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WO1999003397A1 - Procede et dispositif pour therapie par rayonnement et hyperthermie de tumeurs - Google Patents

Procede et dispositif pour therapie par rayonnement et hyperthermie de tumeurs Download PDF

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Publication number
WO1999003397A1
WO1999003397A1 PCT/US1998/014450 US9814450W WO9903397A1 WO 1999003397 A1 WO1999003397 A1 WO 1999003397A1 US 9814450 W US9814450 W US 9814450W WO 9903397 A1 WO9903397 A1 WO 9903397A1
Authority
WO
WIPO (PCT)
Prior art keywords
radiation
tumor
beams
sources
cells
Prior art date
Application number
PCT/US1998/014450
Other languages
English (en)
Inventor
Keith L. Black
Edward M. Halimi
Original Assignee
Medlennium Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medlennium Technologies, Inc. filed Critical Medlennium Technologies, Inc.
Priority to AU83979/98A priority Critical patent/AU8397998A/en
Publication of WO1999003397A1 publication Critical patent/WO1999003397A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1077—Beam delivery systems
    • A61N5/1084—Beam delivery systems for delivering multiple intersecting beams at the same time, e.g. gamma knives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/02—Radiation therapy using microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1077—Beam delivery systems
    • A61N5/1081—Rotating beam systems with a specific mechanical construction, e.g. gantries
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B2018/2035—Beam shaping or redirecting; Optical components therefor
    • A61B2018/20351—Scanning mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B2018/208—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser with multiple treatment beams not sharing a common path, e.g. non-axial or parallel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/1055—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using magnetic resonance imaging [MRI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/1061—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using an x-ray imaging system having a separate imaging source

