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WO1999034785A3 - Traitement de la dyskinesie - Google Patents

Traitement de la dyskinesie Download PDF

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Publication number
WO1999034785A3
WO1999034785A3 PCT/IL1999/000003 IL9900003W WO9934785A3 WO 1999034785 A3 WO1999034785 A3 WO 1999034785A3 IL 9900003 W IL9900003 W IL 9900003W WO 9934785 A3 WO9934785 A3 WO 9934785A3
Authority
WO
WIPO (PCT)
Prior art keywords
dyskinesias
treatment
dyskinesia
riluzole
levodopa
Prior art date
Application number
PCT/IL1999/000003
Other languages
English (en)
Other versions
WO1999034785A2 (fr
Inventor
Eldad Melamed
Ruth Djaldetti
Ilan Ziv
Original Assignee
Mor Research Applic Ltd
Eldad Melamed
Ruth Djaldetti
Ilan Ziv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL12288398A external-priority patent/IL122883A0/xx
Priority claimed from IL12710298A external-priority patent/IL127102A0/xx
Priority to JP2000527236A priority Critical patent/JP2002500181A/ja
Priority to CA002317811A priority patent/CA2317811A1/fr
Priority to PL99342098A priority patent/PL342098A1/xx
Priority to BR9906821-4A priority patent/BR9906821A/pt
Application filed by Mor Research Applic Ltd, Eldad Melamed, Ruth Djaldetti, Ilan Ziv filed Critical Mor Research Applic Ltd
Priority to KR1020007007567A priority patent/KR20010033978A/ko
Priority to US09/582,989 priority patent/US6417210B1/en
Priority to EP99900116A priority patent/EP1043996A2/fr
Priority to IL13719099A priority patent/IL137190A0/xx
Priority to AU17806/99A priority patent/AU1780699A/en
Publication of WO1999034785A2 publication Critical patent/WO1999034785A2/fr
Publication of WO1999034785A3 publication Critical patent/WO1999034785A3/fr
Priority to NO20003529A priority patent/NO20003529L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

On a constaté une amélioration de la dyskinésie induite par la lévodopa et de la dyskinésie tardive en administrant à certains sujets du riluzole.
PCT/IL1999/000003 1998-01-09 1999-01-05 Traitement de la dyskinesie WO1999034785A2 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AU17806/99A AU1780699A (en) 1998-01-09 1999-01-05 Treatment of dyskinesias
IL13719099A IL137190A0 (en) 1998-01-09 1999-01-05 Pharmaceutical compositions for the treatment of dyskinesias
CA002317811A CA2317811A1 (fr) 1998-01-09 1999-01-05 Traitement de la dyskinesie
PL99342098A PL342098A1 (en) 1998-01-09 1999-01-05 Pharmacological compositions for treating diskineses
BR9906821-4A BR9906821A (pt) 1998-01-09 1999-01-05 Composição farmacêutica e processo para melhorar a discinesia induzida por levodopa e discinesia tardia, e, uso de riluzol para a preparação de uma composição farmacêutica
JP2000527236A JP2002500181A (ja) 1998-01-09 1999-01-05 ジスキネジーの処置
KR1020007007567A KR20010033978A (ko) 1998-01-09 1999-01-05 운동이상증의 치료법
US09/582,989 US6417210B1 (en) 1998-01-09 1999-01-05 Treatment of dyskinesias and Parkinson's disease with riluzole and levodopa
EP99900116A EP1043996A2 (fr) 1998-01-09 1999-01-05 Traitement de la dyskinesie
NO20003529A NO20003529L (no) 1998-01-09 2000-07-07 Behandling av dyskinesi-tilstander

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IL122883 1998-01-09
IL12288398A IL122883A0 (en) 1998-01-09 1998-01-09 Pharmaceutical compositions for the treatment of dyskinesias
IL12710298A IL127102A0 (en) 1998-11-17 1998-11-17 Pharmaceutical compositions for the treatment of dyskinesias
IL127102 1998-11-17

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/899,639 Continuation US6669122B2 (en) 1999-01-11 2001-07-05 Method and apparatus for shaping particles by ultrasonic cavitation

Publications (2)

Publication Number Publication Date
WO1999034785A2 WO1999034785A2 (fr) 1999-07-15
WO1999034785A3 true WO1999034785A3 (fr) 1999-09-16

Family

ID=26323572

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL1999/000003 WO1999034785A2 (fr) 1998-01-09 1999-01-05 Traitement de la dyskinesie

Country Status (10)

Country Link
EP (1) EP1043996A2 (fr)
JP (1) JP2002500181A (fr)
KR (1) KR20010033978A (fr)
CN (1) CN1290166A (fr)
AU (1) AU1780699A (fr)
BR (1) BR9906821A (fr)
CA (1) CA2317811A1 (fr)
NO (1) NO20003529L (fr)
PL (1) PL342098A1 (fr)
WO (1) WO1999034785A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790670A1 (fr) * 1999-03-12 2000-09-15 Aventis Pharma Sa Association riluzole et antagoniste des recepteurs ampa
EP1161238A1 (fr) * 1999-03-12 2001-12-12 Aventis Pharma S.A. Traitement de la sclerose laterale amyotrophique avec une association de riluzole et d'un antagoniste des recepteurs ampa
US6297254B1 (en) 1999-12-01 2001-10-02 Aventis Pharma S. A. Method for the prevention or treatment of a motoneuron disease
FR2801793B1 (fr) * 1999-12-01 2003-07-04 Aventis Pharma Sa Association d'une ergoline et de riluzole et son utilisation comme medicament
FR2809620B1 (fr) * 2000-06-05 2002-08-02 Aventis Pharma Sa Utilisation du riluzole ou ses sels pour la prevention et le traitement de l'adrenoleucodystrophie
ATE246919T1 (de) * 2001-05-08 2003-08-15 Sanol Arznei Schwarz Gmbh Verbessertes transdermales therapeutisches system zur behandlung von morbus parkinson

