+

WO1999030677A1 - Pate prophylactique buccale - Google Patents

Pate prophylactique buccale Download PDF

Info

Publication number
WO1999030677A1
WO1999030677A1 PCT/US1998/026637 US9826637W WO9930677A1 WO 1999030677 A1 WO1999030677 A1 WO 1999030677A1 US 9826637 W US9826637 W US 9826637W WO 9930677 A1 WO9930677 A1 WO 9930677A1
Authority
WO
WIPO (PCT)
Prior art keywords
paste
dental
pumice
weight
percent
Prior art date
Application number
PCT/US1998/026637
Other languages
English (en)
Inventor
Kenneth S. Peterson
James M. Sherman
Connie E. Chilcott
Original Assignee
Dentsply International Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dentsply International Inc. filed Critical Dentsply International Inc.
Priority to JP2000538661A priority Critical patent/JP2002511389A/ja
Priority to EP98962113A priority patent/EP1027030A1/fr
Priority to AU17270/99A priority patent/AU1727099A/en
Priority to CA002315033A priority patent/CA2315033A1/fr
Priority claimed from US09/212,952 external-priority patent/US6280707B1/en
Publication of WO1999030677A1 publication Critical patent/WO1999030677A1/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/347Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25Silicon; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • Oral compositions containing triclosan are known.
  • an oral composition which includes an effective antiplaque proportion of triclosan in an oral composition. That composition is in the form of a tooth paste, gel dentrifrice, tooth powder, mouth rinse, mouth wash, tooth hardener, anticalculus composition, gum or lozenge.
  • Such triclosan-containing compositions are known to exhibit an antibacterial effect in the oral cavity.
  • dentrifrice compositions heretofore known in the art are not useful as oral prophylaxis pastes (also referred to as "prophy" pastes) .
  • a main drawback has been that the prior dentrifrices contain low abrasive materials. This is because such dentrifrices are intended to be used on a daily basis. Therefore, prior to the present invention, there has not been a prophylaxis paste which exhibits antimicrobial properties and which is abrasive enough to be employed by the dental practitioner as a prophalaxis paste.
  • a need exhibits for a prophy paste with acceptable abrasive qualities as well as antimicrobial qualities.
  • the present invention as will be discussed below meets this need.
  • a prophylaxis paste comprises a preselected amount and grade of pumice, clay, glycerin and an amount of triclosan.
  • the dental prophalaxis paste composition according to the invention is based upon a moistened pumice baseor clay base, normally containing an amount of pumice or clay, water and preferably a moisture retention agent in the form of glycerin.
  • the novel paste has a pumice base or clay base moistened to a pasty state.
  • the exact amount of moisture added may be varied within reasonable limits because changing the moisture content in small amounts, although altering the paste consistency does not materially alter the characteristics which depend on the addition of further components. It has been found that the moisture retention agent may also be varied within reasonable amounts because its presence within a limited range does not significantly alter the desired flowing and non-splattering characteristics desired in the paste.
  • glycerin and water it is preferred to add glycerin and water to the pumice base in a weight amount ratio of about 16:8:4 of pumice or clay, glycerin and water.
  • the glycerin may readily range from about 6- 9 parts to 16 parts of pumice, while the water can vary between about 4 to 6 parts per 16 parts of base without significantly altering the characteristics of the paste .
  • a prophalaxis paste according to the present invention will be prepared as a fine, medium or coarse grit compound. These designations are relative, and are not necessarily intended to convey exact grades or grit levels. However, preferred explary compositions will be discussed below.
  • the pumice or clay grade used in each of the different grit pastes is based upon the average particle size of the respective pumice. The table given below provides a grade designation and the average particle size in mesh, inches and microns.
  • a fine grit prophalaxis paste according to the invention will include about 40-50 percent by weight of pumice grade 4F.
  • a medium grit paste will include from about 10-15% of pumice grade 3F and 35-40% of grade 2F.
  • a coarse grit composition will contain for example, 35- 40% by weight of pumice grade 2F and 10-15% of pumice grade O. It is envisioned that other composition containing different grit levels are within the scope of the present invention. For example, a more coarse composition might include 35-40% of pumice grade IF and 10-15% by weight of pumice grade O. Again, other amounts of pumice or combinations of pumice may fall within a given designation, without varying from the scope of the present invention. Again, the designations fine, medium and coarse are relative and subjective .
  • fine, medium and coarse grit level compositions according to the invention may contain the following components.
  • the sodium silicate, methyl salicylate and sodium carboxymethycellulose are added to the pumice paste, containing pumice, glycerin and water, as discussed above.
  • the sodium silicate and methyl salicylate together form the curing system of the composition in the ratios of sodium silicate (3-4 parts) to methyl salicylate (0.25-1.25 parts).
  • the sodium carboxymethylcellulose acts as a gum.
  • Other materials may be included as a gum such as agar agar or the like. It has been found that these materials, when employed in the paste, act synergistically to create unique flow characteristics in the paste.
  • the material By blending an amount of a gum system, such as sodium carboxymethylcellulose, and a small amount of the curing system, that is up to about 2% by weight of the gum system and up to about 10% by weight of the cure system, the material will flow smoothly under pressure, without segregation or settling of the pumice.
  • a gum system such as sodium carboxymethylcellulose
  • dacalite is also a useful grit material, as is diatomaceous earth.
  • the polyethylene glycol is also a moisture retaining agent; sodium fluoride is known to be used as an anticarries agent; monosodium phosphate is a buffer; and sodium saccharin is added as a sweetener.
  • Colorant solutions and flavoring agents are optional as are the sweetener and the sodium fluoride.
  • prophalaxis paste without the triclosan is provided in U.S. Patent 3,228,845, which is hereby incorporated by reference for such disclosure. It has been found that the addition of the antimicrobial agent of triclosan in an amount of from 0.2 to about 1.2 percent by weight provides a dental prophalaxis paste with desirable antimicrobial properties .
  • the prophalaxis paste according to the present invention have abrasion values above those of the dentrifices currently known commercially.
  • the abrasive ratings table provided below gives an example of the inventive prophy pastes and their relative dental abrasion (RDA) values as compared to commercially available dentrifrices.
  • the RDA value as used in the present description may be determined by any of the standard methods including the Grabensteder method or the Hefferen method.
  • the Hefferen method is preferred because it is recognized by the American Dental Association.
  • the RDA is the method for evaluation the abrasive nature of normally, toothpaste
  • another method known as the relative enamel abrasion (REA) is normally used for evaluating prophy paste.
  • REA relative enamel abrasion
  • a prophy paste having a REA value of preferably above about 3 is within the scope of the invention.
  • Klebsiella pneumoniae and Streptococcus mutans were used in the assay. The cultures were maintained lyophilized prior to use. Klebsiella pnumoniae was grown on soybean casein digest
  • Test Performance The Klebsiella suspension was added to Mueller Hinton agar and the Streptococcus suspension was added to BAP with sterile cotton swabs using a three direction sweep (Kirby-Bauer method) . Six plates were prepared for each organism.
  • the products were added to sterile 1/4 inch filter paper discs using 10 mg per disc. Twelve discs were prepared for each product .
  • the discs were added to the inoculated plates. One disc containing each product on each plate. The
  • Klebsiella plates were incubated at 37 ⁇ 2°C for 18-24
  • Table 2 contains the results for the products against Klebsiella pneumoniae .
  • Table 3 contains the results for the products against Streptococcus mutans .
  • the tables also contain the average diameter of the zones of inhibition for each product against each organisms. The average zone of inhibition was calculated from six replicates. The products with a 0 mm zone diameter demonstrated inhibition directly under the sample only (no diffusion of antimicrobial activity) .
  • the sample that showed the largest zone of inhibition against Klebsiella pneumoniae was Sample 5.
  • the sample that showed the largest zone of inhibition against Streptoccocus mutans was Sample 8.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

