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WO1999031230A3 - Oligophrenin-1, its expression product, and the diagnostic and therapeutic applications thereof - Google Patents

Oligophrenin-1, its expression product, and the diagnostic and therapeutic applications thereof Download PDF

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Publication number
WO1999031230A3
WO1999031230A3 PCT/EP1998/008557 EP9808557W WO9931230A3 WO 1999031230 A3 WO1999031230 A3 WO 1999031230A3 EP 9808557 W EP9808557 W EP 9808557W WO 9931230 A3 WO9931230 A3 WO 9931230A3
Authority
WO
WIPO (PCT)
Prior art keywords
oligophrenin
diagnostic
expression product
therapeutic applications
nucleotide
Prior art date
Application number
PCT/EP1998/008557
Other languages
French (fr)
Other versions
WO1999031230A2 (en
Inventor
Jamel Chelly
Pierre Billuart
Axel Kahn
Cherif Beldjord
Original Assignee
Inst Nat Sante Rech Med
Jamel Chelly
Pierre Billuart
Axel Kahn
Cherif Beldjord
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med, Jamel Chelly, Pierre Billuart, Axel Kahn, Cherif Beldjord filed Critical Inst Nat Sante Rech Med
Priority to EP98966703A priority Critical patent/EP1037993A2/en
Priority to JP2000539130A priority patent/JP2002508177A/en
Priority to CA002315268A priority patent/CA2315268A1/en
Publication of WO1999031230A2 publication Critical patent/WO1999031230A2/en
Publication of WO1999031230A3 publication Critical patent/WO1999031230A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to the identification of a new gene, called oligophrenin 1, its expression product, and the diagnostic and therapeutic applications of these nucleotide and peptide sequences.
PCT/EP1998/008557 1997-12-15 1998-12-14 Oligophrenin-1, its expression product, and the diagnostic and therapeutic applications thereof WO1999031230A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP98966703A EP1037993A2 (en) 1997-12-15 1998-12-14 A new gene called oligophrenin 1, its expression product, and the diagnostic and therapeutic applications thereof
JP2000539130A JP2002508177A (en) 1997-12-15 1998-12-14 Novel gene called oligofrenin 1, its expression product and its diagnostic and therapeutic use
CA002315268A CA2315268A1 (en) 1997-12-15 1998-12-14 Oligophrenin-1, its expression product, and the diagnostic and therapeutic applications thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97403050.4 1997-12-15
EP97403050 1997-12-15

Publications (2)

Publication Number Publication Date
WO1999031230A2 WO1999031230A2 (en) 1999-06-24
WO1999031230A3 true WO1999031230A3 (en) 1999-08-12

Family

ID=8229926

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/008557 WO1999031230A2 (en) 1997-12-15 1998-12-14 Oligophrenin-1, its expression product, and the diagnostic and therapeutic applications thereof

Country Status (4)

Country Link
EP (1) EP1037993A2 (en)
JP (1) JP2002508177A (en)
CA (1) CA2315268A1 (en)
WO (1) WO1999031230A2 (en)

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BIENVENU, T. ET AL.: "Mapping of the X-breakpoint involved in a balanced X;12 translocation in a female with mild mental retardation.", EUROPEAN JOURNAL OF HUMAN GENETICS, vol. 5, 1997, pages 105 - 109, XP002067476 *
BILLUART, P. ET AL.: "Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation.", NATURE, vol. 392, no. 6679, 30 April 1998 (1998-04-30), pages 923 - 6, XP002104856 *
BILLUART, P. ET AL.: "Oligophrénine-1, une protéine Rho-GAP impliquée dans une forme non spécifique de retard mental lié au chromosome X", MÉDICINE/SCIENCES, vol. 14, no. 5, May 1998 (1998-05-01), pages 679 - 81, XP002104857 *
BILLUERT, P. ET AL.: "L'oligophrénine 1 code pour une protéine rho-GAP impliquée dans un retard mental lié au chromosome X", PATHOLOGIE BIOLOGIE, vol. 46, no. 9, November 1998 (1998-11-01), pages 678, XP002104858 *
DATABASE EMBL - EMHTG 8 November 1996 (1996-11-08), WRAY, P.: "Human DNA sequence *** SEQUENCING IN PROGRESS *** from clone 360E18", XP002067478 *
DATABASE EMBL - EMHUM1 23 August 1997 (1997-08-23), PEARCE, A.: "Human DNA sequence from PAC 63m23 on chromosome Xq13.1-Xq21.1", XP002067479 *
DATABASE EMBL - R45U053 15 April 1998 (1998-04-15), CHELLY, J.: "Homo sapiens mRNA for oligophrenin 1", XP002067477 *

Also Published As

Publication number Publication date
EP1037993A2 (en) 2000-09-27
JP2002508177A (en) 2002-03-19
CA2315268A1 (en) 1999-06-24
WO1999031230A2 (en) 1999-06-24

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