planes, or working with computers.
- Dry eyes can be prevented or at least partially be remedied by reducing the discharge of tear water via the tear-ducts by arranging a little plug in one of the tear-ducts, or in serious cases in both tear-ducts, as a result of which the discharge of tear-water is blocked.
- Disadvantages of the known tear-duct plugs are that they are difficult to arrange and have to be arranged by an ophthalmologist or ophthalmic educated personnel.
- the tear-duct plug known from the US patent 5.334.1 37 may in some cases move during use, and appeared not always to sufficiently close off the tear-duct.
- the object of the invention is to provide a plug for a tear-duct, which during use remains on the same location and which sufficiently closes off the tear-duct.
- the object of the invention is achieved with a plug of the kind mentioned in the preamble, which has said broadened head and hollow curvature, and that the edge of the broadened head is bent back in the direction of the broadened part.
- the broadened head attaches itself firmly like a suction cup to the moist mucous membrane tissue surrounding the opening of the tear-duct.
- the plug is durably and firmly kept in its place after insertion in the tear-duct.
- the head of the plug known from the US patent specification does not have a bent back edge, so that no sucking effect is obtained.
- the plug is made of a moist absorbing material which is not soluble in water, such as for instance HEMA, of which also contact lenses are made.
- HEMA is a moist absorbing synthetic which does not irritate the eyes and mucous membranes.
- HEMA is radio opaque so that it can be perceived with the help of for instance X-ray equipment, whereas the little plug is virtually invisible with the naked eye.
- the HEMA is modified and substances are added for increasing the moist absorption.
- a modified HEMA may swell with a factor 1 .4 as a result of moist absorption.
- an inflammation inhibitor for instance heparin, may also be added to the material from which the plug is made.
- the plug is easier to remove if at the side facing the head, the broadened part of the shaft changes with a gradual running bend into a substantially cylindrical part of the shaft.
- the tear-duct plug is provided with a cavity which from the broadened head tapers off in the longitudinal direction of the plug.
- the plug can be arranged or removed in a simple manner with the help of a pair of tweezers or such like tools. If, as in most cases, the tear-duct has to be completely closed off, this cavity has to be a blind cavity. If the discharge via the tear-duct has to be reduced but not entirely closed off, then a passage can be arranged contiguous to this cavity which passage continues to the extremity opposite the broadened head.
- Figure 1 shows a plug according to the invention in perspective
- Figure 2 shows a human eye provided with a plug in accordance with figure 1 ;
- Figure 3 shows a cross-section of a plug along the line Ill-Ill from figure 1 ;
- Figure 4 shows a cross-section of another embodiment of a plug according to the invention. - 4 -
- Figure 1 shows a tear-duct plug 1 according to the invention, consisting of a shaft 2 with a broadened head 3 which serves to abut the tissue surrounding the tear- duct opening after placing the plug 1 in a tear-duct.
- the broadened head 3 has an edge.
- the other extremity is formed by a broadened part 4 which on the one hand shows a conical course and ends in a pointed extremity 5.
- the broadened part 4 preferably merges with a gradual bend into a substantially cylindrical part 6 of the shaft 2.
- the broadened head 3 is substantially dish- shaped, shows a hollow curvature 7, and the edge of the broadened head 3 is bent back in the direction of the broadened part 4, as can clearly be seen in figure 3 in which the plug 1 is shown in cross-section.
- this hollow curvature and bending back attaches itself firmly like a suction cup to the tissue surrounding the opening or punctum 9 of the a tear-duct or canaliculus 10 to be closed off.
- FIG 2 a part of an eye 1 1 is shown, in which the tear-duct 10, namely a lower tear-duct 12 and an upper tear-duct 1 3, are shown in dotted lines.
- the tear- ducts 1 2, 1 3 consist of a substantially vertical part 14 of about 2 mm long and contiguous to it a substantially horizontal part 1 5 of about 8 mm long, which connects to the tear-bag 1 6.
- a plug 1 is arranged in the lower tear-duct.
