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WO1999036536A3 - Methodes et compositions permettant de modifier la sensibilite des tissus face aux lesions immunitaires, a la mort cellulaire programmee et a la clairance par le systeme reticulo-endothelial - Google Patents

Methodes et compositions permettant de modifier la sensibilite des tissus face aux lesions immunitaires, a la mort cellulaire programmee et a la clairance par le systeme reticulo-endothelial Download PDF

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Publication number
WO1999036536A3
WO1999036536A3 PCT/US1999/001087 US9901087W WO9936536A3 WO 1999036536 A3 WO1999036536 A3 WO 1999036536A3 US 9901087 W US9901087 W US 9901087W WO 9936536 A3 WO9936536 A3 WO 9936536A3
Authority
WO
WIPO (PCT)
Prior art keywords
clearance
compositions
methods
cell death
programmed cell
Prior art date
Application number
PCT/US1999/001087
Other languages
English (en)
Other versions
WO1999036536A9 (fr
WO1999036536A2 (fr
Inventor
Peter J Sims
Therese Wiedmer
Ji Zhao
Original Assignee
Blood Center Res Found Inc
Peter J Sims
Therese Wiedmer
Ji Zhao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blood Center Res Found Inc, Peter J Sims, Therese Wiedmer, Ji Zhao filed Critical Blood Center Res Found Inc
Priority to EP99903179A priority Critical patent/EP1047779A2/fr
Priority to AU23262/99A priority patent/AU2326299A/en
Publication of WO1999036536A2 publication Critical patent/WO1999036536A2/fr
Publication of WO1999036536A9 publication Critical patent/WO1999036536A9/fr
Publication of WO1999036536A3 publication Critical patent/WO1999036536A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne une méthode d'accroissement de la viabilité des cellules ou des tissus mammifères, consistant à inhiber l'expression de la PL-scramblase native dans les cellules ou les tissus. Dans un autre mode de réalisation, l'invention concerne une méthode de réduction du potentiel métastatique et invasif ainsi que du potentiel de viabilité des cellules cancéreuses, des tissus cancéreux, ou des cellules infectées par virus, par l'augmentation de l'expression ou l'activité de la protéine PL-scramblase dans les cellules ou les tissus en question.
PCT/US1999/001087 1998-01-20 1999-01-19 Methodes et compositions permettant de modifier la sensibilite des tissus face aux lesions immunitaires, a la mort cellulaire programmee et a la clairance par le systeme reticulo-endothelial WO1999036536A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99903179A EP1047779A2 (fr) 1998-01-20 1999-01-19 Methodes et compositions permettant de modifier la sensibilite des tissus face aux lesions immunitaires, a la mort cellulaire programmee et a la clairance par le systeme reticulo-endothelial
AU23262/99A AU2326299A (en) 1998-01-20 1999-01-19 Methods and compositions to alter tissue susceptibility to immune injury, to programmed cell death, and to clearance by the reticuloendothelial system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7195098P 1998-01-20 1998-01-20
US60/071,950 1998-01-20

Publications (3)

Publication Number Publication Date
WO1999036536A2 WO1999036536A2 (fr) 1999-07-22
WO1999036536A9 WO1999036536A9 (fr) 1999-11-04
WO1999036536A3 true WO1999036536A3 (fr) 1999-12-09

Family

ID=22104619

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/001087 WO1999036536A2 (fr) 1998-01-20 1999-01-19 Methodes et compositions permettant de modifier la sensibilite des tissus face aux lesions immunitaires, a la mort cellulaire programmee et a la clairance par le systeme reticulo-endothelial

Country Status (3)

Country Link
EP (1) EP1047779A2 (fr)
AU (1) AU2326299A (fr)
WO (1) WO1999036536A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030044979A1 (en) * 2001-04-05 2003-03-06 Isis Pharmaceuticals Inc. Antisense modulation of phospholipid scramblase I expression
US20030139359A1 (en) * 2001-12-04 2003-07-24 Isis Pharmaceuticals Inc. Antisense modulation of phospholipid scramblase 3 expression
IL147812A0 (en) * 2001-03-16 2002-08-14 N S T Neurosurvival Technologi Method for targeting chemical compounds to cells and pharmaceutical compositions used therein

