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WO1999016370A1 - Dispositif d'ablation interstitiel orientable - Google Patents

Dispositif d'ablation interstitiel orientable Download PDF

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Publication number
WO1999016370A1
WO1999016370A1 PCT/US1998/020099 US9820099W WO9916370A1 WO 1999016370 A1 WO1999016370 A1 WO 1999016370A1 US 9820099 W US9820099 W US 9820099W WO 9916370 A1 WO9916370 A1 WO 9916370A1
Authority
WO
WIPO (PCT)
Prior art keywords
elongated housing
electrode
deflectable
ablation device
interstitial ablation
Prior art date
Application number
PCT/US1998/020099
Other languages
English (en)
Inventor
Kimberly A. Paddock
James E. Mayberry
Charles D. Lennox
Original Assignee
Boston Scientific Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Corporation filed Critical Boston Scientific Corporation
Priority to DE69829300T priority Critical patent/DE69829300T2/de
Priority to IL13535398A priority patent/IL135353A/en
Priority to EP98948543A priority patent/EP1018959B1/fr
Priority to AU95092/98A priority patent/AU738287B2/en
Priority to CA002304739A priority patent/CA2304739C/fr
Priority to JP2000513516A priority patent/JP2001517528A/ja
Publication of WO1999016370A1 publication Critical patent/WO1999016370A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1477—Needle-like probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00059—Material properties
    • A61B2018/00071—Electrical conductivity
    • A61B2018/00083—Electrical conductivity low, i.e. electrically insulating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00547—Prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/0091—Handpieces of the surgical instrument or device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/0091—Handpieces of the surgical instrument or device
    • A61B2018/00916—Handpieces of the surgical instrument or device with means for switching or controlling the main function of the instrument or device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00982—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1405—Electrodes having a specific shape
    • A61B2018/1425—Needle