- the broadened head 3 protrudes from the tear-duct 1 2 and abuts the tissue surrounding the tear-duct opening 9.
- the broadened part 4 is in the tear-duct 1 2.
- the tissue of the inner wall of the tear-duct clamps around the broadened part 4, as a result of which because of the sucking effect of the broadened head 3 the plug can less easily slide of its own accord. Because the broadened part 4 is gradually bevelled towards both extremities the plug can both be placed and removed easily.
- the tear-duct plug 1 is made of a moist absorbing material, for instance a modified HEMA
- the plug 1 swells after insertion in the tear-duct.
- the factor with which the modified HEMA swells can be increased to a swell factor of about 1 .4.
- the plug 1 in the unswollen situation immediately after insertion in the tear-duct is shown in dotted lines.
- the same plug 1 is shown after it has swollen to its maximum size.
- the plug 1 remains much more firmly in its place in the tear-duct 10.
- the plug 1 further comprises a blind cylindrical cavity 1 7 which from the broadened head 3 extends in longitudinal direction of the plug 1 .
- a blind cylindrical cavity 1 7 which from the broadened head 3 extends in longitudinal direction of the plug 1 .
- FIG 4 another possible embodiment of a tear-duct plug according to the invention is shown in which contiguous to the cavity 17 a passage 18 is arranged which ends at the pointed extremity 5 of the plug 1 .
- a plug can be used if the discharge of tear-water via the tear-duct should not be entirely impeded, but only partially.
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Prostheses (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU19858/99A AU1985899A (en) | 1998-01-22 | 1999-01-15 | Plug for closing off a tear-duct |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL1008090A NL1008090C2 (nl) | 1998-01-22 | 1998-01-22 | Plug voor het afsluiten van een traanbuis. |
NL1008090 | 1998-01-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999037260A1 true WO1999037260A1 (fr) | 1999-07-29 |
Family
ID=19766388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/NL1999/000023 WO1999037260A1 (fr) | 1998-01-22 | 1999-01-15 | Obturateur de conduit lacrymal |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU1985899A (fr) |
NL (1) | NL1008090C2 (fr) |
WO (1) | WO1999037260A1 (fr) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2813522A1 (fr) * | 2000-09-06 | 2002-03-08 | Alain Fouere | Dispositif de drain lacrymal maintenu en place grace a un filetage externe |
FR2834446A1 (fr) * | 2002-01-08 | 2003-07-11 | Ioltechnologie Production | Clou meatique a expansion |
WO2008094989A2 (fr) | 2007-01-31 | 2008-08-07 | Alcon Research, Ltd. | Bouchons ponctuels et procédés d'administration d'agents thérapeutiques |
WO2010101758A1 (fr) | 2009-03-03 | 2010-09-10 | Alcon Research, Ltd. | Dispositif péricornéen d'administration de médicaments |
WO2011094170A1 (fr) | 2010-01-27 | 2011-08-04 | Alcon Research, Ltd. | Dispositif d'administration de médicaments péricornéens par intermittence |
US8691265B2 (en) | 2006-03-31 | 2014-04-08 | Mati Therapeutics, Inc. | Drug delivery methods, structures, and compositions for nasolacrimal system |
US9132088B2 (en) | 2008-04-30 | 2015-09-15 | Mati Therapeutics Inc. | Composite lacrimal insert and related methods |
US9180045B2 (en) | 2004-07-02 | 2015-11-10 | Mati Therapeutics Inc. | Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device |
US9216108B2 (en) | 2008-02-18 | 2015-12-22 | Mati Therapeutics Inc. | Lacrimal implants and related methods |
