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WO1999035913A1 - Utilisation de neonicotinoides sur des plantes transgeniques - Google Patents

Utilisation de neonicotinoides sur des plantes transgeniques Download PDF

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Publication number
WO1999035913A1
WO1999035913A1 PCT/EP1999/000183 EP9900183W WO9935913A1 WO 1999035913 A1 WO1999035913 A1 WO 1999035913A1 EP 9900183 W EP9900183 W EP 9900183W WO 9935913 A1 WO9935913 A1 WO 9935913A1
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WIPO (PCT)
Prior art keywords
spp
crop
bacterial
thε
transgenic
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Application number
PCT/EP1999/000183
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English (en)
Inventor
Bruce Lee
Marius Sutter
Hubert Buholzer
Original Assignee
Novartis Ag
Novartis-Erfindungen Verwaltungsgesellschaft Mbh
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Priority to GB0017168A priority Critical patent/GB2349088A/en
Priority to BRPI9917838A priority patent/BRPI9917838B1/pt
Priority to DE19982477T priority patent/DE19982477T1/de
Priority to CA002317050A priority patent/CA2317050C/fr
Priority to BRPI9917912A priority patent/BRPI9917912B1/pt
Application filed by Novartis Ag, Novartis-Erfindungen Verwaltungsgesellschaft Mbh filed Critical Novartis Ag
Priority to BRPI9907010-3A priority patent/BR9907010B1/pt
Priority to KR1020007007794A priority patent/KR100593584B1/ko
Priority to HU0100528A priority patent/HU230681B1/hu
Priority to AU25176/99A priority patent/AU744003B2/en
Priority to JP2000539707A priority patent/JP4833404B2/ja
Publication of WO1999035913A1 publication Critical patent/WO1999035913A1/fr
Priority to US11/456,939 priority patent/US20060258747A1/en
Priority to US12/191,707 priority patent/US8399378B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring

