+

WO1999032515A3 - Homologue de l'angiopoietine, adn le codant et procede de production dudit homologue - Google Patents

Homologue de l'angiopoietine, adn le codant et procede de production dudit homologue Download PDF

Info

Publication number
WO1999032515A3
WO1999032515A3 PCT/US1998/027055 US9827055W WO9932515A3 WO 1999032515 A3 WO1999032515 A3 WO 1999032515A3 US 9827055 W US9827055 W US 9827055W WO 9932515 A3 WO9932515 A3 WO 9932515A3
Authority
WO
WIPO (PCT)
Prior art keywords
making
dna encoding
polypeptides
angiopoietin
homolog
Prior art date
Application number
PCT/US1998/027055
Other languages
English (en)
Other versions
WO1999032515A2 (fr
Inventor
Scott R Presnell
Darrell C Conklin
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to AU19315/99A priority Critical patent/AU1931599A/en
Publication of WO1999032515A2 publication Critical patent/WO1999032515A2/fr
Publication of WO1999032515A3 publication Critical patent/WO1999032515A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

On décrit des polypeptides angiogéniques, des procédés concernant leur production, des polynucléotides les codant et des procédés relatifs à leur utilisation. Les polypeptides comprennent une séquence d'acides aminés résiduaires identique au moins à 90% en acides aminés aux résidus 31 à 406 de la SEQ ID NO:2. Ces polypeptides sont utiles pour l'étude et la régulation de l'angiogenèse et pour la mise au point d'inhibiteurs de l'angiogenèse.
PCT/US1998/027055 1997-12-19 1998-12-17 Homologue de l'angiopoietine, adn le codant et procede de production dudit homologue WO1999032515A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU19315/99A AU1931599A (en) 1997-12-19 1998-12-17 Angiopoietin homolog, dna encoding it, and method of making it

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6826897 1997-12-19
US60/068,268 1997-12-19

Publications (2)

Publication Number Publication Date
WO1999032515A2 WO1999032515A2 (fr) 1999-07-01
WO1999032515A3 true WO1999032515A3 (fr) 1999-09-10

Family

ID=22081490

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/027055 WO1999032515A2 (fr) 1997-12-19 1998-12-17 Homologue de l'angiopoietine, adn le codant et procede de production dudit homologue

Country Status (2)

Country Link
AU (1) AU1931599A (fr)
WO (1) WO1999032515A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002516067A (ja) * 1998-03-02 2002-06-04 ミレニアム・フアーマシユーチカルズ・インコーポレーテツド 新規ｆｄｒｇタンパク質および核酸分子、ならびにそのための用途
AU4643699A (en) * 1998-06-24 2000-01-10 Compugen Ltd. Angiopoietin-like growth factor sequences
WO2001002429A2 (fr) * 1999-07-02 2001-01-11 Bayer Aktiengesellschaft Angiopoietine 6 et ses utilisations
EP1484401A1 (fr) * 1999-07-20 2004-12-08 Curagen Corporation Protéines secrètées et polynicleotides correspondant
KR20010070139A (ko) * 1999-10-14 2001-07-25 오철준, 윤혜진 사람 안지오포이에틴-2-443 단백질 및 그 암호화 유전자
WO2001047951A2 (fr) * 1999-12-23 2001-07-05 An-Go-Gen Inc. Analogues de l'angiopoietine
AU2001249929A1 (en) * 2000-04-07 2001-10-23 Dana-Farber Cancer Institute Inc. Fdrg proteins and nucleic acid molecules and uses therefor
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
CA2574791A1 (fr) 2004-07-20 2006-02-09 Genentech, Inc. Compositions et methodes d'utilisation de la proteine 4 analogue a l'angiopoietine
PL1771474T3 (pl) 2004-07-20 2010-07-30 Genentech Inc Inhibitory białka angiopoetyno-4-podobnego, kombinacje i ich zastosowanie

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000353A1 (fr) * 1991-06-20 1993-01-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Sequences caracteristiques de produit de transcription de genes humains
WO1996011269A2 (fr) * 1994-10-07 1996-04-18 Regeneron Pharmaceuticals, Inc. Ligands tie-2, peocedes de production et utilisations de ces ligands
WO1999015654A2 (fr) * 1997-09-19 1999-04-01 Genentech, Inc. Homologues du ligand 'tie' du type tyrosine kinase receptrice