Definitions

  • the present invention relates generally to treating tumors with radiation. More particularly, the present invention is directed to hyperthermia procedures where radiation is used to heat tumor cells to therapeutic temperatures which are lethal to the tumor cells.
  • Radio frequency (RF) radiation have both been used as the source of energy in hyperthermia procedures.
  • Controlling the amount of collateral damage which occurs during radiation hyperthermia treatment of brain tumors and deep body tumors is particularly complicated because the various tissue and bone cells through which radiation must travel to reach the tumor absorb and transmit radiation at different levels. As a result, there is the potential for forming complex patterns of standing waves and hot spots in healthy tissues and other parts of the body.
  • a system and procedures are provided for using radiation hyperthermia to selectively treat brain tumors and/or tumors located deep within the body.
  • the system and procedures provides maximum heating of tumors while at the same time minimizing collateral damage to healthy cells.
  • a system for applying a lethal dose of radiation to tumor cells located within a living mammal.
  • the tumor cells which may be treated by this system are in the form of a tumor or other group of cells having an exterior boundary which defines the tumor body.
  • the system is specifically designed to treat tumor bodies which are surrounded by non-tumorous cells.
  • the system includes a three- dimensional tumor imager that measures the tumor body and provides image data which accurately establishes the location of the tumor within the living mammal.
  • At least two radiation sources are provided which are located exteriorly of the mammal. Each of the radiation sources is capable of producing a well-defined beam of radiation. Beam directors associated with each of the radiation sources are provided to allow controllable pointing of the beams of radiation in desired directions.
  • a final element of the treatment system is a radiation control center, which receives image data from the tumor imager, and uses this data to control the beam directors to provide focusing of the two or more beams of radiation on the tumor body.
  • the radiation control center controls the intensity of radiation in each of the radiation beams, so that each individual beam is non-lethal to the non-tumorous cells, whereas the combined radiation intensities of the two or more beams of radiation focused on the tumor body are lethal to the tumor cells.
  • the present invention combines two principles to provide a single system which is especially well-suited for treating brain tumors and other tumors located deep within the body.
  • the first aspect of the invention deals with accurate three-dimensional imaging of the tumor using any of the current imaging equipment such as CAT scan or magnetic resonance imaging.
  • the three-dimensional boundary of the tumor is then digitized in the X, Y, Z axis with respect to reference points in the body, such as parts of spine joints and other bodily landmarks and the table upon which the patient is secured.
  • the patient is moved along with the table or the imaging equipment is removed and replaced with the therapy equipment.
  • the therapy equipment is positioned so that stored digital information outlining the three-dimensional boundary of the tumor can generate commands for movement of the therapy apparatus by means of actuators through the X, Y, Z axis in the same manner as a (CNC) machine tool.
  • CNC computer-controlled network controller
  • the point of convergence or intersection of radiation beams or other modality can transcribe the space within the volume of the tumor point by point and plane by plane, at a speed which can effectively impart the necessary radiation dosage or temperature rise to the tumor, until the entire volume of the tumor and its boundary layer, as determined by the physician, has received and been treated by the radiation or other prescribed modality.
  • the second aspect of the invention involves the use of multiple sources of radiation or microwave electromagnetic emitters or electron beams or other modality in several planes and from different directions in a manner such that all beams have a point of convergence at the tumor.
  • microwave apertures or point of intersection of various x-ray emitters can form a defined and concentrated point at which all various emitters converge their beams or pass through.
  • this invention also includes provisions for switching between various emitters so that the focal point in the case of phased array (or point of intersection in the case of multiple source emitters) is at all times receiving microwave energy from one or more sources while several of the sources are in the switched off position. This allows dissipation of heat by means of blood flow and conduction from the healthy tissues.
  • FIG. 1 is a side view of an exemplary preferred system for applying a lethal dose of radiation to tumor cells in accordance with the present invention.
  • FIG. 2 is a view of FIG. 1 taken in the 2-2 plane.
  • FIG. 3 is a partial top view of FIG. 1 showing exemplary movement of the radiation sources.
  • FIG. 4 is a schematic representation of a general radiation control center or system which is designed to receive image data from the tumor imager and use this data to provide control of the beam directors in order to focus the radiation beams on the tumor body.
  • the patient is securely strapped down or otherwise secured on a non-metallic surface.
  • An accurate three-dimensional image of the tumor using a magnetic resonance imaging (MRI) system or a CAT scan or such is obtained and digitized.
  • the digitized information is then used to direct the travel of an annular device around the patient to which is attached two or more sources of electromagnetic, ultrasound or other deep heat generating medium.
  • the sources of radiation must be capable of providing a concentrated and narrow beam so that the point of intersection of the multiple beams is at or near the geometrical center of the annular structure.
  • Means are provided for rotational travel of the annular structure around its geometrical center back and forth in predetermined arcs and speeds of rotation with means for adjustment depending on the procedure applied.
  • Means are also provided for changing the angle of sources of energy so that the point of intersection of the beams can be moved away along a line at or close to the geometric center of the annular structure and perpendicular to its plane.