Definitions

  • the invention relates to an interstitial ablation device and method for performing tissue ablation, and in particular, to an improved interstitial ablation device providing enhanced electrode placement and control.
  • Ablation devices can be used to treat tumors in the body.
  • ablation devices can be used to treat benign prostatic hypertrophy or hyperplasia (BPH), a condition resulting in an enlargement of the prostate gland.
  • BPH benign prostatic hypertrophy or hyperplasia
  • An ablating needle can be used with a cystoscope to treat BPH by ablating a prostatic adenoma, which is a benign tumor inside the prostate.
  • a physician inserts a distal end of the cystoscope into the urethra of a patient while viewing the advance through an eye piece of the cystoscope.
  • the needle electrode is also introduced into the urethra through a working channel of the cystoscope.
  • the cystoscope and the needle electrode are typically introduced inside the urethra sequentially.
  • the distal end of the needle electrode is positioned adjacent the prostate near the prostatic adenoma.
  • the physician then causes the needle electrode to penetrate the urethral wall, such that it is positioned inside the prostatic adenoma.
  • Radiofrequency (RF) energy is applied to the needle electrode to coagulate tissue surrounding the electrode.
  • Coagulation causes necrosis of the prostatic adenoma, resulting in atrophy of the prostate and a reduction in the compressive forces that interfere with urine flow through the urethra.
  • RF Radiofrequency
  • Visualization is typically provided by inserting the needle electrode through a cystoscope.
  • One disadvantage of the ablation device insertable through a cystoscope is that it is difficult to feed the device through a working channel of the cystoscope and requires a lot of juggling which can make accurate placement of the needle electrode difficult.
  • the invention features a deflectable interstitial ablation device.
  • the device includes an elongated housing, an electrode mounted within the elongated housing, a driver coupled to the electrode, an imaging device integrally mounted within the elongated housing, and a deflection system disposed within the elongated housing.
  • the elongated housing has a proximal end, a distal end, and a deflectable segment.
  • the electrode is deployable from a first position within the elongated housing to a second position a predetermined distance beyond the distal end of the elongated housing, and has a flexible portion capable of deflecting with the deflectable segment of the elongated housing.
  • the driver exerts a force sufficient to drive the electrode from the first position to the second position in a single motion.
  • the imaging device has a flexible portion capable of deflecting with the deflectable segment of the elongated housing.
  • the deflection system controllably deflects the deflectable segment of the elongated housing to a desired angle.
  • the deflection system has a proximal end in communication with a steering mechanism.
  • the imaging device includes a plurality of illumination optical fibers and a plurality of viewing optical fibers extending from the proximal end to the distal end of the elongated housing.
  • the viewing optical fibers can comprise a fused bundle of viewing optical fibers surrounded by illumination optical fibers, wherein the viewing optical fibers are in communication with a lens disposed at the distal end of the elongated housing.
  • the electrode is a hollow needle electrode and an insulation sheath surrounds the needle electrode. The needle electrode and the insulation sheath are individually and slidably mounted inside the elongated housing, such that the insulation sheath is capable of covering a proximal portion of the needle electrode which extends beyond the distal end of the elongated housing.
  • the driver coupled to the electrode can exert a force within the range of 1/4 lb to 1 lb to drive the electrode from the first position to the second position in a single motion.
  • the device in another embodiment, includes an elongated housing, an electrode mounted within the elongated housing, an imaging device integrally mounted with the elongated housing, a deflection system disposed within the elongated housing, and a foot pedal for deploying the electrode.
  • the invention features a method for treating tissue. A deflectable interstitial ablation device is inserted into a body lumen which provides access to the tissue to be treated.
  • the deflectable interstitial ablation device includes an elongated housing having a deflectable segment, a deployable electrode mounted within the elongated housing, a driver coupled to the electrode for exerting a force to drive the electrode, an imaging device integrally mounted with the elongated housing, and a deflection system disposed within the elongated housing.
  • the distal end of the elongated housing is positioned near the tissue.
  • the deflectable segment of the elongated housing is deflected toward the tissue, thereby deflecting the electrode and the imaging device toward the tissue along with the deflectable segment.
  • the electrode is deployed to penetrate a wall of the lumen and to position a distal end of the electrode adjacent the tissue. Radio frequency energy is applied to the electrode in an amount and for a duration sufficient to ablate the tissue.
  • an insulation sheath is deployed to cover a proximal portion of the deployed electrode to protect the wall of the lumen from directly contacting the needle electrode during the treatment.
  • a balloon disposed on a body of the elongated housing of the deflectable interstitial ablation device is inflated to secure the position of the elongated housing inside the lumen.
  • a basket disposed on a body of the elongated housing of the deflectable interstitial ablation device is expanded to secure a position.
  • the distal end of the elongated housing is connected to an actuator in communication with a foot pedal and the foot pedal is depressed to deploy the electrode.
  • Fig. IB shows a portion of the deflectable insterstital ablation device having a basket for maintaining the placement of the device in a body lumen, according to one embodiment of the invention.
  • Fig. 2 illustrates a deflecting segment of the deflectable interstitial ablation device of Fig.
  • Fig. 3 shows a cross sectional view of the deflectable interstitial ablation device of Fig. 1 A cut through lines 3'-3".
  • Fig. 4 shows a cross sectional view of a distal end of the deflectable interstitial ablation device of Fig. 1 A cut through lines 4'-4" .
  • Fig. 5 A is a side view of a kinetically deployable needle electrode according to one embodiment of the invention.
  • Fig. 5B is a cross sectional view of the kinetically deployable needle electrode of Fig. 5 A prior to deployment.
  • Fig. 5C is a cross sectional view of the kinetically deployable needle electrode of Fig. 5 A in a loaded position.
  • Fig. 5D is a cross sectional view of the kinetically deployable needle electrode of Fig. 5 A with the needle electrode deployed.
  • Fig. 5E is a cross sectional view of the kinetically deployable needle electrode of Fig. 5 A with the needle electrode and the insulation sheath deployed.
  • Fig. 6 shows a transurethral interstitial ablation system employing a foot pedal according to one embodiment of the invention.
  • a deflectable interstitial ablation device 10 includes an elongated housing 12, an electrode 14 extending within the elongated housing 12, an imaging device 16 integrally mounted with the elongated housing 12 and a deflection system 18 disposed within the elongated housing 12.
  • the electrode 14 can comprise a needle electrode having a sharpened tip, or an electrode having a blunt tip.
  • the elongated housing 12 has a proximal end, a distal end and a deflectable segment 22 further as further shown in Fig. 2.
  • the elongated housing 12 can be constructed to be flexible so that the housing 12 may be inserted into the urethra without much discomfort.
  • the housing 12, can be, for example, a flexible multi-lumen catheter.
  • the housing 12, can be, for example, a substantially rigid, single lumen catheter having a deflectable segment 22.
  • the housing 12 can have a diameter from about 15 to 16 French. It is to appreciated that the diameter of the housing 12 can vary depending on the intended use of the ablation device 10.
  • the present invention further provides means for stabilizing the position of the device 10 before deploying the electrode 14.
  • the elongated housing 12 of the invention includes a balloon 24 for securing the position of the device 10 while the electrode 14 is deployed at the ablation site.
  • the elongated housing 12 includes a fluid port with a luer fitting 26 for introducing a fluid such as, for example, air or water for inflating the balloon 24.
  • the fluid enters the balloon 24 through an inflation sleeve further shown in Fig. 2 to inflate the balloon 24.
  • Another advantage provided by the balloon 24 is that the balloon 24 can block the blood vessels on the urethral wall and slow down heat conduction provided by the blood vessels.
  • the balloon 24 is compliant enough to fit inside the urethra.
  • the balloon is constructed of latex or silicone.
  • the diameter of the inflated balloon in one embodiment, can be about 30 French.
  • the elongated housing 12 can include a basket 25 to stabilize the device 10 position during deployment of the electrode 14.
  • the basket 25 can comprise a wire mesh attached to an outer surface of the housing 12 surrounding the electrode 14, the imaging device 16 and the deflection system 18.
  • the housing 12 can further be surrounded by an elongated sheath or catheter 27 such that the wire mesh comprising the basket 25 remains retracted during placement of the device and expands into the basket 25 shown in Fig. IB to secure the position and placement of the electrode 14 after the electrode 14 has been exposed.
  • the proximal end of the elongated body 12 is in communication with a detachable eye piece coupler 28.
  • a detachable eye piece 30 is coupled to the eye piece coupler 28, and the physician observes insertion of the device 10 into the urethra and the electrode 14 deployment by looking into the eye piece 30.
  • the proximal end of the elongated body 12 is also in communication with a handle 32.
  • the handle 32 includes a slide member 34 for controlling deployment of the electrode 14.
  • the handle 32 can include two slide members (not shown), one for controlling the movement of the electrode 14 and the other for controlling the movement of the insulation sheath 40.
  • the slide member 34 can control the movement of the electrode 14 and the insulation sheath 40 secured to the electrode 14, to expose a predetermined amount of the electrode 14.
  • the handle 32 also includes an electrical connector 38 for coupling the proximal end of the electrode 14 to a power source (not shown).
  • the power source is an RF generator, however it is to be appreciated that other energy sources can be used, such as a microwave generator.
  • the handle 32 further includes a luer port 36 for injecting fluid and an irrigation port 31 for removing fluid.
  • the fluid can be a conductive fluid for improving ablation procedures.
  • Conductive fluids can include, for example, saline and lydocaine. The use of a conducting fluid prevents desiccation of tissue and prevents an increase in the impedance during the ablation procedure.
  • the electrode 14 can be deployable from a first position within the elongated housing 12 to a second position beyond the distal end of the elongated housing 12 as shown. In one embodiment, the electrode 14 deploys to a predetermined distance beyond the distal end of the elongated housing 12. It is to be appreciated that the distance the electrode 14 deploys can vary depending on the intended application. As shown, the electrode 14 also has a flexible portion 40a which deflects along with the deflectable segment 22 of the elongated housing 12. In one detailed embodiment, the deflectable segment 22 is located at the distal end of the elongated housing 12 and has a dimension of from about 2.5 cm to about 4.5 cm measured from the distal end of the housing 12.
  • the length of the deflectable segment 22 can fall outside of the above range, depending on the intended application of the device 10.
  • the dimension and position of the flexible portion 40a of the electrode 14 corresponds to that of the deflectable segment 22 of the elongated housing 12. Referring to Fig. 2, illustrated in phantom in a deflected position, is the deflectable segment 22 and electrode's flexible portion 40a at the distal tip of the elongated housing 12.
  • the electrode 14 can be a needle electrode surrounded by an insulation sheath 40.
  • the needle electrode 14 and the insulation sheath 40 are placed inside an electrode guide tube 41 disposed inside the elongated housing 12.
  • the insulation sheath 40 may be constructed from an insulating polymer material such as polyimide.
  • the needle electrode 14 can be coated with an insulator, such as Teflon or ceramic.
  • the needle electrode 14 and the insulation sheath 40 can be individually and slidably mounted inside the elongated housing 12, such that the insulation sheath 40 is capable of covering a proximal portion of the needle electrode 14 extending beyond the distal end of the elongated housing 12.
  • the physician can control the amount of electrode 14 that is exposed, and thus control the conductive region and consequently, the size of the ablation area. This feature is important in transurethral interstitial ablation of prostate tissue, because urethral walls can be protected from being ablated during the procedure.
  • the insulation sheath 40 can be fixed to a proximal portion of the needle electrode 14 and the needle electrode 14 can be slidably mounted inside the elongated housing 12.
  • the electrode 14 can comprise a hollow electrode 14 including a passageway 43.
  • the hollow electrode 14 has an inner diameter of approximately 0.011 inches and an outer diameter of approximately 0.02 inches.
  • the insulation sheath 40 has an outer diameter of approximately 0.03 inches and an inner diameter of about 0.025 inches.
  • the electrode guide tube 41 has an inner diameter of about 0.039 inches. It is to be appreciated that the above dimensions are illustrative, and are not intended to be restrictive, as other dimensions can be used depending in whole or in part, on the intended application of the device.
  • the imaging device 16 disposed inside the elongated housing 12 includes a illumination region 44 and a viewing region 42. Both regions 42 and 44 can include a plurality of optical fibers 46 extending from the proximal end to the distal end of the elongated housing 12.
  • the illumination region 44 includes a plurality of optical fibers 46 in communication with a light source (not shown) at a proximal end.
  • the plurality of optical fibers 46 surrounds the viewing region 42.
  • the viewing region 42 can include a fused bundle of optical fibers 48 in communication with an objective lens 50 at the distal end for focusing an image.
  • An example of the objective lens 50 is a gradient index (GRIN- self) objective lens having a diameter of about 0.039 inches.
  • the illumination region 44 and the viewing region 42 may be arranged in other ways and may comprise optical components other than or in addition to those described above.
  • other imaging devices can be used for viewing the area of tissue in question.
  • the imaging device 16 is surrounded by an outer sheath comprising a polymeric material 47.
  • the imaging device 16 is disposed inside the elongated housing 12 without an outer sheath.
  • the imaging device 16 has a viewing angle 13 of about 70 degrees, as shown in Figs. 1 and 2. It is to be appreciated that the viewing angle 13 can be greater or less than 70 degrees depending in whole or in part, on the intended application of the device.
  • the deflection system 18 controllably deflects the deflectable segment 22 by an angle of up to 180 degrees in one direction and 180 degrees in the opposite direction with respect to the longitudinal axis of the elongated housing 12.
  • the deflection system 18 includes a flexible wire 54 extending from the proximal end to the distal end of the elongated housing 12 and a flat spring 56 in communication with the flexible wire 54 disposed at the distal end of the elongated housing 12.
  • the proximal end of the flexible wire 54 is in communication with a steering mechanism 52, shown in Fig. 1 A as mounted on the handle 32.
  • the steering mechanism 52 can pull the flexible wire 54 and cause the flat spring 56 to gradually deflect toward a direction to which the wire 54 is pulled. Details of the steering mechanism are described in U.S. Patent No. 5,273,535, which is incorporated herein by reference.
  • the deflection system 18 has an outer diameter of approximately 0.02 inches. It is to be appreciated that the diameter of the deflection system 18 can vary depending in whole or in part, on the intended application of the device.
  • the deflectable interstitial ablation device 10 further includes a driver 75 located in the handle 32 and coupled to the electrode 14 for kinetically deploying the electrode 14.
  • the electrode 14 can be a needle electrode having a sharpened tip.
  • the driver 75 exerts a force sufficient to deploy the electrode 14 from inside the elongated housing 12 to a position beyond the distal end of the elongated housing 12 in a single motion.
  • the force of deployment can range from about 1/4 lb to about 1 lb. A force in this range is sufficient to cause the electrode 14 to penetrate the urethral wall in a single motion.
  • Kinetic deployment which permits sudden and high speed deployment facilitates electrode penetration through the urethral wall, reducing patient discomfort and improving the accuracy and control of needle deployment.
  • kinetic deployment is achieved by employing a driver 75 comprising a spring- operated actuating mechanism.
  • the handle 32' includes slots 60 and 61 having levers 62 and 63, respectively, and a recess 64 having an actuator 66 on an outer surface of the handle 32'.
  • slide members 68 and 69 contained within the housing 32' are slide members 68 and 69.
  • the slide member 68 is connected to the insulation sheath 40, and the slide member 69 is connected to the electrode 14.
  • the lever 62 is connected to the slide member 68 and the lever 63 is connected to the slide member 69.
  • Reduced proximal sections 70 and 71 of the slide members 68 and 69 are received within spring coils 72 and 73, respectively.
  • the actuator 66 is operatively coupled to the slide member 69. In this embodiment, the electrode 14 and the insulation sheath 40 are sequentially propelled.
  • the device 10 prior to inserting the elongated sheath 12 inside the body, the device 10 is loaded by pulling the levers 62 and 63 in the proximal direction. As the lever 62 is pulled in the proximal direction, a projection 74 on the slide member 68 slides over and catches the distal surface of a catch or stop 76, and as the lever 63 is pulled, a projection 78 of the slide member 69 catches on a stop 80.
  • the needle electrode 14 and the insulation sheath 40 are deployed by pulling the actuator 66 proximally and then down. Referring to Fig.
  • the insulation sheath 40 propels beyond the distal end of the elongated housing 12 covering a pre-determined portion of the needle electrode 14.
  • the needle electrode 14 is propelled with a spring operated actuating mechanism, while the insulation sheath 40 is glided over the needle electrode 14. Once the needle electrode 14 has penetrated the urethral wall, gliding the insulation sheath 40 over the needle electrode 14 can be easily achieved without causing much discomfort to the patient.
  • depth of needle electrode 14 penetration is controllable, such that different locations within the prostate can be reached by the needle electrode 14.
  • the steering mechanism 52 described above can provide depth control. For deeper penetration, the electrode 14 tip can be deflected closer to 90 degrees, whereas for shallow penetration, the needle electrode 14 tip can be deflected by a smaller angle, such as. for example, 45 degrees.
  • depth of electrode 14 penetration is adjustable using a slide member on the handle 32, which controls movement of the needle electrode 14 relative to the elongated housing 12. In this embodiment, maximum penetration depth may be fixed by placing a stop inside the handle 32.
  • the electrode 14 can be kinetically deployed using a foot pedal.
  • the interstitial ablation system 89 includes a foot pedal 90, a control and power source module 92, an actuator, a light source 98, the deflectable interstitial ablation device 10, and a return electrode 91.
  • the light source 98 supplies light to the illumination region 44 of the imaging device 16, described above in Fig.'s 3 and 4.
  • the return electrode 91 is placed on the patient 110.
  • the foot pedal 90 is coupled to the control and power source module via a cable 94, and the control and power source module 92 is coupled to the actuator 96 via a cable 99.
  • a physician performing an ablation procedure properly places the ablation device 10 inside the patient's body, then steps on the foot pedal 90 to deploy electrode 14, leaving his or her hands free to perform other functions. Additional features such as application of fluid to a treatment site, application of energy to the electrode 14, and the triggering temperature measurement means at the distal end of the electrode 14 may also be activated using the pedal 90.
  • the interstitial ablation system 89 can include several foot pedal actuators for performing each of these functions. In .another embodiment, the interstitial ablation system 89 can include only one foot pedal used to activate multiple functions.
  • the control module 92 may be programmed to control the order of the performance of each function.
  • the actuator 96 which controls electrode deployment.
  • the actuator 96 can comprise a solenoid 100.
  • the solenoid 100 is coupled to the control and power module 92 at a proximal end via a cable 105, and coupled to the proximal end of the electrode 14 at a distal end via a luer fitting 104.
  • the actuator 100 is held within an actuator housing 102, which is coupled to the luer fitting 104.
  • the luer fitting 104 is sized and shaped to attach to the proximal end of the elongated housing 12 of the deflectable interstitial ablation device 10.
  • the luer fitting 104 may be sized and shaped to attach to a working channel of a flexible cystoscope for those applications in which cystoscopes are used.
  • current from the power source 92 is applied to the solenoid 100, which forces the electrode 14 to deploy beyond the distal end of the elongated housing 12.
  • actuators such as a rotary motors and linear motors, as well as other electromechanical devices can be used to perform these functions as well. It is to be appreciated that, a number of foot pedals and actuators for activating a mechanical event can be interchangeably used to actuate the electrode 14, or provide fluid delivery and temperature sensing at the treatment site.
  • the deflectable interstitial ablation device 10 of the invention provides many other features typically performed in ablation procedures.
  • the deflectable interstitial ablation device 10 can be coupled to a fluid source to permits delivery of fluid to the housing 12 or to an internal bore (not shown) formed in the electrode 14 such that fluid is dispensed near the treatment site for providing cooling or for enhancing ablation.
  • the fluid can be for example, an electrolytic fluid which increases the ablation area, or a fluid that provides therapeutic effects.
  • the elongated housing 12 can include a separate passageway suitable for fluid delivery. In both embodiments, fluid can be introduced through the luer port 36 (Fig. 1 A).
  • the solenoid can be coupled to a syringe for introducing fluid inside the elongated housing 12.
  • Application of current to the solenoid in this case would cause the syringe to discharge the fluid held within a fluid source into the elongated housing 12.
  • the deflectable interstitial ablation device 10 can include a temperature sensing system for measuring tissue temperature during the ablation procedure.
  • the temperature sensing system can include a thermocouple disposed near the distal end of the electrode 14, such as by being fixed at the distal end of the insulation sheath 40 that is fixed to the electrode 14.
  • the device 10 can include an impedance monitoring system in communication with the proximal end of the electrode 14. The impedance monitoring system can measure impedance near the distal end of the electrode 14.
  • the interstitial ablation device can further employ a feedback system that uses the temperature and or the impedance data to control the delivery of RF energy to the electrode 14.
  • the control module 92 can, for example, include means for automatically adjusting the magnitude and duration of the ablation energy delivered to the electrode in response to one or both of these parameters.
  • the interstitial ablation system can also include a safety feature which cuts off the delivery of energy when the temperature or the impedance value exceeds a threshold value.
  • the deflectable interstitial ablation device 10 of the present invention does not require the use of an endoscope and therefore can be entirely disposable.
  • the disposable device can attach to reusable eye piece and other equipment such as a light source, and a control and power source module.
  • the imaging system 16 can be removed from the device 10 for subsequent reuse.
  • the present invention features an improved transurethral interstitial ablation apparatus and method for performing transurethral ablation. While the invention has been particularly shown and described with reference to specific preferred embodiments, it should be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

