WO1999030677A1 - Pate prophylactique buccale - Google Patents
Pate prophylactique buccale Download PDFInfo
- Publication number
- WO1999030677A1 WO1999030677A1 PCT/US1998/026637 US9826637W WO9930677A1 WO 1999030677 A1 WO1999030677 A1 WO 1999030677A1 US 9826637 W US9826637 W US 9826637W WO 9930677 A1 WO9930677 A1 WO 9930677A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- paste
- dental
- pumice
- weight
- percent
- Prior art date
Links
- 239000008262 pumice Substances 0.000 claims abstract description 30
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000000203 mixture Substances 0.000 claims abstract description 24
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000011187 glycerol Nutrition 0.000 claims abstract description 12
- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 8
- 239000004927 clay Substances 0.000 claims abstract description 8
- 239000004115 Sodium Silicate Substances 0.000 claims abstract description 7
- 229960001047 methyl salicylate Drugs 0.000 claims abstract description 7
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229910052911 sodium silicate Inorganic materials 0.000 claims abstract description 7
- 230000014759 maintenance of location Effects 0.000 claims abstract description 6
- 229920001817 Agar Polymers 0.000 claims description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 5
- 235000010419 agar Nutrition 0.000 claims description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 5
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 5
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 5
- 238000005299 abrasion Methods 0.000 claims description 4
- 241000206672 Gelidium Species 0.000 claims description 2
- 208000002697 Tooth Abrasion Diseases 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 210000003298 dental enamel Anatomy 0.000 claims description 2
- 230000000069 prophylactic effect Effects 0.000 claims 11
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 abstract description 12
- 229960003500 triclosan Drugs 0.000 abstract description 12
- 238000009472 formulation Methods 0.000 abstract description 5
- 239000003082 abrasive agent Substances 0.000 abstract description 3
- 239000005909 Kieselgur Substances 0.000 abstract description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract description 2
- 239000006072 paste Substances 0.000 description 37
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 8
- 229940034610 toothpaste Drugs 0.000 description 8
- 239000000606 toothpaste Substances 0.000 description 8
- 230000005764 inhibitory process Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 238000011321 prophylaxis Methods 0.000 description 6
- 208000006558 Dental Calculus Diseases 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 4
- 239000011775 sodium fluoride Substances 0.000 description 4
- 235000013024 sodium fluoride Nutrition 0.000 description 4
- 241000588748 Klebsiella Species 0.000 description 3
- 241000588747 Klebsiella pneumoniae Species 0.000 description 3
- 241000194017 Streptococcus Species 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 3
- 235000019799 monosodium phosphate Nutrition 0.000 description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 3
- 239000001488 sodium phosphate Substances 0.000 description 3
- 235000010469 Glycine max Nutrition 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 241000194019 Streptococcus mutans Species 0.000 description 2
- 239000005018 casein Substances 0.000 description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
- 235000021240 caseins Nutrition 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000002324 mouth wash Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 238000002768 Kirby-Bauer method Methods 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002272 anti-calculus Effects 0.000 description 1
- 230000002882 anti-plaque Effects 0.000 description 1
- 229940076292 aquafresh Drugs 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000004848 polyfunctional curative Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- Oral compositions containing triclosan are known.
- an oral composition which includes an effective antiplaque proportion of triclosan in an oral composition. That composition is in the form of a tooth paste, gel dentrifrice, tooth powder, mouth rinse, mouth wash, tooth hardener, anticalculus composition, gum or lozenge.
- Such triclosan-containing compositions are known to exhibit an antibacterial effect in the oral cavity.
- dentrifrice compositions heretofore known in the art are not useful as oral prophylaxis pastes (also referred to as "prophy" pastes) .
- a main drawback has been that the prior dentrifrices contain low abrasive materials. This is because such dentrifrices are intended to be used on a daily basis. Therefore, prior to the present invention, there has not been a prophylaxis paste which exhibits antimicrobial properties and which is abrasive enough to be employed by the dental practitioner as a prophalaxis paste.