  • the annular structure is supported by an overall structure which can travel in the X, Y, Z axis by means of computer controlled actuators receiving movement signals from the computer fed with the three-dimensional digitized image data of the tumor.
  • the energy sources are activated, the annular structure is given a circular movement around its geometric center and the geometric center of the annular structure which is also the center and point of intersection.
  • the multiple sources are controlled to systematically move the beam intersection or focal point within the volume of the tumor to be treated at a pre-determined speed which is calculated to generate the desired temperature rise within the tumor.
  • the calculations must take into account the intensity of the energy source, specific absorption rate (SAR) of the tissue and intensity of blood flow within the tissue.
  • SAR specific absorption rate
  • the rotational speed and travel arc of the annular structure around its geometrical center is calculated with respect to the absolute location of the tumor and with respect to the relative location of the tumor body with respect to the surrounding healthy skin, fat, tissue and bones in the path of heat generating radiation beams.
  • the geometric center of the annular structure and therefore point of application of the multiple beams remains within the tumor at all times.
  • the pathway of the beams through healthy body parts is varied.
  • natural blood flow reduces any heat buildup in the momentary pathway of the beams. Since the beams are constantly changing their pathway, any momentary temperature rise is reduced before the healthy tissues are subjected to toxic levels of radiation.
  • the above-described general procedure is preferably carried out using a system of the type shown generally at 10 in FIGS. 1 and 2.
  • the system 10 includes a three-dimensional tumor imager, such as an MRI or CAT scan which is shown generically at 1 2. Although a CAT scan or MRI is preferred, any imaging system may be used which is capable of providing image data which establishes accurately the location of the tumor body 14 within the patient 1 6.
  • the radiation sources 18, 20 and 22 are mounted to an annular ring 24.
  • the radiation sources 18, 20 and 22 are mounted to the annular ring 24 by way of beam directors 26, 28 and 30, respectively.
  • the beam directors 26, 28 and 30 are preferably servo- actuated universal movement devices, which provide a movable universal mounting for each of the radiation sources to the annular ring 24. As best shown by the double-headed arrows in FIGS. 2 and 3, the beam directors 26, 28 and 30 allow movement of the radiation sources 1 8, 20 and 22 in all three dimensions.
  • the use of servomotor mountings to provide accurate three- dimensional positioning of attached radiation devices is well known. Any of the highly accurate servomounting systems may be utilized.
  • the beam directors 26, 28 and 30 include sufficient mounting hardware and servomotors to allow accurate focusing of the radiation beams on the tumor 14 as best shown in FIGS. 2 and 3, where the phantom lines traveling from the radiation sources 1 8, 20 and 22 to the tumor body 14 are represented in phantom at 32.
  • a rotational drive mechanism be provided which can rotate the radiation sources around the tumor as represented by double-headed arrow 34.
  • a gear drive mechanism 36 and rollers 38 and 40 are provided for providing controlled rotation of the radiation sources 18, 20 and 22 about the patient 16.
  • a radiation control center or system (shown as control panel 42) is provided for receiving image data from the MRI 12.
  • the control center 42 is further designed to use this data to control the beam directors 26, 28 and 30 to focus the radiation beams 32 onto the tumor body 14 as best shown in FIGS. 2 and 3.
  • the control center 42 is designed also to provide control of the intensity of the radiation beams and rotation of annular ring 24, so that each individual beam is non-lethal to the non-tumorous cells whereas the combined radiation intensities of the beams as they intersect or focus upon tumor body
  • FIG. 4 An exemplary control system is shown in FIG. 4 where the numerical designations to the various schematic boxes correspond to the numerical designations in FIGS. 1 , 2 and 3.
  • the control system outlined in FIG. 4 is exemplary only, with it being understood that other control systems are possible provided that accurate feedback between the imaging system and radiation beam directors is provided so that accurate focusing of the radiation beams onto the tumor body is achieved.
  • the radiation sources 1 8, 20 and 22 may be switched on and off in order to further limit the exposure of normal tissues to radiation.
  • the switching frequency can be adjusted from several seconds on or off for each source, to several cycles per second with further adjustments. For instance, if twenty emitters are used with five sources on and fifteen sources off at any given time, then each emitter has a duty cycle of 25%. This means that for each second of microwave energy exposure in a healthy tissue, there are three seconds during which the healthy tissue can be cooled by blood flow, while the tumor is receiving constant dosage from five sources, or twenty times the dosage of a healthy tissue without pause for cooling down.
  • Systematic switching of the sources have various benefits over the use of multiple sources without switching the sources in an on-and-off fashion.
  • on-and-off switching eliminates standing waves which otherwise form at the boundary of bones or fat and tissue which result in formation of hot spots regardless of how benign each source is.
  • on-and-off switching allows natural heat conduction and blood flow to reduce any elevated temperatures at boundaries of various fat, tissue and bone formation.
  • the microwave sources By switching the microwave sources on and off based on the tumor temperature, energy output of microwave sources at the point of intersection of microwave beams, estimate of blood flow through the tumor and speed of traversing the intersection point of beams through the tumor, it is possible to calculate the temperature rise through the tumor within acceptable tolerances for effective destruction of tumor cells and without collateral damage to healthy tissues. Switching is carried out by the electronic control center 42 which will turn the emitting sources systematically on and off and can be programmed for various exposure modes depending on the size and nature of the tumor and its location in the body as well as the nature of surrounding healthy tissues and bone structure.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)

