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WO1999033453A3 - R-procyclidine for treating urinary incontinence - Google Patents

R-procyclidine for treating urinary incontinence Download PDF

Info

Publication number
WO1999033453A3
WO1999033453A3 PCT/US1998/027704 US9827704W WO9933453A3 WO 1999033453 A3 WO1999033453 A3 WO 1999033453A3 US 9827704 W US9827704 W US 9827704W WO 9933453 A3 WO9933453 A3 WO 9933453A3
Authority
WO
WIPO (PCT)
Prior art keywords
procyclidine
urinary incontinence
enantiomerically enriched
treating urinary
pharmaceutically acceptable
Prior art date
Application number
PCT/US1998/027704
Other languages
French (fr)
Other versions
WO1999033453A2 (en
Inventor
Vincent L Fabiano
John R Mccullough
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Priority to EP98964970A priority Critical patent/EP1043992A2/en
Priority to AU20179/99A priority patent/AU2017999A/en
Priority to CA002315840A priority patent/CA2315840A1/en
Priority to JP2000526210A priority patent/JP2001527038A/en
Publication of WO1999033453A2 publication Critical patent/WO1999033453A2/en
Publication of WO1999033453A3 publication Critical patent/WO1999033453A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (R)-procyclidine. The method comprises administering a therapeutically effective amount of enantiomerically enriched (R)-procyclidine, or a pharmaceutically acceptable salt thereof, substantially free of the (S)-procyclidine enantiomer. Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (R)-procyclidine, or a pharmaceutically acceptable salt thereof, and an acceptable carrier are also disclosed.
PCT/US1998/027704 1997-12-31 1998-12-29 R-procyclidine for treating urinary incontinence WO1999033453A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP98964970A EP1043992A2 (en) 1997-12-31 1998-12-29 $i(R)-PROCYCLIDINE FOR TREATING URINARY INCONTINENCE
AU20179/99A AU2017999A (en) 1997-12-31 1998-12-29 (r)-procyclidine for treating urinary incontinence
CA002315840A CA2315840A1 (en) 1997-12-31 1998-12-29 R-procyclidine for treating urinary incontinence
JP2000526210A JP2001527038A (en) 1997-12-31 1998-12-29 R-Procyclidin for treating urinary incontinence

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7027397P 1997-12-31 1997-12-31
US60/070,273 1997-12-31

Publications (2)

Publication Number Publication Date
WO1999033453A2 WO1999033453A2 (en) 1999-07-08
WO1999033453A3 true WO1999033453A3 (en) 1999-10-07

Family

ID=22094274

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/027704 WO1999033453A2 (en) 1997-12-31 1998-12-29 R-procyclidine for treating urinary incontinence

Country Status (5)

Country Link
EP (1) EP1043992A2 (en)
JP (1) JP2001527038A (en)
AU (1) AU2017999A (en)
CA (1) CA2315840A1 (en)
WO (1) WO1999033453A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996031208A2 (en) * 1995-04-05 1996-10-10 Byk Gulden Lomberg Chemische Fabrik Gmbh Use of substituted piperidine or pyrrolidine compounds for treating sigma-receptor modulated disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996031208A2 (en) * 1995-04-05 1996-10-10 Byk Gulden Lomberg Chemische Fabrik Gmbh Use of substituted piperidine or pyrrolidine compounds for treating sigma-receptor modulated disorders

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ALBERTS P: "CLASSIFICATION OF THE PRESYNAPTIC MUSCARINIC RECEPTOR SUBTYPE THAT REGULATES 3H-ACETHYLCHOLINE SECRETION IN THE GUINEA PIG URINARY BLADDER IN VITRO", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 274, no. 1, 1 July 1995 (1995-07-01), pages 458 - 468, XP000572112 *
ARIENS E J: "STEREOSELECTIVITY IN PHARMACODYNAMICS AND PHARMACOKINETICS", SCHWEIZ.MED.WSCHR, vol. 120, no. 5, 3 February 1990 (1990-02-03), pages 131 - 134, XP002051314 *
BARLOW, R. B. ET AL: "A comparison of stereospecificity at central and peripheral 'muscarine-sensitive' acetylcholine receptors: observations with the enantiomeric forms of procyclidine and tricyclamol", BR. J. PHARMACOL. (1981), 72(2), 277-80 CODEN: BJPCBM;ISSN: 0007-1188, XP002107613 *
BARLOW, RICHARD B.: "Differences in the stereospecificity of closely related compounds;a reinvestigation of the enantiomers of procyclidine, benzhexol, and their metho- and etho-salts", J. PHARM., PHARMACOL. (1971), 23(2), 90-7 CODEN: JPPMAB, XP002107611 *
JUNEMANN ET AL.: "Blasenfunktionsstörungen bei Parkinson-Syndrom", UROLOGY - AUSGABE A, vol. 29, no. 4, 1990, pages 170 - 175, XP002107614 *
MAGALI WAELBROCCK ET AL: "Stereoselective interaction of procyclidine, hexahydro-difenidol,hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors", EUROPEAN JOURNAL OF PHARMACOLOGY. MOLECULAR PHARMACOLOGY SECTION, vol. 227, no. 1, 1992, pages 33 - 42 42, XP002103656 *
MURPHY L.J.T.: "Urological problems in aged patients", AUSTRALIAN FAMILY PHYSICIAN, vol. 6, no. 1, 1977, pages 17 - 28, XP002107615 *
NORONHA-BLOB L ET AL: "ENANTIOMERS OF OXYBUTYNIN: IN VITRO PHARMACOLOGICAL CHARACTERIZATION AT M1, M2 AND M3 MUSCARINIC RECEPTORS AND IN VIVO EFFECTS ON URINARY BLADDER CONTRACTION, MYDRIASIS AND SALIVARY SECRETION IN GUINEA PIGS", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 256, no. 2, 1 February 1991 (1991-02-01), pages 562 - 567, XP000572006 *
WAELBROECK M ET AL: "STEREOSELECTIVITY OF PROCYCLIDINE BINDING TO MUSCARINIC RECEPTOR SUBTYPES M-1 M-2 AND M-4.", EUR J PHARMACOL MOL PHARMACOL SECT, (1990) 3 (2-3), 135-142. CODEN: EJPPET. ISSN: 0922-4106., XP002107612 *
WAELBROECK, M. ET AL: "Thermodynamics of antagonist binding to rat muscarinic M2 receptors: Antimuscarinics of the pridinol, sila-pridinol, diphenidol and sila-diphenidol type", BR. J. PHARMACOL. (1993), 109(2), 360-70 CODEN: BJPCBM;ISSN: 0007-1188, XP002107610 *

Also Published As

Publication number Publication date
AU2017999A (en) 1999-07-19
WO1999033453A2 (en) 1999-07-08
EP1043992A2 (en) 2000-10-18
JP2001527038A (en) 2001-12-25
CA2315840A1 (en) 1999-07-08

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