US9445944B2 (en) | 2007-09-07 | 2016-09-20 | Mati Therapeutics Inc. | Lacrimal implants and related methods |
US9463114B2 (en) | 2004-04-15 | 2016-10-11 | Mati Therapeutics Inc. | Punctal plug with active agent |
US9610271B2 (en) | 2011-08-29 | 2017-04-04 | Mati Therapeutics Inc. | Sustained release delivery of active agents to treat glaucoma and ocular hypertension |
US9949942B2 (en) | 2008-05-09 | 2018-04-24 | Mati Therapeutics Inc. | Sustained release delivery of active agents to treat glaucoma and ocular hypertension |
US9974685B2 (en) | 2011-08-29 | 2018-05-22 | Mati Therapeutics | Drug delivery system and methods of treating open angle glaucoma and ocular hypertension |
US10238535B2 (en) | 2009-02-23 | 2019-03-26 | Mati Therapeutics Inc. | Lacrimal implants and related methods |
US11141312B2 (en) | 2007-09-07 | 2021-10-12 | Mati Therapeutics Inc. | Lacrimal implant detection |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2737953A (en) * | 1954-08-26 | 1956-03-13 | Wiltein Rudolph | Medical ointment retainer |
US4364392A (en) * | 1980-12-04 | 1982-12-21 | Wisconsin Alumni Research Foundation | Detachable balloon catheter |
WO1991014406A1 (fr) * | 1990-03-29 | 1991-10-03 | Herrick Robert S | Implant canaliculaire comportant une section rentrable et methode concernant celui-ci |
US5283063A (en) * | 1992-01-31 | 1994-02-01 | Eagle Vision | Punctum plug method and apparatus |
US5334137A (en) | 1992-02-21 | 1994-08-02 | Eagle Vision, Inc. | Lacrimal fluid control device |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5417651A (en) | 1993-07-01 | 1995-05-23 | Guena; Nicolas | Punctum plug and monocanalicular probe for lacrimal pathology |
-
1998
- 1998-01-22 NL NL1008090A patent/NL1008090C2/nl not_active IP Right Cessation
-
1999
- 1999-01-15 WO PCT/NL1999/000023 patent/WO1999037260A1/fr active Application Filing
- 1999-01-15 AU AU19858/99A patent/AU1985899A/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2737953A (en) * | 1954-08-26 | 1956-03-13 | Wiltein Rudolph | Medical ointment retainer |
US4364392A (en) * | 1980-12-04 | 1982-12-21 | Wisconsin Alumni Research Foundation | Detachable balloon catheter |
WO1991014406A1 (fr) * | 1990-03-29 | 1991-10-03 | Herrick Robert S | Implant canaliculaire comportant une section rentrable et methode concernant celui-ci |
US5283063A (en) * | 1992-01-31 | 1994-02-01 | Eagle Vision | Punctum plug method and apparatus |
US5334137A (en) | 1992-02-21 | 1994-08-02 | Eagle Vision, Inc. | Lacrimal fluid control device |
Cited By (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2813522A1 (fr) * | 2000-09-06 | 2002-03-08 | Alain Fouere | Dispositif de drain lacrymal maintenu en place grace a un filetage externe |
FR2834446A1 (fr) * | 2002-01-08 | 2003-07-11 | Ioltechnologie Production | Clou meatique a expansion |
WO2003057101A1 (fr) * | 2002-01-08 | 2003-07-17 | Ioltechnologie-Production | Clou meatique a expansion |
US9463114B2 (en) | 2004-04-15 | 2016-10-11 | Mati Therapeutics Inc. | Punctal plug with active agent |
US9180045B2 (en) | 2004-07-02 | 2015-11-10 | Mati Therapeutics Inc. | Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device |
US10610407B2 (en) | 2004-07-02 | 2020-04-07 | Mati Therapeutics Inc. | Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such delivery device |
US9820884B2 (en) | 2004-07-02 | 2017-11-21 | Mati Therapeutics Inc. | Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such delivery device |
