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WO1999011778B1 - Traitement antisense de l'hypertension pulmonaire - Google Patents

Traitement antisense de l'hypertension pulmonaire

Info

Publication number
WO1999011778B1
WO1999011778B1 PCT/GB1998/002584 GB9802584W WO9911778B1 WO 1999011778 B1 WO1999011778 B1 WO 1999011778B1 GB 9802584 W GB9802584 W GB 9802584W WO 9911778 B1 WO9911778 B1 WO 9911778B1
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic composition
inhaler
seq
composition according
oligonucleotide
Prior art date
Application number
PCT/GB1998/002584
Other languages
English (en)
Other versions
WO1999011778A1 (fr
Inventor
Timothy Higenbottam
Keith Mccormack
Adrian Smith
Original Assignee
Univ Sheffield
Timothy Higenbottam
Keith Mccormack
Adrian Smith
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Sheffield, Timothy Higenbottam, Keith Mccormack, Adrian Smith filed Critical Univ Sheffield
Priority to AU88741/98A priority Critical patent/AU8874198A/en
Priority to CA002302167A priority patent/CA2302167A1/fr
Priority to JP2000508789A priority patent/JP2001515011A/ja
Priority to EP98940410A priority patent/EP1009822A1/fr
Publication of WO1999011778A1 publication Critical patent/WO1999011778A1/fr
Publication of WO1999011778B1 publication Critical patent/WO1999011778B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne une méthode de traitement de l'hypertension pulmonaire par une thérapie antisens faisant appel à des molécules antisens dérivées de ET-1 administrées dans les poumons comme une impulsion/pointe dans un inhalateur.
PCT/GB1998/002584 1997-09-02 1998-09-02 Traitement antisense de l'hypertension pulmonaire WO1999011778A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU88741/98A AU8874198A (en) 1997-09-02 1998-09-02 Antisense treatment of pulmonary hypertension
CA002302167A CA2302167A1 (fr) 1997-09-02 1998-09-02 Traitement antisense de l'hypertension pulmonaire
JP2000508789A JP2001515011A (ja) 1997-09-02 1998-09-02 肺高血圧症のアンチセンス治療
EP98940410A EP1009822A1 (fr) 1997-09-02 1998-09-02 Traitement antisense de l'hypertension pulmonaire

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9718487.3 1997-09-02
GBGB9718487.3A GB9718487D0 (en) 1997-09-02 1997-09-02 Pulmonary hypertension

Publications (2)

Publication Number Publication Date
WO1999011778A1 WO1999011778A1 (fr) 1999-03-11
WO1999011778B1 true WO1999011778B1 (fr) 1999-04-15

Family

ID=10818333

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/002584 WO1999011778A1 (fr) 1997-09-02 1998-09-02 Traitement antisense de l'hypertension pulmonaire

Country Status (6)

Country Link
EP (1) EP1009822A1 (fr)
JP (1) JP2001515011A (fr)
AU (1) AU8874198A (fr)
CA (1) CA2302167A1 (fr)
GB (1) GB9718487D0 (fr)
WO (1) WO1999011778A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1086116A4 (fr) * 1998-05-21 2004-03-17 Isis Pharmaceuticals Inc Compositions destinees a l'administration pulmonaire d'acides nucleiques et procedes
JP2002515513A (ja) * 1998-05-21 2002-05-28 アイシス・ファーマシューティカルス・インコーポレーテッド 核酸の肺送達のための組成物および方法
US6087343A (en) * 1998-09-14 2000-07-11 University Of Florida Antisense oligonucleotides targeted to β-1 adrenoceptor and methods of use
WO2000055314A2 (fr) * 1999-03-18 2000-09-21 United Therapeutics Corporation Inhibiteurs de synthese de l'endotheline-1
AU2001289861A1 (en) * 2000-09-19 2002-04-02 Epidauros Biotechnologie Ag Polymorphisms in human genes of cardiovascular regulators and their use in diagnostic and therapeutic applications
WO2016083624A1 (fr) * 2014-11-28 2016-06-02 Silence Therapeutics Gmbh Moyens d'inhibition de l'expression d'edn1

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2279014B (en) * 1993-06-02 1997-07-16 Niall Keaney Device for controlling delivery of respiratory drugs
GB9320978D0 (en) * 1993-10-12 1993-12-01 Higenbottam Timohy W Nitric oxide treatment
US5994315A (en) * 1995-06-07 1999-11-30 East Carolina University Low adenosine agent, composition, kit and method for treatment of airway disease
GB2320900B (en) * 1997-01-07 2000-08-30 Univ Sheffield Inhalers

Also Published As

Publication number Publication date
WO1999011778A1 (fr) 1999-03-11
JP2001515011A (ja) 2001-09-18
EP1009822A1 (fr) 2000-06-21
CA2302167A1 (fr) 1999-03-11
GB9718487D0 (en) 1997-11-05
AU8874198A (en) 1999-03-22

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