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WO1999017869A3 - Compositions for organic synthesis on solid phase and methods of using the same - Google Patents

Compositions for organic synthesis on solid phase and methods of using the same Download PDF

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Publication number
WO1999017869A3
WO1999017869A3 PCT/US1998/020912 US9820912W WO9917869A3 WO 1999017869 A3 WO1999017869 A3 WO 1999017869A3 US 9820912 W US9820912 W US 9820912W WO 9917869 A3 WO9917869 A3 WO 9917869A3
Authority
WO
WIPO (PCT)
Prior art keywords
solid phase
compositions
methods
same
organic synthesis
Prior art date
Application number
PCT/US1998/020912
Other languages
French (fr)
Other versions
WO1999017869A2 (en
Inventor
Yonghan Hu
Jeffrey W Labadie
John Anthony Porco Jr
Barry Martin Trost
Original Assignee
Argonaut Technologies
Yonghan Hu
Jeffrey W Labadie
John Anthony Porco Jr
Barry Martin Trost
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/163,889 external-priority patent/US6147159A/en
Application filed by Argonaut Technologies, Yonghan Hu, Jeffrey W Labadie, John Anthony Porco Jr, Barry Martin Trost filed Critical Argonaut Technologies
Publication of WO1999017869A2 publication Critical patent/WO1999017869A2/en
Publication of WO1999017869A3 publication Critical patent/WO1999017869A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/12—Chemical modification
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/42—Introducing metal atoms or metal-containing groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A modified solid support for use in solid phase synthesis which comprises: a solid support having a linker group extending therefrom having general formula (1) wherein R1 and R2 are each independently selected from the group consisting of alkyl, cycloalkyl, aryl, alkoxy, aryloxy, fluorine, chlorine, iodine and bromine.
PCT/US1998/020912 1997-10-03 1998-10-02 Compositions for organic synthesis on solid phase and methods of using the same WO1999017869A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6078197P 1997-10-03 1997-10-03
US60/060,781 1997-10-03
US09/163,889 1998-09-30
US09/163,889 US6147159A (en) 1998-09-30 1998-09-30 Compositions for organic synthesis on solid phase and methods of using the same

Publications (2)

Publication Number Publication Date
WO1999017869A2 WO1999017869A2 (en) 1999-04-15
WO1999017869A3 true WO1999017869A3 (en) 1999-06-17

Family

ID=26740356

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/020912 WO1999017869A2 (en) 1997-10-03 1998-10-02 Compositions for organic synthesis on solid phase and methods of using the same

Country Status (1)

Country Link
WO (1) WO1999017869A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6416861B1 (en) 1999-02-16 2002-07-09 Northwestern University Organosilicon compounds and uses thereof
DE10013995A1 (en) * 2000-03-22 2001-09-27 Chemagen Biopolymer Technologi Magnetic polyvinyl alcohol carrier material in particle, filter or membrane form for use in isolation of e.g. DNA or in automatic diagnoses is at least partly surface silanized
FR2818651B1 (en) * 2000-12-26 2003-10-24 Hoechst Marion Roussel Inc SYNTHESIS OF NEW OXYGENATED HETEROCYCLIC MOLECULES BY METATHESIS REACTION ON SOLID SUPPORT USING NEW SILYLATED LINKERS
JP2004518015A (en) * 2001-01-29 2004-06-17 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト Trace-free N-carbamyl-N'-dimethylsilylmethyl-piperazine linker for solid-phase synthesis of phenyl-based libraries
CN108516993B (en) * 2018-05-07 2020-11-10 广东工业大学 Sulfur poisoning resistant platinum complex and application thereof
CN112007634B (en) * 2019-05-28 2023-08-29 新特能源股份有限公司 Novel vinyl trichlorosilane catalyst, preparation method thereof and method for preparing vinyl trichlorosilane by catalysis of novel vinyl trichlorosilane catalyst

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2536752A1 (en) * 1982-11-25 1984-06-01 Brossas Jean Liq. crosslinkable polydiene resin
FR2616152A1 (en) * 1987-06-03 1988-12-09 Inst Rech Appliquee Polym New polysilanes, corresponding modified polysilanes, their preparation and their application in crosslinkable compositions
DE4234898C1 (en) * 1992-10-16 1994-04-07 Goldschmidt Ag Th Polysiloxane(s) with silane gp. at one end and another gp. at the other - by anionic polymerisation of hexa:methyl:cyclo:tri:siloxane with lithium alcoholate, and addn of a functional silane chain-stopper
US5859277A (en) * 1997-06-25 1999-01-12 Wisconsin Alumni Research Foundation Silicon-containing solid support linker

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2536752A1 (en) * 1982-11-25 1984-06-01 Brossas Jean Liq. crosslinkable polydiene resin
FR2616152A1 (en) * 1987-06-03 1988-12-09 Inst Rech Appliquee Polym New polysilanes, corresponding modified polysilanes, their preparation and their application in crosslinkable compositions
DE4234898C1 (en) * 1992-10-16 1994-04-07 Goldschmidt Ag Th Polysiloxane(s) with silane gp. at one end and another gp. at the other - by anionic polymerisation of hexa:methyl:cyclo:tri:siloxane with lithium alcoholate, and addn of a functional silane chain-stopper
US5859277A (en) * 1997-06-25 1999-01-12 Wisconsin Alumni Research Foundation Silicon-containing solid support linker

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BOEHM T. L. AND SHOWALTER H. D.: "Development of a novel silyl ether linker for solid-phase organic synthesis", JOURNAL OF ORGANIC CHEMISTRY, vol. 61, 1996, pages 6498 - 6499, XP002097133 *
CHENERA B. ET AL.: "Photodetachable arylsilane polymer linkages for use in solid phase organic synthesis", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 117, 1995, pages 11999 - 12000, XP002097132 *
MUZAFAROV A M ET AL: "DEGRADABLE HYPERBRANCHED POLY(BIS(UNDECENYLOXY)METHYLSILANE)S", MACROMOLECULES, vol. 28, no. 24, 20 November 1995 (1995-11-20), pages 8444 - 8446, XP000539448 *
WOOLARD F. X. ET AL.: "A silicon linker for direct loading of aromatic compounds to supports. Traceless synthesis of pyridine-based tricyclics", JOURNAL OF ORGANIC CHEMISTRY, vol. 62, 1997, pages 6102 - 6103, XP002097134 *

Also Published As

Publication number Publication date
WO1999017869A2 (en) 1999-04-15

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