Cette pâte prophylactique buccale comprend un degré et une dose préalablement choisis de matière abrasive, comme de l'argile de ponce ou de la terre de diatomées. On a humidifié la matière abrasive avec de l'eau et on a inclus un agent de rétention de l'humidité, comme de la glycérine. On emploie un système de durcissement, comme du silicate de sodium et du salicylate de méthyle. Cette formulation possède des propriétés antimicrobiennes grâce à l'inclusion de triclosan.
PCT/US1998/026637 1997-12-16 1998-12-15 Pate prophylactique buccale WO1999030677A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000538661A JP2002511389A (ja) 1997-12-16 1998-12-15 口腔予防ペースト
EP98962113A EP1027030A1 (fr) 1997-12-16 1998-12-15 Pate prophylactique buccale
AU17270/99A AU1727099A (en) 1997-12-16 1998-12-15 Oral prophalaxis paste
CA002315033A CA2315033A1 (fr) 1997-12-16 1998-12-15 Pate prophylactique buccale

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6969397P 1997-12-16 1997-12-16
US60/069,693 1997-12-16
US09/212,952 1998-12-15
US09/212,952 US6280707B1 (en) 1998-12-15 1998-12-15 Oral prophalaxis paste

Publications (1)

Publication Number Publication Date
WO1999030677A1 true WO1999030677A1 (fr) 1999-06-24

Family

ID=26750325

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/026637 WO1999030677A1 (fr) 1997-12-16 1998-12-15 Pate prophylactique buccale

Country Status (5)

