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WO1999011252A3 - Chlorure de n,n-bis (phenylcarbamoylmethyl) dimethylammonium et ses derives, servant au traitement de la douleur - Google Patents

Chlorure de n,n-bis (phenylcarbamoylmethyl) dimethylammonium et ses derives, servant au traitement de la douleur Download PDF

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Publication number
WO1999011252A3
WO1999011252A3 PCT/CA1998/000842 CA9800842W WO9911252A3 WO 1999011252 A3 WO1999011252 A3 WO 1999011252A3 CA 9800842 W CA9800842 W CA 9800842W WO 9911252 A3 WO9911252 A3 WO 9911252A3
Authority
WO
WIPO (PCT)
Prior art keywords
phenylcarbamoylmethyl
pain
bis
derivatives
treatment
Prior art date
Application number
PCT/CA1998/000842
Other languages
English (en)
Other versions
WO1999011252A2 (fr
Inventor
Bernard A Macleod
David M J Quastel
Original Assignee
Nortran Pharmaceuticals Inc
Bernard A Macleod
David M J Quastel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nortran Pharmaceuticals Inc, Bernard A Macleod, David M J Quastel filed Critical Nortran Pharmaceuticals Inc
Priority to BR9812182-0A priority Critical patent/BR9812182A/pt
Priority to AT98941201T priority patent/ATE238047T1/de
Priority to JP2000508355A priority patent/JP2001514216A/ja
Priority to CA002303815A priority patent/CA2303815A1/fr
Priority to DE69813839T priority patent/DE69813839T2/de
Priority to EP98941201A priority patent/EP1009397B1/fr
Priority to AU89701/98A priority patent/AU8970198A/en
Publication of WO1999011252A2 publication Critical patent/WO1999011252A2/fr
Publication of WO1999011252A3 publication Critical patent/WO1999011252A3/fr
Priority to HK00108104A priority patent/HK1028957A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

On a découvert que le chlorure de N,N-bis (phénylcarbamoylméthyl) diméthylammonium et ses dérivés sont utiles dans le traitement de la douleur et évitent les effets secondaires associés aux médicaments classiques.
PCT/CA1998/000842 1997-09-03 1998-09-03 Chlorure de n,n-bis (phenylcarbamoylmethyl) dimethylammonium et ses derives, servant au traitement de la douleur WO1999011252A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
BR9812182-0A BR9812182A (pt) 1997-09-03 1998-09-03 Cloreto de n,n-bis(fenilcarbamoilmetil) dimetilamÈnio e seus derivados no tratamento da dor
AT98941201T ATE238047T1 (de) 1997-09-03 1998-09-03 Verwendung von n,n-bis (phenylcarbamoylmethyl) dimethylammoniumchlorid und derivaten davon zur behandlung von chronischem schmerz
JP2000508355A JP2001514216A (ja) 1997-09-03 1998-09-03 痛み治療における塩化ｎ，ｎ−ビス（フェニルカルバモイルメチル）ジメチルアンモニウムおよび誘導体
CA002303815A CA2303815A1 (fr) 1997-09-03 1998-09-03 Chlorure de n,n-bis (phenylcarbamoylmethyl) dimethylammonium et ses derives, servant au traitement de la douleur
DE69813839T DE69813839T2 (de) 1997-09-03 1998-09-03 Verwendung von n,n-bis (phenylcarbamoylmethyl) dimethylammoniumchlorid und derivaten davon zur behandlung von chronischem schmerz
EP98941201A EP1009397B1 (fr) 1997-09-03 1998-09-03 Utilisation de chlorure de n,n-bis (phenylcarbamoylmethyl) dimethylammonium et ses derives pour le traitement de la douleur chronique
AU89701/98A AU8970198A (en) 1997-09-03 1998-09-03 N,n-bis (phenylcarbamoylmethyl) dimethylammonium chloride and derivatives in thetreatment of pain
HK00108104A HK1028957A1 (en) 1997-09-03 2000-12-15 Use of n,n-bis (phenylcarbamoylmethyl) dimethylammonium chloride and derivatives in the treatment of chronic pain

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5631297P 1997-09-03 1997-09-03
US60/056,312 1997-09-03

Publications (2)

Publication Number Publication Date
WO1999011252A2 WO1999011252A2 (fr) 1999-03-11
WO1999011252A3 true WO1999011252A3 (fr) 1999-05-06

Family

ID=22003584

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1998/000842 WO1999011252A2 (fr) 1997-09-03 1998-09-03 Chlorure de n,n-bis (phenylcarbamoylmethyl) dimethylammonium et ses derives, servant au traitement de la douleur

Country Status (12)