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  • Escalators And Moving Walkways (AREA)

Abstract

Un dispositif (10) d'ablation interstitiel orientable comprend un boîtier (12) allongé, une électrode (14) montée dans le boîtier (12) allongé, un excitateur (75) couplé à l'électrode (14), un dispositif d'imagerie incorporé dans le boîtier (12) allongé et un système (18) de déviation placé dans le boîtier (12) allongé. Le boîtier (12) allongé comprend une extrémité proximale, une extrémité distale et un segment (22) orientable. L'électrode (14) peut se déployer entre une première position à l'intérieur du boîtier (12) allongé et une deuxième position dans laquelle elle se trouve à une distance prédéterminée au-delà de l'extrémité distale du boîtier allongé. L'électrode (14) présente également une partie souple pouvant s'infléchir avec le segment (22) orientable du boîtier (12) allongé et cette électrode peut être déployée par l'excitateur (75) avec une force suffisante pour que s'effectue en un seul mouvement la pénétration de la paroi urétrale. Le dispositif d'imagerie comprend en outre une partie souple qui peut s'infléchir avec la partie (22) orientable du boîtier (12) allongé. Le système (18) de déviation comprend une extrémité proximale qui communique avec un mécanisme (52) de commande pour dévier de manière contrôlée le segment (22) orientable du boîtier (12) allongé de n'importe quel angle. La déflexion du segment (22) orientable permet d'infléchir l'électrode (14) et le dispositif d'imagerie, ceci facilitant la bonne mise en place de l'électrode (14).
PCT/US1998/020099 1997-09-30 1998-09-25 Dispositif d'ablation interstitiel orientable WO1999016370A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE69829300T DE69829300T2 (de) 1997-09-30 1998-09-25 Biegungsfähiges interstitielles ablationsgerät
IL13535398A IL135353A (en) 1997-09-30 1998-09-25 Deflectable interstitial tissue ablation device
EP98948543A EP1018959B1 (fr) 1997-09-30 1998-09-25 Dispositif d'ablation interstitiel orientable
AU95092/98A AU738287B2 (en) 1997-09-30 1998-09-25 Deflectable interstitial ablation device
CA002304739A CA2304739C (fr) 1997-09-30 1998-09-25 Dispositif d'ablation interstitiel orientable
JP2000513516A JP2001517528A (ja) 1997-09-30 1998-09-25 偏向可能間質切除装置

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/940,519 US6238389B1 (en) 1997-09-30 1997-09-30 Deflectable interstitial ablation device
US08/940,519 1997-09-30

Publications (1)

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WO1999016370A1 true WO1999016370A1 (fr) 1999-04-08

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PCT/US1998/020099 WO1999016370A1 (fr) 1997-09-30 1998-09-25 Dispositif d'ablation interstitiel orientable

Country Status (8)

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US (4) US6238389B1 (fr)
EP (1) EP1018959B1 (fr)
JP (2) JP2001517528A (fr)
AU (1) AU738287B2 (fr)
CA (1) CA2304739C (fr)
DE (1) DE69829300T2 (fr)
IL (1) IL135353A (fr)
WO (1) WO1999016370A1 (fr)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8364237B2 (en) 2005-03-28 2013-01-29 Vessix Vascular, Inc. Tuned RF energy for selective treatment of atheroma and other target tissues and/or structures
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US8401667B2 (en) 2008-11-17 2013-03-19 Vessix Vascular, Inc. Selective accumulation of energy with or without knowledge of tissue topography
US8496653B2 (en) 2007-04-23 2013-07-30 Boston Scientific Scimed, Inc. Thrombus removal
US8551096B2 (en) 2009-05-13 2013-10-08 Boston Scientific Scimed, Inc. Directional delivery of energy and bioactives
US8920414B2 (en) 2004-09-10 2014-12-30 Vessix Vascular, Inc. Tuned RF energy and electrical tissue characterization for selective treatment of target tissues
US9125667B2 (en) 2004-09-10 2015-09-08 Vessix Vascular, Inc. System for inducing desirable temperature effects on body tissue
US9125666B2 (en) 2003-09-12 2015-09-08 Vessix Vascular, Inc. Selectable eccentric remodeling and/or ablation of atherosclerotic material
US9277955B2 (en) 2010-04-09 2016-03-08 Vessix Vascular, Inc. Power generating and control apparatus for the treatment of tissue
US9579149B2 (en) 2014-03-13 2017-02-28 Medtronic Ardian Luxembourg S.A.R.L. Low profile catheter assemblies and associated systems and methods
US9757193B2 (en) 2002-04-08 2017-09-12 Medtronic Ardian Luxembourg S.A.R.L. Balloon catheter apparatus for renal neuromodulation
US9827040B2 (en) 2002-04-08 2017-11-28 Medtronic Adrian Luxembourg S.a.r.l. Methods and apparatus for intravascularly-induced neuromodulation
US9919144B2 (en) 2011-04-08 2018-03-20 Medtronic Adrian Luxembourg S.a.r.l. Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery
US9974607B2 (en) 2006-10-18 2018-05-22 Vessix Vascular, Inc. Inducing desirable temperature effects on body tissue
US10350004B2 (en) 2004-12-09 2019-07-16 Twelve, Inc. Intravascular treatment catheters
US10543037B2 (en) 2013-03-15 2020-01-28 Medtronic Ardian Luxembourg S.A.R.L. Controlled neuromodulation systems and methods of use
US10709490B2 (en) 2014-05-07 2020-07-14 Medtronic Ardian Luxembourg S.A.R.L. Catheter assemblies comprising a direct heating element for renal neuromodulation and associated systems and methods