Country Link
EP (1) EP1027030A1 (fr)
JP (1) JP2002511389A (fr)
AU (1) AU1727099A (fr)
CA (1) CA2315033A1 (fr)
WO (1) WO1999030677A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100361321B1 (ko) * 2000-06-17 2002-11-18 주식회사 태평양 트리클로산을 함유한 구강용 조성물의 제조방법 및 이방법에 의해 제조된 구강용 조성물
CN102480945A (zh) * 2009-06-03 2012-05-30 艾克斯特克有限责任公司 皮肤处理组合物
US8858921B2 (en) 2008-03-13 2014-10-14 3M Innovative Properties Company Composition containing a water-miscible liquid and a water-soluble particle, method of production and use thereof
CN107405261A (zh) * 2015-03-20 2017-11-28 株式会社Gc 牙科用固化性组合物及其制造方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3228845A (en) * 1963-02-28 1966-01-11 William K Najjar Dental cleanser paste
US4144322A (en) * 1975-01-28 1979-03-13 Colgate Palmolive Company Reduction of abrasiveness in dentrifices
US4235874A (en) * 1979-06-11 1980-11-25 Colgate Palmolive Company Dentifrice
EP0161899A2 (fr) * 1984-05-09 1985-11-21 Unilever Plc Compositions dentifrices
WO1992004884A1 (fr) * 1990-09-10 1992-04-02 Beecham Incorporated Pate dentifrice antimicrobienne
US5605676A (en) * 1995-06-26 1997-02-25 Colgate-Palmolive Company Oral composition exhibiting improved uptake and retention of antibacterial compounds on dental tissue surfaces

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3228845A (en) * 1963-02-28 1966-01-11 William K Najjar Dental cleanser paste
US4144322A (en) * 1975-01-28 1979-03-13 Colgate Palmolive Company Reduction of abrasiveness in dentrifices
US4235874A (en) * 1979-06-11 1980-11-25 Colgate Palmolive Company Dentifrice
EP0161899A2 (fr) * 1984-05-09 1985-11-21 Unilever Plc Compositions dentifrices
WO1992004884A1 (fr) * 1990-09-10 1992-04-02 Beecham Incorporated Pate dentifrice antimicrobienne
US5605676A (en) * 1995-06-26 1997-02-25 Colgate-Palmolive Company Oral composition exhibiting improved uptake and retention of antibacterial compounds on dental tissue surfaces

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100361321B1 (ko) * 2000-06-17 2002-11-18 주식회사 태평양 트리클로산을 함유한 구강용 조성물의 제조방법 및 이방법에 의해 제조된 구강용 조성물
US8858921B2 (en) 2008-03-13 2014-10-14 3M Innovative Properties Company Composition containing a water-miscible liquid and a water-soluble particle, method of production and use thereof
CN102480945A (zh) * 2009-06-03 2012-05-30 艾克斯特克有限责任公司 皮肤处理组合物
EP2437596A4 (fr) * 2009-06-03 2013-01-16 Ex Tek Llc Compositions de traitement cutané
CN107405261A (zh) * 2015-03-20 2017-11-28 株式会社Gc 牙科用固化性组合物及其制造方法
CN107405261B (zh) * 2015-03-20 2020-07-31 株式会社Gc 牙科用固化性组合物及其制造方法

Also Published As

Publication number Publication date
JP2002511389A (ja) 2002-04-16
EP1027030A1 (fr) 2000-08-16
AU1727099A (en) 1999-07-05
CA2315033A1 (fr) 1999-06-24

Similar Documents

Publication Publication Date Title
TWI468179B (zh) 口腔保健療程
AU596123B2 (en) Oral hygiene composition
US6280707B1 (en) Oral prophalaxis paste
EP1139993A1 (fr) Composition de dentifrice a haute teneur en eau et procede de fabrication
JPWO2007069429A1 (ja) 歯磨組成物
CA2960007A1 (fr) Composition de dentifrice renfermant une cire et un phosphate de calcium
US4559223A (en) Silver sulfadiazine and/or zinc sulfadiazine-containing toothpaste or oral medicament
JP5420811B2 (ja) 口腔用組成物
FI84021C (fi) Oral komposition foer foerhindrande av human dentalplack och gingivit.
EP1027030A1 (fr) Pate prophylactique buccale
CN1191053C (zh) 含珍珠岩的口腔组合物
KR100951396B1 (ko) 구취제거, 플라그제거 및 항균효과가 우수한 치약 조성물
JP2004123684A (ja) 歯磨組成物
JP4645830B2 (ja) 歯磨組成物及び歯磨組成物の耐乾燥性を向上する方法
JP6105261B2 (ja) 口腔用組成物
AU679696B2 (en) Gel-type toothpaste composition
JP2017114818A (ja) 口腔用ポリマーゲル製剤
JP2020083831A (ja) 歯磨剤組成物
JP7571410B2 (ja) 歯磨剤組成物
JPH11116453A (ja) 歯周病原性細菌の付着防止剤
WO2018221609A1 (fr) Composition de dentifrice
JPWO2018221622A1 (ja) 歯磨剤組成物
WO2010114005A1 (fr) Composition pour dentifrice
KR20070081613A (ko) 자몽 종자 추출물만을 방부제로 함유하는 치약 조성물
JP7078043B2 (ja) 歯磨剤組成物

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU CA JP MX

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 17270/99

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 1998962113

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2315033

Country of ref document: CA

Ref document number: 2315033

Country of ref document: CA

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 2000 538661

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: PA/A/2000/005966

Country of ref document: MX

WWP Wipo information: published in national office

Ref document number: 1998962113

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1998962113

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务,不要输入任何密码和下载