- a need exhibits for a prophy paste with acceptable abrasive qualities as well as antimicrobial qualities.
- the present invention as will be discussed below meets this need.
- a prophylaxis paste comprises a preselected amount and grade of pumice, clay, glycerin and an amount of triclosan.
- the dental prophalaxis paste composition according to the invention is based upon a moistened pumice baseor clay base, normally containing an amount of pumice or clay, water and preferably a moisture retention agent in the form of glycerin.
- the novel paste has a pumice base or clay base moistened to a pasty state.
- the exact amount of moisture added may be varied within reasonable limits because changing the moisture content in small amounts, although altering the paste consistency does not materially alter the characteristics which depend on the addition of further components. It has been found that the moisture retention agent may also be varied within reasonable amounts because its presence within a limited range does not significantly alter the desired flowing and non-splattering characteristics desired in the paste.
- glycerin and water it is preferred to add glycerin and water to the pumice base in a weight amount ratio of about 16:8:4 of pumice or clay, glycerin and water.
- the glycerin may readily range from about 6- 9 parts to 16 parts of pumice, while the water can vary between about 4 to 6 parts per 16 parts of base without significantly altering the characteristics of the paste .
- a prophalaxis paste according to the present invention will be prepared as a fine, medium or coarse grit compound. These designations are relative, and are not necessarily intended to convey exact grades or grit levels. However, preferred explary compositions will be discussed below.
- the pumice or clay grade used in each of the different grit pastes is based upon the average particle size of the respective pumice. The table given below provides a grade designation and the average particle size in mesh, inches and microns.
- a fine grit prophalaxis paste according to the invention will include about 40-50 percent by weight of pumice grade 4F.
- a medium grit paste will include from about 10-15% of pumice grade 3F and 35-40% of grade 2F.
- a coarse grit composition will contain for example, 35- 40% by weight of pumice grade 2F and 10-15% of pumice grade O. It is envisioned that other composition containing different grit levels are within the scope of the present invention. For example, a more coarse composition might include 35-40% of pumice grade IF and 10-15% by weight of pumice grade O. Again, other amounts of pumice or combinations of pumice may fall within a given designation, without varying from the scope of the present invention. Again, the designations fine, medium and coarse are relative and subjective .
- fine, medium and coarse grit level compositions according to the invention may contain the following components.
- the sodium silicate, methyl salicylate and sodium carboxymethycellulose are added to the pumice paste, containing pumice, glycerin and water, as discussed above.
- the sodium silicate and methyl salicylate together form the curing system of the composition in the ratios of sodium silicate (3-4 parts) to methyl salicylate (0.25-1.25 parts).
- the sodium carboxymethylcellulose acts as a gum.
- Other materials may be included as a gum such as agar agar or the like. It has been found that these materials, when employed in the paste, act synergistically to create unique flow characteristics in the paste.
- the material By blending an amount of a gum system, such as sodium carboxymethylcellulose, and a small amount of the curing system, that is up to about 2% by weight of the gum system and up to about 10% by weight of the cure system, the material will flow smoothly under pressure, without segregation or settling of the pumice.
- a gum system such as sodium carboxymethylcellulose
- dacalite is also a useful grit material, as is diatomaceous earth.
- the polyethylene glycol is also a moisture retaining agent; sodium fluoride is known to be used as an anticarries agent; monosodium phosphate is a buffer; and sodium saccharin is added as a sweetener.
- Colorant solutions and flavoring agents are optional as are the sweetener and the sodium fluoride.
- prophalaxis paste without the triclosan is provided in U.S. Patent 3,228,845, which is hereby incorporated by reference for such disclosure. It has been found that the addition of the antimicrobial agent of triclosan in an amount of from 0.2 to about 1.2 percent by weight provides a dental prophalaxis paste with desirable antimicrobial properties .