Families Citing this family (276)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6120520A (en) 1997-05-27 2000-09-19 Angiotrax, Inc. Apparatus and methods for stimulating revascularization and/or tissue growth
US6051008A (en) 1996-12-02 2000-04-18 Angiotrax, Inc. Apparatus having stabilization members for percutaneously performing surgery and methods of use
US6102926A (en) * 1996-12-02 2000-08-15 Angiotrax, Inc. Apparatus for percutaneously performing myocardial revascularization having means for sensing tissue parameters and methods of use
US8079982B1 (en) 1998-06-04 2011-12-20 Biosense Webster, Inc. Injection catheter with needle electrode
US6575931B1 (en) * 1998-06-04 2003-06-10 Biosense Webster, Inc. Catheter with injection needle
US7416547B2 (en) 1999-03-29 2008-08-26 Biosense Webster Inc. Injection catheter
US6540725B1 (en) * 1998-06-04 2003-04-01 Biosense Webster, Inc. Injection catheter with controllably extendable injection needle
US6905476B2 (en) * 1998-06-04 2005-06-14 Biosense Webster, Inc. Catheter with injection needle
US6623473B1 (en) * 1998-06-04 2003-09-23 Biosense Webster, Inc. Injection catheter with multi-directional delivery injection needle
US6022362A (en) * 1998-09-03 2000-02-08 Rubicor Medical, Inc. Excisional biopsy devices and methods
US6440147B1 (en) 1998-09-03 2002-08-27 Rubicor Medical, Inc. Excisional biopsy devices and methods
US6936014B2 (en) * 2002-10-16 2005-08-30 Rubicor Medical, Inc. Devices and methods for performing procedures on a breast
US7517348B2 (en) * 1998-09-03 2009-04-14 Rubicor Medical, Inc. Devices and methods for performing procedures on a breast
US7329253B2 (en) * 2003-12-09 2008-02-12 Rubicor Medical, Inc. Suction sleeve and interventional devices having such a suction sleeve
US6852120B1 (en) * 1999-08-10 2005-02-08 Biosense Webster, Inc Irrigation probe for ablation during open heart surgery
US6394956B1 (en) * 2000-02-29 2002-05-28 Scimed Life Systems, Inc. RF ablation and ultrasound catheter for crossing chronic total occlusions
ATE290827T1 (de) * 2000-06-13 2005-04-15 Atrionix Inc Chirurgische ablationssonde zum formen einer ringförmigen läsion
US7588554B2 (en) * 2000-06-26 2009-09-15 Boston Scientific Scimed, Inc. Method and apparatus for treating ischemic tissue
WO2002005866A2 (fr) * 2000-07-13 2002-01-24 Bioheart, Inc. Systeme de deploiement destine a un materiau cellulaire du myocarde
US6726700B1 (en) * 2000-08-21 2004-04-27 Counter Clockwise, Inc. Manipulatable delivery catheter for occlusive devices
US6482221B1 (en) * 2000-08-21 2002-11-19 Counter Clockwise, Inc. Manipulatable delivery catheter for occlusive devices (II)
US6416523B1 (en) * 2000-10-03 2002-07-09 Scimed Life Systems, Inc. Method and apparatus for creating channels through vascular total occlusions
US6676657B2 (en) 2000-12-07 2004-01-13 The United States Of America As Represented By The Department Of Health And Human Services Endoluminal radiofrequency cauterization system
US20020072739A1 (en) 2000-12-07 2002-06-13 Roberta Lee Methods and devices for radiofrequency electrosurgery
US20020183739A1 (en) 2001-03-30 2002-12-05 Long Gary L. Endoscopic ablation system with sealed sheath
US20020177847A1 (en) * 2001-03-30 2002-11-28 Long Gary L. Endoscopic ablation system with flexible coupling
US7097644B2 (en) 2001-03-30 2006-08-29 Ethicon Endo-Surgery, Inc. Medical device with improved wall construction
EP1420702B1 (fr) * 2001-08-31 2005-04-20 Boston Scientific Limited Dispositif d'occlusion percutanee de type pringle
US12121289B2 (en) * 2008-05-09 2024-10-22 Atricure, Inc. Conduction block systems and methods
US7749157B2 (en) * 2001-12-04 2010-07-06 Estech, Inc. (Endoscopic Technologies, Inc.) Methods and devices for minimally invasive cardiac surgery for atrial fibrillation
US7399300B2 (en) * 2001-12-04 2008-07-15 Endoscopic Technologies, Inc. Cardiac ablation devices and methods
US7226448B2 (en) * 2001-12-04 2007-06-05 Estech, Inc. (Endoscopic Technologies, Inc.) Cardiac treatment devices and methods
US7591818B2 (en) 2001-12-04 2009-09-22 Endoscopic Technologies, Inc. Cardiac ablation devices and methods
US7137981B2 (en) 2002-03-25 2006-11-21 Ethicon Endo-Surgery, Inc. Endoscopic ablation system with a distally mounted image sensor
US6974455B2 (en) * 2002-04-10 2005-12-13 Boston Scientific Scimed, Inc. Auto advancing radio frequency array
US6875179B2 (en) 2002-06-17 2005-04-05 Board Of Trustees Of The University Of Arkansas Ultrasonic guided catheter deployment system
US20040006355A1 (en) * 2002-07-03 2004-01-08 Rubicor Medical, Inc. Methods and devices for cutting and collecting soft tissue
US7044956B2 (en) * 2002-07-03 2006-05-16 Rubicor Medical, Inc. Methods and devices for cutting and collecting soft tissue
US7029451B2 (en) * 2002-11-06 2006-04-18 Rubicor Medical, Inc. Excisional devices having selective cutting and atraumatic configurations and methods of using same
US7039450B2 (en) * 2002-11-15 2006-05-02 Biosense Webster, Inc. Telescoping catheter
US7682305B2 (en) * 2002-12-06 2010-03-23 Endoscopic Technologies, Inc. Methods and devices for cardiac surgery
US8021359B2 (en) 2003-02-13 2011-09-20 Coaptus Medical Corporation Transseptal closure of a patent foramen ovale and other cardiac defects
US7257450B2 (en) 2003-02-13 2007-08-14 Coaptus Medical Corporation Systems and methods for securing cardiovascular tissue
US20040199179A1 (en) * 2003-04-02 2004-10-07 Elliott Christopher J. Steerable ablation probe
FR2854052A1 (fr) * 2003-04-25 2004-10-29 Medtronic Inc Distribution de fluide au cours du traitement transuretral de la prostate
US20040215181A1 (en) * 2003-04-25 2004-10-28 Medtronic, Inc. Delivery of fluid during transurethral prostate treatment
US7615003B2 (en) * 2005-05-13 2009-11-10 Ethicon Endo-Surgery, Inc. Track for medical devices
US7615005B2 (en) * 2003-05-16 2009-11-10 Ethicon Endo-Surgery, Inc. Medical apparatus for use with an endoscope
US7815565B2 (en) 2003-05-16 2010-10-19 Ethicon Endo-Surgery, Inc. Endcap for use with an endoscope
US7122011B2 (en) * 2003-06-18 2006-10-17 Rubicor Medical, Inc. Methods and devices for cutting and collecting soft tissue
US8308708B2 (en) * 2003-07-15 2012-11-13 Abbott Cardiovascular Systems Inc. Deployment system for myocardial cellular material
US7569052B2 (en) * 2003-09-12 2009-08-04 Boston Scientific Scimed, Inc. Ablation catheter with tissue protecting assembly
WO2005113051A2 (fr) 2004-05-14 2005-12-01 Ethicon Endo-Surgery, Inc. Instrument médical avec guide métallique médical
US7785269B2 (en) 2004-05-14 2010-08-31 Ethicon Endo-Surgery, Inc. Medical instrument having a guidewire and an add-to catheter
US7533439B2 (en) * 2004-06-25 2009-05-19 Healthy Gain Investments Limited Handle assembly for a cleaning apparatus
US7232438B2 (en) 2004-07-09 2007-06-19 Ethicon Endo-Surgery, Inc. Ablation device with clear probe
NL1026884C2 (nl) * 2004-08-19 2006-02-21 Univ Delft Tech Instrument omvattende een kabel of slang voorzien van een voortstuwingsorgaan.
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
JP2008514271A (ja) * 2004-09-27 2008-05-08 ビブラテック・アクチボラゲット 腫瘍の治療のための機構
US7473252B2 (en) 2004-10-07 2009-01-06 Coaptus Medical Corporation Systems and methods for shrinking and/or securing cardiovascular tissue
US7753907B2 (en) * 2004-10-29 2010-07-13 Boston Scientific Scimed, Inc. Medical device systems and methods
US7918795B2 (en) 2005-02-02 2011-04-05 Gynesonics, Inc. Method and device for uterine fibroid treatment
US20060258903A1 (en) * 2005-05-13 2006-11-16 David Stefanchik Method of inserting a feeding tube
US7905830B2 (en) * 2005-05-13 2011-03-15 Ethicon Endo-Surgery, Inc. Sheath for use with an endoscope
US20060258904A1 (en) * 2005-05-13 2006-11-16 David Stefanchik Feeding tube and track
US7857754B2 (en) 2005-05-13 2010-12-28 Ethicon Endo-Surgery, Inc. Apparatus useful for positioning a device on an endoscope
US7648457B2 (en) * 2005-05-13 2010-01-19 Ethicon Endo-Surgery, Inc. Method of positioning a device on an endoscope
US20060264832A1 (en) * 2005-05-20 2006-11-23 Medtronic, Inc. User interface for a portable therapy delivery device
CA2611477C (fr) * 2005-06-10 2012-01-17 Wilson-Cook Medical, Inc. Catheter de cauterisation
US20070060988A1 (en) 2005-07-18 2007-03-15 Grenon Stephen M Melting meibomian gland obstructions
US7981146B2 (en) * 2006-05-15 2011-07-19 Tearscience Inc. Inner eyelid treatment for treating meibomian gland dysfunction
US7981095B2 (en) * 2005-07-18 2011-07-19 Tearscience, Inc. Methods for treating meibomian gland dysfunction employing fluid jet
US7981145B2 (en) 2005-07-18 2011-07-19 Tearscience Inc. Treatment of meibomian glands
US20070016256A1 (en) * 2005-07-18 2007-01-18 Korb Donald R Method and apparatus for treating gland dysfunction
US8950405B2 (en) * 2006-05-15 2015-02-10 Tearscience, Inc. Treatment of obstructive disorders of the eye or eyelid
US20080114423A1 (en) 2006-05-15 2008-05-15 Grenon Stephen M Apparatus for inner eyelid treatment of meibomian gland dysfunction
WO2013003594A2 (fr) 2011-06-28 2013-01-03 Tearscience, Inc. Procédés et systèmes de traitement de dysfonctionnement de la glande de meibomius à l'aide d'énergie radiofréquence
US20090043365A1 (en) 2005-07-18 2009-02-12 Kolis Scientific, Inc. Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma
US8550743B2 (en) * 2005-09-30 2013-10-08 Medtronic, Inc. Sliding lock device
US20070100324A1 (en) * 2005-10-17 2007-05-03 Coaptus Medical Corporation Systems and methods for applying vacuum to a patient, including via a disposable liquid collection unit
US20080249525A1 (en) * 2005-11-08 2008-10-09 U & I Corporation Radio Frequency Ablation Electrode for Selected Tissue Removal
US20070142699A1 (en) * 2005-12-16 2007-06-21 Acoustx Corporation Methods and implantable apparatuses for treating an esophageal disorder such as gastroesophageal reflux disease
US20070142884A1 (en) * 2005-12-16 2007-06-21 Acoustx Corporation Methods and apparatuses for treating an esophageal disorder such as gastroesophageal reflux disease
US9357977B2 (en) 2006-01-12 2016-06-07 Gynesonics, Inc. Interventional deployment and imaging system
US10058342B2 (en) 2006-01-12 2018-08-28 Gynesonics, Inc. Devices and methods for treatment of tissue
US11259825B2 (en) 2006-01-12 2022-03-01 Gynesonics, Inc. Devices and methods for treatment of tissue
