WO1999006552A3 - Est 5' pour proteines secretees exprimees dans le cerveau - Google Patents
Est 5' pour proteines secretees exprimees dans le cerveau Download PDFInfo
- Publication number
- WO1999006552A3 WO1999006552A3 PCT/IB1998/001236 IB9801236W WO9906552A3 WO 1999006552 A3 WO1999006552 A3 WO 1999006552A3 IB 9801236 W IB9801236 W IB 9801236W WO 9906552 A3 WO9906552 A3 WO 9906552A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ests
- secreted proteins
- brain
- proteins expressed
- sequences
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 210000004556 brain Anatomy 0.000 title 1
- 108020004635 Complementary DNA Proteins 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 238000003200 chromosome mapping Methods 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 239000013606 secretion vector Substances 0.000 abstract 1
- 238000011144 upstream manufacturing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98936594A EP1000150B1 (fr) | 1997-08-01 | 1998-07-31 | Est 5' pour proteines secretees exprimees dans le cerveau |
CA002296667A CA2296667A1 (fr) | 1997-08-01 | 1998-07-31 | Est 5' pour proteines secretees exprimees dans le cerveau |
DE69834190T DE69834190T2 (de) | 1997-08-01 | 1998-07-31 | 5' ests für sekretierte proteine die im gehirn expremiert werden |
AU85555/98A AU8555598A (en) | 1997-08-01 | 1998-07-31 | 5' ests for secreted proteins expressed in brain |
JP2000505293A JP2001512015A (ja) | 1997-08-01 | 1998-07-31 | 脳における分泌タンパク質の5’est |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/905,223 | 1997-08-01 | ||
US08/905,223 US6222029B1 (en) | 1997-08-01 | 1997-08-01 | 5′ ESTs for secreted proteins expressed in brain |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1999006552A2 WO1999006552A2 (fr) | 1999-02-11 |
WO1999006552A3 true WO1999006552A3 (fr) | 1999-04-22 |
WO1999006552B1 WO1999006552B1 (fr) | 1999-06-03 |
Family
ID=25420448
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB1998/001236 WO1999006552A2 (fr) | 1997-08-01 | 1998-07-31 | Est 5' pour proteines secretees exprimees dans le cerveau |
Country Status (8)
Country | Link |
---|---|
US (1) | US6222029B1 (fr) |
EP (1) | EP1000150B1 (fr) |
JP (1) | JP2001512015A (fr) |
AT (1) | ATE323161T1 (fr) |
AU (1) | AU8555598A (fr) |
CA (1) | CA2296667A1 (fr) |
DE (1) | DE69834190T2 (fr) |
WO (1) | WO1999006552A2 (fr) |
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US7119190B2 (en) | 1997-04-14 | 2006-10-10 | Arena Pharmaceuticals, Inc. | Endogenous and non-endogenous versions of human G protein-coupled receptors |
US6555339B1 (en) | 1997-04-14 | 2003-04-29 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human protein-coupled receptors |
US20020127576A1 (en) * | 1997-06-16 | 2002-09-12 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
CA2248971A1 (fr) * | 1997-10-31 | 1999-04-30 | Kyowa Hakko Kogyo Co., Ltd. | Beta-1,3-n-acetylglucosaminyltransferase, adn l'encodant et son utilisation |
US6548633B1 (en) | 1998-12-22 | 2003-04-15 | Genset, S.A. | Complementary DNA's encoding proteins with signal peptides |
US7045612B2 (en) | 1998-01-16 | 2006-05-16 | Mcgill University | Human methionine synthase reductase: cloning, and methods for evaluating risk of neural tube defects, cardiovascular disease, and cancer |
