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WO1999021971A3 - Alcool deshydrogenases thermostables - Google Patents

Alcool deshydrogenases thermostables Download PDF

Info

Publication number
WO1999021971A3
WO1999021971A3 PCT/US1998/022607 US9822607W WO9921971A3 WO 1999021971 A3 WO1999021971 A3 WO 1999021971A3 US 9822607 W US9822607 W US 9822607W WO 9921971 A3 WO9921971 A3 WO 9921971A3
Authority
WO
WIPO (PCT)
Prior art keywords
alcohol dehydrogenases
thermostable
proteins
dehydrogenase activity
alcohol dehydrogenase
Prior art date
Application number
PCT/US1998/022607
Other languages
English (en)
Other versions
WO1999021971A9 (fr
WO1999021971A2 (fr
Inventor
Larry Allen
Igor Brikun
John H Alkens
David C Demirjian
Ramesh Matur
Yuri Nikolsky
David Rozzell
Original Assignee
Thermogen Inc
Larry Allen
Igor Brikun
John H Alkens
David C Demirjian
Ramesh Matur
Yuri Nikolsky
David Rozzell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thermogen Inc, Larry Allen, Igor Brikun, John H Alkens, David C Demirjian, Ramesh Matur, Yuri Nikolsky, David Rozzell filed Critical Thermogen Inc
Priority to EP98957372A priority Critical patent/EP1027427A2/fr
Priority to CA002308095A priority patent/CA2308095A1/fr
Priority to AU13648/99A priority patent/AU1364899A/en
Publication of WO1999021971A2 publication Critical patent/WO1999021971A2/fr
Publication of WO1999021971A9 publication Critical patent/WO1999021971A9/fr
Publication of WO1999021971A3 publication Critical patent/WO1999021971A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention se rapporte à des protéines possédant une activité d'alcool déshydrogénase. Dans une réalisation particulière, l'invention concerne des protéines possédant une activité d'alcool déshydrogénase produisant sélectivement des alcools chiraux. Dans une autre réalisation, l'invention concerne des protéines possédant une activité d'alcool déshydrogénase thermostable.
PCT/US1998/022607 1997-10-27 1998-10-26 Alcool deshydrogenases thermostables WO1999021971A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP98957372A EP1027427A2 (fr) 1997-10-27 1998-10-26 Alcool deshydrogenases thermostables
CA002308095A CA2308095A1 (fr) 1997-10-27 1998-10-26 Alcool deshydrogenases thermostables
AU13648/99A AU1364899A (en) 1997-10-27 1998-10-26 Thermostable alcohol dehydrogenases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6351797P 1997-10-27 1997-10-27
US60/063,517 1997-10-27

Publications (3)

Publication Number Publication Date
WO1999021971A2 WO1999021971A2 (fr) 1999-05-06
WO1999021971A9 WO1999021971A9 (fr) 1999-08-19
WO1999021971A3 true WO1999021971A3 (fr) 1999-10-28

Family

ID=22049741

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/022607 WO1999021971A2 (fr) 1997-10-27 1998-10-26 Alcool deshydrogenases thermostables

Country Status (4)

Country Link
EP (1) EP1027427A2 (fr)
AU (1) AU1364899A (fr)
CA (1) CA2308095A1 (fr)
WO (1) WO1999021971A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2738574A1 (fr) 2008-09-26 2010-04-01 Kesen Ma Alcool deshydrogenase thermostable issue de thermococcus guaymasensis

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352885A (en) * 1980-05-09 1982-10-05 Wisconsin Alumni Research Foundation Preparation of a novel NADP linked alcohol-aldehyde/ketone oxidoreductase from thermophilic anaerobic bacteria for analytical and commercial use
FR2706906A1 (en) * 1993-06-21 1994-12-30 Ifremer Alcohol dehydrogenase, microorganism producing it and its uses
WO1997032012A1 (fr) * 1996-02-27 1997-09-04 Michigan State University Clonage et expression du gene codant la dehydrogenase d'alcool secondaire thermoanaerobacter ethanolicus 39e et caracterisation biochimique d'enzymes
EP0796914A2 (fr) * 1996-03-21 1997-09-24 Roche Diagnostics GmbH Alcool déshydrogénase et son utilisation pour la préparation enzymatique de liaisons hydroxy chirales

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352885A (en) * 1980-05-09 1982-10-05 Wisconsin Alumni Research Foundation Preparation of a novel NADP linked alcohol-aldehyde/ketone oxidoreductase from thermophilic anaerobic bacteria for analytical and commercial use
FR2706906A1 (en) * 1993-06-21 1994-12-30 Ifremer Alcohol dehydrogenase, microorganism producing it and its uses
WO1997032012A1 (fr) * 1996-02-27 1997-09-04 Michigan State University Clonage et expression du gene codant la dehydrogenase d'alcool secondaire thermoanaerobacter ethanolicus 39e et caracterisation biochimique d'enzymes
EP0796914A2 (fr) * 1996-03-21 1997-09-24 Roche Diagnostics GmbH Alcool déshydrogénase et son utilisation pour la préparation enzymatique de liaisons hydroxy chirales

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RELLOS P ET AL: "Polymerase chain reaction-based random mutagenesis: production and characterization of thermostable mutants of Zymomonas mobilis alcohol dehydrogenase-2", PROTEIN EXPRESSION AND PURIFICATION, vol. 5, 1994, pages 270 - 277, XP002076286 *

Also Published As

Publication number Publication date
AU1364899A (en) 1999-05-17
WO1999021971A9 (fr) 1999-08-19
WO1999021971A2 (fr) 1999-05-06
CA2308095A1 (fr) 1999-05-06
EP1027427A2 (fr) 2000-08-16

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