US7815571B2 (en) 2006-04-20 2010-10-19 Gynesonics, Inc. Rigid delivery systems having inclined ultrasound and needle
US7874986B2 (en) 2006-04-20 2011-01-25 Gynesonics, Inc. Methods and devices for visualization and ablation of tissue
US20070179491A1 (en) * 2006-01-31 2007-08-02 Medtronic, Inc. Sensing needle for ablation therapy
US20070179496A1 (en) * 2006-01-31 2007-08-02 Medtronic, Inc. Flexible catheter for ablation therapy
CA2642568C (fr) * 2006-02-22 2015-11-24 Custom Medical Applications, Inc. Instruments d'ablation et methodes en rapport
US8206300B2 (en) 2008-08-26 2012-06-26 Gynesonics, Inc. Ablation device with articulated imaging transducer
US10595819B2 (en) 2006-04-20 2020-03-24 Gynesonics, Inc. Ablation device with articulated imaging transducer
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
US8007524B2 (en) * 2006-05-15 2011-08-30 Tearscience, Inc. Heat treatment and heat loss reduction for treating meibomian gland dysfunction
US7976573B2 (en) * 2006-05-15 2011-07-12 Tearscience, Inc. Inner eyelid heat and pressure treatment for treating meibomian gland dysfunction
US9314369B2 (en) * 2006-05-15 2016-04-19 Tearscience, Inc. System for inner eyelid treatment of meibomian gland dysfunction
US8128674B2 (en) 2006-05-15 2012-03-06 Tearscience, Inc. System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction
US8137390B2 (en) * 2006-05-15 2012-03-20 Tearscience, Inc. System for providing heat treatment and heat loss reduction for treating meibomian gland dysfunction
US7981147B2 (en) * 2006-05-15 2011-07-19 Tearscience, Inc. Outer eyelid heat and pressure treatment for treating meibomian gland dysfunction
US8128673B2 (en) * 2006-05-15 2012-03-06 Tearscience, Inc. System for inner eyelid heat and pressure treatment for treating meibomian gland dysfunction
US20080045863A1 (en) * 2006-08-17 2008-02-21 Ethicon Endo-Surgery, Inc. Guidewire structure including a medical guidewire
US8002714B2 (en) * 2006-08-17 2011-08-23 Ethicon Endo-Surgery, Inc. Guidewire structure including a medical guidewire and method for using a medical instrument
WO2008027069A1 (fr) * 2006-08-21 2008-03-06 Tearscience, Inc. Procédé et appareil de traitement du dysfonctionnement de la glande de meibomius au moyen d'un fluide
US20080097331A1 (en) * 2006-09-05 2008-04-24 Ethicon Endo-Surgery, Inc. Guidewire structure including a medical guidewire and method for using
US20080064920A1 (en) * 2006-09-08 2008-03-13 Ethicon Endo-Surgery, Inc. Medical drive system for providing motion to at least a portion of a medical apparatus
US8048069B2 (en) 2006-09-29 2011-11-01 Medtronic, Inc. User interface for ablation therapy
US7785289B2 (en) * 2006-10-17 2010-08-31 Boston Scientific Scimed, Inc. Catheter with flexible, non-kinking elongate member
WO2008063621A2 (fr) * 2006-11-21 2008-05-29 Bridgepoint Medical, Inc. Dispositifs endovasculaires et méthodes d'exploitation de l'espace intramural
US9561053B2 (en) 2007-04-25 2017-02-07 Medtronic, Inc. Implant tool to facilitate medical device implantation
US9399130B2 (en) 2007-04-25 2016-07-26 Medtronic, Inc. Cannula configured to deliver test stimulation
US8945114B2 (en) * 2007-04-26 2015-02-03 Medtronic, Inc. Fluid sensor for ablation therapy
US8814856B2 (en) * 2007-04-30 2014-08-26 Medtronic, Inc. Extension and retraction mechanism for a hand-held device
US20080275440A1 (en) * 2007-05-03 2008-11-06 Medtronic, Inc. Post-ablation verification of lesion size
US8216221B2 (en) * 2007-05-21 2012-07-10 Estech, Inc. Cardiac ablation systems and methods
US9186207B2 (en) * 2007-06-14 2015-11-17 Medtronic, Inc. Distal viewing window of a medical catheter
US20090093726A1 (en) * 2007-10-04 2009-04-09 Olympus Medical Systems Corp. Cardiovascular ultrasound probe and ultrasound image system
US8192353B2 (en) * 2007-10-05 2012-06-05 Tyco Healthcare Group Lp Visual obturator
US8308763B2 (en) 2007-10-05 2012-11-13 Coaptus Medical Corporation Systems and methods for transeptal cardiac procedures, including separable guidewires
US8088072B2 (en) 2007-10-12 2012-01-03 Gynesonics, Inc. Methods and systems for controlled deployment of needles in tissue
US10136909B2 (en) * 2007-12-20 2018-11-27 Atricure, Inc. Magnetic introducer systems and methods
USD613408S1 (en) 2008-02-06 2010-04-06 Tearscience, Inc. Eye treatment head gear
USD617443S1 (en) 2008-02-06 2010-06-08 Tearscience, Inc. Eye treatment goggles
US9782566B1 (en) * 2008-05-01 2017-10-10 Annex Medical, Inc. Bend limiting access sheath
US10695126B2 (en) 2008-10-06 2020-06-30 Santa Anna Tech Llc Catheter with a double balloon structure to generate and apply a heated ablative zone to tissue
US9561068B2 (en) 2008-10-06 2017-02-07 Virender K. Sharma Method and apparatus for tissue ablation
CN102238920B (zh) * 2008-10-06 2015-03-25 维兰德.K.沙马 用于组织消融的方法和装置
US10064697B2 (en) 2008-10-06 2018-09-04 Santa Anna Tech Llc Vapor based ablation system for treating various indications
US9561066B2 (en) 2008-10-06 2017-02-07 Virender K. Sharma Method and apparatus for tissue ablation
US9079028B2 (en) 2008-10-09 2015-07-14 Virender K. Sharma Method and apparatus for stimulating the vascular system
US10603489B2 (en) 2008-10-09 2020-03-31 Virender K. Sharma Methods and apparatuses for stimulating blood vessels in order to control, treat, and/or prevent a hemorrhage
SMT201800248T1 (it) 2008-11-06 2018-07-17 Nxthera Inc Sistemi e metodi per il trattamento di tessuto prostatico
JP2012508068A (ja) 2008-11-06 2012-04-05 エヌエックスセラ インコーポレイテッド 前立腺組織の治療のためのシステム及び方法
CN102271595A (zh) 2008-11-06 2011-12-07 恩克斯特拉公司 用于bph的治疗的系统和方法
US8808345B2 (en) * 2008-12-31 2014-08-19 Medtronic Ardian Luxembourg S.A.R.L. Handle assemblies for intravascular treatment devices and associated systems and methods
US8388611B2 (en) * 2009-01-14 2013-03-05 Nxthera, Inc. Systems and methods for treatment of prostatic tissue
US20100179416A1 (en) * 2009-01-14 2010-07-15 Michael Hoey Medical Systems and Methods
WO2010093603A1 (fr) 2009-02-11 2010-08-19 Boston Scientific Scimed, Inc. Dispositifs de cathéters d'ablation isolés et procédés d'utilisation
US8262574B2 (en) 2009-02-27 2012-09-11 Gynesonics, Inc. Needle and tine deployment mechanism
US8292879B2 (en) * 2009-04-17 2012-10-23 Domain Surgical, Inc. Method of treatment with adjustable ferromagnetic coated conductor thermal surgical tool
US9833277B2 (en) 2009-04-27 2017-12-05 Nxthera, Inc. Systems and methods for prostate treatment
US8430875B2 (en) 2009-05-19 2013-04-30 Estech, Inc. (Endoscopic Technologies, Inc.) Magnetic navigation systems and methods
US8954161B2 (en) 2012-06-01 2015-02-10 Advanced Cardiac Therapeutics, Inc. Systems and methods for radiometrically measuring temperature and detecting tissue contact prior to and during tissue ablation
US9226791B2 (en) 2012-03-12 2016-01-05 Advanced Cardiac Therapeutics, Inc. Systems for temperature-controlled ablation using radiometric feedback
US8926605B2 (en) 2012-02-07 2015-01-06 Advanced Cardiac Therapeutics, Inc. Systems and methods for radiometrically measuring temperature during tissue ablation
US9277961B2 (en) 2009-06-12 2016-03-08 Advanced Cardiac Therapeutics, Inc. Systems and methods of radiometrically determining a hot-spot temperature of tissue being treated
US20100331838A1 (en) * 2009-06-25 2010-12-30 Estech, Inc. (Endoscopic Technologies, Inc.) Transmurality clamp systems and methods
JP5490235B2 (ja) 2009-06-30 2014-05-14 ボストン サイエンティフィック サイムド，インコーポレイテッド マップ及び切除のための開放洗浄ハイブリッドカテーテル
US9572624B2 (en) 2009-08-05 2017-02-21 Atricure, Inc. Bipolar belt systems and methods
US10123821B2 (en) 2009-09-10 2018-11-13 Atricure, Inc. Scope and magnetic introducer systems and methods
USD638128S1 (en) 2009-10-06 2011-05-17 Tearscience, Inc. Ocular device design
AU2011230568B2 (en) * 2010-03-25 2016-02-18 Boston Scientific Scimed, Inc. Systems and methods for prostate treatment
US9192790B2 (en) 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
US8974451B2 (en) 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
US9220558B2 (en) 2010-10-27 2015-12-29 Boston Scientific Scimed, Inc. RF renal denervation catheter with multiple independent electrodes
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
US9060761B2 (en) 2010-11-18 2015-06-23 Boston Scientific Scime, Inc. Catheter-focused magnetic field induced renal nerve ablation
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
US9089340B2 (en) 2010-12-30 2015-07-28 Boston Scientific Scimed, Inc. Ultrasound guided tissue ablation
WO2012100095A1 (fr) 2011-01-19 2012-07-26 Boston Scientific Scimed, Inc. Cathéter à grande électrode compatible avec un guide pour ablation de nerf rénal à lésion artérielle réduite
EP2701623B1 (fr) 2011-04-25 2016-08-17 Medtronic Ardian Luxembourg S.à.r.l. Appareil relatifs au déploiement restreint de ballonnets cryogéniques pour une ablation cryogénique limitée de parois de vaisseaux
JP2014516723A (ja) 2011-06-01 2014-07-17 ボストン サイエンティフィック サイムド，インコーポレイテッド 超音波映像性能を備えた切除プローブ
CN103619566B (zh) 2011-06-22 2017-04-05 帝斯曼知识产权资产管理有限公司 用于箔从材料层分离的设备和方法
CN103813745B (zh) 2011-07-20 2016-06-29 波士顿科学西美德公司 用以可视化、对准和消融神经的经皮装置及方法
AU2012287189B2 (en) 2011-07-22 2016-10-06 Boston Scientific Scimed, Inc. Nerve modulation system with a nerve modulation element positionable in a helical guide
WO2013036900A1 (fr) 2011-09-10 2013-03-14 Cook Medical Technologies Llc Poignées de commande pour dispositifs médicaux
CN103917200B (zh) 2011-09-13 2016-03-30 恩克斯特拉公司 用于前列腺治疗的系统和方法
AU2012308557B2 (en) 2011-09-14 2017-03-09 Boston Scientific Scimed, Inc. Ablation device with multiple ablation modes
US9603659B2 (en) 2011-09-14 2017-03-28 Boston Scientific Scimed Inc. Ablation device with ionically conductive balloon
EP2757933B1 (fr) 2011-09-22 2019-02-06 The George Washington University Systèmes visualisation de tissu enlevé
AU2012312066C1 (en) 2011-09-22 2016-06-16 460Medical, Inc. Systems and methods for visualizing ablated tissue
US9186210B2 (en) 2011-10-10 2015-11-17 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
US9420955B2 (en) 2011-10-11 2016-08-23 Boston Scientific Scimed, Inc. Intravascular temperature monitoring system and method
WO2013055815A1 (fr) 2011-10-11 2013-04-18 Boston Scientific Scimed, Inc. Dispositif d'électrode hors paroi pour une modulation nerveuse