AU3648499A (en) * | 1998-04-17 | 1999-11-08 | Emory University | Protein phosphatase methylesterase dna |
AU2006202355B2 (en) * | 1998-05-01 | 2009-08-20 | Glaxosmithkline Biologicals Sa | Neisseria meningitidis antigens and compositions |
US6096526A (en) | 1998-05-20 | 2000-08-01 | Incyte Pharmaceuticals, Inc. | Human nucleic acid methylases |
US6825328B1 (en) * | 1998-07-20 | 2004-11-30 | Stephen W. Scherer | Lafora's disease gene |
DK1098972T3 (da) * | 1998-07-22 | 2011-01-03 | Smithkline Beecham Ltd | Protein med lighed med neuroendokrinspecifikt protein samt cDNA kodende derfor |
WO2000011163A1 (fr) * | 1998-08-20 | 2000-03-02 | Regeneron Pharmaceuticals, Inc. | Dcr5, proteine de fixation de proteines morphogenetiques osseuses, et ses applications |
US7465785B2 (en) * | 1999-03-08 | 2008-12-16 | Genentech, Inc. | Polypeptide encoded by a nucleic acid over-expressed in melanoma |
AU782985B2 (en) * | 1999-04-09 | 2005-09-15 | Curagen Corporation | Novel human proteins and polynucleotides encoding them |
JP2001269184A (ja) * | 1999-06-28 | 2001-10-02 | Takeda Chem Ind Ltd | 新規タンパク質およびそのdna |
WO2001000799A1 (fr) * | 1999-06-28 | 2001-01-04 | Takeda Chemical Industries, Ltd. | Nouvelle proteine et son adn |
US6596527B1 (en) * | 1999-07-31 | 2003-07-22 | Board Of Regents, The University Of Texas Sytem | Composition and methods relating to SENP 1- a sentrin-specific protease |
ES2189560B1 (es) * | 1999-10-01 | 2005-01-01 | Consejo Superior De Investigaciones Cientificas | Dna polimerasa k, nuevo marcador tumoral. |
WO2001036471A2 (fr) * | 1999-11-17 | 2001-05-25 | Arena Pharmaceuticals, Inc. | Versions endogenes et non-endogenes de recepteurs couples a la proteine g humaine |
AU2001252585A1 (en) * | 2000-04-28 | 2001-11-26 | Takeda Chemical Industries Ltd. | Novel g protein-coupled receptor protein and dna thereof |
CA2409752A1 (fr) * | 2000-05-16 | 2001-11-22 | Children's Mercy Hospital | Sondes d'hybridation genomiques a copie unique et procede de generation de telles sondes |
US6828097B1 (en) * | 2000-05-16 | 2004-12-07 | The Childrens Mercy Hospital | Single copy genomic hybridization probes and method of generating same |
AU7931301A (en) * | 2000-08-04 | 2002-02-18 | Dmi Biosciences Inc | Method of using diketopiperazines and composition containing them |
US7048931B1 (en) | 2000-11-09 | 2006-05-23 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
WO2002083921A2 (fr) | 2001-04-10 | 2002-10-24 | Agensys, Inc. | Acides nucleiques et proteines correspondantes utiles pour la detection et le traitement de divers cancers |
US7927597B2 (en) | 2001-04-10 | 2011-04-19 | Agensys, Inc. | Methods to inhibit cell growth |
US6902902B2 (en) | 2001-11-27 | 2005-06-07 | Arena Pharmaceuticals, Inc. | Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders |
US20030023042A1 (en) * | 2001-12-06 | 2003-01-30 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
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EP2537524B1 (fr) | 2003-05-15 | 2016-07-06 | Ampio Pharmaceuticals, Inc. | Traitement de maladies induites par les lymphocytes T |
WO2004111085A1 (fr) * | 2003-06-10 | 2004-12-23 | Xantos Biomedicine Ag | Facteur angiogenique et son utilisation medicale |