Country Link
EP (1) EP1009397B1 (fr)
JP (1) JP2001514216A (fr)
CN (1) CN1276722A (fr)
AT (1) ATE238047T1 (fr)
AU (1) AU8970198A (fr)
BR (1) BR9812182A (fr)
CA (1) CA2303815A1 (fr)
DE (1) DE69813839T2 (fr)
ES (1) ES2197500T3 (fr)
HK (1) HK1028957A1 (fr)
TW (1) TW536401B (fr)
WO (1) WO1999011252A2 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ID27178A (id) 1998-04-01 2001-03-08 Nortran Pharmaceuticals Inc Senyawa aminosikloheksil eter dan penggunaannya
AU762127B2 (en) * 1998-06-09 2003-06-19 Nortran Pharmaceuticals Inc. Compositions and methods for treatment of cough
US7507545B2 (en) 1999-03-31 2009-03-24 Cardiome Pharma Corp. Ion channel modulating activity method
US7057053B2 (en) 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US7524879B2 (en) 2000-10-06 2009-04-28 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
WO2004099137A1 (fr) 2003-05-02 2004-11-18 Cardiome Pharma Corp. Composes a base d'aminocyclohexyle-ether et leurs utilisations
US7345086B2 (en) 2003-05-02 2008-03-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
WO2005018635A2 (fr) 2003-08-07 2005-03-03 Cardiome Pharma Corp. Activite i modulant des canaux ioniques
US7345087B2 (en) 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
WO2005097087A2 (fr) 2004-04-01 2005-10-20 Cardiome Pharma Corp. Composes combines de modulation du canal ionique et utilisation desdits composes
WO2005113011A2 (fr) 2004-04-01 2005-12-01 Cardiome Pharma Corp. Promedicaments de composes modulant les canaux ioniques et leurs utilisations
EP1868598B1 (fr) 2004-11-08 2014-04-23 Cardiome Pharma Corp. Schemas posologiques pour modulateurs de canaux ioniques pour le traitement de la fibrillation auriculaire aigue chez l'homme
CA2668652C (fr) 2006-11-20 2018-06-12 President And Fellows Of Harvard College Inhibiteurs de canaux ioniques potentiel-dependants a utiliser dans le traitement de la douleur et du prurit
CA2767646C (fr) 2009-07-10 2019-01-29 President And Fellows Of Harvard College Bloqueurs de canaux sodiques et calciques charges de maniere permanente comme agents anti-inflammatoires
CN108348774A (zh) 2015-08-03 2018-07-31 哈佛大学校长及研究员协会 带电离子通道阻断剂及其应用
CA3129089A1 (fr) 2019-03-11 2020-09-17 Bridget Mccarthy Cole Bloqueurs de canaux ioniques substitues par un ester et methodes d'utilisation
US10786485B1 (en) 2019-03-11 2020-09-29 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
KR20210143791A (ko) 2019-03-11 2021-11-29 녹시온 테라퓨틱스 인코포레이티드 하전된 이온 채널 차단제 및 사용 방법
CN113795248A (zh) 2019-03-11 2021-12-14 诺西恩医疗公司 带电荷的离子通道阻滞剂及其使用方法
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP7628539B2 (ja) 2019-11-06 2025-02-10 ノシオン セラピューティクス，インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
CA3155568A1 (fr) 2019-11-06 2021-05-14 Bridget Mccarthy Cole Bloqueurs de canaux ioniques charges et leurs procedes d'utilisation
JP2023517604A (ja) 2020-03-11 2023-04-26 ノシオン セラピューティクス，インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
US12162851B2 (en) 2020-03-11 2024-12-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
KR20240110799A (ko) * 2021-11-30 2024-07-16 마루호 코 엘티디 의약 조성물
WO2023100836A1 (fr) * 2021-11-30 2023-06-08 マルホ株式会社 Composition pharmaceutique

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
FRAZIER, DONALD T. ET AL: "Site of action and active form of local anesthetics. II. Experiments with quaternary compounds", J. PHARMACOL. EXP. THER. (1970), 171(1), 45-51 CODEN: JPETAB, XP002093770 *
KENDIG, JOAN J. ET AL: "Pressure antagonism to nerve conduction block by anesthetic agents", ANESTHESIOLOGY (1977), 47(1), 6-10 CODEN: ANESAV, XP002093772 *
NARAHASHI, TOSHIO ET AL: "Comparison of tertiary and quaternary amine local anesthetics in their ability to depress membrane ionic conductances", J. NEUROBIOL. (1972), 3(3), 267-76 CODEN: JNEUBZ, XP002093766 *
NISHIZAWA, YUKIO ET AL: "Local anesthetics: stimulation of incorporation of inositol into phosphoinositides in guinea pig cerebral cortical synaptoneurosomes", BIOCHIM. BIOPHYS. ACTA (1990), 1054(2), 213-18 CODEN: BBACAQ;ISSN: 0006-3002, XP002093768 *
VANDERHOEK, JACK Y. ET AL: "Local anesthetics, chlorpromazine and propranolol inhibit stimulus-activation of phospholipase A2 in human platelets", MOL. PHARMACOL. (1979), 16(1), 171-80 CODEN: MOPMA3;ISSN: 0026-895X, XP002093767 *
VOLPI, M. ET AL: "Local anesthetics, mepacrine, and propranolol are antagonists of calmodulin", PROC. NATL. ACAD. SCI. U. S. A. (1981), 78(2), 795-9 CODEN: PNASA6;ISSN: 0027-8424, XP002093771 *
WONG, KIN ET AL: "On the mechanisms of potentiation of local anesthetics by bicarbonate buffer: drug structure-activity studies on isolated peripheral nerve", ANESTH. ANALG. (N. Y.) (1993), 76(1), 131-43 CODEN: AACRAT;ISSN: 0003-2999, XP002093769 *

Also Published As

Publication number Publication date
BR9812182A (pt) 2002-01-15
DE69813839D1 (de) 2003-05-28
ES2197500T3 (es) 2004-01-01
DE69813839T2 (de) 2004-03-04
ATE238047T1 (de) 2003-05-15
EP1009397B1 (fr) 2003-04-23
JP2001514216A (ja) 2001-09-11
TW536401B (en) 2003-06-11
HK1028957A1 (en) 2001-03-16
EP1009397A2 (fr) 2000-06-21
WO1999011252A2 (fr) 1999-03-11
CA2303815A1 (fr) 1999-03-11
AU8970198A (en) 1999-03-22
CN1276722A (zh) 2000-12-13

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