US9364284B2 (en) 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
US9079000B2 (en) 2011-10-18 2015-07-14 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
US9162046B2 (en) 2011-10-18 2015-10-20 Boston Scientific Scimed, Inc. Deflectable medical devices
EP2775948B1 (fr) 2011-11-08 2018-04-04 Boston Scientific Scimed, Inc. Ablation ostiale du nerf rénal
US9119600B2 (en) 2011-11-15 2015-09-01 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
US9265969B2 (en) 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
US9037259B2 (en) 2011-12-23 2015-05-19 Vessix Vascular, Inc. Methods and apparatuses for remodeling tissue of or adjacent to a body passage
WO2013102072A1 (fr) 2011-12-28 2013-07-04 Boston Scientific Scimed, Inc. Sonde d'ablation ayant une capacité d'imagerie ultrasonore
CN104135958B (zh) 2011-12-28 2017-05-03 波士顿科学西美德公司 用有聚合物消融元件的新消融导管调变神经的装置和方法
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
AU2013207994B2 (en) 2012-01-10 2015-05-07 Boston Scientific Scimed, Inc. Electrophysiology system
JP5830614B2 (ja) 2012-01-31 2015-12-09 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 超音波組織撮像のための流体に基づいた音響結合を有するアブレーションプローブ、および、アブレーションおよび超音波撮像システム
US9782583B2 (en) 2012-02-21 2017-10-10 Virender K. Sharma System and method for electrical stimulation of anorectal structures to treat urinary dysfunction
US8706234B2 (en) 2012-02-21 2014-04-22 Virender K. Sharma System and method for electrical stimulation of anorectal structures to treat anal dysfunction
US10576278B2 (en) 2012-02-21 2020-03-03 Virender K. Sharma System and method for electrical stimulation of anorectal structures to treat urinary dysfunction
US9010320B2 (en) 2012-03-12 2015-04-21 Furman Medical Llc Manually articulated intubation stylet, intubation device and intubation method
US10349958B2 (en) 2012-03-27 2019-07-16 Cook Medical Technologies Llc Lithotripsy probes and methods for performing lithotripsy
EP2833815B1 (fr) 2012-04-03 2020-11-11 Boston Scientific Scimed, Inc. Générateur de vapeur à bobine d'induction
US10660703B2 (en) 2012-05-08 2020-05-26 Boston Scientific Scimed, Inc. Renal nerve modulation devices
US9192426B2 (en) * 2012-06-26 2015-11-24 Covidien Lp Ablation device having an expandable chamber for anchoring the ablation device to tissue
WO2014031857A2 (fr) 2012-08-22 2014-02-27 Tearscience, Inc. Appareils et méthodes de diagnostic et/ou de traitement du déficit en transport des lipides dans des films de larmes oculaires, et composants et dispositifs afférents
US10321946B2 (en) 2012-08-24 2019-06-18 Boston Scientific Scimed, Inc. Renal nerve modulation devices with weeping RF ablation balloons
CN104780859B (zh) 2012-09-17 2017-07-25 波士顿科学西美德公司 用于肾神经调节的自定位电极系统及方法
US10549127B2 (en) 2012-09-21 2020-02-04 Boston Scientific Scimed, Inc. Self-cooling ultrasound ablation catheter
WO2014047411A1 (fr) 2012-09-21 2014-03-27 Boston Scientific Scimed, Inc. Système de modulation des nerfs et blocage des nerfs par gradient thermique inoffensif
EP2906135A2 (fr) 2012-10-10 2015-08-19 Boston Scientific Scimed, Inc. Dispositifs et procédés de modulation de nerf rénal
EP3964151A3 (fr) 2013-01-17 2022-03-30 Virender K. Sharma Appareil d'ablation de tissu
US9956033B2 (en) 2013-03-11 2018-05-01 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9693821B2 (en) 2013-03-11 2017-07-04 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9808311B2 (en) 2013-03-13 2017-11-07 Boston Scientific Scimed, Inc. Deflectable medical devices
EP2967503A4 (fr) 2013-03-14 2017-01-18 Nxthera, Inc. Systèmes et procédés pour le traitement du cancer de la prostate
CN105473090B (zh) 2013-03-15 2019-05-03 波士顿科学国际有限公司 重建身体通道的组织或邻近身体通道的组织的方法及装置
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
WO2014149690A2 (fr) 2013-03-15 2014-09-25 Boston Scientific Scimed, Inc. Dispositifs médicaux et méthodes de traitement de l'hypertension à l'aide d'une compensation d'impédance
US20140309524A1 (en) 2013-04-16 2014-10-16 Transmed7, Llc Methods, devices and therapeutic platform for automated, selectable, soft tissue resection
US9763827B2 (en) 2013-04-30 2017-09-19 Tear Film Innovations, Inc. Systems and methods for the treatment of eye conditions
ES2942724T3 (es) 2013-04-30 2023-06-06 Alcon Inc Sistemas para el tratamiento de enfermedades del ojo
JP2016523147A (ja) 2013-06-21 2016-08-08 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 同乗型電極支持体を備えた腎除神経バルーンカテーテル
JP2016524949A (ja) 2013-06-21 2016-08-22 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 回転可能シャフトを有する腎神経アブレーション用医療装置
US9707036B2 (en) 2013-06-25 2017-07-18 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation using localized indifferent electrodes
US9833283B2 (en) 2013-07-01 2017-12-05 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
US10413357B2 (en) 2013-07-11 2019-09-17 Boston Scientific Scimed, Inc. Medical device with stretchable electrode assemblies
CN105377169B (zh) 2013-07-11 2019-04-19 波士顿科学国际有限公司 用于神经调制的装置和方法
WO2015010074A1 (fr) 2013-07-19 2015-01-22 Boston Scientific Scimed, Inc. Ballonnet de dénervation rénale à électrode bipolaire en spirale
US10342609B2 (en) 2013-07-22 2019-07-09 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
EP3024405A1 (fr) 2013-07-22 2016-06-01 Boston Scientific Scimed, Inc. Cathéter d'ablation de nerf rénal ayant un ballonnet de torsion
JP6159888B2 (ja) 2013-08-22 2017-07-05 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 腎神経変調バルーンへの接着性を向上させたフレキシブル回路
CN105555218B (zh) 2013-09-04 2019-01-15 波士顿科学国际有限公司 具有冲洗和冷却能力的射频(rf)球囊导管
EP3043733A1 (fr) 2013-09-13 2016-07-20 Boston Scientific Scimed, Inc. Ballonnet d'ablation à couche de revêtement déposée en phase vapeur
CN105592778B (zh) 2013-10-14 2019-07-23 波士顿科学医学有限公司 高分辨率心脏标测电极阵列导管
US11246654B2 (en) 2013-10-14 2022-02-15 Boston Scientific Scimed, Inc. Flexible renal nerve ablation devices and related methods of use and manufacture
US9770606B2 (en) 2013-10-15 2017-09-26 Boston Scientific Scimed, Inc. Ultrasound ablation catheter with cooling infusion and centering basket
EP3057520A1 (fr) 2013-10-15 2016-08-24 Boston Scientific Scimed, Inc. Ballonnet de dispositif médical
CN105636538B (zh) 2013-10-18 2019-01-15 波士顿科学国际有限公司 具有柔性导线的球囊导管及其使用和制造的相关方法
WO2015061457A1 (fr) 2013-10-25 2015-04-30 Boston Scientific Scimed, Inc. Thermocouple intégré dans un circuit souple d'énervation
EP3068280B1 (fr) * 2013-11-14 2021-06-02 Clph, Llc Appareil et systèmes pour l'imagerie et l'injection épicardiques
US11096584B2 (en) 2013-11-14 2021-08-24 The George Washington University Systems and methods for determining lesion depth using fluorescence imaging
CN105744883B (zh) 2013-11-20 2022-03-01 乔治华盛顿大学 用于心脏组织高光谱分析的系统和方法
WO2015089190A1 (fr) 2013-12-10 2015-06-18 Nxthera, Inc. Systèmes et procédés d'ablation à la vapeur
US9968395B2 (en) 2013-12-10 2018-05-15 Nxthera, Inc. Systems and methods for treating the prostate
WO2015103617A1 (fr) 2014-01-06 2015-07-09 Boston Scientific Scimed, Inc. Ensemble circuit souple résistant aux déchirures
US11000679B2 (en) 2014-02-04 2021-05-11 Boston Scientific Scimed, Inc. Balloon protection and rewrapping devices and related methods of use
EP3102136B1 (fr) 2014-02-04 2018-06-27 Boston Scientific Scimed, Inc. Variante de placement de capteurs thermiques sur une électrode bipolaire
US10524684B2 (en) 2014-10-13 2020-01-07 Boston Scientific Scimed Inc Tissue diagnosis and treatment using mini-electrodes
CN106604675B (zh) 2014-10-24 2020-01-10 波士顿科学医学有限公司 具有耦接到消融尖头的柔性电极组件的医疗设备
US10722301B2 (en) 2014-11-03 2020-07-28 The George Washington University Systems and methods for lesion assessment
US10143517B2 (en) 2014-11-03 2018-12-04 LuxCath, LLC Systems and methods for assessment of contact quality
JP6825789B2 (ja) 2014-11-19 2021-02-03 エピックス セラピューティクス，インコーポレイテッド 組織の高分解能マッピングのためのシステムおよび方法
CN107148249B (zh) 2014-11-19 2022-02-22 Epix 疗法公司 使用高分辨率电极组件的消融装置、系统和方法
WO2016081611A1 (fr) 2014-11-19 2016-05-26 Advanced Cardiac Therapeutics, Inc. Cartographie haute résolution de tissus avec stimulation cardiaque
EP3223735A4 (fr) * 2014-11-25 2018-07-11 Luxcath, LLC Cathéters de visualisation
CN106999080B (zh) 2014-12-18 2020-08-18 波士顿科学医学有限公司 针对病变评估的实时形态分析
US10342593B2 (en) 2015-01-29 2019-07-09 Nxthera, Inc. Vapor ablation systems and methods
US9636164B2 (en) 2015-03-25 2017-05-02 Advanced Cardiac Therapeutics, Inc. Contact sensing systems and methods
CN113197661B (zh) 2015-05-13 2024-08-20 波士顿科学医学有限公司 用于使用可冷凝蒸气治疗膀胱的系统和方法
US10779904B2 (en) 2015-07-19 2020-09-22 460Medical, Inc. Systems and methods for lesion formation and assessment
US10328271B2 (en) 2015-11-12 2019-06-25 Medtronic, Inc. Implantable electrical stimulator with deflecting tip lead
US10252035B2 (en) 2015-12-07 2019-04-09 Cook Medical Techonologies Llc Rotatable control handles for medical devices and methods of using rotatable control handles
AU2017235224A1 (en) 2016-03-15 2018-11-08 Epix Therapeutics, Inc. Improved devices, systems and methods for irrigated ablation
US11331140B2 (en) 2016-05-19 2022-05-17 Aqua Heart, Inc. Heated vapor ablation systems and methods for treating cardiac conditions
US10974063B2 (en) 2016-06-30 2021-04-13 Alcon Inc. Light therapy for eyelash growth
ES2927968T3 (es) 2016-11-11 2022-11-14 Gynesonics Inc Tratamiento controlado del tejido e interacción dinámica con datos del tejido y/o tratamiento y comparación de datos del tejido y/o tratamiento
CN110177508B (zh) 2016-12-21 2022-10-28 波士顿科学医学有限公司 蒸汽消融系统及方法
JP7193463B2 (ja) 2017-01-06 2022-12-20 ボストン サイエンティフィック サイムド，インコーポレイテッド 経腹膜蒸気焼灼システム及び方法
EP3614946B1 (fr) 2017-04-27 2024-03-20 EPiX Therapeutics, Inc. Détermination de la nature d'un contact entre une pointe de cathéter et un tissu
AU2019279011B2 (en) 2018-06-01 2025-04-03 Santa Anna Tech Llc Multi-stage vapor-based ablation treatment methods and vapor generation and delivery systems
EP4061240A4 (fr) * 2019-11-18 2024-01-24 CIRCA Scientific, Inc. Passage d'instrument pour ablation épicardique avec structures épicardiques anatomiques et dispositif de traitement d'image de lésion en temps réel
US12076081B2 (en) 2020-01-08 2024-09-03 460Medical, Inc. Systems and methods for optical interrogation of ablation lesions
WO2022261639A1 (fr) * 2021-06-08 2022-12-15 Promedica Health System, Inc. Dispositif d'injection de bloc robinet
CN118415745B (zh) * 2024-05-23 2025-01-21 上海澍能医疗科技有限公司 一种用于调整消融位置的消融导管