EP1802659A2 (fr) * | 2004-07-02 | 2007-07-04 | Genentech, Inc. | Compositions et procedes pour le traitement de lymphome non hodgkinien |
US8354237B2 (en) * | 2007-02-02 | 2013-01-15 | University Of Vermont And State Agriculture College | Anti-methylation-controlled j protein antibodies and uses thereof |
WO2009146320A1 (fr) | 2008-05-27 | 2009-12-03 | Dmi Life Sciences, Inc. | Procédés et composés thérapeutiques |
US8507496B2 (en) | 2010-09-07 | 2013-08-13 | Dmi Acquisition Corp. | Treatment of diseases |
EP3721884A1 (fr) | 2011-10-10 | 2020-10-14 | Ampio Pharmaceuticals, Inc. | Traitement de maladies articulaires dégénératives avec da-dkp (= diketopiperazine aspartyl-alanyl) |
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SG11201400283RA (en) | 2011-10-28 | 2014-03-28 | Ampio Pharmaceuticals Inc | Treatment of rhinitis |
WO2014011742A1 (fr) | 2012-07-11 | 2014-01-16 | University Of Vermont And State Agricultural College | Procédé et composition pour régulation métabolique |
CN105101965B (zh) | 2013-03-15 | 2021-03-09 | 安皮奥制药股份有限公司 | 用于干细胞活动化、归巢、扩增和分化的组合物及其使用方法 |
EP3183240A4 (fr) | 2014-08-18 | 2018-06-27 | Ampio Pharmaceuticals, Inc. | Traitement de pathologies articulaires |
AU2016220024B2 (en) | 2015-02-18 | 2020-10-15 | University Of Vermont And State Agricultural College | MCJ agonists and uses therefor |
US11389512B2 (en) | 2015-06-22 | 2022-07-19 | Ampio Pharmaceuticals, Inc. | Use of low molecular weight fractions of human serum albumin in treating diseases |
EP3319636A2 (fr) | 2015-07-10 | 2018-05-16 | University of Vermont and State Agricultural College | Procédés et compositions pour traiter des maladies et des états induits par des médicaments |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0279582A2 (fr) * | 1987-02-17 | 1988-08-24 | Pharming B.V. | Séquences d'ADN pour diriger des protéines vers les glandes mammaires afin d'être sécrétées efficacement |
EP0625572A1 (fr) * | 1992-09-25 | 1994-11-23 | The Kanagawa Academy Of Science And Technology Foundation | PROCEDE POUR SYNTHETISER UN ADNc DE LONGUEUR COMPLETE, PROCEDE POUR PRODUIRE UN INTERMEDIAIRE DE CET ADNc, ET PROCEDE POUR PRODUIRE UN VECTEUR DE RECOMBINAISON CONTENANT CET ADNc |
WO1996034981A2 (fr) * | 1995-05-02 | 1996-11-07 | Genset Sa | METHODE DE COUPLAGE SPECIFIQUE DE LA COIFFE DE L'EXTREMITE 5' D'UN FRAGMENT D'ARNm ET PREPARATION D'ARNm ET D'ADNc COMPLET |
WO1997007198A2 (fr) * | 1995-08-11 | 1997-02-27 | Genetics Institute, Inc. | Sequences d'adn et proteines secretees codees par celles-ci |
-
1997
- 1997-08-01 US US08/905,223 patent/US6222029B1/en not_active Expired - Lifetime
-
1998
- 1998-07-31 CA CA002296667A patent/CA2296667A1/fr not_active Abandoned
- 1998-07-31 DE DE69834190T patent/DE69834190T2/de not_active Expired - Lifetime
- 1998-07-31 AT AT98936594T patent/ATE323161T1/de not_active IP Right Cessation
- 1998-07-31 WO PCT/IB1998/001236 patent/WO1999006552A2/fr active IP Right Grant
- 1998-07-31 JP JP2000505293A patent/JP2001512015A/ja active Pending
- 1998-07-31 AU AU85555/98A patent/AU8555598A/en not_active Abandoned
- 1998-07-31 EP EP98936594A patent/EP1000150B1/fr not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0279582A2 (fr) * | 1987-02-17 | 1988-08-24 | Pharming B.V. | Séquences d'ADN pour diriger des protéines vers les glandes mammaires afin d'être sécrétées efficacement |