US10383817B2 (en) | 2006-03-31 | 2019-08-20 | Mati Therapeutics Inc. | Nasolacrimal drainage system implants for drug therapy |
US9610194B2 (en) | 2006-03-31 | 2017-04-04 | Mati Therapeutics Inc. | Drug delivery methods, structures, and compositions for nasolacrimal system |
US10300014B2 (en) | 2006-03-31 | 2019-05-28 | Mati Therapeutics Inc. | Nasolacrimal drainage system implants for drug therapy |
US9168222B2 (en) | 2006-03-31 | 2015-10-27 | Mati Therapeutics Inc. | Nasolacrimal drainage system implants for drug therapy |
US8691265B2 (en) | 2006-03-31 | 2014-04-08 | Mati Therapeutics, Inc. | Drug delivery methods, structures, and compositions for nasolacrimal system |
US10874606B2 (en) | 2006-03-31 | 2020-12-29 | Mati Therapeutics Inc. | Nasolacrimal drainage system implants for drug therapy |
US9849082B2 (en) | 2006-03-31 | 2017-12-26 | Mati Therapeutics Inc. | Nasolacrimal drainage system implants for drug therapy |
US12226525B2 (en) | 2006-03-31 | 2025-02-18 | Mati Therapeutics, Inc. | Nasolacrimal drainage system implants for drug therapy |
US11406592B2 (en) | 2006-03-31 | 2022-08-09 | Mati Therapeutics Inc. | Drug delivery methods, structures, and compositions for nasolacrimal system |
US8753666B2 (en) | 2007-01-31 | 2014-06-17 | Alcon Research, Ltd. | Punctal plugs and methods of delivering therapeutic agents |
WO2008094989A2 (fr) | 2007-01-31 | 2008-08-07 | Alcon Research, Ltd. | Bouchons ponctuels et procédés d'administration d'agents thérapeutiques |
US11951038B2 (en) | 2007-09-07 | 2024-04-09 | Mati Therapeutics Inc. | Lacrimal implants and related methods |
US9445944B2 (en) | 2007-09-07 | 2016-09-20 | Mati Therapeutics Inc. | Lacrimal implants and related methods |
US10434009B2 (en) | 2007-09-07 | 2019-10-08 | Mati Therapeutics Inc. | Lacrimal implants and related methods |
US11141312B2 (en) | 2007-09-07 | 2021-10-12 | Mati Therapeutics Inc. | Lacrimal implant detection |
US9216108B2 (en) | 2008-02-18 | 2015-12-22 | Mati Therapeutics Inc. | Lacrimal implants and related methods |
US9764066B2 (en) | 2008-04-30 | 2017-09-19 | Mati Therapeutics Inc. | Composite lacrimal insert and related methods |
US9132088B2 (en) | 2008-04-30 | 2015-09-15 | Mati Therapeutics Inc. | Composite lacrimal insert and related methods |
US9949942B2 (en) | 2008-05-09 | 2018-04-24 | Mati Therapeutics Inc. | Sustained release delivery of active agents to treat glaucoma and ocular hypertension |
US10238535B2 (en) | 2009-02-23 | 2019-03-26 | Mati Therapeutics Inc. | Lacrimal implants and related methods |
WO2010101758A1 (fr) | 2009-03-03 | 2010-09-10 | Alcon Research, Ltd. | Dispositif péricornéen d'administration de médicaments |
WO2011094170A1 (fr) | 2010-01-27 | 2011-08-04 | Alcon Research, Ltd. | Dispositif d'administration de médicaments péricornéens par intermittence |
US8469934B2 (en) | 2010-01-27 | 2013-06-25 | Alcon Research, Ltd. | Pulsatile peri-corneal drug delivery device |
US10632012B2 (en) | 2011-08-29 | 2020-04-28 | Mati Therapeutics Inc. | Sustained release delivery of active agents to treat glaucoma and ocular hypertension |
US9974685B2 (en) | 2011-08-29 | 2018-05-22 | Mati Therapeutics | Drug delivery system and methods of treating open angle glaucoma and ocular hypertension |
US9610271B2 (en) | 2011-08-29 | 2017-04-04 | Mati Therapeutics Inc. | Sustained release delivery of active agents to treat glaucoma and ocular hypertension |
Also Published As
Publication number | Publication date |
---|---|
AU1985899A (en) | 1999-08-09 |
NL1008090C2 (nl) | 1999-07-26 |
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