WO1999036775A1 - Method for detecting the origin of livestock and the products obtained therefrom - Google Patents
Method for detecting the origin of livestock and the products obtained therefrom Download PDFInfo
- Publication number
- WO1999036775A1 WO1999036775A1 PCT/DE1998/000113 DE9800113W WO9936775A1 WO 1999036775 A1 WO1999036775 A1 WO 1999036775A1 DE 9800113 W DE9800113 W DE 9800113W WO 9936775 A1 WO9936775 A1 WO 9936775A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- immunogen
- livestock
- farm animal
- enzyme
- use according
- Prior art date
Links
- 244000144972 livestock Species 0.000 title claims abstract description 22
- 238000000034 method Methods 0.000 title claims abstract description 19
- 241001465754 Metazoa Species 0.000 claims abstract description 34
- 238000001514 detection method Methods 0.000 claims abstract description 19
- 230000000984 immunochemical effect Effects 0.000 claims abstract description 14
- 241000283690 Bos taurus Species 0.000 claims abstract description 4
- 239000000427 antigen Substances 0.000 claims abstract 3
- 102000036639 antigens Human genes 0.000 claims abstract 3
- 108091007433 antigens Proteins 0.000 claims abstract 3
- 230000002163 immunogen Effects 0.000 claims description 34
- 102000004190 Enzymes Human genes 0.000 claims description 13
- 108090000790 Enzymes Proteins 0.000 claims description 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 13
- 108090000623 proteins and genes Proteins 0.000 claims description 13
- 102000004169 proteins and genes Human genes 0.000 claims description 10
- 230000001900 immune effect Effects 0.000 claims description 9
- 235000013372 meat Nutrition 0.000 claims description 9
- 238000003127 radioimmunoassay Methods 0.000 claims description 7
- 238000002965 ELISA Methods 0.000 claims description 6
- 235000013305 food Nutrition 0.000 claims description 6
- 238000002372 labelling Methods 0.000 claims description 6
- 238000012360 testing method Methods 0.000 claims description 6
- 230000028327 secretion Effects 0.000 claims description 5
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 238000009304 pastoral farming Methods 0.000 claims description 4
- 229960005486 vaccine Drugs 0.000 claims description 4
- 241000282887 Suidae Species 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 238000003018 immunoassay Methods 0.000 claims description 3
- 239000008267 milk Substances 0.000 claims description 3
- 210000004080 milk Anatomy 0.000 claims description 3
- 235000013336 milk Nutrition 0.000 claims description 3
- 210000004400 mucous membrane Anatomy 0.000 claims description 3
- 239000007943 implant Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 102000053602 DNA Human genes 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 238000003119 immunoblot Methods 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 241000282414 Homo sapiens Species 0.000 abstract description 2
- 241000282898 Sus scrofa Species 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 3
- 235000013622 meat product Nutrition 0.000 description 3
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000032258 transport Effects 0.000 description 2
- NSOITZIGPJTCMQ-KCXFZFQESA-N (4r,7s,10s,13s,16s,19s,22r)-22-[[(2s,3s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-1-[(2s)-2-[[(2s,3s)-2-[[(2s)-6-amino-2-[[(2s,3s)-2-[[(2s)-2-[[2-[[2-[[(2s)-2-[[(2s)-2-amino-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]acetyl]amino]-4-methylpentanoyl]a Chemical compound C([C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CSSC1)C(O)=O)[C@@H](C)O)C(C)C)=O)C1=CC=CC=C1 NSOITZIGPJTCMQ-KCXFZFQESA-N 0.000 description 1
- 102000007469 Actins Human genes 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 1
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 1
- 102000007625 Hirudins Human genes 0.000 description 1
- 108010007267 Hirudins Proteins 0.000 description 1
- 241000237988 Patellidae Species 0.000 description 1
- 101710153172 Pheromonotropin Proteins 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000005090 green fluorescent protein Substances 0.000 description 1
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 description 1
- 229940006607 hirudin Drugs 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 229940097496 nasal spray Drugs 0.000 description 1
- 230000008488 polyadenylation Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 108010047804 ranalexin Proteins 0.000 description 1
- 238000003307 slaughter Methods 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- LYTCVQQGCSNFJU-LKGYBJPKSA-N α-bungarotoxin Chemical compound C(/[C@H]1O[C@H]2C[C@H]3O[C@@H](CC(=C)C=O)C[C@H](O)[C@]3(C)O[C@@H]2C[C@@H]1O[C@@H]1C2)=C/C[C@]1(C)O[C@H]1[C@@]2(C)O[C@]2(C)CC[C@@H]3O[C@@H]4C[C@]5(C)O[C@@H]6C(C)=CC(=O)O[C@H]6C[C@H]5O[C@H]4C[C@@H](C)[C@H]3O[C@H]2C1 LYTCVQQGCSNFJU-LKGYBJPKSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K11/00—Marking of animals
Definitions
- the invention relates to a method and a use for verifying the origin of farm animals, in particular cattle, pigs and the like. the like , as well as products from it.