- the prophalaxis paste according to the present invention have abrasion values above those of the dentrifices currently known commercially.
- the abrasive ratings table provided below gives an example of the inventive prophy pastes and their relative dental abrasion (RDA) values as compared to commercially available dentrifrices.
- the RDA value as used in the present description may be determined by any of the standard methods including the Grabensteder method or the Hefferen method.
- the Hefferen method is preferred because it is recognized by the American Dental Association.
- the RDA is the method for evaluation the abrasive nature of normally, toothpaste
- another method known as the relative enamel abrasion (REA) is normally used for evaluating prophy paste.
- REA relative enamel abrasion
- a prophy paste having a REA value of preferably above about 3 is within the scope of the invention.
- Klebsiella pneumoniae and Streptococcus mutans were used in the assay. The cultures were maintained lyophilized prior to use. Klebsiella pnumoniae was grown on soybean casein digest
- Test Performance The Klebsiella suspension was added to Mueller Hinton agar and the Streptococcus suspension was added to BAP with sterile cotton swabs using a three direction sweep (Kirby-Bauer method) . Six plates were prepared for each organism.
- the products were added to sterile 1/4 inch filter paper discs using 10 mg per disc. Twelve discs were prepared for each product .
- the discs were added to the inoculated plates. One disc containing each product on each plate. The
- Klebsiella plates were incubated at 37 ⁇ 2°C for 18-24
- Table 2 contains the results for the products against Klebsiella pneumoniae .
- Table 3 contains the results for the products against Streptococcus mutans .
- the tables also contain the average diameter of the zones of inhibition for each product against each organisms. The average zone of inhibition was calculated from six replicates. The products with a 0 mm zone diameter demonstrated inhibition directly under the sample only (no diffusion of antimicrobial activity) .
- the sample that showed the largest zone of inhibition against Klebsiella pneumoniae was Sample 5.
- the sample that showed the largest zone of inhibition against Streptoccocus mutans was Sample 8.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
Cette pâte prophylactique buccale comprend un degré et une dose préalablement choisis de matière abrasive, comme de l'argile de ponce ou de la terre de diatomées. On a humidifié la matière abrasive avec de l'eau et on a inclus un agent de rétention de l'humidité, comme de la glycérine. On emploie un système de durcissement, comme du silicate de sodium et du salicylate de méthyle. Cette formulation possède des propriétés antimicrobiennes grâce à l'inclusion de triclosan.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000538661A JP2002511389A (ja) | 1997-12-16 | 1998-12-15 | 口腔予防ペースト |
| EP98962113A EP1027030A1 (fr) | 1997-12-16 | 1998-12-15 | Pate prophylactique buccale |
| AU17270/99A AU1727099A (en) | 1997-12-16 | 1998-12-15 | Oral prophalaxis paste |
| CA002315033A CA2315033A1 (fr) | 1997-12-16 | 1998-12-15 | Pate prophylactique buccale |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6969397P | 1997-12-16 | 1997-12-16 | |
| US60/069,693 | 1997-12-16 | ||
| US09/212,952 | 1998-12-15 | ||
| US09/212,952 US6280707B1 (en) | 1998-12-15 | 1998-12-15 | Oral prophalaxis paste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1999030677A1 true WO1999030677A1 (fr) | 1999-06-24 |
Family