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273535A (en) 1991-11-08 1993-12-28 Ep Technologies, Inc. Catheter with electrode tip having asymmetric left and right curve configurations
WO1994017856A1 (fr) * 1993-02-02 1994-08-18 Vidamed, Inc. Procede et dispositif d'ablation a aiguille transuretrale
EP0629382A1 (fr) * 1992-08-12 1994-12-21 Vidamed, Inc. Sonde médicale et procédé associé
US5403311A (en) * 1993-03-29 1995-04-04 Boston Scientific Corporation Electro-coagulation and ablation and other electrotherapeutic treatments of body tissue
WO1997000049A1 (fr) * 1995-06-19 1997-01-03 Vidamed, Inc. Dispositif electrochirurgical comportant un ensemble de declenchement d'actionnement et son procede
WO1997033524A1 (fr) * 1996-03-15 1997-09-18 Rita Medical Systems, Inc. Appareil et procede d'ablation a antennes multiples a element de refroidissement

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5675131A (en) 1979-11-22 1981-06-22 Olympus Optical Co Endoscope apparatus
US4565200A (en) 1980-09-24 1986-01-21 Cosman Eric R Universal lesion and recording electrode system
US5421819A (en) 1992-08-12 1995-06-06 Vidamed, Inc. Medical probe device
US5435805A (en) 1992-08-12 1995-07-25 Vidamed, Inc. Medical probe device with optical viewing capability
US4770654A (en) 1985-09-26 1988-09-13 Alcon Laboratories Inc. Multimedia apparatus for driving powered surgical instruments
US4699463A (en) 1985-11-01 1987-10-13 Circon Corporation Multidirectional viewing borescope
JPS6397154A (ja) 1986-10-13 1988-04-27 オリンパス光学工業株式会社 内視鏡用処置具
US4765331A (en) 1987-02-10 1988-08-23 Circon Corporation Electrosurgical device with treatment arc of less than 360 degrees
US4748969A (en) 1987-05-07 1988-06-07 Circon Corporation Multi-lumen core deflecting endoscope
US4936842A (en) 1987-05-08 1990-06-26 Circon Corporation Electrosurgical probe apparatus
US4823791A (en) 1987-05-08 1989-04-25 Circon Acmi Division Of Circon Corporation Electrosurgical probe apparatus
US4745908A (en) 1987-05-08 1988-05-24 Circon Corporation Inspection instrument fexible shaft having deflection compensation means
US4776840A (en) 1987-09-28 1988-10-11 Alteron, Inc. Hand-held medical evacuator and irrigation device
US4917082A (en) 1988-06-02 1990-04-17 Circon Corporation Resectoscope electrode
US4921484A (en) 1988-07-25 1990-05-01 Cordis Corporation Mesh balloon catheter device
US4911148A (en) 1989-03-14 1990-03-27 Intramed Laboratories, Inc. Deflectable-end endoscope with detachable flexible shaft assembly
US4917100A (en) 1989-05-08 1990-04-17 Nottke James E Biopsy needle for use with spring-operated actuating mechanism
US5007908A (en) 1989-09-29 1991-04-16 Everest Medical Corporation Electrosurgical instrument having needle cutting electrode and spot-coag electrode
US5091656A (en) 1989-10-27 1992-02-25 Storz Instrument Company Footswitch assembly with electrically engaged detents
US5069223A (en) 1990-02-14 1991-12-03 Georgetown University Method of evaluating tissue changes resulting from therapeutic hyperthermia
US5431645A (en) * 1990-05-10 1995-07-11 Symbiosis Corporation Remotely activated endoscopic tools such as endoscopic biopsy forceps
US5195958A (en) 1990-05-25 1993-03-23 Phillips Edward H Tool for laparoscopic surgery
US5199417A (en) 1990-12-21 1993-04-06 Circon Corporation Endoscope having a deflectable distal section and a semi-rigid proximal section
US5409453A (en) * 1992-08-12 1995-04-25 Vidamed, Inc. Steerable medical probe with stylets
US5271379A (en) * 1991-07-26 1993-12-21 The Regents Of The University Of California Endoscopic device actuator and method
US5562703A (en) 1994-06-14 1996-10-08 Desai; Ashvin H. Endoscopic surgical instrument
EP0566731A4 (fr) * 1991-11-08 1995-02-22 Ep Technologies Systeme d'ablation a haute frequence a detection de puissance sensible a la phase.
US5197963A (en) 1991-12-02 1993-03-30 Everest Medical Corporation Electrosurgical instrument with extendable sheath for irrigation and aspiration
US5902272A (en) * 1992-01-07 1999-05-11 Arthrocare Corporation Planar ablation probe and method for electrosurgical cutting and ablation
MX9300607A (es) 1992-02-06 1993-10-01 American Med Syst Aparato y metodo para tratamiento intersticial.
US5186714A (en) 1992-05-18 1993-02-16 Yab Revo-Tech Inc. Multifunctional surgical instrument
US5281218A (en) 1992-06-05 1994-01-25 Cardiac Pathways Corporation Catheter having needle electrode for radiofrequency ablation
WO1994000178A1 (fr) 1992-06-26 1994-01-06 Schneider (Usa) Inc. Catheter pourvu d'une pointe a treillis en fil metallique extensible
US5667488A (en) * 1992-08-12 1997-09-16 Vidamed, Inc. Transurethral needle ablation device and method for the treatment of the prostate
US5486161A (en) * 1993-02-02 1996-01-23 Zomed International Medical probe device and method
US5720719A (en) * 1992-08-12 1998-02-24 Vidamed, Inc. Ablative catheter with conformable body
US5324311A (en) * 1992-09-04 1994-06-28 Siemens Pacesetter, Inc. Coaxial bipolar connector assembly for implantable medical device
US5636634A (en) * 1993-03-16 1997-06-10 Ep Technologies, Inc. Systems using guide sheaths for introducing, deploying, and stabilizing cardiac mapping and ablation probes
US5921982A (en) * 1993-07-30 1999-07-13 Lesh; Michael D. Systems and methods for ablating body tissue
US5456689A (en) 1993-10-13 1995-10-10 Arnold J. Kresch Method and device for tissue resection
US5599346A (en) 1993-11-08 1997-02-04 Zomed International, Inc. RF treatment system
US5458597A (en) 1993-11-08 1995-10-17 Zomed International Device for treating cancer and non-malignant tumors and methods
US5595185A (en) 1994-08-11 1997-01-21 N.M.B. Medical Applications Ltd. Single puncture multi-biopsy gun
US5885278A (en) * 1994-10-07 1999-03-23 E.P. Technologies, Inc. Structures for deploying movable electrode elements
WO1997017027A1 (fr) 1995-11-08 1997-05-15 Femrx, Inc. Dispositif electrochirurgical a rouleaux pour l'ablation et la segmentation de tissus
WO1996011638A1 (fr) 1994-10-13 1996-04-25 Femrx Procede et dispositif pour la resection de tissus
DE69635933T2 (de) * 1995-01-30 2006-09-07 Boston Scientific Corp., Natick Elektrochirurgische Entfernung von Geweben
WO1996026675A1 (fr) 1995-02-28 1996-09-06 Boston Scientific Corporation Catheter a deflexion pour l'ablation d'un tissu cardiaque
US5704899A (en) 1995-10-10 1998-01-06 Conceptus, Inc. Protective sheath for a fiberoptic image guide within an articulated endoscope
WO1997017028A1 (fr) 1995-11-07 1997-05-15 Femrx, Inc. Dispositif de resection de tissus a pince retirable d'ablation/coagulation
US6096053A (en) 1996-05-03 2000-08-01 Scimed Life Systems, Inc. Medical retrieval basket
NL1003497C2 (nl) 1996-07-03 1998-01-07 Cordis Europ Katheter met tijdelijk vena-cava filter.
US6066158A (en) 1996-07-25 2000-05-23 Target Therapeutics, Inc. Mechanical clot encasing and removal wire
NL1004721C2 (nl) 1996-12-06 1998-06-09 Ideamed N V Beademingsinrichting.
US5871481A (en) * 1997-04-11 1999-02-16 Vidamed, Inc. Tissue ablation apparatus and method
US5891138A (en) * 1997-08-11 1999-04-06 Irvine Biomedical, Inc. Catheter system having parallel electrodes
US6179809B1 (en) * 1997-09-24 2001-01-30 Eclipse Surgical Technologies, Inc. Drug delivery catheter with tip alignment
WO1999039648A1 (fr) 1998-02-10 1999-08-12 Dubrul William R Appareil de capture et procede d'utilisation
JP3733580B2 (ja) 1998-04-06 2006-01-11 ニプロ株式会社 欠損閉塞用閉鎖栓回収具
US6905476B2 (en) * 1998-06-04 2005-06-14 Biosense Webster, Inc. Catheter with injection needle
US6030406A (en) 1998-10-05 2000-02-29 Origin Medsystems, Inc. Method and apparatus for tissue dissection
US6179859B1 (en) 1999-07-16 2001-01-30 Baff Llc Emboli filtration system and methods of use
US6213976B1 (en) 1999-07-22 2001-04-10 Advanced Research And Technology Institute, Inc. Brachytherapy guide catheter
US6168579B1 (en) 1999-08-04 2001-01-02 Scimed Life Systems, Inc. Filter flush system and methods of use
US6443926B1 (en) 2000-02-01 2002-09-03 Harold D. Kletschka Embolic protection device having expandable trap