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000353A1 (fr) * 1991-06-20 1993-01-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Sequences caracteristiques de produit de transcription de genes humains
WO1996011269A2 (fr) * 1994-10-07 1996-04-18 Regeneron Pharmaceuticals, Inc. Ligands tie-2, peocedes de production et utilisations de ces ligands
WO1999015654A2 (fr) * 1997-09-19 1999-04-01 Genentech, Inc. Homologues du ligand 'tie' du type tyrosine kinase receptrice

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BECK L. JR. AND D'AMORE P.A.: "Vascular development: cellular and molecular regulation", THE FASEB JOURNAL, vol. 11, April 1997 (1997-04-01), pages 365 - 373, XP002102631 *
DATABASE EMBL [online] "EST06114 Infant Brain, Bento Soares Homo sapiens cDNA clone HIBBA76 5' end similar to Fibrinogen, beta chain, mRNA sequence.", XP002102752, retrieved from EBI *
DAVIS S. ET AL.: "Isolation of Angiopoietin-1, a ligand for Tie2 receptor, by secretion-trap expression cloning", CELL, vol. 87, 27 December 1996 (1996-12-27), pages 1161 - 1167, XP002102730 *
MAISONPIERRE P.C. ET AL.: "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis", SCIENCE, vol. 277, no. 3/04, 4 July 1997 (1997-07-04), pages 55 - 60, XP002046280 *

Also Published As

Publication number Publication date
WO1999032515A2 (fr) 1999-07-01
AU1931599A (en) 1999-07-12

Similar Documents

Publication Publication Date Title
IL205233A0 (en) A polypeptide comprising the amino acid sequence of osteoprotegerin from residues 22 to 401 inclusive, or a fragment or trunaction thereof
NZ504548A (en) Polypeptides and nucleic acids encoding human chordin
HK1031100A1 (en) Ligand binding site of rage and uses thereof
WO1999032515A3 (fr) Homologue de l'angiopoietine, adn le codant et procede de production dudit homologue
WO1998055508A3 (fr) Proteines humaines ayant des domaines transmembranaires et adn codant ces proteines
WO2001070775A3 (fr) Nouveaux polypeptides et acides nucleiques codant ces polypeptides
AU7165287A (en) DNA encoding streptavidin, streptavidin produced therefrom, fused polypeptides which include amino acid sequences present in streptavidin and uses thereof
EP1717315A3 (fr) Protéines de liaison et récepteurs d'ostéoprotégérine
IL121520A (en) Polypeptide comprising the amino acid sequence of osteoprotegerin from residues 22 to 401 inclusive or a fragment or truncation thereof
WO1998024811A3 (fr) Facteur de croissance endotheliale vasculaire
NZ333215A (en) a nucleic acid sequence encoding a lactoferrin variant or portion thereof which has modified iron binding capacity
DE69714475D1 (de) Neue (alpha-aminophosphino) peptide, verfahren zu ihrer herstellung und ihre therapeutische verwendung
EP1092727A3 (fr) Recepteur de proteine g
EP1037999A4 (fr) Polypeptides et nucleotides porphyromonas gingivalis
WO1998024888A3 (fr) Polypeptides llg de la famille des triacylglycerol lipases, compositions et procedes destines a l'utilisation de ceux-ci dans des hydrolyses enzymatiques, et therapies geniques et protidiques
AU1239997A (en) Polypeptides corresponding to the amino acid sequences of proteins p57 or p9.5 of Borna disease virus, nucleic acid fragments coding therefore and their use for diagnostic and immunization purposes
GB9416536D0 (en) Orphan receptor
WO2002038607A3 (fr) Recepteur
CA2194032A1 (fr) Sequence d'adn fusionnee, proteine fusionnee exprimee par ladite sequence d'adn et methode d'expression de ladite proteine fusionnee
EP0816498A3 (fr) Récepteur pour acide aminé excitateur et acides nucléiques liés
ZA200007619B (en) New peptide fragments for protein purification.
EP1013665A4 (fr) Nouveau polypeptide deployant une activite de circulation de l'eau et sequence d'adn
WO1999001540A3 (fr) Clonage et caracterisation d'une adenyl cyclase a des enylcyclase humaines
WO2001055337A3 (fr) Procedes et substances relatifs a des polypeptides de type antigene carcino-embryonnaire (cea) et a des polynucleotides
ES2008391A6 (es) Un metodo para producir isopenicilina n sintetasa.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载