ID=26750325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1998/026637 WO1999030677A1 (fr) | 1997-12-16 | 1998-12-15 | Pate prophylactique buccale |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1027030A1 (fr) |
| JP (1) | JP2002511389A (fr) |
| AU (1) | AU1727099A (fr) |
| CA (1) | CA2315033A1 (fr) |
| WO (1) | WO1999030677A1 (fr) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100361321B1 (ko) * | 2000-06-17 | 2002-11-18 | 주식회사 태평양 | 트리클로산을 함유한 구강용 조성물의 제조방법 및 이방법에 의해 제조된 구강용 조성물 |
| CN102480945A (zh) * | 2009-06-03 | 2012-05-30 | 艾克斯特克有限责任公司 | 皮肤处理组合物 |
| US8858921B2 (en) | 2008-03-13 | 2014-10-14 | 3M Innovative Properties Company | Composition containing a water-miscible liquid and a water-soluble particle, method of production and use thereof |
| CN107405261A (zh) * | 2015-03-20 | 2017-11-28 | 株式会社Gc | 牙科用固化性组合物及其制造方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3228845A (en) * | 1963-02-28 | 1966-01-11 | William K Najjar | Dental cleanser paste |
| US4144322A (en) * | 1975-01-28 | 1979-03-13 | Colgate Palmolive Company | Reduction of abrasiveness in dentrifices |
| US4235874A (en) * | 1979-06-11 | 1980-11-25 | Colgate Palmolive Company | Dentifrice |
| EP0161899A2 (fr) * | 1984-05-09 | 1985-11-21 | Unilever Plc | Compositions dentifrices |
| WO1992004884A1 (fr) * | 1990-09-10 | 1992-04-02 | Beecham Incorporated | Pate dentifrice antimicrobienne |
| US5605676A (en) * | 1995-06-26 | 1997-02-25 | Colgate-Palmolive Company | Oral composition exhibiting improved uptake and retention of antibacterial compounds on dental tissue surfaces |
-
1998
- 1998-12-15 JP JP2000538661A patent/JP2002511389A/ja active Pending
- 1998-12-15 CA CA002315033A patent/CA2315033A1/fr not_active Abandoned
- 1998-12-15 WO PCT/US1998/026637 patent/WO1999030677A1/fr not_active Application Discontinuation
- 1998-12-15 EP EP98962113A patent/EP1027030A1/fr not_active Withdrawn
- 1998-12-15 AU AU17270/99A patent/AU1727099A/en not_active Abandoned
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3228845A (en) * | 1963-02-28 | 1966-01-11 | William K Najjar | Dental cleanser paste |
| US4144322A (en) * | 1975-01-28 | 1979-03-13 | Colgate Palmolive Company | Reduction of abrasiveness in dentrifices |
| US4235874A (en) * | 1979-06-11 | 1980-11-25 | Colgate Palmolive Company | Dentifrice |
| EP0161899A2 (fr) * | 1984-05-09 | 1985-11-21 | Unilever Plc | Compositions dentifrices |
| WO1992004884A1 (fr) * | 1990-09-10 | 1992-04-02 | Beecham Incorporated | Pate dentifrice antimicrobienne |
| US5605676A (en) * | 1995-06-26 | 1997-02-25 | Colgate-Palmolive Company | Oral composition exhibiting improved uptake and retention of antibacterial compounds on dental tissue surfaces |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100361321B1 (ko) * | 2000-06-17 | 2002-11-18 | 주식회사 태평양 | 트리클로산을 함유한 구강용 조성물의 제조방법 및 이방법에 의해 제조된 구강용 조성물 |
| US8858921B2 (en) | 2008-03-13 | 2014-10-14 | 3M Innovative Properties Company | Composition containing a water-miscible liquid and a water-soluble particle, method of production and use thereof |
| CN102480945A (zh) * | 2009-06-03 | 2012-05-30 | 艾克斯特克有限责任公司 | 皮肤处理组合物 |
| EP2437596A4 (fr) * | 2009-06-03 | 2013-01-16 | Ex Tek Llc | Compositions de traitement cutané |
| CN107405261A (zh) * | 2015-03-20 | 2017-11-28 | 株式会社Gc | 牙科用固化性组合物及其制造方法 |
| CN107405261B (zh) * | 2015-03-20 | 2020-07-31 | 株式会社Gc | 牙科用固化性组合物及其制造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002511389A (ja) | 2002-04-16 |
| EP1027030A1 (fr) | 2000-08-16 |
| AU1727099A (en) | 1999-07-05 |
| CA2315033A1 (fr) | 1999-06-24 |
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