Definitions

  • the present invention relates to a method of controlling pests with a nitroimino- or nitroguanidino-compound, especially thiamethoxam; more specifically to a novel method of controlling pests in and on transgenic crops of useful plants with a nitroimino- or nitroguanidino-compound.
  • the present invention therefore relates to a method of controlling pests in crops of transgenic useful plants, such as, for example, in crops of maize, cereals, soya beans, tomatoes, cotton, potatoes, rice and mustard, characterized in that a pesticidal composition comprising a nitroimino- or nitroguanidino-compound, especially thiamethoxam, imidacloprid, Ti-435 or thiacloprid in free form or in agrochemically useful salt form and at least one auxiliary is applied to the pests or their environment, in particular to the crop plant itself; to the use of the composition in question and to propagation material of transgenic plants which has been treated with it.
  • a pesticidal composition comprising a nitroimino- or nitroguanidino-compound, especially thiamethoxam, imidacloprid, Ti-435 or thiacloprid in free form or in agrochemically useful salt form and at least one auxiliary is applied to the pests
  • a nitroimino- or nitroguanidino-compound compound for controlling pests on transgenic useful plants which contain - for instance - one or more genes expressing a pesticidaliy, particularly insecticidally, acaricidally, nematocidally or fugicidally active ingredient, or which are tolerant against herbicides or resistent against the attack of fungi, has a synergistic effect.
  • nitroimino- or nitroguanidino-compound in combination with a transgenic plant exceeds the additive effect, to be expected in principle, on the pests to be controlled and thus extends the range of action of the nitroimino- or nitroguanidino-compound and of the active principle expressed by the transgenic plant in particular in two respects:
  • the pesticidal activity of a nitroimino- or nitroguanidino-compound in combination with the effect expressed by the transgenic useful plant is not only additive in comparison with the pesticidal activities of the nitroimino- or nitroguanidino-compound alone and of the transgenic crop plant alone, as can generally be expected, but that a synergistic effect is present.
  • the term "synergistic”, however, is in no way to be understood in this connection as being restricted to the pesticidal activity, but the term also refers to other advantageous properties of the method according to the invention compared with the nitroimino- or nitroguanidino-compound and the transgenic useful plant alone.
  • Nitroimino- and nitroguanidino-cpmpounds such as thiamethoxam (5-(2-Chlorthiazol-5- ylmethyl)-3-methyl-4-nitroimino-perhydro-1 ,3,5-oxadiazin), are known from EP-A-0'580'553. Within the scope of invention thiamethoxam is preferred.
  • the agrochemically compatible salts of the nitroimino- or nitroguanidino-compounds are, for example, acid addition salts of inorganic and organic acids, in particular of hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, perchloric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, malonic acid, toluenesulfonic acid or benzoic acid.
  • Preferred within the scope of the present invention is a composition known per se which comprises, as active ingredient, thiamethoxam and imidacloprid, each in the free form, especially thiamethoxam.
  • the transgenic plants used according to the invention are plants, or propagation material thereof, which are transformed by means of recombinant DNA technology in such a way that they are - for instance - capable of synthesizing selectively acting toxins as are known, for example, from toxin-producinginvertebrates, especially of the phylum Arthropoda, as can be obtained from Bacillus thuringiensis strains; or as are known from plants, such as lectins; or in the alternative capable of expressing a herbicidal or fungicidal resistance.
  • the methods for generating such transgenic plants are widely known to those skilled in the art and described, for example, in the publications mentioned above.
  • the toxins which can be expressed by such transgenic plants include, for example, toxins, such as proteins which have insecticidal properties and which are expressed by transgenic plants, for example Bacillus cereus proteins or Bacillus popiiae proteins; or Bacillus thuringiensis endotoxins (B.t.), such as CrylA(a), CrylA(b), CrylA(c), CryllA, CrylllA, CrylllB2 orCytA; VIP1 ; VIP2; VIP3; or insecticidal proteins of bacteria colonising nematodes like Photorhabdus spp or Xenorhabdus spp such as Photorhabdus luminescens, Xenorhabdus nematophilus etc..
  • proteinase inhibitors such as trypsin inhibitors, se ⁇ ne protease inhibitors, patatin, cystatin, papam inhibitors; ribosome-inactivating proteins (RIP), such as ncin, maize RIP, ab ⁇ n, luffin, saponn or bryodin; plant lectins such as pea lectins, barley lectins or snowdrop lectins; or agglutmins; toxins produced by animals, such as scorpion toxins, spider venoms, wasp venoms and other insect-specific neurotoxins; steroid metabolism enzymes, such as 3-hydroxysteroid oxidase, ecdysteroid UDP-glycosyl transferase, cholesterol oxidases, ecdysone inhibitors, HMG-COAreductase, ion channel blockers such as sodium and calcium, juvenile hormone esterase, diuretic hormone receptors, stilbene synthase, bibenzyl synthas
  • transgenic plants which comprise one or more genes which encode insecticidal resistance and express one or more toxins are the following: KnockOut® (maize), YieldGard® (maize); NuCOTN 33B® (cotton), Bollgard® (cotton), NewLeaf® (potatoes), NatureGard® and Protecta®.
  • the following tables comprise further examples of targets and principles and crop phenotypes of transgenic crops which show tolerance against pests mainly insects, mites, nematodes, virus, bacteria and diseases or are tolerant to specific herbicides or classes of herbicides.
  • AcetylCoA Carboxyiase (ACCase) Aryloxyphenoxyalkanecarboxyiic acids, cyciohexanediones Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • Hydroxyphenylpyruvate dioxygenase Isoxazoles such as Isoxaflutol or
  • ADSL Adenylosuccinate Lyase
  • Nitrilase 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl
  • EPSPS Synthase
  • Glyphosate oxidoreductase Glyphosate or sulfosate
  • Protoporphyrinogen oxidase Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
  • Cytochrome P450 eg. P450 SU1 Xenobiotics and herbicides such as
  • Bx1 gene Helminthosporium turcicum
  • Rhopalosiphum maydis, Diplodia m o ⁇ /Hie f" ⁇ etrir»io ni i ilolic lorwHfM-vf-ar-a en
  • CMIII small basic maize seed peptide plant pathogenes eg. fusarium, altemaria, sclerotina
  • Corn- SAFP (zeamatin) plant pathogenes eg. fusarium, altemaria, sclerotina, rhizoctonia, chaetomium.phycomyces
  • Hm1 gene Cochliobulus Chitinases plant pathogenes Glucanases plant pathogenes Coat proteins viruses such as maize dwarf mosaic Effected target or expressed principle(s) Crop phenotype / Tolerance to virus, maize chlorotic dwarf virus
  • Xenorhabdus toxins heliothis zea armyworms eg. spodoptera frugiperda, com rootworms, sesamia sp., black cutworm, asian corn borer.weevils
  • Aminopeptidase inhibitors eg. Leucine lepidoptera, coleoptera, diptera, aminopeptidase inhibitor (LAPI) nematodes, eg. ostrinia nubilalis, heliothis zea, armyworms eg. spodoptera frugiperda, corn rootworms, sesamia sp., black cutworm, asian com borer, weevils
  • LAPI aminopeptidase inhibitor
  • Protease Inhibitors eg. cystatin, patatin, weevils, com rootworm virgiferin, CPTI ribosome inactivating protein lepidoptera, coleoptera, diptera, nematodes, eg. ostrinia nubilalis, heliothis zea, armyworms eg. spodoptera frugiperda, com rootworms, sesamia sp., black cutworm, asian com borer, weevils maize 5C9 polypeptide lepidoptera, coleoptera, diptera, nematodes, eg.
  • ostrinia nubilalis heliothis zea
  • armyworms eg. spodoptera frugiperda
  • com rootworms sesamia sp.
  • black cutworm asian corn borer, weevils
  • AcetylCoA Carboxylase (ACCase) Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones
  • Hydroxyphenylpyruvate dioxygenase Isoxazoles such as Isoxafiutol or
  • ADSL Adenylosuccinate Lyase
  • Nitrilase 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl
  • EPSPS Synthase
  • Glyphosate oxidoreductase Glyphosate or sulfosate
  • Protopo ⁇ hyrinogen oxidase Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
  • Cytochrome P450 eg. P450 SU1 Xenobiotics and herbicides such as
  • Hypersensitive response eliciting plant pathogenes eg. fusarium, septoria polypeptide and other diseases
  • SAR resistance
  • Glucanases plant pathogenes double stranded ribonuclease viruses such as BYDV and MSMV
  • Coat proteins viruses such as BYDV and MSMV
  • Aminopeptidase inhibitors eg. Leucine lepidoptera, coleoptera, diptera, aminopeptidase inhibitor nematodes,
  • Protease Inhibitors eg. cystatin, patatin, lepidoptera, coleoptera, diptera, virgiferin, CPTI nematodes, aphids ribosome inactivating protein lepidoptera, coleoptera, diptera, nematodes, aphids
  • AcetylCoA Carboxyiase (ACCase) Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones
  • Hydroxyphenylpyruvate dioxygenase isoxazoles such as isoxaflutol or
  • ADSL Adenylosuccinate Lyase
  • Nitriiase 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl
  • EPSPS Synthase
  • Glyphosate oxidoreductase Glyphosate or sulfosate
  • Protoporphyrinogen oxidase Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
  • Cytochrome P450 eg. P450 SU1 Xenobiotics and herbicides such as
  • Hypersensitive response eliciting plant pathogenes eg. fusarium, septoria polypeptide and other diseases
  • SAR resistance
  • Glucanases plant pathogenes double stranded ribonuclease viruses such as BYDV and MSMV
  • Coat proteins viruses such as BYDV and MSMV
  • Aminopeptidase inhibitors eg. Leucine lepidoptera, coleoptera, diptera, aminopeptidase inhibitor nematodes,
  • Protease Inhibitors eg. cystatin, patatin, lepidoptera, coleoptera, diptera, virgiferin, CPTI nematodes, aphids ribosome inactivating protein lepidoptera, coleoptera, diptera, nematodes, aphids
  • AcetylCoA Carboxylase (ACCase) Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones
