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WO1999006838A3 - Novel method of detecting amyloid-like fibrils or protein aggregates - Google Patents

Novel method of detecting amyloid-like fibrils or protein aggregates Download PDF

Info

Publication number
WO1999006838A3
WO1999006838A3 PCT/EP1998/004810 EP9804810W WO9906838A3 WO 1999006838 A3 WO1999006838 A3 WO 1999006838A3 EP 9804810 W EP9804810 W EP 9804810W WO 9906838 A3 WO9906838 A3 WO 9906838A3
Authority
WO
WIPO (PCT)
Prior art keywords
fibrils
protein aggregates
disease
novel method
aggregates
Prior art date
Application number
PCT/EP1998/004810
Other languages
French (fr)
Other versions
WO1999006838A2 (en
Inventor
Erich Wanker
Hans Lehrach
Eberhard Scherzinger
Gillian Bates
Original Assignee
Max Planck Gesellschaft
Erich Wanker
Hans Lehrach
Eberhard Scherzinger
Gillian Bates
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft, Erich Wanker, Hans Lehrach, Eberhard Scherzinger, Gillian Bates filed Critical Max Planck Gesellschaft
Priority to DE69834193T priority Critical patent/DE69834193T2/en
Priority to EP98943817A priority patent/EP1005654B1/en
Priority to US09/485,005 priority patent/US7595199B1/en
Publication of WO1999006838A2 publication Critical patent/WO1999006838A2/en
Publication of WO1999006838A3 publication Critical patent/WO1999006838A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to methods of detecting the presence of detergent- or urea-insoluble amyloid-like fibrils or protein aggregates on filters. Preferably, said fibrils or aggregates are indicative of a disease, preferably of a neurodegenerative disease such as Alzheimer's disease or Huntington's disease. In addition, the present invention relates to inhibitors identified by the method of the invention, to pharmaceutical compositions comprising said inhibitors and to diagnostic compositions useful for the investigation of said amyloid-like fibrils or aggregates.
PCT/EP1998/004810 1997-08-01 1998-07-31 Novel method of detecting amyloid-like fibrils or protein aggregates WO1999006838A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE69834193T DE69834193T2 (en) 1997-08-01 1998-07-31 METHOD FOR DETERMINING AMYLOID-RELATED FIBRILLES OR PROTEIN AGGREGATES
EP98943817A EP1005654B1 (en) 1997-08-01 1998-07-31 Novel method of detecting amyloid-like fibrils or protein aggregates
US09/485,005 US7595199B1 (en) 1998-07-31 1998-07-31 Method of detecting amyloid-like fibrils or protein aggregates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97113320.2 1997-08-01
EP97113320 1997-08-01

Publications (2)

Publication Number Publication Date
WO1999006838A2 WO1999006838A2 (en) 1999-02-11
WO1999006838A3 true WO1999006838A3 (en) 1999-07-08

Family

ID=8227164

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/004810 WO1999006838A2 (en) 1997-08-01 1998-07-31 Novel method of detecting amyloid-like fibrils or protein aggregates

Country Status (3)

Country Link
AT (1) ATE323288T1 (en)
DE (1) DE69834193T2 (en)
WO (1) WO1999006838A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6846640B2 (en) * 2002-04-30 2005-01-25 Pharmacia & Upjohn Company Time-resolved fluorescence assay for the detection of multimeric forms of A-beta 1-40
EP3174898A2 (en) 2014-07-29 2017-06-07 Neurimmune Holding AG Human-derived anti-huntingtin (htt) antibodies and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0206302A2 (en) * 1985-06-25 1986-12-30 Ciba-Geigy Ag New Assay and purification of amyloid components, applications, and kits therefor
US5234814A (en) * 1989-06-01 1993-08-10 Du Pont Merck Pharmaceutical Company Diagnostic assay for alzheimer's disease
WO1996012544A1 (en) * 1994-10-19 1996-05-02 The General Hospital Corporation A DIAGNOSTIC ASSAY FOR ALZHEIMER'S DISEASE: ASSESSMENT OF Aβ ABNORMALITIES
EP0854364A1 (en) * 1997-01-18 1998-07-22 Harash Kumar Narang Diagnosis of neuro-degenerative disorders

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0206302A2 (en) * 1985-06-25 1986-12-30 Ciba-Geigy Ag New Assay and purification of amyloid components, applications, and kits therefor
US5234814A (en) * 1989-06-01 1993-08-10 Du Pont Merck Pharmaceutical Company Diagnostic assay for alzheimer's disease
WO1996012544A1 (en) * 1994-10-19 1996-05-02 The General Hospital Corporation A DIAGNOSTIC ASSAY FOR ALZHEIMER'S DISEASE: ASSESSMENT OF Aβ ABNORMALITIES
EP0854364A1 (en) * 1997-01-18 1998-07-22 Harash Kumar Narang Diagnosis of neuro-degenerative disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TATEISHI, J. ET AL: "Removal of causative agent of Creutzfeldt-Jakob disease (CJD) through membrane filtration method.", MEMBRANE, vol. 18, no. 6, 1993, pages 357 - 362, XP002101228 *

Also Published As

Publication number Publication date
WO1999006838A2 (en) 1999-02-11
DE69834193T2 (en) 2007-04-19
DE69834193D1 (en) 2006-05-24
ATE323288T1 (en) 2006-04-15

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