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037225A1 (fr) * 1996-04-02 1997-10-09 Blood Center Research Foundation PREPARATION D'UNE PROTEINE QUI CONTROLE LE MOUVEMENT Ca2+-DEPENDANT DES PHOSPHOLIPIDES DES MEMBRANES PLASMIQUES A TRAVERS LES COUCHES DOUBLES ET INHIBITEURS DE CETTE PROTEINE
WO1999019352A2 (fr) * 1997-10-10 1999-04-22 Blood Center Research Foundation Methodes et compositions permettant de modifier l'expression de la surface cellulaire de la phosphatidylserine et d'autres phospholipides de membrane plasmique favorisant la formation de caillots

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037225A1 (fr) * 1996-04-02 1997-10-09 Blood Center Research Foundation PREPARATION D'UNE PROTEINE QUI CONTROLE LE MOUVEMENT Ca2+-DEPENDANT DES PHOSPHOLIPIDES DES MEMBRANES PLASMIQUES A TRAVERS LES COUCHES DOUBLES ET INHIBITEURS DE CETTE PROTEINE
WO1999019352A2 (fr) * 1997-10-10 1999-04-22 Blood Center Research Foundation Methodes et compositions permettant de modifier l'expression de la surface cellulaire de la phosphatidylserine et d'autres phospholipides de membrane plasmique favorisant la formation de caillots

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
B VERHOEVEN ET AL: "Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 182, no. 182, 1995, pages 1597 - 1601, XP002099796, ISSN: 0022-1007 *
BRATTON, D.: "Polyamine inhibition of transbilayer movement of plasma membrane phospholipids in the erythrocyte ghost", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 269, 9 September 1994 (1994-09-09), pages 22517 - 22523, XP002107581, ISSN: 0021-9258 *
E F SMEETS ET AL: "Calcium-induced transbilayer scrambling of fluorescent phopholipids analogs in platelets and erythrocytes", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1195, no. 1195, 1994, pages 281 - 286, XP002099795, ISSN: 0006-3002 *
STOUT J G ET AL: "Change in conformation of plasma membrane phospholipid scramblase induced by occupancy of its Ca2+ binding site.", BIOCHEMISTRY, (1998 OCT 20) 37 (42) 14860-6., XP002107584 *
UTSUGI ET AL: "Elevated Expression of Phosphatidylseine in the Outer Membrane Leaflet of Human Tumor Cells and Recognition by Activated Human Blood Monocytes", CANCER RESEARCH, vol. 51, no. 51, 1 June 1991 (1991-06-01), pages 3062 - 3066, XP002101466 *
ZHAO J ET AL: "Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids.", BIOCHEMISTRY, (1998 MAY 5) 37 (18) 6361-6., XP002107583 *
ZHAO, J. ET AL.: "Level of expression of phospholipid scramblase regulates induced movement of phosphatidylserine to the cell surface", JOURNAL OF BIOLOGICAL CHEMISTRY, (1998 MAR 20) 273 (12) 6603-6., XP002115839 *
ZHOU Q ET AL: "Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids.", BIOCHEMISTRY, (1998 FEB 24) 37 (8) 2356-60., XP002098910 *
ZHOU Q ET AL: "Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids.", JOURNAL OF BIOLOGICAL CHEMISTRY, (1997 JUL 18) 272 (29) 18240-4., XP002098868 *
ZHOU, Q. ET AL.: "Sequences of human and mouse plasma membrane PL scramblase reveal residues required for Ca2+-induced reorganization of membrane phospholipids.", MOLECULAR BIOLOGY OF THE CELL, (NOV., 1997) VOL. 8, NO. SUPPL., PAGE 292A; ABSTRACT 1693., XP002107580 *
ZWAAL, R. & SCHROIT, A.: "Pathophysiologic implications of membrane phospholipid asymmetry in blood cells", BLOOD, vol. 89, 15 February 1997 (1997-02-15), pages 1121 - 1132, XP002107582, ISSN: 0006-4971 *

Also Published As

Publication number Publication date
EP1047779A2 (fr) 2000-11-02
WO1999036536A9 (fr) 1999-11-04
AU2326299A (en) 1999-08-02
WO1999036536A2 (fr) 1999-07-22

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