  • Hydroxyphenyipyruvate dioxygenase Isoxazoles such as isoxaflutol or
  • ADSL Adenylosuccinate Lyase Inhibitors of IMP and AMP synthesis Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • Nitrilase 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl
  • EPSPS Synthase
  • Glyphosate oxidoreductase Glyphosate or sulfosate
  • Protopo ⁇ hyrinogen oxidase Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
  • Cytochrome P450 eg. P450 SU1 Xenobiotics and herbicides such as
  • PAL Phenylalanine ammonia lyase
  • SAR resistance
  • Chitinases plant pathogenes eg bacterial leaf blight and rice blast
  • Glucanases plant pathogenes Effected target or expressed principle(s) Crop phenotype / Tolerance to double stranded ribonuclease viruses such as BYDV and MSMV
  • Coat proteins viruses such as BYDV and MSMV
  • Xenorhabdus toxins eg brown rice hopper
  • Peroxidase lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper
  • Aminopeptidase inhibitors eg. Leucine lepidoptera eg. stemborer, coleoptera eg aminopeptidase inhibitor rice water weevil, diptera, rice hoppers eg brown rice hopper
  • Lectines lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper
  • Protease Inhibitors lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper ribosome inactivating protein lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper ribosome inactivating protein lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper
  • HMG-CoA reductase lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper
  • AcetylCoA Carboxylase (ACCase) Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones
  • Hydroxyphenylpyruvate dioxygenase Isoxazoles such as Isoxaflutol or
  • ADSL Adenylosuccinate Lyase
  • Nitrilase 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl
  • EPSPS Synthase
  • Glyphosate oxidoreductase Glyphosate or sulfosate
  • Protopo ⁇ hyrinogen oxidase Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.
  • Cytochrome P450 eg. P450 SU1 or Xenobiotics and herbicides such as selection Sulfonylureas
  • Phenylalanine ammonia lyase bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot phytoalexins plant pathogenes eg bacterial leaf blight and rice blast
  • B-1 ,3-glucanase antisense plant pathogenes eg bacterial leaf blight and rice blast receptor kinase bacterial and fungal pathogens such as fusa ⁇ um, sclerotinia, stemrot
  • SAR resistance
  • Glucanases bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot double stranded ⁇ bonuclease viruses such as BPMV and SbMV
  • Coat proteins viruses such as BYDV and MSMV
  • Aminopeptidase inhibitors eg. Leucine lepidoptera, coleoptera, aphids aminopeptidase inhibitor
  • Protease Inhibitors eg virgifenn lepidoptera, coleoptera, aphids Effected target or expressed principle(s) Crop phenotype / Tolerance to ribosome inactivating protein lepidoptera, coleoptera, aphids
  • Antifeeding principles nematodes eg root knot nematodes and cyst nematodes
  • AcetylCoA Carboxyiase (ACCase) Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones
  • Hydroxyphenylpyruvate dioxygenase isoxazoles such as Isoxaflutol or
  • ADSL Adenylosuccinate Lyase
  • Nitrilase 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl
  • EPSPS Synthase
  • Protopo ⁇ hyrinogen oxidase Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopyiate, oxadiazoies etc.
  • Cytochrome P450 eg. P450 SU1 or Xenobiotics and herbicides such as selection Sultonylureas
  • Metallothionein bacterial and fungal pathogens such as phytophtora
  • Antifungal polypeptide AlyAFP bacterial and fungal pathogens such as phytophtora oxalate oxidase bacterial and fungal pathogens such as
  • Phytophtora Verticiliium, Rhizoctonia pyrrolnitrin synthesis genes bacterial and fungal pathogens such as
  • serine/threonine kinases bacterial and fungal pathogens such as
  • Cecropin B bacteria such as corynebacterium sepedonicum, Erwinia carotovora
  • Phenylalanine ammonia lyase (PAL) bacterial and fungal pathogens such as
  • Phytophtora Verticiliium, Rhizoctonia phytoalexins bacterial and fungal pathogens such as
  • B-1 ,3-glucanase antisense bacterial and fungal pathogens such as
  • Phytophtora, Verticiliium, Rhizoctonia receptor kinase bacterial and fungal pathogens such as Phytophtora, Verticiliium, Rhizoctonia Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • Hypersensitive response eliciting bacterial and fungal pathogens such as polypeptide Phytophtora, Verticiliium, Rhizoctonia
  • SAR resistance
  • Glucanases bacterial and fungal pathogens such as
  • Coat proteins viruses such as PLRV, PVY and TRV
  • 17kDa or 60 kDa protein viruses such as PLRV, PVY and TRV
  • Nuclear inclusion proteins eg. a or b viruses such as PLRV, PVY and TRV
  • Pseudoubiquitin viruses such as PLRV, PVY and TRV
  • Replicase viruses such as PLRV, PVY and TRV
  • Bacillus thuringiensis toxins VIP 3, coleoptera eg Colorado potato beetle,
  • Aminopeptidase inhibitors eg. Leucine coleoptera eg Colorado potato beetle, aminopeptidase inhibitor aphids stilbene synthase coleoptera eg Colorado potato beetle, aphids Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • Protease Inhibitors eg cystatin, patatin coleoptera eg Colorado potato beetle, aphids
  • ribosome inactivating protein coleoptera eg coiorado potato beetle, aphids
  • Antifeeding principles nematodes eg root knot nematodes and cyst nematodes
  • AcetylCoA Carboxylase (ACCase) Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones
  • Hydroxyphenylpyruvate dioxygenase Isoxazoles such as Isoxaflutol or
  • ADSL Adenylosuccinate Lyase
  • Nitrilase 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl
  • EPSPS Synthase
  • Glyphosate oxidoredi ictase Glyphosate or sulfosate
  • Protopo ⁇ hyrinogen oxidase Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopyiate, oxadiazoies etc.
  • Cytochrome P450 eg P450 SU1 or Xenobiotics and herbicides such as selection Sulfonylureas
  • Metallothionein bacterial and fungal pathogens such as phytophtora
  • Antifungal polypeptide AlyAFP bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
  • oxalate oxidase bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
  • glucose oxidase bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
  • pyrrolnitrin synthesis genes bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould Effected target or expressed principle(s) Crop phenotype / Tolerance to etc. serine/threonine kinases bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
  • Cecropin B bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
  • Phenylalanine ammonia lyase bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
  • bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
  • Polygalacturonase inhibitors bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
  • Prf regulatory gene bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
  • Fusarium resistance locus fusarium phytoalexins bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould Effected target or expressed principle(s) Crop phenotype / Tolerance to etc.
  • B-1 ,3-glucanase antisense bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
  • receptor kinase bactenal and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
  • Hypersensitive response eliciting bacterial and fungal pathogens such as polypeptide bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
  • SAR resistance
  • Chitinases bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
  • Glucanases bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.
  • double stranded ribonuclease viruses such as PLRV, PVY and ToMoV
  • Coat proteins viruses such as PLRV, PVY and ToMoV
  • 17kDa or 60 kDa protein viruses such as PLRV, PVY and ToMoV
  • Nuclear inclusion proteins eg. a or b or viruses such as PLRV, PVY and ToMoV Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • Pseudoubiquitin viruses such as PLRV, PVY and ToMoV
  • Replicase viruses such as PLRV, PVY and ToMoV
  • Aminopeptidase inhibitors eg. Leucine lepidoptera eg heliothis, whitefiies aminopeptidase inhibitor aphids
  • Protease Inhibitors eg cystatin, patatin lepidoptera eg heliothis, whitefiies aphids ribosome inactivating protein lepidoptera eg heliothis, whitefiies aphids stilbene synthase lepidoptera eg heliothis, whitefiies aphids
  • HMG-CoA reductase lepidoptera eg heliothis, whitefiies aphids
  • Antifeeding principles nematodes eg root knot nematodes and cyst nematodes
  • Acetolactate synthase Sulfonylureas, Imidazolinones, Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • AcetylCoA Carboxylase (ACCase) Aryloxyphenoxyalkanecarboxylic acids, cyciohexanediones
  • Hydroxyphenylpyruvate dioxygenase Isoxazoles such as Isoxaflutol or
  • ADSL Adenylosuccinate Lyase
  • Nitrilase 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl
  • EPSPS Synthase
  • Glyphosate oxidoreductase Glyphosate or sulfosate
  • Protopo ⁇ hyrinogen oxidase Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopyiate, oxadiazoies etc.
  • Cytochrome P450 eg. P450 SU1 or Xenobiotics and herbicides such as selection Sulfonylureas
  • Antifungal polypeptide AlyAFP bacterial and fungal pathogens oxalate oxidase bacterial and fungal pathogens glucose oxidase bacterial and fungal pathogens pyrrolnitrin synthesis genes bacterial and fungal pathogens Effected target or expressed principle(s) Crop phenotype / Tolerance to serine/threonine kinases bacterial and fungal pathogens
  • Phenylalanine ammonia lyase (PAL) bacterial and fungal pathogens Phenylalanine ammonia lyase (PAL) bacterial and fungal pathogens
  • SAR resistance
  • Glucanases bacterial and fungal pathogens double stranded ribonuclease viruses such as CMV, TEV
  • Coat proteins viruses such as CMV, TEV
  • 17kDa or 60 kDa protein viruses such as CMV, TEV
  • Nuclear inclusion proteins eg. a or b or viruses such as CMV, TEV
  • Pseudoubiquitin viruses such as CMV, TEV
  • Replicase viruses such as CMV, TEV
  • Xenorhabdus toxins Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • Aminopeptidase inhibitors eg. Leucine lepidoptera, whitefiies aphids aminopeptidase inhibitor
  • Protease Inhibitors eg cystatin, patatin lepidoptera, whitefiies aphids ribosome inactivating protein lepidoptera, whitefiies aphids stilbene synthase lepidoptera, whitefiies aphids
  • Antifeeding principles nematodes eg root knot nematodes and cyst nematodes