Abstract

Cette invention se rapporte à un système (10) comportant un imageur (12) de tumeur en trois dimensions du type dispositif pour examen IRM ou TDM, conçu pour permettre la localisation (14) d'une tumeur chez un patient (16). A cet effet, on dispose au minimum de deux sources (18, 20) de rayonnement disposées à l'extérieur du patient, qui peuvent délivrer un faisceau de rayonnement ayant une intensité sélectionnée.
PCT/US1998/014450 1997-07-17 1998-07-15 Procede et dispositif pour therapie par rayonnement et hyperthermie de tumeurs WO1999003397A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU83979/98A AU8397998A (en) 1997-07-17 1998-07-15 Method and apparatus for radiation and hyperthermia therapy of tumors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89576397A 1997-07-17 1997-07-17
US08/895,763 1997-07-17

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WO1999003397A1 true WO1999003397A1 (fr) 1999-01-28

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Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1257325A2 (fr) * 2000-02-18 2002-11-20 William Beaumont Hospital Tomographie informatisee a faisceau conique avec un imageur a panneau plat
FR2839894A1 (fr) * 2002-05-21 2003-11-28 Chabunda Christophe Mwanza Procedes, appareils de cyclotherapie image-guidee et mode d'obtention d'images scanographiques diagnostiques instantanees pour la planification et la dosimetrie en ligne
EP1371389A1 (fr) * 2001-03-12 2003-12-17 ICHIKAWA, Masahide Methode de desagregation de tissus de cellules cancereuses par rayonnement microelectromagnetique et emetteur microelectromagnetique
WO2006115920A2 (fr) * 2005-04-28 2006-11-02 Boston Scientific Scimed, Inc. Système d'ablation de tissus à l'aide de faisceaux rf convergents multipoints
WO2007046983A2 (fr) * 2005-10-20 2007-04-26 Spectros Corporation Dispositif de tres grande specificite et procedes de criblage de tumeurs in vivo
WO2007067830A3 (fr) * 2005-12-09 2007-09-20 Boston Scient Scimed Inc Systeme de suivi d'une ablation aux rayons
EP1844814A1 (fr) * 2005-01-27 2007-10-17 Anatoly Vassilievich Kobzev Dispositif physiotherapeutique
EP1872827A1 (fr) * 2006-06-26 2008-01-02 Jan Forster Dispositif destiné à l'irradiation de tissus avec au moins une source d'électrons tout comme un grand nombre de têtes d'émetteurs de rayonnement
DE102007060189A1 (de) * 2007-12-14 2009-02-19 Siemens Ag Strahlentherapievorrichtung und Verfahren zur Steuerung einer Strahlentherapievorrichtung
WO2009045411A2 (fr) 2007-10-01 2009-04-09 Inspired Surgical Technologies, Inc. Système de chirurgie non invasive à base de photonique comprenant une régulation et une éradication cellulaire automatisés via une commande en aval précalculée plus une commande de rétroaction d'image pour un apport d'énergie ciblé
JP2009106695A (ja) * 2007-11-01 2009-05-21 Mitsubishi Heavy Ind Ltd 放射線治療システム
EP2124813A2 (fr) * 2006-11-21 2009-12-02 Mark Frazer Miller Procédé et système non effractifs d'utilisation d'une hyperthermie induite par radiofréquence pour le traitement de maladie
WO2011137514A1 (fr) * 2010-05-03 2011-11-10 University Health Network Agent pouvant être imagé et activé pour une radiothérapie et procédé et système pour une radiothérapie
US8588367B2 (en) 2007-02-07 2013-11-19 Koninklijke Philips N.V. Motion compensation in quantitative data analysis and therapy
US8611490B2 (en) 2006-04-14 2013-12-17 William Beaumont Hospital Tetrahedron beam computed tomography
US8983024B2 (en) 2006-04-14 2015-03-17 William Beaumont Hospital Tetrahedron beam computed tomography with multiple detectors and/or source arrays
US9192786B2 (en) 2006-05-25 2015-11-24 William Beaumont Hospital Real-time, on-line and offline treatment dose tracking and feedback process for volumetric image guided adaptive radiotherapy
US9320917B2 (en) 2010-01-05 2016-04-26 William Beaumont Hospital Intensity modulated arc therapy with continuous coach rotation/shift and simultaneous cone beam imaging
US9339243B2 (en) 2006-04-14 2016-05-17 William Beaumont Hospital Image guided radiotherapy with dual source and dual detector arrays tetrahedron beam computed tomography
US9421399B2 (en) 2002-12-18 2016-08-23 Varian Medical Systems, Inc. Multi-mode cone beam CT radiotherapy simulator and treatment machine with a flat panel imager
US9498167B2 (en) 2005-04-29 2016-11-22 Varian Medical Systems, Inc. System and methods for treating patients using radiation
US9630025B2 (en) 2005-07-25 2017-04-25 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US10004650B2 (en) 2005-04-29 2018-06-26 Varian Medical Systems, Inc. Dynamic patient positioning system
USRE46953E1 (en) 2007-04-20 2018-07-17 University Of Maryland, Baltimore Single-arc dose painting for precision radiation therapy
CN109646822A (zh) * 2019-02-26 2019-04-19 青岛大学附属医院 一种用于肿瘤医疗临床的放射定位设备及其使用方法
CN111200987A (zh) * 2017-09-06 2020-05-26 技术研发基金会有限公司 用于微创手术的机器人系统
US10773101B2 (en) 2010-06-22 2020-09-15 Varian Medical Systems International Ag System and method for estimating and manipulating estimated radiation dose
CN112107359A (zh) * 2019-06-19 2020-12-22 李峰 一种肿瘤高频热疗装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5485839A (en) * 1992-02-28 1996-01-23 Kabushiki Kaisha Toshiba Method and apparatus for ultrasonic wave medical treatment using computed tomography

