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WO1999009161A8 - Pancreas-derived plasminogen activator inhibitor - Google Patents

Pancreas-derived plasminogen activator inhibitor

Info

Publication number
WO1999009161A8
WO1999009161A8 PCT/US1998/003217 US9803217W WO9909161A8 WO 1999009161 A8 WO1999009161 A8 WO 1999009161A8 US 9803217 W US9803217 W US 9803217W WO 9909161 A8 WO9909161 A8 WO 9909161A8
Authority
WO
WIPO (PCT)
Prior art keywords
plasminogen activator
activator inhibitor
pancreas
derived plasminogen
methods
Prior art date
Application number
PCT/US1998/003217
Other languages
French (fr)
Other versions
WO1999009161A1 (en
Inventor
Jian Ni
Reiner L Gentz
Steven M Ruben
Y Eric Shi
Original Assignee
Human Genome Sciences Inc
Long Island Jewish Medical Ct
Jian Ni
Reiner L Gentz
Steven M Ruben
Y Eric Shi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc, Long Island Jewish Medical Ct, Jian Ni, Reiner L Gentz, Steven M Ruben, Y Eric Shi filed Critical Human Genome Sciences Inc
Priority to AU61758/98A priority Critical patent/AU6175898A/en
Publication of WO1999009161A1 publication Critical patent/WO1999009161A1/en
Publication of WO1999009161A8 publication Critical patent/WO1999009161A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8132—Plasminogen activator inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a novel member of the plasminogen activator inhibitor protein family. In particular, isolated nucleic acid molecules are provided encoding the pancreas-derived plasminogen activator inhibitor protein. Pancreas-derived plasminogen activator inhibitor polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to methods for treating physiologic and pathologic disease conditions, including breast cancer, and diagnostic methods for detecting pathologic disorders.
PCT/US1998/003217 1997-08-15 1998-02-18 Pancreas-derived plasminogen activator inhibitor WO1999009161A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU61758/98A AU6175898A (en) 1997-08-15 1998-02-18 Pancreas-derived plasminogen activator inhibitor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93401197A 1997-08-15 1997-08-15
US08/934,011 1997-08-15

Publications (2)

Publication Number Publication Date
WO1999009161A1 WO1999009161A1 (en) 1999-02-25
WO1999009161A8 true WO1999009161A8 (en) 1999-04-08

Family

ID=25464804

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/003217 WO1999009161A1 (en) 1997-08-15 1998-02-18 Pancreas-derived plasminogen activator inhibitor

Country Status (2)

Country Link
AU (1) AU6175898A (en)
WO (1) WO1999009161A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003039588A1 (en) * 2001-11-09 2003-05-15 Novo Nordisk Health Care Ag Pharmaceutical composition comprising factor vii polypeptides and tissue plasminogen inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5804376A (en) * 1995-05-02 1998-09-08 Incyte Pharmaceuticals, Inc. Pancreas-derived serpin

Also Published As

Publication number Publication date
AU6175898A (en) 1999-03-08
WO1999009161A1 (en) 1999-02-25

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