  • AcetylCoA Carboxylase (ACCase) Aryloxyphenoxyalkanecarboxylic acids, cyciohexanediones
  • Hydroxyphenylpyruvate dioxygenase Isoxazoles such as isoxaflutol or
  • ADSL Adenylosuccinate Lyase
  • Nitrilase 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl
  • EPSPS 5-Enolpyruvyl-3phosphoshikimate Glyphosate or sulfosate Synthase
  • PROTOX Protopo ⁇ hyrinogen oxidase
  • Cytochrome P450 eg. P450 SU1 or Xenobiotics and herbicides such as selection Sulfonylureas
  • Metallothionein bacterial and fungal pathogens like Botrytis and powdery mildew
  • Antifungal polypeptide AlyAFP bacterial and fungal pathogens like Botrytis and powdery mildew oxalate oxidase bacterial and fungai pathogens like Botrytis and powdery mildew glucose oxidase bacterial and fungal pathogens like Botrytis and powdery mildew pyrrolnitrin synthesis genes bacterial and fungal pathogens like Botrytis and powdery mildew serine/threonine kinases bacterial and fungal pathogens like Botrytis and powdery mildew
  • Cecropin B bacterial and fungal pathogens like Botrytis and powdery mildew
  • Phenylalanine ammonia lyase bacterial and fungal pathogens like Botrytis and powdery mildew
  • Cf genes eg. Cf 9 Cf5 Cf4 Cf2 bacterial and fungal pathogens like Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • Prf regulatory gene bacterial and fungal pathogens like
  • Hypersensitive response eliciting bacterial and fungal pathogens like polypeptide Botrytis and powdery mildew
  • SAR resistance
  • Nuclear inclusion proteins eg. a or b or viruses Effected target or expressed p ⁇ nc ⁇ ple(s) Crop phenotype / Tolerance to
  • Aminopeptidase inhibitors eg. Leucine lepidoptera, aphids aminopeptidase inhibitor
  • Protease Inhibitors eg cystatin, patatin lepidoptera, aphids ribosome inactivating protein lepidoptera, aphids stilbene synthase lepidoptera, aphids, diseases
  • Antifeeding principles nematodes eg root knot nematodes or root cyst nematodes
  • AcetylCoA Carboxylase (ACCase) Aryloxyphenoxyalkanecarboxylic acids, cyciohexanediones
  • Hydroxyphenylpyruvate dioxygenase Isoxazoles such as isoxaflutol or
  • HPPD HPPD Isoxachlortol, Tnones such as Effected target or expressed principle(s) Crop phenotype / Tolerance to mesotrione or sulcotrione
  • ADSL Adenylosuccinate Lyase
  • Nitrilase 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl
  • EPSPS Synthase
  • Glyphosate oxidoreductase Glyphosate or sulfosate
  • Protopo ⁇ hyrinogen oxidase Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopyiate, oxadiazoies etc.
  • Cytochrome P450 eg. P450 SU1 or Xenobiotics and herbicides such as selection Sulfonylureas
  • Antifungal polypeptide AlyAFP bacterial and fungal pathogens like
  • Cylindrosporium, Phoma, Sclerotinia Effected target or expressed principle(s) Crop phenotype / Tolerance to serine/threonine kinases bacterial and fungal pathogens like
  • Cecropin B bacterial and fungal pathogens like
  • Phenylalanine ammonia lyase PAL
  • Prf regulatory gene bacterial and fungal pathogens like
  • Hypersensitive response eliciting bacterial and fungal pathogens like polypeptide Cylindrosporium, Phoma, Sclerotinia
  • SAR resistance
  • Nuclear inclusion proteins eg. a or b or viruses
  • Aminopeptidase inhibitors eg. Leucine lepidoptera, aphids aminopeptidase inhibitor
  • Protease Inhibitors eg cystatin, patatin, lepidoptera, aphids
  • Table A11 Crop Brassica vegetable (cabbage, brussel sprouts, broccoli etc.) Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • AcetylCoA Carboxylase (ACCase) Aryloxyphenoxyalkanecarboxylic acids, cyciohexanediones
  • Hydroxyphenylpyruvate dioxygenase Isoxazoles such as Isoxaflutol or
  • ADSL Adenylosuccinate Lyase
  • Nitrilase 3,5-dihalo-4-hydroxy-benzonitriies such as Bromoxynil and loxinyl
  • EPSPS Synthase
  • Glyphosate oxidoreductase Glyphosate or sulfosate
  • Protopo ⁇ hyrinogen oxidase Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopyiate, oxadiazoies etc.
  • Cytochrome P450 eg. P450 SU1 or Xenobiotics and herbicides such as selection Sulfonylureas
  • Antifungal polypeptide AlyAFP bacterial and fungal pathogens oxalate oxidase bacterial and fungal pathogens glucose oxidase bacterial and fungal pathogens Effected target or expressed principle(s) Crop phenotype / Tolerance to pyrrolnitrin synthesis genes bacterial and fungai pathogens serine/threonine kinases bacterial and fungal pathogens
  • Phenylalanine ammonia lyase (PAL) bacterial and fungal pathogens Phenylalanine ammonia lyase (PAL) bacterial and fungal pathogens
  • SAR resistance
  • Nuclear inclusion proteins eg. a or b or viruses
  • Peroxidase lepidoptera, aphids Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • Aminopeptidase inhibitors eg. Leucine lepidoptera, aphids aminopeptidase inhibitor
  • Protease Inhibitors eg cystatin, patatin, lepidoptera, aphids
  • Table A12 Crop Pome fruits eg apples, pears
  • AcetylCoA Carboxylase (ACCase) Aryloxyphenoxyalkanecarboxylic acids, cyciohexanediones
  • Hydroxyphenylpyruvate dioxygenase Isoxazoles such as Isoxaflutol or
  • ADSL Adenylosuccinate Lyase
  • Nitrilase 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl
  • EPSPS Synthase
  • Glyphosate oxidoreductase Glyphosate or sulfosate
  • Protopo ⁇ hyrinogen oxidase Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopyiate, oxadiazoies etc.
  • Cytochrome P450 eg. P450 SU1 or Xenobiotics and herbicides such as selection Sulfonylureas
  • Antifungal polypeptide AlyAFP bacterial and fungal pathogens like apple scab or fireblight oxalate oxidase bacterial and fungal pathogens like apple scab or fireblight glucose oxidase bacterial and fungal pathogens like apple scab or fireblight pyrrolnitrin synthesis genes bacterial and fungal pathogens like apple scab or fireblight serine/threonine kinases bacterial and fungal pathogens like apple scab or fireblight
  • Cecropin B bacterial and fungal pathogens like apple scab or fireblight
  • Phenylalanine ammonia lyase bacterial and fungal pathogens like apple scab or fireblight
  • Cf genes eg. Cf 9 Cf5 Cf4 Cf2 bacterial and fungal pathogens like Effected target or expressed principle(s) Crop phenotype / Tolerance to apple scab or fireblight
  • Osmotin bacterial and fungal pathogens like apple scab or fireblight
  • Alpha Hordothionin bacterial and fungal pathogens like apple scab or fireblight
  • Hypersensitive response eliciting bacterial and fungal pathogens like polypeptide apple scab or fireblight
  • SAR resistance
  • Lytic protein bacterial and fungal pathogens like apple scab or fireblight
  • Lysozym bacterial and fungal pathogens like apple scab or fireblight
  • Nuclear inclusion proteins eg. a or b or viruses
  • Aminopeptidase inhibitors eg. Leucine lepidoptera, aphids, mites aminopeptidase inhibitor
  • Protease Inhibitors eg cystatin, patatin, lepidoptera, aphids , mites
  • CPTI ribosome inactivating protein lepidoptera aphids, mites stilbene synthase lepidoptera, aphids, diseases, mites
  • HMG-CoA reductase lepidoptera HMG-CoA reductase lepidoptera, aphids, mites
  • Acetolactate synthase Sulfonylureas, Imidazolinones, Triazolopyrimidines, Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • AcetylCoA Carboxylase (ACCase) Aryloxyphenoxyalkanecarboxylic acids, cyciohexanediones
  • Hydroxyphenylpyruvate dioxygenase isoxazoles such as isoxaflutol or
  • ADSL Adenylosuccinate Lyase
  • Nitrilase 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl
  • EPSPS Synthase
  • Glyphosate oxidoreductase Glyphosate or sulfosate
  • Protopo ⁇ hyrinogen oxidase Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopyiate, oxadiazoies etc.
  • Cytochrome P450 eg. P450 SU1 or Xenobiotics and herbicides such as selection Sulfonylureas
  • Antifungal polypeptide AlyAFP bacterial or fungal pathogens like phytophtora Effected target or expressed principle(s) Crop phenotype / Tolerance to oxalate oxidase bacterial or fungal pathogens like phytophtora glucose oxidase bacterial or fungai pathogens like phytophtora pyrrolnitrin synthesis genes bacterial or fungai pathogens like phytophtora serine/threonine kinases bacterial or fungal pathogens like phytophtora
  • Phenylalanine ammonia lyase bacterial or fungal pathogens like phytophtora
  • Cf genes eg. Cf 9 Cf5 Cf4 Cf2 bacterial or fungal pathogens like phytophtora
  • Osmotin bacterial or fungal pathogens like phytophtora
  • Hypersensitive response eliciting bacterial or fungal pathogens like polypeptide phytophtora Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • SAR resistance
  • Lytic protein bacterial or fungal pathogens like phytophtora
  • Glucanases bacterial or fungal pathogens like phytophtora double stranded ribonuclease viruses as CMV,, PRSV, WMV2, SMV,
  • 17kDa or 60 kDa protein viruses as CMV,, PRSV, WMV2, SMV,
  • Nuclear inclusion proteins eg. a or b or viruses as CMV,, PRSV, WMV2, SMV,
  • Pseudoubiquitin viruses as CMV, PRSV, WMV2, SMV,
  • Replicase viruses as CMV, PRSV, WMV2, SMV,
  • Aminopeptidase inhibitors eg. Leucine lepidoptera, aphids, mites, whitefly aminopeptidase inhibitor Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • Protease Inhibitors eg cystatin, patatin, lepidoptera, aphids, mites, whitefly
  • CPTI virgiferin ribosome inactivating protein lepidoptera
  • aphids mites
  • whitefly stilbene synthase lepidoptera aphids, mites, whitefly
  • HMG-CoA reductase lepidoptera aphids, mites, wnitefly
  • AcetylCoA Carboxylase (ACCase) Aryloxyphenoxyalkanecarboxylic acids, cyciohexanediones
  • Hydroxyphenylpyruvate dioxygenase isoxazoles such as Isoxaflutol or
  • ADSL Adenylosuccinate Lyase
  • Nitrilase 3,5-dihalo-4-hydroxy-benzonitriles such Effected target or expressed principie(s) Crop phenotype / Tolerance to as Bromoxynil and loxinyl
  • EPSPS 5-Enolpyruvyl-3phosphoshikimate Glyphosate or sulfosate Synthase
  • EPSPS Glyphosate oxidoreductase
  • PROTOX Protopo ⁇ hyrinogen oxidase
  • Cytochrome P450 eg. P450 SU1 or Xenobiotics and herbicides such as selection Sulfonylureas
  • Antifungal polypeptide AlyAFP bacteria or funga pathogens oxalate oxidase bacteria or funga pathogens glucose oxidase bacteria or funga: pathogens pyrrolnitrin synthesis genes bacteria or funga pathogens serine/threonine kinases bacteria or funga pathogens
