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WO1999005172A3 - Pharmaceuticals for modulating hormone responsiveness - Google Patents

Pharmaceuticals for modulating hormone responsiveness Download PDF

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Publication number
WO1999005172A3
WO1999005172A3 PCT/CA1998/000715 CA9800715W WO9905172A3 WO 1999005172 A3 WO1999005172 A3 WO 1999005172A3 CA 9800715 W CA9800715 W CA 9800715W WO 9905172 A3 WO9905172 A3 WO 9905172A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
proteins
sequence
hormone
calreticulin
Prior art date
Application number
PCT/CA1998/000715
Other languages
French (fr)
Other versions
WO1999005172A2 (en
Inventor
Shoukat Dedhar
Claus-Jens Walter Doersen
Adam Weislaw Mazur
Original Assignee
Shoukat Dedhar
Doersen Claus Jens Walter
Adam Weislaw Mazur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/377,432 external-priority patent/US5854202A/en
Priority claimed from US08/900,241 external-priority patent/US6518397B1/en
Application filed by Shoukat Dedhar, Doersen Claus Jens Walter, Adam Weislaw Mazur filed Critical Shoukat Dedhar
Priority to AU85251/98A priority Critical patent/AU8525198A/en
Priority to EP98936040A priority patent/EP1001986A2/en
Priority to CA002298930A priority patent/CA2298930A1/en
Priority to JP2000556581A priority patent/JP2002519306A/en
Priority to KR1020007000808A priority patent/KR20010022235A/en
Publication of WO1999005172A2 publication Critical patent/WO1999005172A2/en
Publication of WO1999005172A3 publication Critical patent/WO1999005172A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725—Proteoglycans, e.g. aggreccan
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention relates to isolated and purified proteins, such as calreticulin and mimetics and inhibitors of calreticulin, for a novel use of modulating hormone responsiveness. These proteins are useful in gene therapy and in manufacturing pharmaceuticals for treating a variety of diseases, including cancer, osteoporosis and chronic inflammatory disease. The proteins include or bind to an amino acid sequence [SEQ ID NO:1] KXFFX1R, wherein X is either G, A or V and X1 is either K or R. This sequence is present in the DNA-binding domain, and is critical for the DNA binding activity, of a variety of hormone receptors, including glucocorticoid receptor, minerolcorticoid receptor, androgen receptor, progesterone receptor, estrogen receptor, retinoic acid receptor, thyroid hormone receptor and vitamin D receptor. Proteins which bind to this sequence may inhibit hormone receptor induced gene transcription. Proteins which include this sequence may promote hormone receptor induced gene transcription. The invention includes isolated DNA molecules for these proteins, methods of treating diseases using these proteins, synthetic peptides or their mimetics.
PCT/CA1998/000715 1995-01-24 1998-07-24 Pharmaceuticals for modulating hormone responsiveness WO1999005172A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU85251/98A AU8525198A (en) 1997-07-24 1998-07-24 Pharmaceuticals for modulating hormone responsiveness
EP98936040A EP1001986A2 (en) 1997-07-24 1998-07-24 Pharmaceuticals for modulating hormone responsiveness
CA002298930A CA2298930A1 (en) 1997-07-24 1998-07-24 Pharmaceuticals for modulating hormone responsiveness
JP2000556581A JP2002519306A (en) 1997-07-24 1998-07-24 Pharmaceuticals for regulating hormone responsiveness
KR1020007000808A KR20010022235A (en) 1997-07-24 1998-07-24 Pharmaceuticals for modulating hormone responsiveness

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/377,432 US5854202A (en) 1995-01-24 1995-01-24 Peptide fragments of calreticulin, peptide mimetics thereof, and pharmaceutical compostions comprising same
US08/900,241 US6518397B1 (en) 1997-07-24 1997-07-24 Pharmaceuticals for modulating hormone responsiveness
US08/900,241 1997-07-24

Publications (2)

Publication Number Publication Date
WO1999005172A2 WO1999005172A2 (en) 1999-02-04
WO1999005172A3 true WO1999005172A3 (en) 1999-04-15

Family

ID=27007809

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1998/000715 WO1999005172A2 (en) 1995-01-24 1998-07-24 Pharmaceuticals for modulating hormone responsiveness

Country Status (1)

Country Link
WO (1) WO1999005172A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020084005A1 (en) * 2018-10-23 2020-04-30 Myelopro Diagnostics And Research Gmbh Compounds targeting mutant calreticulin

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993014098A1 (en) * 1992-01-10 1993-07-22 Sloan-Kettering Institute For Cancer Research Antigen recognized by patients with antibody associated lambert-eaton myasthenic syndrome (lems), dna encoding same and uses thereof
CA2140814A1 (en) * 1995-01-23 1996-07-24 Shoukat Dedhar Use of calreticulin in modulating hormone responsiveness and new pharmaceuticals for treating cancer, osteoporosis and chronic inflammatory disease
WO1996023001A1 (en) * 1995-01-24 1996-08-01 Shoukat Dedhar New pharmaceuticals for modulating hormone responsiveness

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993014098A1 (en) * 1992-01-10 1993-07-22 Sloan-Kettering Institute For Cancer Research Antigen recognized by patients with antibody associated lambert-eaton myasthenic syndrome (lems), dna encoding same and uses thereof
CA2140814A1 (en) * 1995-01-23 1996-07-24 Shoukat Dedhar Use of calreticulin in modulating hormone responsiveness and new pharmaceuticals for treating cancer, osteoporosis and chronic inflammatory disease
WO1996023001A1 (en) * 1995-01-24 1996-08-01 Shoukat Dedhar New pharmaceuticals for modulating hormone responsiveness

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
COPPOLINO M G ET AL: "CALRETICULIN IS ESSENTIAL FOR INTEGRIN-MEDIATED CALCIUM SIGNALLING AND CELL ADHESION", NATURE, vol. 386, 24 April 1997 (1997-04-24), pages 843 - 847, XP002072201 *
Y. CHOI ET AL.: "Tissue-specific and developmental regulation of a gene encoding a low-molecular weight sulfur-rich protein in soybean seeds", MOL. GEN. GENET, vol. 246, 1995, pages 266 - 268, XP002092536 *

Also Published As

Publication number Publication date
WO1999005172A2 (en) 1999-02-04

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