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WO1999032447A3 - 2,4,6-trisubstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof - Google Patents

2,4,6-trisubstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof Download PDF

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Publication number
WO1999032447A3
WO1999032447A3 PCT/US1998/026363 US9826363W WO9932447A3 WO 1999032447 A3 WO1999032447 A3 WO 1999032447A3 US 9826363 W US9826363 W US 9826363W WO 9932447 A3 WO9932447 A3 WO 9932447A3
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WO
WIPO (PCT)
Prior art keywords
carbon atoms
chain alkyl
phenyl
methods
solid phase
Prior art date
Application number
PCT/US1998/026363
Other languages
French (fr)
Other versions
WO1999032447A2 (en
Inventor
Chingfan Chiu
Zhilian Tang
John Watson Ellingboe
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Priority to AU33528/99A priority Critical patent/AU3352899A/en
Publication of WO1999032447A2 publication Critical patent/WO1999032447A2/en
Publication of WO1999032447A3 publication Critical patent/WO1999032447A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The present invention relates to novel substituted pyridine compounds of Formula (I) wherein the moiety Z is selected from the group: n is an integer of a 1 or 2; R1 is straight chain alkyl of 1 to 6 carbon atoms, branched chain alkyl of 3 to 7 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl, or phenyl substituted with fluoro, chloro, bromo, straight chain alkyl of 1 to 6 carbon atoms, branched chain alkyl of 3 to 7 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl, alkoxy of 1 to 6 carbon atoms, or methylenedioxy; and R2 is furanyl, pyridyl, thieny, naphthalenyl, phenyl, or phenyl substituted with fluoro, chloro, bromo, straight chain alkyl of 1 to 6 carbon atoms, branched chain alkyl of 3 to 7 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, alkoxy of 1 to 6 carbon atoms, or methylenedioxy, having estrogenic activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, to methods of treatment and to pharmaceutical compositions thereof.
PCT/US1998/026363 1997-12-11 1998-12-10 2,4,6-trisubstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof WO1999032447A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU33528/99A AU3352899A (en) 1997-12-11 1998-12-10 2,4,6-trisubstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98905797A 1997-12-11 1997-12-11
US08/989,057 1997-12-11

Publications (2)

Publication Number Publication Date
WO1999032447A2 WO1999032447A2 (en) 1999-07-01
WO1999032447A3 true WO1999032447A3 (en) 1999-10-14

Family

ID=25534714

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/026363 WO1999032447A2 (en) 1997-12-11 1998-12-10 2,4,6-trisubstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof

Country Status (2)

Country Link
AU (1) AU3352899A (en)
WO (1) WO1999032447A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106831972A (en) * 2017-03-17 2017-06-13 上海海洋大学 The many types of vitellogenin Vtg full length genes sequence of mudskipper and its cloning process

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903610D0 (en) * 1999-10-06 1999-10-06 Astra Ab Novel compounds II
ATE374765T1 (en) 2000-07-27 2007-10-15 Lilly Co Eli SUBSTITUTED HETEROCYCLIC AMIDES
US7163938B2 (en) 2000-11-28 2007-01-16 Eli Lilly And Company Substituted carboxamides
US7276523B2 (en) 2001-03-30 2007-10-02 Smithkline Beecham Corporation Aminopyridine derivatives as estrogen receptor modulators
JP2005524609A (en) 2001-12-17 2005-08-18 スミスクライン ビーチャム コーポレーション Pyrazolopyridazine derivatives
US11833156B2 (en) 2017-09-22 2023-12-05 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
CA3076476A1 (en) 2017-10-18 2019-04-25 Jubilant Epipad LLC Imidazo-pyridine compounds as pad inhibitors
BR112020008851A2 (en) 2017-11-06 2020-10-20 Jubilant Prodel LLC compound of formula i, process for preparing compounds of formula i, pharmaceutical composition, method for treating and / or preventing various diseases, use, method for treating cancer, method of treating cancer and method for treating and / or prevention of cancer and infectious diseases
DK3704120T3 (en) 2017-11-24 2024-05-21 Jubilant Episcribe Llc HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS
US11529341B2 (en) 2018-03-13 2022-12-20 Jubilant Prodel LLC Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027604A1 (en) * 1993-05-28 1994-12-08 Taisho Pharmaceutical Co., Ltd. Medicinal use of pyridine derivative
WO1996021656A1 (en) * 1995-01-09 1996-07-18 Pfizer, Inc. Estrogen agonists/antagonists
EP0792640A2 (en) * 1996-02-28 1997-09-03 Pfizer Inc. Use of (E)-1-(4'-(2-alkylaminoethioxy)-phenyl)-1-(3'-hydroxyphenyl)-2-phenylbut-1-enes for inhibiting pathological conditions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027604A1 (en) * 1993-05-28 1994-12-08 Taisho Pharmaceutical Co., Ltd. Medicinal use of pyridine derivative
WO1996021656A1 (en) * 1995-01-09 1996-07-18 Pfizer, Inc. Estrogen agonists/antagonists
EP0792640A2 (en) * 1996-02-28 1997-09-03 Pfizer Inc. Use of (E)-1-(4'-(2-alkylaminoethioxy)-phenyl)-1-(3'-hydroxyphenyl)-2-phenylbut-1-enes for inhibiting pathological conditions

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 9503, Derwent World Patents Index; Class B03, AN 95-022440, XP002111168 *
DILTHEY W ET AL: "Beitrag zur Kenntnis der o-Violone", J. PRAKT. CHEM., vol. 114, 1926, pages 153 - 178, XP002111164 *
DILTHEY W ET AL: "Über arylierte Pyridine und ihre Beziehungen zu den entsprechenden Pyryliumverbindungen. II.", J. PRAKT CHEM., vol. 102, 1921, pages 209 - 240, XP002111166 *
DILTHEY W ET AL: "Über arylierte Pyridine und ihre Beziehungen zu den entsprechenden Pyryliumverbindungen. IV.", J. PRAKT. CHEM., vol. 104, 1922, pages 28 - 36, XP002111165 *
KROEHNKE F: "Synthesis using pyridinium salts . 5. The specific synthesisof pyridines and oligopyridines.", SYNTHESIS, no. 1, 1976, pages 1 - 25, XP002111167 *
OLEKHNOVICH E P ET AL: "Photoinitiated processes in 2-(2-hydroxyaryl)pyridine molecules. I. Synthesis, structure and physiochemical properties of 2-(2-hydroxyaryl)-4,6-diarylpyridines", RUSS. J. ORG. CHEM. (ENGL. TRANSL.), vol. 32, no. 7, 1996, pages 1055 - 1058, XP002111163 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106831972A (en) * 2017-03-17 2017-06-13 上海海洋大学 The many types of vitellogenin Vtg full length genes sequence of mudskipper and its cloning process

Also Published As

Publication number Publication date
AU3352899A (en) 1999-07-12
WO1999032447A2 (en) 1999-07-01

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