  • Phenylalanine ammonia lyase (PAL) bacteria or funga pathogens Phenylalanine ammonia lyase (PAL) bacteria or funga pathogens
  • Cf genes eg. Cf 9 Cf5 Cf4 Cf2 bacteria or funga pathogens
  • Prf regulatory gene bacteria or funga pathogens phytoalexins bacteria or funga pathogens
  • Systemic acquires resistance (SAR) viral, bacterial, fungal, nematodal Effected target or expressed principle(s) Crop phenotype / Tolerance to genes pathogens
  • Nuclear inclusion proteins eg. a or b or viruses as Banana bunchy top virus
  • BBTV Nucleoprotein
  • BBTV Banana bunchy top virus
  • BBTV Banana bunchy top virus
  • Aminopeptidase inhibitors eg. Leucine lepidoptera, aphids, mites, nematodes aminopeptidase inhibitor
  • Protease Inhibitors eg cystatin , patatin, lepidoptera, aphids, mites, nematodes
  • CPTI virgiferin ribosome inactivating protein lepidoptera
  • aphids mites
  • nematodes stilbene synthase lepidoptera
  • aphids mites
  • nematodes stilbene synthase lepidoptera
  • HMG-CoA reductase lepidoptera aphids, mites, nematodes
  • Cyst nematode hatching stimulus cyst nematodes Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • AcetylCoA Carboxylase (ACCase) Aryloxyphenoxyalkanecarboxylic acids, cyciohexanediones
  • Hydroxyphenylpyruvate dioxygenase isoxazoles such as Isoxaflutol or
  • ADSL Adenylosuccinate Lyase
  • Nitrilase 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl
  • EPSPS Synthase
  • Glyphosate oxidoreductase Glyphosate or sulfosate
  • Protopo ⁇ hyrinogen oxidase Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopyiate, oxadiazoies etc. Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • Cytochrome P450 eg. P450 SU1 or Xenobiol ics and herbicides such as selection Sulfonylureas
  • Antifungal polypeptide AlyAFP bacterial or fungal pathogens oxalate oxidase bacterial or fungal pathogens glucose oxidase bacterial or fungal pathogens pyrrolnitrin synthesis genes bacterial or fungal pathogens serine/threonine kinases bacterial or fungal pathogens
  • Phenylalanine ammonia lyase bacterial or fungal pathogens
  • Prf regulatory gene bacterial or fungal pathogens phytoalexins bacterial or fungal pathogens
  • SAR resistance
  • Nuclear inclusion proteins eg. a or b or viruses as wound tumor virus (WTV)
  • Bacillus thuringiensis toxins VIP 3, lepidoptera, aphids, mites, nematodes,
  • Aminopeptidase inhibitors eg. Leucine lepidoptera, aphids, mites, nematodes, aminopeptidase inhibitor whitefly
  • Protease inhibitors eg cystatin, patatin, lepidoptera, aphids, mites, nematodes,
  • CPTI virgiferin whitefly ribosome inactivating protein lepidoptera, aphids, mites, nematodes, whitefly stilbene synthase lepidoptera, aphids, mites, nematodes, whitefly
  • HMG-CoA reductase lepidoptera aphids, mites, nematodes, whitefly
  • AcetylCoA Carboxylase (ACCase) Aryloxyphenoxyalkanecarboxylic acids, cyciohexanediones
  • Isoxazoles such as Isoxaflutol or (HPPD) Isoxachlortol, Triones such as mesotrione or sulcotrione
  • Nitrilase 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl
  • EPSPS 5-Enolpyruvyl-3phosphoshikimate Glyphosate or sulfosate Synthase
  • PROTOX Protopo ⁇ hyrinogen oxidase
  • Cytochrome P450 eg. P450 SU1 or Xenobiotics and herbicides such as selection Sulfonylureas
  • Antifungal polypeptide AlyAFP bacterial or fungal pathogens Effected target or expressed principle(s) Crop phenotype / Tolerance to oxalate oxidase bacterial or fungal I pathogens glucose oxidase bacterial or funga! I pathogens pyrrolnitrin synthesis genes bacterial or funga I pathogens serine/threonine kinases bacterial or funga I pathogens
  • SAR resistance
  • Nuclear inclusion proteins eg. a or b or viruses as SCMV, SrMV
  • Replicase viruses as SCMV, SrMV Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • Bacillus thuringiensis toxins VIP 3, lepidoptera, aphids, mites, nematodes, Bacillus cereus toxins, Photorabdus and whitefly, beetles eg mexican rice borer
  • Xenorhabdus toxins 3- Hydroxysteroid oxidase lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer
  • Peroxidase lepidoptera aphids, mites, nematodes, whitefly, beetles eg mexican nee borer
  • Aminopeptidase inhibitors eg. Leucine lepidoptera, aphids, mites, nematodes, aminopeptidase inhibitor whitefly, beetles eg mexican rice borer
  • Protease Inhibitors eg cystatin, patatin, lepidoptera, aphids, mites, nematodes,
  • CPTI virgiferin whitefly, beetles eg mexican rice borer ribosome inactivating protein lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer stilbene synthase lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer
  • HMG-CoA reductase lepidoptera aphids, mites, nematodes, whitefly, beetles eg mexican rice borer
  • Acetolactate synthase Sulfonylureas, imidazolinones, Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • AcetylCoA Carboxylase (ACCase) Aryloxyphenoxyalkanecarboxylic acids, cyciohexanediones
  • Hydroxyphenylpyruvate dioxygenase Isoxazoles such as Isoxaflutol or
  • ADSL Adenylosuccinate Lyase
  • Nitrilase 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl
  • EPSPS Synthase
  • Glyphosate oxidoreductase Glyphosate or sulfosate
  • Protopo ⁇ hyrinogen oxidase Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopyiate, oxadiazoies etc.
  • Cytochrome P450 eg. P450 SU1 or Xenobiotics and herbicides such as selection Sulfonylureas
  • Antifungal polypeptide AlyAFP bacterial or fungal pathogens oxalate oxidase bacterial or fungal pathogens eg sclerotinia glucose oxidase bacterial or fungal pathogens Effected target or expressed pr ⁇ nc ⁇ ple(s) Crop phenotype / Tolerance to pyrrolnitrin synthesis genes bactenal or fungal pathogens serine/threonine kinases bacterial or fungal pathogens
  • Phenylalanine ammonia lyase (PAL) bacte ⁇ al or fungal pathogens
  • Prf regulatory gene bactenal or fungal pathogens phytoalexins bacterial or fungal pathogens
  • SAR resistance
  • Nuclear inclusion proteins eg. a or b or viruses as CMV, TMV
  • Bacillus thuringiensis toxins VIP 3, lepidoptera, aphids, mites, nematodes,
  • Xenorhabdus toxins Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • Aminopeptidase inhibitors eg. Leucine lepidoptera, aphids, mites, nematodes, aminopeptidase inhibitor whitefly, beetles
  • Protease Inhibitors eg cystatin, patatin, lepidoptera, aphids, mites, nematodes,
  • CPTI virgiferin whitefly, beetles ribosome inactivating protein lepidoptera, aphids, mites, nematodes, whitefly, beetles stilbene synthase lepidoptera, aphids, mites, nematodes, whitefly, beetles
  • HMG-CoA reductase lepidoptera aphids, mites, nematodes, whitefly, beetles
  • Table A 18 Crop Sugarbeet, Beet root
  • Acetolactate synthase Sulfonylureas, imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides
  • AcetylCoA Carboxylase Aryloxyphenoxyalkanecarboxylic acids, Effected target or expressed principle(s) Crop phenotype / Tolerance to cyciohexanediones
  • Isoxazoles such as Isoxaflutol or (HPPD) Isoxachlortol, Triones such as mesotrione or sulcotrione
  • Nitrilase 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl
  • EPSPS 5-Enolpyruvyl-3phosphoshikimate Glyphosate or sulfosate Synthase
  • PROTOX Protopo ⁇ hyrinogen oxidase
  • Cytochrome P450 eg. P450 SU1 or Xenobiotics and herbicides such as selection Sulfonylureas
  • Antifungal polypeptide AlyAFP bacterial or fungal pathogens oxalate oxidase bacterial or fungal pathogens eg sclerotinia glucose oxidase bacterial or fungal pathogens pyrrolnitrin synthesis genes bacterial or fungal pathogens serine/threonine kinases bacterial or fungal pathogens Cecropin B bacterial or fungal pathogens Effected target or expressed principle(s) Crop phenotype / Tolerance to
  • Phenylalanine ammonia lyase bacterial or fungal pathogens
  • Prf regulatory gene bacterial or fungal pathogens phytoalexins bacterial or fungal pathogens
  • SAR resistance
  • Nuclear inclusion proteins eg. a or b or viruses as BNYVV
  • Bacillus thuringiensis toxins VIP 3, lepidoptera, aphids, mites, nematodes,
  • Peroxidase lepidoptera aphids, mites, nematodes, whitefly, beetles, rootflies
  • Aminopeptidase inhibitors eg. Leucine lepidoptera, aphids, mites, nematodes, aminopeptidase inhibitor whitefly, beetles, rootflies
  • Protease Inhibitors eg cystatin, patatin, lepidoptera, aphids, mites, nematodes,
  • CPTI virgiferin whitefly, beetles, rootflies ribosome inactivating protein lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies stilbene synthase lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies
  • HMG-CoA reductase lepidoptera aphids, mites, nematodes, whitefly, beetles, rootflies
  • the abovementioned animal pests which can be controlled by the method according to the invention include; for example, insects, representatives of the order acarina and representatives of the class nematoda; especially from the order Lepidoptera Acleris spp., Adoxophyes spp., especially Adoxophyes reticulana; Aegeria spp., Agrotis spp., especially Agrotis spinifera; Alabama argillaceae, Amylois spp., Anticarsia gemmatalis, Archips spp., Argyrotaenia spp., Autographa spp., Busseola fusca, Cadra cautella, Carposina nipponensis, Chilo spp., Choristoneura spp., Clysia ambiguella, Cnaphaiocrocis spp., Cnephasia spp., Cochylis spp., Coleophora spp
  • Trogoderma spp. from the order Orthoptera, for example Blatta spp., Blattelia spp., Gryllotalpa spp., Leucophaea maderae, Locusta spp., Periplaneta spp. and Schistocerca spp.; from the order Isoptera, for example Reticulitermes spp.; from the order Psocoptera, for example Liposcelis spp.; from the order Anoplura, for example Haematopinus spp., Linognathus spp., Pediculus spp., Pemphigus spp.
  • Leptocorisa spp. Leptocorisa spp., Nezara spp., Piesma spp., Rhodnius spp., Sahlbergella singuiaris, Scotinophara spp. and Triatoma spp.; from the order Homoptera, for example Aleurothrixus floccosus, Aleyrodes brassicae, Aonidiella aurantii, Aphididae, Aphis craccivora, A. fabae, A.
  • Homoptera for example Aleurothrixus floccosus, Aleyrodes brassicae, Aonidiella aurantii, Aphididae, Aphis craccivora, A. fabae, A.
  • Vespa spp. from the order Diptera, for example Aedes spp., Antherigona soccata, Bibio hortulanus, Calliphora erythrocephala, Ceratitis spp., Chrysomyia spp., Culex spp., Cuterebra spp., Dacus spp., Drosophila melanogaster, Fannia spp., Gastrophilus spp., Glossina spp., Hypoderma spp., Hyppobosca spp., Liriomyza spp., Lucilia spp., Melanagromyza spp., Musca spp., Oestrus spp., Orseolia spp., Oscinella frit, Pegomyia hyoscyami, Phorbia spp., Rhagoletis pomonella, Sciara spp., Stomoxy