- livestock such as cattle and pigs
- an identifier for proof of origin which is stamped on a tag attached to the ear of the livestock (tattoo, transponder, etc. systems).
- the farm animals are grouped according to their origin.
- the meat of the slaughtered animals is then given a group-specific stamp.
- the company has started to produce accompanying documents for every farm animal.
- the proof of origin used according to the prior art is insufficient.
- the object of the invention is to eliminate the disadvantages of the prior art.
- forgery-proof proof is to be provided, with which the origin of both the live farm animal and products derived from it, such as meat, meat products and food of animal origin, can be reliably verified.
- the method according to the invention has the advantage that the biological marking is inextricably linked to the farm animal and therefore cannot be exchanged or counterfeited. It is also possible to prove the origin of meat without a stamp of origin, even of meat used in the manufacture of meat products.
- a protein and / or peptide is / are advantageously used as the immunogen (s), which / s neither as a vaccine nor via the food chain, nor via the environment in which usual livestock farming gets into the organism of the livestock and against which no antibodies are naturally formed in the livestock.
- a protein and / or peptide coupled with a carrier is expediently used. - This enables a specific marking to be achieved in a simple manner, which is easily detectable and completely harmless for human consumption.
- the immunogen is designed in such a way that the specific antibodies formed remain permanently in the organism of the livestock and can be detected by means of an enzyme-immunological or immunochemical detection method.
- the marking can be carried out by a single application, which is expediently carried out at the earliest possible time after the birth of the farm animal.
- the application can take place by the immunogen being applied to the farm animal by injection.
- the immunogen can also pass through the mucous membrane, preferably the nasal mucosa, of the farm animal, e.g. with a nasal spray or by means of an implant.
- a mixture of several different immunogens is advantageously applied.
- a first immunogen can be used to identify the region of origin, such as Western Europe, Eastern Europe, South America, etc.
- a second immunogen can be used to identify the country of origin
- a third immunogen can be used to identify administrative units in the country concerned.
- individual production and sales organizations eg producer rings, quality meat programs
- the DNA coding for it can also be applied with a suitable expression vector. In this way, the immunogen is repeatedly re-expressed. In this case, repeated application of the immunogen to refresh the label is unnecessary.
- Blood, milk or other body secretions can be used to detect the antibodies in the live farm animal, and blood and body secretions such as the dripping or squeezed juice of the meat can also be used in the slaughtered animal.
- enzyme immunological or immunochemical detection is particularly simple if it is carried out using test sticks. - If the marking remains reserved for veterinarians under state supervision, the origin of e.g. products obtained from slaughtered livestock are practically checked and ascertained by everyone.
- the immunogen can be a protein and / or peptide or a mixture of these which does not enter the organism of the livestock either as a vaccine or as a medicament, nor via the food chain in normal livestock farming and against which no antibodies are naturally formed in the livestock ; the protein and / or peptide can be coupled to a carrier.
- an immunogen which is foreign to the organism to be labeled but which is harmless for biological labeling enables a surprisingly simple, inexpensive and forgery-proof proof of origin.
- the DNA coding for it can also be applied.
- the corresponding immunogen is formed in the body of the farm animal by expression. This ensures permanent marking.
- the farm-animal can immunogens such as "keyhole limpet hemocyanin", "green fluorescent protein” are administered from Aequoria victoria, inactive snake toxins and Viruspro ⁇ teine.
- immunogens such as "keyhole limpet hemocyanin", "green fluorescent protein” are administered from Aequoria victoria, inactive snake toxins and Viruspro ⁇ teine.