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5485839A (en) * 1992-02-28 1996-01-23 Kabushiki Kaisha Toshiba Method and apparatus for ultrasonic wave medical treatment using computed tomography

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US8135111B2 (en) 2000-02-18 2012-03-13 William Beaumont Hospital Cone beam computed tomography with a flat panel imager
EP1257325A4 (fr) * 2000-02-18 2006-01-04 Beaumont Hospital William Tomographie informatisee a faisceau conique avec un imageur a panneau plat
US7826592B2 (en) 2000-02-18 2010-11-02 William Beaumont Hospital Cone-beam computed tomography with a flat-panel imager
US7471765B2 (en) 2000-02-18 2008-12-30 William Beaumont Hospital Cone beam computed tomography with a flat panel imager
EP1257325A2 (fr) * 2000-02-18 2002-11-20 William Beaumont Hospital Tomographie informatisee a faisceau conique avec un imageur a panneau plat
CN101422372B (zh) * 2000-02-18 2013-06-12 威廉博蒙特医院 带有平板成像器的锥面束计算机x线断层扫描系统
EP1371389A1 (fr) * 2001-03-12 2003-12-17 ICHIKAWA, Masahide Methode de desagregation de tissus de cellules cancereuses par rayonnement microelectromagnetique et emetteur microelectromagnetique
EP1371389A4 (fr) * 2001-03-12 2009-10-21 Masahide Ichikawa Methode de desagregation de tissus de cellules cancereuses par rayonnement microelectromagnetique et emetteur microelectromagnetique
FR2839894A1 (fr) * 2002-05-21 2003-11-28 Chabunda Christophe Mwanza Procedes, appareils de cyclotherapie image-guidee et mode d'obtention d'images scanographiques diagnostiques instantanees pour la planification et la dosimetrie en ligne
US11344748B2 (en) 2002-12-18 2022-05-31 Varian Medical Systems, Inc. Multi-mode cone beam CT radiotherapy simulator and treatment machine with a flat panel imager
US9421399B2 (en) 2002-12-18 2016-08-23 Varian Medical Systems, Inc. Multi-mode cone beam CT radiotherapy simulator and treatment machine with a flat panel imager
US9901750B2 (en) 2002-12-18 2018-02-27 Varian Medical Systems, Inc. Multi-mode cone beam CT radiotherapy simulator and treatment machine with a flat panel imager
EP1844814A1 (fr) * 2005-01-27 2007-10-17 Anatoly Vassilievich Kobzev Dispositif physiotherapeutique
EP1844814A4 (fr) * 2005-01-27 2009-02-25 Anatoly Vassilievich Kobzev Dispositif physiotherapeutique
WO2006115920A3 (fr) * 2005-04-28 2006-12-21 Boston Scient Scimed Inc Système d'ablation de tissus à l'aide de faisceaux rf convergents multipoints
WO2006115920A2 (fr) * 2005-04-28 2006-11-02 Boston Scientific Scimed, Inc. Système d'ablation de tissus à l'aide de faisceaux rf convergents multipoints
US9974494B2 (en) 2005-04-29 2018-05-22 Varian Medical Systems, Inc. System and methods for treating patients using radiation
US10004650B2 (en) 2005-04-29 2018-06-26 Varian Medical Systems, Inc. Dynamic patient positioning system
US9498167B2 (en) 2005-04-29 2016-11-22 Varian Medical Systems, Inc. System and methods for treating patients using radiation
US10881878B2 (en) 2005-04-29 2021-01-05 Varian Medical Systems, Inc. Dynamic patient positioning system
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US9788783B2 (en) 2005-07-25 2017-10-17 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US11642027B2 (en) 2005-07-25 2023-05-09 Siemens Healthineers International Ag Methods and apparatus for the planning and delivery of radiation treatments
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US9764159B2 (en) 2005-07-25 2017-09-19 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
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WO2007046983A3 (fr) * 2005-10-20 2007-05-31 Spectros Corp Dispositif de tres grande specificite et procedes de criblage de tumeurs in vivo
WO2007046983A2 (fr) * 2005-10-20 2007-04-26 Spectros Corporation Dispositif de tres grande specificite et procedes de criblage de tumeurs in vivo