EP0625572A1 (fr) * | 1992-09-25 | 1994-11-23 | The Kanagawa Academy Of Science And Technology Foundation | PROCEDE POUR SYNTHETISER UN ADNc DE LONGUEUR COMPLETE, PROCEDE POUR PRODUIRE UN INTERMEDIAIRE DE CET ADNc, ET PROCEDE POUR PRODUIRE UN VECTEUR DE RECOMBINAISON CONTENANT CET ADNc |
WO1996034981A2 (fr) * | 1995-05-02 | 1996-11-07 | Genset Sa | METHODE DE COUPLAGE SPECIFIQUE DE LA COIFFE DE L'EXTREMITE 5' D'UN FRAGMENT D'ARNm ET PREPARATION D'ARNm ET D'ADNc COMPLET |
WO1997007198A2 (fr) * | 1995-08-11 | 1997-02-27 | Genetics Institute, Inc. | Sequences d'adn et proteines secretees codees par celles-ci |
Non-Patent Citations (11)
Title |
---|
ADAMS M D ET AL: "3,400 NEW EXPRESSED SEQUENCE TAGS IDENTIFY DIVERSITY OF TRANSCRIPTS IN HUMAN BRAIN", NATURE GENETICS, vol. 4, no. 3, July 1993 (1993-07-01), pages 256 - 267, XP000645060 * |
ADAMS M D ET AL: "RAPID CDNA SEQUENCING (EXPRESSED SEQUENCE TAGS) FROM A DIRECTIONALLY CLONED HUMAN INFANT BRAIN CDNA LIBRARY", NATURE GENETICS, vol. 4, no. 4, August 1993 (1993-08-01), pages 373 - 380, STANDARD, XP002064427 * |
CARNINCI P. ET AL.: "High-efficiency full-length cDNA cloning by biotinylated CAP trapper", GENOMICS, vol. 37, no. 3, 1 November 1996 (1996-11-01), pages 327 - 336, XP002081729 * |
DATABASE EMBL - R55U017 22 August 1996 (1996-08-22), LLOYD, D.: "Human DNA sequence *** SEQUENCING IN PROGRESS *** from clone 181C9", XP002083782 * |
GREENWOOD M T ET AL: "Cloning of the gene encoding human somatostatin receptor 2: sequence analysis of the 5@?-flanking promoter region", GENE, vol. 159, no. 2, 4 July 1995 (1995-07-04), pages 291-292, XP004042228 * |
HEIJNE VON G.: "A new method for predicting signal sequence cleavage sites", NUCLEIC ACIDS RESEARCH, vol. 14, no. 11, 1986, pages 4683 - 4690, XP002053954 * |
KATO S. ET AL.: "Construction of a human full-length cDNA bank", GENE, vol. 150, 1994, pages 243 - 250, XP002081364 * |
LIN Y ET AL: "INHIBITION OF NUCLEAR TRANSLOCATION OF TRANSCRIPTION FACTOR NF-KB BY A SYNTHETIC PEPTIDE CONTAINING A CELL MEMBRANE-PERMEABLE MOTIF AND NUCLEAR LOCALIZATION SEQUENCE", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 24, 16 June 1995 (1995-06-16), pages 14255 - 14258, XP002050723 * |
LOCKHART D J ET AL: "EXPRESSION MONITORING BY HYBRIDIZATION TO HIGH-DENSITY OLIGONUCLEOTIDE ARRAYS", BIO/TECHNOLOGY, vol. 14, no. 13, December 1996 (1996-12-01), pages 1675 - 1680, XP002022521 * |
TASHIRO K. ET AL.: "Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins", SCIENCE, vol. 261, 30 July 1993 (1993-07-30), pages 600 - 603, XP000673204 * |
YOKOYAMA-KOBAYASHI M. ET AL.: "A signal sequence detection system using secreted protease activity as an indicator", GENE, vol. 163, 1995, pages 193 - 196, XP002053953 * |
Also Published As
Publication number | Publication date |
---|---|
US6222029B1 (en) | 2001-04-24 |
EP1000150B1 (fr) | 2006-04-12 |
DE69834190T2 (de) | 2007-01-11 |
CA2296667A1 (fr) | 1999-02-11 |
DE69834190D1 (de) | 2006-05-24 |
AU8555598A (en) | 1999-02-22 |
ATE323161T1 (de) | 2006-04-15 |
WO1999006552B1 (fr) | 1999-06-03 |
JP2001512015A (ja) | 2001-08-21 |
WO1999006552A2 (fr) | 1999-02-11 |
EP1000150A2 (fr) | 2000-05-17 |
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