  • Bryobia praetiosa Calipitrimerus spp., Chorioptes spp., Dermanyssus gallinae, Eotetranychus spp., especially E.ca ⁇ ini and E. orientalis; Eriophyes spp., especially E. vitis; Hyalomma spp., Ixodes spp., Olygonychus pratensis, Omithodoros spp., Panonychus spp., especially P. uimi and P. citri; Phyllocoptruta spp., especially P. oleivora; Poiyphagotarsonemus spp., especially P.
  • nematodes selected from the group consisting of root knot nematodes, cyst-forming nematodes, stem eelworms and foliar nematodes; (2) nematodes selected from the group consisting of Anguina spp.; Apheienchoides spp.;
  • nematodes selected from the group consisting of Heterodera spp., for example Heterodera glycines; and Meloidogyne spp., for example Meloidogyne incognita.
  • the method according to the invention allows pests of the abovementioned type to be controlled, i.e. contained or destroyed, which occur, in particular, on transgenic plants, mainly useful plants and ornamentals in agriculture, in horticulture and in forests, or on parts, such as fruits, flowers, foliage, stalks, tubers or roots, of such plants, the protection against these pests in some cases even extending to plant parts which form at a later point in time.
  • the method according to the invention can be employed advantageously for controlling pests in rice, cereals such as maize or sorghum; in fruit, for example stone fruit, pome fruit and soft fruit such as apples, pears, plums, peaches, almonds, cherries or berries, for example strawberries, raspberries and blackberries; in legumes such as beans, lentils, peas or soya beans; in oil crops such as oilseed rape, mustard, poppies, olives, sunflowers, coconuts, castor-oil plants, cacao or peanuts; in the marrow family such as pumpkins, cucumbers or melons; in fibre plants such as cotton, flax, hemp or jute; in citrus fruit such as oranges, lemons, grapefruit or tangerines; in vegetables such as spinach, lettuce, asparagus, cabbage species, carrots, onions, tomatoes, potatoes, beet or capsicum; in the laurel family such as avocado, Cinnamonium or camphor; or in tobacco, nuts, coffee, egg plants, sugar cane, tea, pepper, grapevine
  • the method according to the invention is valuable preventatively and/or curatively in the field of pest control even at low use concentrations of the pesticidal composition and that a very favourable biocidal spectrum is achieved thereby.
  • the method according to the invention can be employed against all or individual developmental stages of normally-sensitive, but also of normally-resistant, animal pests such as insects and representatives of the order Acarina, depending on the species of the transgenic crop plant to be protected from attack by pests.
  • the insecticidal and/or acaricidal effect of the method according to the invention may become apparent directly, i.e.
  • the good action corresponding to a destruction rate (mortality) of at least 40 to 50%.
  • the pesticides within the scope of invention are emulsifiable concentrates, suspension concentrates, directly sprayable or dilutabie solutions, spreadabie pastes, dilute emulsions, wettable powders, soluble powders, dispersible powders, wettable powders, dusts, granules or encapsulations in polymeric substances which comprise a nitroimino- or nitroguanidino- compound.
  • the active ingredients are employed in these compositions together with at least one of the auxiliaries conventionally used in art of formulation, such as extenders, for example solvents or solid carriers, or such as surface-active compounds (surfactants).
  • auxiliaries such as extenders, for example solvents or solid carriers, or such as surface-active compounds (surfactants).
  • Formulation auxiliaries which are used are, for example, solid carriers, solvents, stabilizers, "slow release” auxiliaries, colourants and, if appropriate, surface-active substances (surfactants).
  • Suitable carriers and auxiliaries are all those substances which are conventionally used for crop protection products.
  • Suitable auxiliaries such as solvents, solid carriers, surface-active compounds, non-ionic surfactants, cationic surfactants, anionic surfactants and other auxiliaries in the compositions employed according to the invention are, for example, those which have been described in EP-A-736 252.
  • compositions for controlling pests can be formulated, for example, as wettable powders, dusts, granules, solutions, emulsifiable concentrates, emulsions, suspension concentrates or aerosols.
  • the compositions are of the type described in EP- A-736 252.
  • compositions within the scope of invention which comprise a nitroimino- or nitroguanidino-compound can be extended substantially and adapted to prevailing circumstances by adding other insecticidally, acaricidally and/or fungicidally active ingredients.
  • Suitable examples of added active ingredients are representatives of the following classes of active ingredients: organophosphorous compounds, nitrophenols and derivatives, formamidines, ureas, carbamates, pyrethroids, chlorinated hydrocarbons; especially preferred components in mixtures are, for example, abamectin, emamectin, spinosad, pymetrozine, fenoxycarb, Ti-435, fipronil, pyriproxyfen, diazinon or diafenthiuron.
  • the compositions within the scope of invention comprise 0.1 to 99%, in particular 0.1 to 95 %, of a nitroimino- or nitroguanidino-compound and 1 to 99.9 %, in particular 5 to 99.9 %, of - at least - one solid or liquid auxiliary, it being possible, as a rule, for 0 to 25 %, in particular 0.1 to 20 %, of the compositions to be surfactants (% in each case meaning per cent by weight). While concentrated compositions are more preferred as commercial products, the end user will, as a rule, use dilute compositions which have considerably lower concentrations of active ingredient.
  • compositions according to the invention may also comprise other solid or liquid auxiliaries, such as stabilisers, for example epoxidized or unepoxidized vegetable oils (for example epoxidized coconut oil, rapeseed oil or soya bean oil), antifoams, for example silicone oil, preservatives, viscosity regulators, binders and/or tackifiers, and also fertilizers or other active ingredients for achieving specific effects, for example, bactericides, fungicides, nematicides, molluscicides or herbicides.
  • stabilisers for example epoxidized or unepoxidized vegetable oils (for example epoxidized coconut oil, rapeseed oil or soya bean oil), antifoams, for example silicone oil, preservatives, viscosity regulators, binders and/or tackifiers, and also fertilizers or other active ingredients for achieving specific effects, for example, bactericides, fungicides, nematicides, mollus
  • compositions according to the invention are produced in a known manner, for example prior to mixing with the auxiliary/auxiliaries by grinding, screening and/or compressing the active ingredient, for example to give a particular particle size, and by intimately mixing and/or grinding the active ingredient with the auxiliary/auxiliaries.
  • the method according to the invention for controlling pests of the abovementioned type is carried out in a manner known per se to those skilled in the art, depending on the intended aims and prevailing circumstances, that is to say by spraying, wetting, atomizing, dusting, brushing on, seed dressing, scattering or pouring of the composition.
  • Typical use concentrations are between 0.1 and 1000 ppm, preferably between 0.1 and 500 ppm of active ingredient.
  • the application rate may vary within wide ranges and depends on the soil constitution, the type of application (foliar application; seed dressing; application in the seed furrow), the transgenic crop plant, the pest to be controlled, the climatic circumstances prevailing in each case, and other factors determined by the type of application, timing of application and target crop.
  • the application rates per hectare are generally 1 to 2000 g of nitroimino- or nitroguanidino-compound per hectare, in particular 10 to 1000 g/ha, preferably 10 to 500 g/ha, especially preferably 10 to 200 g/ha.
  • a preferred type of application in the field of crop protection within the scope of invention is application to the foliage of the plants (foliar application), it being possible to adapt frequency and rate of application to the risk of infestation with the pest in question.
  • the active ingredient may also enter into the plants via the root system (systemic action), by drenching the site of the plants with a liquid composition or by inco ⁇ orating the active ingredient in solid form into the site of the plants, for example into the soil, for example in the form of granules (soil application). In the case of paddy rice crops, such granules may be metered into the flooded paddy field.
  • compositions according to invention are also suitable for protecting propagation material of transgenic plants, for example seed, such as fruits, tubers or kernels, or plant cuttings, from animal pests, in particular insects and representatives of the order Acarina.
  • the propagation material can be treated with the composition prior to application, for example, seed being dressed prior to sowing.
  • the active ingredient may also be applied to seed kernels (coating), either by soaking the kernels in a liquid composition or by coating them with a solid composition.
  • the composition may also be applied to the site of application when applying the propagation material, for example into the seed furrow during sowing.
  • Examples of formulations of nitroimino- or nitroguanidino-compounds which can be used in the method according to the invention for instance solutions, granules, dusts, sprayable powders, emulsion concentrates, coated granules and suspension concentrates, are of the type as has been described in, for example, EP-A-580 553, Examples F1 to F10.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Catching Or Destruction (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Road Signs Or Road Markings (AREA)