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0558861A1 (fr) * 1992-03-06 1993-09-08 Aventis Pharma S.A. Application de l'amino-2-trifluoromethoxy-6-benzothiazole (Riluzole) pour obtenir un médicament destiné au traitement des maladies du motoneurone
WO1994015601A1 (fr) * 1993-01-07 1994-07-21 Rhone-Poulenc Rorer S.A. Application du riluzole dans le traitement de la maladie de parkinson et des syndromes parkinsoniens

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0558861A1 (fr) * 1992-03-06 1993-09-08 Aventis Pharma S.A. Application de l'amino-2-trifluoromethoxy-6-benzothiazole (Riluzole) pour obtenir un médicament destiné au traitement des maladies du motoneurone
WO1994015601A1 (fr) * 1993-01-07 1994-07-21 Rhone-Poulenc Rorer S.A. Application du riluzole dans le traitement de la maladie de parkinson et des syndromes parkinsoniens

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
"riluzole; rilutek", DRUGS FUTURE, vol. 21, no. 10, 1996, pages 1077 - 1078, XP002109884 *
A. BENAZZOUZ ET AL.: "Riluzole prevents MPTP-induced parkinsonism in the rhesus monkey: a pilot study", EUR.J.PHARMACOL., vol. 284, no. 3, 1995, pages 299 - 307, XP000600898 *
A. DOBLE: "Excitatory amino acid receptors and neurodegeneration", THÉRAPIE, vol. 50, no. 4, 1995, pages 319 - 337, XP002109885 *
A. RICHTER ET AL.: "Prodystonic effects of riluzole in an animal model of idiopathic dystonia related to decreased total power in the red nucleus?", EUR. J. PHARMACOL., vol. 332, no. 2, 1997, pages 133 - 141, XP002109887 *
A.IMPERATO ET AL.: "RILUZOLE PREVENTS DYSKINESIAS IN PARKINSONIAN MARMOSETS, BEHAVIOR AND HISTOLOGY.", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 24, no. 1-2, 1998, pages 763, XP002109889 *
G.C.KIEL: "Schlüsselfunktion von Glutamat im Netzwerk neurodegenerativer Prozesse", NEUROL.REHABIL., vol. 4, no. 6, 1998, pages 326 - 327, XP002109888 *
J.-L-VIDALUC: "MPTP as a Molecular Paradigm for Neurodegeneration. A Review of its Connections with Relevant Molecules", CURR.MED.CHEM., vol. 3, no. 2, 1996, pages 117 - 138, XP002109892 *
M.S.STARR ET AL.: "Stimulation of Basal and L-DOPA-induced Motor Activity by Glutamate Antagonists in Animal Models of Parkinson's Disease", NEUROSCI. BIOBEHAV. REV., vol. 21, no. 4, 1997, pages 437 - 446, XP002094843 *
O.K. HASSANI: "CONTROLE DOPAMINERGIQUE DU NOYAU SUBTHALAMIQUE CHEZ LE RAT NORMAL ET CHEZ LE RAT MODELE DE LA MALADIE DE PARKINSON (RATS 6-OHDA)", DIALOG (R) FILE 144: PASCAL (C): ACCESSION NUMBER 13759700: THESIS, 1997, université de paris, XP002109891 *
O.RASCOL ET AL.: "Pharmacologie clinique des dyskinésies induites par la L-Dopa chez les malades parkinsoniens", THÉRAPIE, vol. 53, no. 1, February 1998 (1998-02-01), pages 43 - 48, XP002094840 *
P. BARNÉOUD ET AL.: "NEUROPROTECTIVE EFFECTS OF RILUZOLE ON A MODEL OF PARKINON'S DISEASE IN THE RAT", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 21, no. 1-3, 1995, pages 1256, XP002109883 *
P. BARNÉOUD ET AL.: "NEUROPROTECTIVE EFFECTS OF RILUZOLE ON A MODEL OF PARKINSON'S DISEASE IN THE RAT", NEUROSCIENCE, vol. 74, no. 4, October 1996 (1996-10-01), pages 971 - 983, XP002109882 *
S. PALFI ET AL.: "Riluzole Reduces Incidence of Abnormal Movements but Not Striatal Cell Death in a Primate Model of Progressive Striatal Degeneration", EXP.NEUROL., vol. 146, no. 1, July 1997 (1997-07-01), pages 135 - 141, XP002109886 *
S. PALFI: "Nouvelles Approches Therapeutiques Experimentales pour le Traitement des Deficits Moteurs et Cognitifs de la Maladie de Huntington", DIALOG(R) FILE 144: PASCAL (C): ACCESSION NUMBER 13608133: THESIS, 1997, UNIVERSITÉ DE PARIS, XP002109890 *

Also Published As

Publication number Publication date
KR20010033978A (ko) 2001-04-25
EP1043996A2 (fr) 2000-10-18
JP2002500181A (ja) 2002-01-08
NO20003529D0 (no) 2000-07-07
NO20003529L (no) 2000-09-08
CN1290166A (zh) 2001-04-04
CA2317811A1 (fr) 1999-07-15
PL342098A1 (en) 2001-05-21
AU1780699A (en) 1999-07-26
WO1999034785A2 (fr) 1999-07-15
BR9906821A (pt) 2000-10-17

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