- naturally occurring peptides or polypeptides such as hirudin, pheromonotropin or ranalexin can also be applied.
- synthetically produced fragments of partial amino acid sequences of naturally occurring immunogens can also be used for biomarking.
- artificial proteins and peptides, their amino acid sequence can also serve as immunogens does not correspond to any previously known substance, but is only assembled or manufactured for the purpose of biomarking
- a DNA can also be applied which has a nucleotide sequence coding for the immunogen.
- the DNA can contain partial sequences or the entire gene of "keyhole limpet hemocyanine". However, it can also be designed such that it describes only a short peptide, it being possible for several immunogens to be encoded on a single DNA. In the case of naturally occurring genes or sequences derived therefrom, both cDNA and genomic DNA with intron sequences can be applied.
- the DNA can contain further sequences which are important for the expression and processing of the immunogen in the livestock organism.
- promoter sequences and sequences which bring about transcription termination and polyadenylation of the mRNA and intracellular "trafficking" of the immunogen.
- Suitable expression regulators are promoters which ensure a high transcription rate of the DNA, e.g. the "immediate early" promoter of the cytomegalovirus or the promoter of a livestock-specific "house-keeping" gene such as ⁇ -actin.
- promoters are also suitable which specifically restrict the expression of the immunogen to predetermined body cells.
- the polypeptide formed can be directed into the lumen of the endoplasmic reticulum by suitable "trafficking" signal sequences and directed into cellular distribution channels for secretion or expression and presentation on the cell surface.
- the antibodies induced by the substances mentioned are detected by common detection methods such as ELISA, EIA and RIA, preferably using test sticks, e.g. be immersed in the dripping juice of the meat of the slaughtered farm animal.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Birds (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98905259A EP1047940A1 (en) | 1998-01-14 | 1998-01-14 | Method for detecting the origin of livestock and the products obtained therefrom |
PCT/DE1998/000113 WO1999036775A1 (en) | 1998-01-14 | 1998-01-14 | Method for detecting the origin of livestock and the products obtained therefrom |
CA002315023A CA2315023A1 (en) | 1998-01-14 | 1998-01-14 | Method for detecting the origin of livestock and products originating therefrom |
JP2000540436A JP2002509251A (en) | 1998-01-14 | 1998-01-14 | Methods for detecting the origin of livestock and products obtained therefrom |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/DE1998/000113 WO1999036775A1 (en) | 1998-01-14 | 1998-01-14 | Method for detecting the origin of livestock and the products obtained therefrom |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999036775A1 true WO1999036775A1 (en) | 1999-07-22 |
Family
ID=6918612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE1998/000113 WO1999036775A1 (en) | 1998-01-14 | 1998-01-14 | Method for detecting the origin of livestock and the products obtained therefrom |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1047940A1 (en) |
JP (1) | JP2002509251A (en) |
CA (1) | CA2315023A1 (en) |
WO (1) | WO1999036775A1 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000022433A1 (en) * | 1998-10-13 | 2000-04-20 | november Aktiengesellschaft Gesellschaft für Molekulare Medizin | Method and use for marking and identifying applied substances |
WO2001019178A1 (en) | 1999-09-15 | 2001-03-22 | november Aktiengesellschaft Gesellschaft für Molekulare Medizin | Method for marking an animal and products derived therefrom |
DE10011741A1 (en) * | 2000-03-13 | 2001-09-20 | Rausch Hans | Biologically marking an animal for determining their place of origin comprises the oral administration of an immunogen which produces detectable changes |
DE10130321A1 (en) * | 2001-06-22 | 2003-01-09 | Hans-Lorenz Werner | Identifying individuals, useful for preventing falsification of urine samples, comprises administering a marker that can be detected in body fluids |
