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WO1999004301A1 - Microscope a balayage, a tete miniature - Google Patents

Microscope a balayage, a tete miniature Download PDF

Info

Publication number
WO1999004301A1
WO1999004301A1 PCT/AU1998/000561 AU9800561W WO9904301A1 WO 1999004301 A1 WO1999004301 A1 WO 1999004301A1 AU 9800561 W AU9800561 W AU 9800561W WO 9904301 A1 WO9904301 A1 WO 9904301A1
Authority
WO
WIPO (PCT)
Prior art keywords
scanning microscope
light
scanner
microscope
optical
Prior art date
Application number
PCT/AU1998/000561
Other languages
English (en)
Inventor
Martin Russell Harris
Original Assignee
Optiscan Pty. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Optiscan Pty. Ltd. filed Critical Optiscan Pty. Ltd.
Priority to GB9924347A priority Critical patent/GB2340332B/en
Priority to DE19882512T priority patent/DE19882512T1/de
Priority to AU83249/98A priority patent/AU8324998A/en
Publication of WO1999004301A1 publication Critical patent/WO1999004301A1/fr

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes

Definitions

  • the optical head of the scanning microscope In order to construct a scanning microscope which has an optical head small enough to be inserted in the body to act as an endoscope, whereby internal organs of the body may be inspected at a microscopic level, the optical head of the scanning microscope must be able to be located physically independently of the bulky light source and photo-multiplier tube, and also must be miniaturised.
  • a scanner mounted in an optical head casing with the light focusing means, to cause the illuminated point observational field to scan over a two- dimensional cross-section of the object such that an image of the object emanated light received by the detector over the cross section may be constructed; wherein the scanner comprises counterbalancing elements to balance reactive forces caused by operation of the scanner, such that vibration of the light focusing means caused by coupling of the reactive forces to the light focusing means is reduced.
  • the scanner scans the point observational field in a raster fashion, the scanner having a fast scanner to scan over rows and a slow scanner operating in a transverse direction to the fast scanner to displace consecutive rows .
  • the counterbalancing elements may balance the reactive forces associated with the fast scan.
  • the microscope may be non-confocal .
  • at least a portion of the object emanated light emanating from the point observational field may be collected and returned via means other than the exit end of the optical transmission means .
  • Such a non-con ocal microscope may be adapted to two-photon microscopy.
  • the slow scanner may function by contraction and elongation of a wire whose dimensions are controlled by temperature variation caused by a varying electrical control current through the wire.
  • the slow scanner may function by a hydraulic actuator mechanism connected by a fluid conducting tube to a hydraulic driver pump remotely located which pumps fluid into and out of the hydraulic actuator in the optical head case.
  • the inertia may be reduced by hydrofluoric acid etching of the region of the fibre proximate the exit end.
  • optical head case 1 providing an endoscope head shown in juxtaposition to tissue 2 for ⁇ n vivo observation.
  • Optical transmission means 3 in the form of a single mode optical fibre passes down flexible endoscope tube 30 from a remotely located laser light source, detector and electronics .
  • the remotely located component may be constructed in accordance with the single fibre embodiments described in US Patent 5,120,953 by Harris and need not be repeated here.
  • Modifications may be made to the invention as would be apparent to a person skilled in the art of scanning microscope design.
  • the scope of the invention is not limited to confocal arrangements, and suitably miniaturised heads may be provided which make use of two photon fluorescence, which does not require a confocal return of illumination.
  • the cladding of the fibre 3 can be used to return near- confocal, as described in PCT/AU96/00159.
  • etching of the exit end of the fibre to reduce inertia may need to be performed so as to produce a step rather than a taper.
  • the use of a specially produced fibre with reduced diameter cladding, of total glass diameter about 25 microns is also contemplated.

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Microscoopes, Condenser (AREA)

Abstract

L'invention concerne un microscope à balayage comprenant: (1) une source lumineuse pour l'alimentation en faisceau lumineux; (2) un moyeu de transmission optique pour la transmission du faisceau lumineux d'une extrémité d'entrée de celui-ci, située à proximité de la source lumineuse, à une extrémité de sortie de celui-ci, située à proximité d'un moyen de concentration de lumière qui concentre la lumière sortant de l'extrémité de sortie pour illuminer un champ d'observation ponctuel sur ou dans un objet à examiner; (3) un détecteur pour détecter la lumière dégagée par un objet et provenant du champ d'observation ponctuel; (4) un scanneur monté dans un boîtier de tête optique conjointement avec le moyen de concentration de lumière, permet au champ d'observation ponctuel illuminé de balayer une section bidimensionnelle de l'objet de sorte que l'image de la lumière dégagée par l'objet et reçue par le détecteur sur la section puisse être construite. Ledit scanneur comporte des éléments d'équilibrage qui équilibrent les forces réactives induites par le fonctionnement du scanneur, de sorte que la vibration du moyen de concentration de lumière induite par le couplage des forces réactives au moyen de concentration de lumière soit réduite.
PCT/AU1998/000561 1997-07-16 1998-07-16 Microscope a balayage, a tete miniature WO1999004301A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB9924347A GB2340332B (en) 1997-07-16 1998-07-16 Scanning microscope with miniature head
DE19882512T DE19882512T1 (de) 1997-07-16 1998-07-16 Abtastmikroskop mit Miniaturkopf
AU83249/98A AU8324998A (en) 1997-07-16 1998-07-16 Scanning microscope with miniature head

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPO7901 1997-07-16
AUPO7901A AUPO790197A0 (en) 1997-07-16 1997-07-16 Scanning microscope with miniature head

Publications (1)

Publication Number Publication Date
WO1999004301A1 true WO1999004301A1 (fr) 1999-01-28

