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WO1999033985A3 - C1F150/hTAFII150 IS NECESSARY FOR CELL CYCLE PROGRESSION - Google Patents

C1F150/hTAFII150 IS NECESSARY FOR CELL CYCLE PROGRESSION Download PDF

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Publication number
WO1999033985A3
WO1999033985A3 PCT/US1998/027665 US9827665W WO9933985A3 WO 1999033985 A3 WO1999033985 A3 WO 1999033985A3 US 9827665 W US9827665 W US 9827665W WO 9933985 A3 WO9933985 A3 WO 9933985A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell cycle
htafii150
cif150
cycle progression
progression
Prior art date
Application number
PCT/US1998/027665
Other languages
French (fr)
Other versions
WO1999033985A2 (en
Inventor
Joerg Kaufmann
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Priority to AU19483/99A priority Critical patent/AU1948399A/en
Publication of WO1999033985A2 publication Critical patent/WO1999033985A2/en
Publication of WO1999033985A3 publication Critical patent/WO1999033985A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A human protein termed CIF150/hTAFII150 recognizes and selects TATA-less core promoters for cell cycle specific genes. Thus, CIF150/hTAFII150 plays an important and selective role in establishing gene expression patterns necessary for progression through the cell cycle. The CIF150/hTAFII150 gene and its expression products can be used to alter the spatial or temporal patterns of mitosis or cell cycle progression of a human cell and to treat disorders involving alterations in the regulation of mitosis or cell cycle progression.
PCT/US1998/027665 1997-12-30 1998-12-28 C1F150/hTAFII150 IS NECESSARY FOR CELL CYCLE PROGRESSION WO1999033985A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU19483/99A AU1948399A (en) 1997-12-30 1998-12-28 C1f150/h TAF II 150 is necessary for cell cycle progression

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6895697P 1997-12-30 1997-12-30
US60/068,956 1997-12-30

Publications (2)

Publication Number Publication Date
WO1999033985A2 WO1999033985A2 (en) 1999-07-08
WO1999033985A3 true WO1999033985A3 (en) 1999-08-19

Family

ID=22085795

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/027665 WO1999033985A2 (en) 1997-12-30 1998-12-28 C1F150/hTAFII150 IS NECESSARY FOR CELL CYCLE PROGRESSION

Country Status (2)

Country Link
AU (1) AU1948399A (en)
WO (1) WO1999033985A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4434499A (en) 1998-06-12 1999-12-30 Chiron Corporation Cif130 inhibits cell cycle progression

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994017087A1 (en) * 1993-01-28 1994-08-04 The Regents Of The University Of California Tata-binding protein associated factors, nucleic acids encoding tafs, and methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994017087A1 (en) * 1993-01-28 1994-08-04 The Regents Of The University Of California Tata-binding protein associated factors, nucleic acids encoding tafs, and methods of use

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE EMEST 19 E.M.B.L. Databases; 30 October 1996 (1996-10-30), MARRA M ET AL: "Mus musculus cDNA clone 554617 5' similar to:G541665 DTAFII-150 mRNA", XP002106718 *
DATABASE EMROD E.M.B.L. Databases; 1 March 1991 (1991-03-01), WODNAR-FILIPOWICZ A ET AL: "Cloning and sequence analysis of cDNA for rat spleen thymosin beta 4", XP002106719 *
KAUFMANN J ET AL: "CIF, an essential cofactor for TFIID-dependent initiator function", GENES AND DEVELOPMENT, vol. 10, no. 7, 1 April 1996 (1996-04-01), pages 873 - 886, XP002106713 *
KAUFMANN J ET AL: "CIF150, a human cofactor for transcription factor IID-dependent initiator function", MOL. CELL. BIOL., vol. 18, no. 1, January 1998 (1998-01-01), pages 233 - 239, XP002106714 *
MARTINEZ E ET AL: "Novel cofactors and TFIIA mediate functional core promoter selectivity by the human TAFII150-containing TFIID complex", MOL. CELL. BIOL., vol. 18, no. 11, November 1998 (1998-11-01), pages 6571 - 6583, XP002106715 *
VERRIJZER C ET AL: "Drosophila TAFII150: similarity to yeast gene TSM-1 and specific binding to core promoter DNA", SCIENCE, vol. 264, no. 5161, 13 May 1994 (1994-05-13), pages 933 - 941, XP002106716 *
WALKER S ET AL: "Transcription activation in cells lacking TAFIIs", NATURE, vol. 383, 12 September 1996 (1996-09-12), pages 185 - 188, XP002106747 *

Also Published As

Publication number Publication date
AU1948399A (en) 1999-07-19
WO1999033985A2 (en) 1999-07-08

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