WO2004073738A3 (en) * | 2003-02-18 | 2004-10-28 | Responsif Gmbh | Composition to be administered to a living being and method for marking agents |
WO2004078926A3 (en) * | 2003-02-28 | 2004-12-29 | Univ Michigan | Immunologigal markers |
DE10112470B4 (en) * | 2001-03-15 | 2008-02-28 | Keller, Ruprecht, Priv.-Doz. Dr.Dr. | A method for sample identification in a mammal and kit for carrying out this method |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4152412A (en) * | 1976-04-02 | 1979-05-01 | Brewer John H | Marking vaccine |
EP0336800A1 (en) * | 1988-03-18 | 1989-10-11 | Idetek, Inc. | Methods and kit for determining sulfamethazine in animal fluids or feed |
GB2271848A (en) * | 1992-10-23 | 1994-04-27 | Richard James Guy | Method of marking an animal or plant. |
WO1998018003A2 (en) * | 1996-10-23 | 1998-04-30 | Manfred Gareis | Method of establishing the origin of useful animals and products produced therefrom |
GB2320960A (en) * | 1997-01-03 | 1998-07-08 | Gregory Scott Armitage | Marking or tagging of livestock |
-
1998
- 1998-01-14 EP EP98905259A patent/EP1047940A1/en not_active Withdrawn
- 1998-01-14 CA CA002315023A patent/CA2315023A1/en not_active Abandoned
- 1998-01-14 JP JP2000540436A patent/JP2002509251A/en active Pending
- 1998-01-14 WO PCT/DE1998/000113 patent/WO1999036775A1/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4152412A (en) * | 1976-04-02 | 1979-05-01 | Brewer John H | Marking vaccine |
EP0336800A1 (en) * | 1988-03-18 | 1989-10-11 | Idetek, Inc. | Methods and kit for determining sulfamethazine in animal fluids or feed |
GB2271848A (en) * | 1992-10-23 | 1994-04-27 | Richard James Guy | Method of marking an animal or plant. |
WO1998018003A2 (en) * | 1996-10-23 | 1998-04-30 | Manfred Gareis | Method of establishing the origin of useful animals and products produced therefrom |
GB2320960A (en) * | 1997-01-03 | 1998-07-08 | Gregory Scott Armitage | Marking or tagging of livestock |
Non-Patent Citations (1)
Title |
---|
"AGRICOLA DATABASE ABSTRACT 85:9020 "Marking new Lines of Brown Swiss Cattle with alleles of B-system of blood groups."Gurkovich, K.A. und Chernushenko, V.K Biulleten' nauchnykh rabot - Vsesoiuznyi n.issledovatel'skii institut,1981 S. 81-85", STN CHEMICAL ABSTRACTS, XP002059373 * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000022433A1 (en) * | 1998-10-13 | 2000-04-20 | november Aktiengesellschaft Gesellschaft für Molekulare Medizin | Method and use for marking and identifying applied substances |
WO2001019178A1 (en) | 1999-09-15 | 2001-03-22 | november Aktiengesellschaft Gesellschaft für Molekulare Medizin | Method for marking an animal and products derived therefrom |
DE10011741A1 (en) * | 2000-03-13 | 2001-09-20 | Rausch Hans | Biologically marking an animal for determining their place of origin comprises the oral administration of an immunogen which produces detectable changes |
WO2001068149A3 (en) * | 2000-03-13 | 2002-06-20 | Denzel Klaus | Method and use for biologically marking animals and animal products |
DE10112470B4 (en) * | 2001-03-15 | 2008-02-28 | Keller, Ruprecht, Priv.-Doz. Dr.Dr. | A method for sample identification in a mammal and kit for carrying out this method |
US7820444B2 (en) | 2001-03-15 | 2010-10-26 | Ruprecht Keller | Method for sample identification in a mammal as well as a kit for performing this method |
USRE44859E1 (en) * | 2001-03-15 | 2014-04-22 | Ruprecht Keller | Method for sample identification in a mammal as well as a kit for performing this method |
DE10130321A1 (en) * | 2001-06-22 | 2003-01-09 | Hans-Lorenz Werner | Identifying individuals, useful for preventing falsification of urine samples, comprises administering a marker that can be detected in body fluids |
WO2004073738A3 (en) * | 2003-02-18 | 2004-10-28 | Responsif Gmbh | Composition to be administered to a living being and method for marking agents |
WO2004078926A3 (en) * | 2003-02-28 | 2004-12-29 | Univ Michigan | Immunologigal markers |
Also Published As
Publication number | Publication date |
---|---|
JP2002509251A (en) | 2002-03-26 |
EP1047940A1 (en) | 2000-11-02 |
CA2315023A1 (en) | 1999-07-22 |
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