Abstract

L'invention concerne un procédé de lutte antiparasitaire à l'aide de composés nitroimino ou nitroguanidino. Elle porte plus spécifiquement sur un procédé de lutte antiparasitaire dans et sur les cultures transgéniques de plantes utiles, comme par exemple, les cultures de maïs, de céréales, de germes de soja, de tomates, de coton, de pommes de terre, de riz et de moutarde, à l'aide d'un composé nitroimino ou nitroguanidino, en particulier du thiaméthoxame. Ledit procédé se caractérise en qu'il consiste à appliquer une composition pesticide comprenant un composé nitroimino ou nitroguanidino se présentant sous forme libre ou sous forme de sel utile en agrochimie, et au moins un auxiliaire, sur les parasites ou leur environnement, en particulier sur la plante cultivée elle-même.
PCT/EP1999/000183 1998-01-16 1999-01-14 Utilisation de neonicotinoides sur des plantes transgeniques WO1999035913A1 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP2000539707A JP4833404B2 (ja) 1998-01-16 1999-01-14 形質転換植物に対するネオニコチノイド類の使用
KR1020007007794A KR100593584B1 (ko) 1998-01-16 1999-01-14 유전자전이된 식물에 대한 네오니코디노이드의 용도
DE19982477T DE19982477T1 (de) 1998-01-16 1999-01-14 Verwendung von Neonicotinoiden auf transgenen Pflanzen
CA002317050A CA2317050C (fr) 1998-01-16 1999-01-14 Utilisation de neonicotinoides sur des plantes transgeniques
BRPI9917912A BRPI9917912B1 (pt) 1998-01-16 1999-01-14 método de controle de pragas em culturas de plantas trangênicas úteis
GB0017168A GB2349088A (en) 1998-01-16 1999-01-14 Use of neonicodinoids on transgenic plants
BRPI9907010-3A BR9907010B1 (pt) 1998-01-16 1999-01-14 mÉtodo de controle de pragas em culturas de plantas transgÊnicas éteis.
BRPI9917838A BRPI9917838B1 (pt) 1998-01-16 1999-01-14 método de controle de pragas em culturas de planta transgênica útil que expressa uma endotoxina de bacillus thuringiensis cry ia(c)
HU0100528A HU230681B1 (en) 1998-01-16 1999-01-14 Use of neonicotinoids on transgenic plants
AU25176/99A AU744003B2 (en) 1998-01-16 1999-01-14 Use of neonicodinoids on transgenic plants
US11/456,939 US20060258747A1 (en) 1998-01-16 2006-07-12 Use of neonicotinoids in pest control
US12/191,707 US8399378B2 (en) 1998-01-16 2008-08-14 Use of neonicotinoids in pest control

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH80/98 1998-01-16
CH8098 1998-01-16
CH70698 1998-03-25
CH706/98 1998-03-25

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09600384 A-371-Of-International 1999-01-14
US10/125,136 Continuation US6844339B2 (en) 1998-01-16 2002-04-18 Use of neonicotinoids in pest control

Publications (1)

Publication Number Publication Date
WO1999035913A1 true WO1999035913A1 (fr) 1999-07-22

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JP (2) JP4833404B2 (fr)
KR (2) KR100593584B1 (fr)
CN (1) CN1220435C (fr)
AR (4) AR018264A1 (fr)
AU (1) AU744003B2 (fr)
BR (4) BRPI9917838B1 (fr)
CA (1) CA2317050C (fr)
CH (1) CH693525A5 (fr)
CO (1) CO4810306A1 (fr)
DE (1) DE19982477T1 (fr)
EG (1) EG21988A (fr)
ES (1) ES2181568B1 (fr)
FR (1) FR2773672B1 (fr)
GB (1) GB2349088A (fr)
GR (1) GR1008462B (fr)
HK (1) HK1088791A1 (fr)
HU (1) HU230681B1 (fr)
IN (1) IN2000CH00170A (fr)
IT (1) IT1306202B1 (fr)
MX (1) MX233459B (fr)
NL (1) NL1011057C2 (fr)
TR (1) TR200001958T2 (fr)
WO (1) WO1999035913A1 (fr)

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WO2002030201A3 (fr) * 2000-10-06 2002-06-20 Monsanto Technology Llc Traitement des graines au moyen de combinaisons de pyrethrines/pyrethroides et de thiamethoxam
WO2002028185A3 (fr) * 2000-10-06 2002-06-20 Monsanto Technology Llc Procede permettant de reduire les prelevements alimentaires de depredateurs sur le mais par traitement des semences de mais transgeniques au moyen de pesticide thiamethoxam
WO2002030202A3 (fr) * 2000-10-06 2002-06-20 Monsanto Technology Llc Traitement des graines au moyen de combinaisons de pyrethrines/pyrethroides et de clothianidine
WO2002030205A3 (fr) * 2000-10-06 2002-07-04 Monsanto Technology Llc Traitement de graines de mais transgenique au moyen d'un pesticide pour reduire les degats infliges a la plante par des ravageurs
WO2002028186A3 (fr) * 2000-10-06 2003-03-13 Monsanto Technology Llc Traitement de semences avec des melanges d'insecticides
WO2006015697A1 (fr) * 2004-08-03 2006-02-16 Bayer Cropscience Ag Procede pour ameliorer la tolerance de plantes aux glyphosates
EP1844655A3 (fr) * 2000-10-06 2008-04-09 Monsanto Technology, LLC Traitement de graines avec combinaisons de pyréthines/pyréthroides et thiaméthoxames
EP1581057A4 (fr) * 2002-12-16 2010-02-03 Eden Bioscience Corp Procede permettant de renforcer l'efficacite de produits chimiques agricoles
WO2010046427A1 (fr) * 2008-10-22 2010-04-29 Basf Se Utilisation de néonicotinoïdes sur des plantes cultivées
EP2392662A2 (fr) 2007-04-23 2011-12-07 Basf Se Amélioration de la productivité des plantes en combinant les agents chimiques avec des modifications transgéniques
US8754009B2 (en) 2005-06-09 2014-06-17 Bayer Cropscience Ag Active compound combinations
US9365863B2 (en) 2013-05-08 2016-06-14 Monsanto Technology Llc Compositions and methods for deploying a transgenic refuge seed blend
US9816104B2 (en) 2000-10-06 2017-11-14 Monsanto Technology Llc Compositions and methods for deploying a transgenic refuge as a seed blend
US9980423B2 (en) 2009-05-03 2018-05-29 Monsanto Technology Llc Systems and processes for combining different types of seeds
US10036036B1 (en) 2007-03-15 2018-07-31 Monsanto Technology Llc Compositions and methods for deploying a transgenic refuge as a seed blend
CN117982398A (zh) * 2024-02-04 2024-05-07 广州姿采化妆品厂 一种植物复合提取物及其制备方法及其应用

