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WO1999035266A3 - Human urotensin ii - Google Patents

Human urotensin ii Download PDF

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Publication number
WO1999035266A3
WO1999035266A3 PCT/US1999/000489 US9900489W WO9935266A3 WO 1999035266 A3 WO1999035266 A3 WO 1999035266A3 US 9900489 W US9900489 W US 9900489W WO 9935266 A3 WO9935266 A3 WO 9935266A3
Authority
WO
WIPO (PCT)
Prior art keywords
human urotensin
polypeptides
polynucleotides
disclosed
methods
Prior art date
Application number
PCT/US1999/000489
Other languages
French (fr)
Other versions
WO1999035266A2 (en
Inventor
Jeffrey S Culp
Dean E Mcnulty
Catherine E Ellis
Stephen A Douglas
Robert N Willette
Nambi V Aiyar
Anne Romanic Arnold
Nassirah Khandoudi
Bernard Gout
Kamal Al-Barazanji
Original Assignee
Smithkline Beecham Corp
Smithkline Beecham Plc
Smithkline Beecham Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/027,381 external-priority patent/US6075137A/en
Application filed by Smithkline Beecham Corp, Smithkline Beecham Plc, Smithkline Beecham Lab filed Critical Smithkline Beecham Corp
Priority to JP2000527650A priority Critical patent/JP2002500045A/en
Priority to EP99902140A priority patent/EP1045908A2/en
Publication of WO1999035266A2 publication Critical patent/WO1999035266A2/en
Publication of WO1999035266A3 publication Critical patent/WO1999035266A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)

Abstract

Human Urotensin II polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human Urotensin II polypeptides and polynucleotides in therapy, and diagnostic assays for such.
PCT/US1999/000489 1998-01-09 1999-01-08 Human urotensin ii WO1999035266A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2000527650A JP2002500045A (en) 1998-01-09 1999-01-08 Human urotensin II
EP99902140A EP1045908A2 (en) 1998-01-09 1999-01-08 Human urotensin ii

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US7238398P 1998-01-09 1998-01-09
US7361698P 1998-02-04 1998-02-04
US09/027,381 US6075137A (en) 1998-01-09 1998-02-20 Human urotensin II
US22574799A 1999-01-05 1999-01-05
US09/225,747 1999-01-05
US60/073,616 1999-01-05
US09/027,381 1999-01-05
US60/072,383 1999-01-05

Publications (2)

Publication Number Publication Date
WO1999035266A2 WO1999035266A2 (en) 1999-07-15
WO1999035266A3 true WO1999035266A3 (en) 1999-09-30

Family

ID=27487580

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/000489 WO1999035266A2 (en) 1998-01-09 1999-01-08 Human urotensin ii

Country Status (3)

Country Link
EP (1) EP1045908A2 (en)
JP (1) JP2002500045A (en)
WO (1) WO1999035266A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2786489B1 (en) * 1998-11-26 2002-12-27 Inst Nat Sante Rech Med UROTENSINS II OF MAMMALS AND THEIR APPLICATIONS
EP1136503A1 (en) * 1998-11-30 2001-09-26 Takeda Chemical Industries, Ltd. Novel physiologically active substance, process for producing the same and utilization thereof
AU6514400A (en) * 1999-08-24 2001-03-19 Regents Of The University Of California, The Method of identifying urotensin ii receptor antagonists
WO2002014513A1 (en) * 2000-08-10 2002-02-21 Takeda Chemical Industries, Ltd. Use of polypeptide
WO2002015934A1 (en) * 2000-08-25 2002-02-28 Takeda Chemical Industries, Ltd. Preventives and remedies for central nervous system diseases
EP1241479B1 (en) * 2001-03-12 2007-08-01 Immundiagnostik AG Method of determining urotensin II in body fluids and diagnosis of cardiovascular diseases
GB0216191D0 (en) * 2002-07-11 2002-08-21 Univ Leicester Plasma urotensin in human heart failure
US20060183174A1 (en) * 2005-02-11 2006-08-17 Leong Ng Diagnosis
WO2009033823A1 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of a peptide combination comprising urotensin ii as a therapeutic agent
FR2982488B1 (en) * 2011-11-10 2013-12-27 Univ Rouen UROTENSIN II FOR USE IN THE TREATMENT AND / OR PREVENTION OF PATHOLOGIES INVOLVING GASTRIC MOTILITY

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997049386A1 (en) * 1996-06-26 1997-12-31 Peptide Delivery Systems Pty. Ltd. Oral delivery of peptides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997049386A1 (en) * 1996-06-26 1997-12-31 Peptide Delivery Systems Pty. Ltd. Oral delivery of peptides

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CONLON J.M. ET AL.: "Distribution and molecular forms of Urotensin II and its role in cardiovascular regulation in vertebrates", THE JOURNAL OF EXPERIMENTAL ZOOLOGY, vol. 275, no. 2 3, 1 June 1996 (1996-06-01) - 15 June 1996 (1996-06-15), pages 226 - 238, XP002110995 *
CONLON J.M. ET AL.: "Somatostatin- and Urotensin II-related peptides: molecular diversity and evolutionary perspectives", REGULATORY PEPTIDES, vol. 69, no. 2, 26 March 1997 (1997-03-26), pages 95 - 103, XP002110991 *
COULOUARN Y. ET AL.: "Cloning of the cDNA encoding the Urotensin II precursor in frog and human reveals intense expression of the Urotensin II gene in motoneurons of the spinal cord", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 95, no. 26, 22 December 1998 (1998-12-22), pages 15803 - 15808, XP002110994 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002110997, Database accession no. AA535545 *
ITOH H. ET AL.: "Functional receptors for fish neuropeptide Urotensin II in major rat arteries", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 149, 1988, pages 61 - 66, XP002110996 *
MCMASTER D. ET AL.: "Characterization of the biologically and antigenically important regions of Urotensin II", PROCEEDINGS OF THE WESTERN PHARMACOLOGY SOCIETY, vol. 29, 1986, pages 205 - 208, XP002110992 *
PERKINS T.D.J. ET AL.: "Molecular modelling and design of analogues of the peptide hormone Urotensin II", BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 18, no. 5, October 1990 (1990-10-01), pages 918 - 919, XP002110993 *

Also Published As

Publication number Publication date
WO1999035266A2 (en) 1999-07-15
EP1045908A2 (en) 2000-10-25
JP2002500045A (en) 2002-01-08

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