US7962197B2 (en) 2005-12-09 2011-06-14 Boston Scientific Scimed, Inc. Radiation ablation tracking system and method
WO2007067830A3 (fr) * 2005-12-09 2007-09-20 Boston Scient Scimed Inc Systeme de suivi d'une ablation aux rayons
US7751869B2 (en) 2005-12-09 2010-07-06 Boston Scientific Scimed, Inc. Radiation ablation tracking system and method
US8983024B2 (en) 2006-04-14 2015-03-17 William Beaumont Hospital Tetrahedron beam computed tomography with multiple detectors and/or source arrays
US9339243B2 (en) 2006-04-14 2016-05-17 William Beaumont Hospital Image guided radiotherapy with dual source and dual detector arrays tetrahedron beam computed tomography
US8611490B2 (en) 2006-04-14 2013-12-17 William Beaumont Hospital Tetrahedron beam computed tomography
US9192786B2 (en) 2006-05-25 2015-11-24 William Beaumont Hospital Real-time, on-line and offline treatment dose tracking and feedback process for volumetric image guided adaptive radiotherapy
EP1872827A1 (fr) * 2006-06-26 2008-01-02 Jan Forster Dispositif destiné à l'irradiation de tissus avec au moins une source d'électrons tout comme un grand nombre de têtes d'émetteurs de rayonnement
EP2124813A4 (fr) * 2006-11-21 2011-06-22 Mark Frazer Miller Procédé et système non effractifs d'utilisation d'une hyperthermie induite par radiofréquence pour le traitement de maladie
EP2124813A2 (fr) * 2006-11-21 2009-12-02 Mark Frazer Miller Procédé et système non effractifs d'utilisation d'une hyperthermie induite par radiofréquence pour le traitement de maladie
US8588367B2 (en) 2007-02-07 2013-11-19 Koninklijke Philips N.V. Motion compensation in quantitative data analysis and therapy
USRE46953E1 (en) 2007-04-20 2018-07-17 University Of Maryland, Baltimore Single-arc dose painting for precision radiation therapy
WO2009045411A2 (fr) 2007-10-01 2009-04-09 Inspired Surgical Technologies, Inc. Système de chirurgie non invasive à base de photonique comprenant une régulation et une éradication cellulaire automatisés via une commande en aval précalculée plus une commande de rétroaction d'image pour un apport d'énergie ciblé
WO2009045411A3 (fr) * 2007-10-01 2009-11-19 Inspired Surgical Technologies, Inc. Système de chirurgie non invasive à base de photonique comprenant une régulation et une éradication cellulaire automatisés via une commande en aval précalculée plus une commande de rétroaction d'image pour un apport d'énergie ciblé
JP2009106695A (ja) * 2007-11-01 2009-05-21 Mitsubishi Heavy Ind Ltd 放射線治療システム
DE102007060189A1 (de) * 2007-12-14 2009-02-19 Siemens Ag Strahlentherapievorrichtung und Verfahren zur Steuerung einer Strahlentherapievorrichtung
US9320917B2 (en) 2010-01-05 2016-04-26 William Beaumont Hospital Intensity modulated arc therapy with continuous coach rotation/shift and simultaneous cone beam imaging
WO2011137514A1 (fr) * 2010-05-03 2011-11-10 University Health Network Agent pouvant être imagé et activé pour une radiothérapie et procédé et système pour une radiothérapie
US10773101B2 (en) 2010-06-22 2020-09-15 Varian Medical Systems International Ag System and method for estimating and manipulating estimated radiation dose
US11986671B2 (en) 2010-06-22 2024-05-21 Siemens Healthineers International Ag System and method for estimating and manipulating estimated radiation dose
CN111200987A (zh) * 2017-09-06 2020-05-26 技术研发基金会有限公司 用于微创手术的机器人系统
CN111200987B (zh) * 2017-09-06 2024-02-06 技术研发基金会有限公司 用于微创手术的机器人系统
US12201386B2 (en) 2017-09-06 2025-01-21 Technion Research & Development Foundation Limited Robotic system for minimally invasive surgery
CN109646822A (zh) * 2019-02-26 2019-04-19 青岛大学附属医院 一种用于肿瘤医疗临床的放射定位设备及其使用方法
CN112107359A (zh) * 2019-06-19 2020-12-22 李峰 一种肿瘤高频热疗装置

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