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ES2331022T3 (es) * 2005-06-15 2009-12-18 Bayer Bioscience N.V. Metodos para aumentar la resistencia de las plantas a condiciones hipoxicas.
JP5560601B2 (ja) * 2009-06-12 2014-07-30 住友化学株式会社 有害生物の防除方法
SE536971C2 (sv) * 2012-03-29 2014-11-18 Olof Hartelius Fordonslås

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EP1844655A3 (fr) * 2000-10-06 2008-04-09 Monsanto Technology, LLC Traitement de graines avec combinaisons de pyréthines/pyréthroides et thiaméthoxames
US6838473B2 (en) 2000-10-06 2005-01-04 Monsanto Technology Llc Seed treatment with combinations of pyrethrins/pyrethroids and clothiandin
WO2002028185A3 (fr) * 2000-10-06 2002-06-20 Monsanto Technology Llc Procede permettant de reduire les prelevements alimentaires de depredateurs sur le mais par traitement des semences de mais transgeniques au moyen de pesticide thiamethoxam
WO2002030202A3 (fr) * 2000-10-06 2002-06-20 Monsanto Technology Llc Traitement des graines au moyen de combinaisons de pyrethrines/pyrethroides et de clothianidine
WO2002030205A3 (fr) * 2000-10-06 2002-07-04 Monsanto Technology Llc Traitement de graines de mais transgenique au moyen d'un pesticide pour reduire les degats infliges a la plante par des ravageurs
WO2002028186A3 (fr) * 2000-10-06 2003-03-13 Monsanto Technology Llc Traitement de semences avec des melanges d'insecticides
US6586365B2 (en) 2000-10-06 2003-07-01 Monsanto Technology, Llc Method for reducing pest damage to corn by treating transgenic corn seeds with clothianidin pesticide
US6593273B2 (en) * 2000-10-06 2003-07-15 Monsanto Technology Llc Method for reducing pest damage to corn by treating transgenic corn seeds with pesticide
US6660690B2 (en) * 2000-10-06 2003-12-09 Monsanto Technology, L.L.C. Seed treatment with combinations of insecticides
US8080496B2 (en) 2000-10-06 2011-12-20 Syngenta Crop Protection, Inc. Method for reducing pest damage to corn by treating transgenic corn seeds with thiamethoxam pesticide
US6903093B2 (en) 2000-10-06 2005-06-07 Monsanto Technology Llc Seed treatment with combinations of pyrethrins/pyrethroids and thiamethoxam
AU2001296476B2 (en) * 2000-10-06 2005-09-22 Basf Corporation Seed treatment with combinations of pyrethrins/pyrethroids and clothianidin
US9816104B2 (en) 2000-10-06 2017-11-14 Monsanto Technology Llc Compositions and methods for deploying a transgenic refuge as a seed blend
AU2002214627B2 (en) * 2000-10-06 2006-05-04 Basf Corporation Treatment of transgenic corn seeds with clothianidin
CN1317952C (zh) * 2000-10-06 2007-05-30 孟山都技术有限公司 用噻虫胺处理玉米种子的方法
KR100808730B1 (ko) * 2000-10-06 2008-02-29 바이엘 크롭사이언스 아게 파이레트린류/파이레트로이드류와 클로티아니딘의 조합에의한 종자처리방법
WO2002030201A3 (fr) * 2000-10-06 2002-06-20 Monsanto Technology Llc Traitement des graines au moyen de combinaisons de pyrethrines/pyrethroides et de thiamethoxam
US8592648B2 (en) 2000-10-06 2013-11-26 Monsanto Technology, Llc Seed treatment with combinations of pyrethrins/pyrethroids and thiamethoxam
WO2002028184A1 (fr) * 2000-10-06 2002-04-11 Monsanto Technology, Llc Traitement à la clothianidine de semences de maïs transgéniques
US8524634B2 (en) 2000-10-06 2013-09-03 Jawed Asrar Seed treatment with combinations of pyrethrins/pyrethroids and clothianidin
EP1581057A4 (fr) * 2002-12-16 2010-02-03 Eden Bioscience Corp Procede permettant de renforcer l'efficacite de produits chimiques agricoles
US8232228B2 (en) 2002-12-16 2012-07-31 Plant Health Care, Inc. Method for increasing the efficacy of agricultural chemicals
WO2006015697A1 (fr) * 2004-08-03 2006-02-16 Bayer Cropscience Ag Procede pour ameliorer la tolerance de plantes aux glyphosates
US8754009B2 (en) 2005-06-09 2014-06-17 Bayer Cropscience Ag Active compound combinations
US9414600B2 (en) 2005-06-09 2016-08-16 Bayer Intellectual Property Gmbh Active compound combinations
US10036036B1 (en) 2007-03-15 2018-07-31 Monsanto Technology Llc Compositions and methods for deploying a transgenic refuge as a seed blend
US10745713B2 (en) 2007-03-15 2020-08-18 Monsanto Technology Llc Compositions and methods for deploying a transgenic refuge as a seed blend
EP2392662A2 (fr) 2007-04-23 2011-12-07 Basf Se Amélioration de la productivité des plantes en combinant les agents chimiques avec des modifications transgéniques
WO2010046427A1 (fr) * 2008-10-22 2010-04-29 Basf Se Utilisation de néonicotinoïdes sur des plantes cultivées
US9980423B2 (en) 2009-05-03 2018-05-29 Monsanto Technology Llc Systems and processes for combining different types of seeds
US10687455B2 (en) 2009-05-03 2020-06-23 Monsanto Technology Llc Systems and processes for combining different types of seeds
US9365863B2 (en) 2013-05-08 2016-06-14 Monsanto Technology Llc Compositions and methods for deploying a transgenic refuge seed blend
CN117982398A (zh) * 2024-02-04 2024-05-07 广州姿采化妆品厂 一种植物复合提取物及其制备方法及其应用

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BR9907010B1 (pt) 2013-04-16
AU744003B2 (en) 2002-02-14
HK1088791A1 (en) 2006-11-17
GB2349088A (en) 2000-10-25
MX233459B (es) 2006-01-06
AR076816A2 (es) 2011-07-13
JP4833404B2 (ja) 2011-12-07
DE19982477T1 (de) 2000-11-30
KR20010024860A (ko) 2001-03-26
CH693525A5 (de) 2003-09-30
IT1306202B1 (it) 2001-05-30
ES2181568A1 (es) 2003-02-16
KR20060029293A (ko) 2006-04-05
CN1220435C (zh) 2005-09-28
CA2317050A1 (fr) 1999-07-22
CO4810306A1 (es) 1999-06-30
BRPI9917838B1 (pt) 2016-01-05
HUP0100528A3 (en) 2002-03-28
AR018264A1 (es) 2001-11-14
TR200001958T2 (tr) 2000-12-21
FR2773672A1 (fr) 1999-07-23
AR076818A2 (es) 2011-07-13
ITMI990051A1 (it) 2000-07-14
JP2002509865A (ja) 2002-04-02
BRPI9917912B1 (pt) 2015-12-22
JP5932260B2 (ja) 2016-06-08
ES2181568B1 (es) 2004-06-16
HU230681B1 (en) 2017-08-28
GB0017168D0 (en) 2000-08-30
BR9917836B1 (pt) 2013-04-24
NL1011057A1 (nl) 1999-07-19
JP2011231123A (ja) 2011-11-17
CN1291076A (zh) 2001-04-11
IN2000CH00170A (fr) 2005-03-04
EG21988A (en) 2002-05-31
GR980100481A (el) 1999-11-30
FR2773672B1 (fr) 2006-08-04
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HUP0100528A2 (hu) 2001-06-28
BR9907010A (pt) 2000-10-17
GR1008462B (el) 2015-04-08
KR100701817B1 (ko) 2007-04-02
KR100593584B1 (ko) 2006-06-28
AU2517699A (en) 1999-08-02
NL1011057C2 (nl) 1999-11-22
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AR076817A2 (es) 2011-07-13

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