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273535A (en) 1991-11-08 1993-12-28 Ep Technologies, Inc. Catheter with electrode tip having asymmetric left and right curve configurations
EP0629382A1 (fr) * 1992-08-12 1994-12-21 Vidamed, Inc. Sonde médicale et procédé associé
WO1994017856A1 (fr) * 1993-02-02 1994-08-18 Vidamed, Inc. Procede et dispositif d'ablation a aiguille transuretrale
US5403311A (en) * 1993-03-29 1995-04-04 Boston Scientific Corporation Electro-coagulation and ablation and other electrotherapeutic treatments of body tissue
WO1997000049A1 (fr) * 1995-06-19 1997-01-03 Vidamed, Inc. Dispositif electrochirurgical comportant un ensemble de declenchement d'actionnement et son procede
WO1997033524A1 (fr) * 1996-03-15 1997-09-18 Rita Medical Systems, Inc. Appareil et procede d'ablation a antennes multiples a element de refroidissement

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10420606B2 (en) 2002-04-08 2019-09-24 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US10376311B2 (en) 2002-04-08 2019-08-13 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravascularly-induced neuromodulation
US10105180B2 (en) 2002-04-08 2018-10-23 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravascularly-induced neuromodulation
US9827041B2 (en) 2002-04-08 2017-11-28 Medtronic Ardian Luxembourg S.A.R.L. Balloon catheter apparatuses for renal denervation
US9827040B2 (en) 2002-04-08 2017-11-28 Medtronic Adrian Luxembourg S.a.r.l. Methods and apparatus for intravascularly-induced neuromodulation
US9757193B2 (en) 2002-04-08 2017-09-12 Medtronic Ardian Luxembourg S.A.R.L. Balloon catheter apparatus for renal neuromodulation
US9510901B2 (en) 2003-09-12 2016-12-06 Vessix Vascular, Inc. Selectable eccentric remodeling and/or ablation
US10188457B2 (en) 2003-09-12 2019-01-29 Vessix Vascular, Inc. Selectable eccentric remodeling and/or ablation
US9125666B2 (en) 2003-09-12 2015-09-08 Vessix Vascular, Inc. Selectable eccentric remodeling and/or ablation of atherosclerotic material
US9125667B2 (en) 2004-09-10 2015-09-08 Vessix Vascular, Inc. System for inducing desirable temperature effects on body tissue
US8939970B2 (en) 2004-09-10 2015-01-27 Vessix Vascular, Inc. Tuned RF energy and electrical tissue characterization for selective treatment of target tissues
US8920414B2 (en) 2004-09-10 2014-12-30 Vessix Vascular, Inc. Tuned RF energy and electrical tissue characterization for selective treatment of target tissues
US11272982B2 (en) 2004-12-09 2022-03-15 Twelve, Inc. Intravascular treatment catheters
US10350004B2 (en) 2004-12-09 2019-07-16 Twelve, Inc. Intravascular treatment catheters
US8364237B2 (en) 2005-03-28 2013-01-29 Vessix Vascular, Inc. Tuned RF energy for selective treatment of atheroma and other target tissues and/or structures
US9486355B2 (en) 2005-05-03 2016-11-08 Vessix Vascular, Inc. Selective accumulation of energy with or without knowledge of tissue topography
US10213252B2 (en) 2006-10-18 2019-02-26 Vessix, Inc. Inducing desirable temperature effects on body tissue
US12161392B2 (en) 2006-10-18 2024-12-10 Boston Scientific Scimed, Inc. System for inducing desirable temperature effects on body tissue
US10413356B2 (en) 2006-10-18 2019-09-17 Boston Scientific Scimed, Inc. System for inducing desirable temperature effects on body tissue
US9974607B2 (en) 2006-10-18 2018-05-22 Vessix Vascular, Inc. Inducing desirable temperature effects on body tissue
US8496653B2 (en) 2007-04-23 2013-07-30 Boston Scientific Scimed, Inc. Thrombus removal
US9327100B2 (en) 2008-11-14 2016-05-03 Vessix Vascular, Inc. Selective drug delivery in a lumen
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US8401667B2 (en) 2008-11-17 2013-03-19 Vessix Vascular, Inc. Selective accumulation of energy with or without knowledge of tissue topography
US8551096B2 (en) 2009-05-13 2013-10-08 Boston Scientific Scimed, Inc. Directional delivery of energy and bioactives
US9277955B2 (en) 2010-04-09 2016-03-08 Vessix Vascular, Inc. Power generating and control apparatus for the treatment of tissue
US9919144B2 (en) 2011-04-08 2018-03-20 Medtronic Adrian Luxembourg S.a.r.l. Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery
US10543037B2 (en) 2013-03-15 2020-01-28 Medtronic Ardian Luxembourg S.A.R.L. Controlled neuromodulation systems and methods of use
US9579149B2 (en) 2014-03-13 2017-02-28 Medtronic Ardian Luxembourg S.A.R.L. Low profile catheter assemblies and associated systems and methods
US10709490B2 (en) 2014-05-07 2020-07-14 Medtronic Ardian Luxembourg S.A.R.L. Catheter assemblies comprising a direct heating element for renal neuromodulation and associated systems and methods

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DE69829300D1 (de) 2005-04-14
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IL135353A (en) 2004-02-19
US6482203B2 (en) 2002-11-19
US7909821B2 (en) 2011-03-22
US6238389B1 (en) 2001-05-29
US6352534B1 (en) 2002-03-05
EP1018959A1 (fr) 2000-07-19
CA2304739A1 (fr) 1999-04-08
AU738287B2 (en) 2001-09-13
JP2001517528A (ja) 2001-10-09
JP2007117753A (ja) 2007-05-17
AU9509298A (en) 1999-04-23
US20020040221A1 (en) 2002-04-04
US20030028188A1 (en) 2003-02-06
IL135353A0 (en) 2001-05-20
DE69829300T2 (de) 2006-04-13
EP1018959B1 (fr) 2005-03-09

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