Family

ID=3802191

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU1998/000561 WO1999004301A1 (fr) 1997-07-16 1998-07-16 Microscope a balayage, a tete miniature

Country Status (4)

Country Link
AU (1) AUPO790197A0 (fr)
DE (1) DE19882512T1 (fr)
GB (1) GB2340332B (fr)
WO (1) WO1999004301A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000075712A1 (fr) * 1999-06-08 2000-12-14 Optiscan Pty Ltd Systeme de diapason electrique
AU759742B2 (en) * 1999-06-08 2003-05-01 Optiscan Pty Limited Electrically operated tuning fork
US7023622B2 (en) 2002-08-06 2006-04-04 Dmetrix, Inc. Miniature microscope objective lens
US7113651B2 (en) 2002-11-20 2006-09-26 Dmetrix, Inc. Multi-spectral miniature microscope array
US7248390B2 (en) 2002-03-26 2007-07-24 Pentax Corporation Light scanning device
US7532375B2 (en) 2004-09-24 2009-05-12 Hoya Corporation Tuning-fork-type scanning apparatus with a counterweight
US8840566B2 (en) 2007-04-02 2014-09-23 University Of Washington Catheter with imaging capability acts as guidewire for cannula tools
US9161684B2 (en) 2005-02-28 2015-10-20 University Of Washington Monitoring disposition of tethered capsule endoscope in esophagus
US9226687B2 (en) 2003-12-12 2016-01-05 University Of Washington Catheterscope 3D guidance and interface system
US9561078B2 (en) 2006-03-03 2017-02-07 University Of Washington Multi-cladding optical fiber scanner

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1592992B1 (fr) 2003-01-24 2012-05-30 University of Washington Systeme de balayage a faisceau optique destine a l'affichage ou l'acquisition d'images compact

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5330394A (en) * 1992-10-23 1994-05-24 Monash University Confocal microscope and endoscope
GB2289759A (en) * 1994-05-11 1995-11-29 Khaled Karrau Scanning probe microscope
AU4933296A (en) * 1995-03-24 1996-10-16 Optiscan Pty Limited Optical fibre confocal imager with variable near-confocal control
US5788639A (en) * 1995-07-13 1998-08-04 Lucid Technologies, Inc. Confocal imaging through thick dermal tissue

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04296811A (ja) * 1991-03-27 1992-10-21 Fuji Photo Film Co Ltd 走査型顕微鏡
JPH05127682A (ja) * 1991-11-05 1993-05-25 Fuji Photo Film Co Ltd 音叉の駆動音消音装置および走査型顕微鏡
JPH09159925A (ja) * 1995-12-14 1997-06-20 Ishikawajima Harima Heavy Ind Co Ltd 走査式レーザ顕微鏡

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5330394A (en) * 1992-10-23 1994-05-24 Monash University Confocal microscope and endoscope
GB2289759A (en) * 1994-05-11 1995-11-29 Khaled Karrau Scanning probe microscope
AU4933296A (en) * 1995-03-24 1996-10-16 Optiscan Pty Limited Optical fibre confocal imager with variable near-confocal control
US5788639A (en) * 1995-07-13 1998-08-04 Lucid Technologies, Inc. Confocal imaging through thick dermal tissue

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DERWENT ABSTRACT, Accession No. 97-376446, Class U11; & JP,A,09 159 925 (ISHIKA WAJIMA HARIMA HEAVY IND) 20 June 1997. *
PATENT ABSTRACTS OF JAPAN; & JP,A,04 296 811 (FUJI PHOTO FILM CO LTD) 21 October 1992. *
PATENT ABSTRACTS OF JAPAN; & JP,A,05 127 682 (FUJI PHOTO FILM CO LTD) 25 May 1993. *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000075712A1 (fr) * 1999-06-08 2000-12-14 Optiscan Pty Ltd Systeme de diapason electrique
AU759742B2 (en) * 1999-06-08 2003-05-01 Optiscan Pty Limited Electrically operated tuning fork
US7010978B1 (en) 1999-06-08 2006-03-14 Optiscan Pty Ltd. Electrically operated tuning fork
US7248390B2 (en) 2002-03-26 2007-07-24 Pentax Corporation Light scanning device
US7023622B2 (en) 2002-08-06 2006-04-04 Dmetrix, Inc. Miniature microscope objective lens
US7113651B2 (en) 2002-11-20 2006-09-26 Dmetrix, Inc. Multi-spectral miniature microscope array
US9226687B2 (en) 2003-12-12 2016-01-05 University Of Washington Catheterscope 3D guidance and interface system
US9554729B2 (en) 2003-12-12 2017-01-31 University Of Washington Catheterscope 3D guidance and interface system
US7532375B2 (en) 2004-09-24 2009-05-12 Hoya Corporation Tuning-fork-type scanning apparatus with a counterweight
US9161684B2 (en) 2005-02-28 2015-10-20 University Of Washington Monitoring disposition of tethered capsule endoscope in esophagus
US9872613B2 (en) 2005-02-28 2018-01-23 University Of Washington Monitoring disposition of tethered capsule endoscope in esophagus
US9561078B2 (en) 2006-03-03 2017-02-07 University Of Washington Multi-cladding optical fiber scanner
US8840566B2 (en) 2007-04-02 2014-09-23 University Of Washington Catheter with imaging capability acts as guidewire for cannula tools

Also Published As

Publication number Publication date
GB2340332B (en) 2001-05-30
GB2340332A (en) 2000-02-16
DE19882512T1 (de) 2000-09-07
GB9924347D0 (en) 1999-12-15
AUPO790197A0 (en) 1997-08-07

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