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WO1999002659A3 - Method of altering the domains of cyclosporin synthetase to give a modified cyclosporin synthetase - Google Patents

Method of altering the domains of cyclosporin synthetase to give a modified cyclosporin synthetase Download PDF

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Publication number
WO1999002659A3
WO1999002659A3 PCT/EP1998/004265 EP9804265W WO9902659A3 WO 1999002659 A3 WO1999002659 A3 WO 1999002659A3 EP 9804265 W EP9804265 W EP 9804265W WO 9902659 A3 WO9902659 A3 WO 9902659A3
Authority
WO
WIPO (PCT)
Prior art keywords
cyclosporin
synthetase
cyclosporin synthetase
modified
altering
Prior art date
Application number
PCT/EP1998/004265
Other languages
French (fr)
Other versions
WO1999002659A2 (en
Inventor
Kurt Schoergendorfer
Guenther Stempfer
Holger Husi
Malcolm Douglas Walkinshaw
Original Assignee
Biochemie Gmbh
Kurt Schoergendorfer
Guenther Stempfer
Holger Husi
Malcolm Douglas Walkinshaw
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie Gmbh, Kurt Schoergendorfer, Guenther Stempfer, Holger Husi, Malcolm Douglas Walkinshaw filed Critical Biochemie Gmbh
Priority to AU86311/98A priority Critical patent/AU8631198A/en
Priority to EP98937563A priority patent/EP0994943A2/en
Publication of WO1999002659A2 publication Critical patent/WO1999002659A2/en
Publication of WO1999002659A3 publication Critical patent/WO1999002659A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The method of altering the domains of cyclosporin synthetase, to modified cyclosproin synthetase, to methods for the production of cyclosporin-like peptides or derivatives using the modified cyclosporin synthetase and to the cyclosporin-like peptides or derivatives.
PCT/EP1998/004265 1997-07-09 1998-07-09 Method of altering the domains of cyclosporin synthetase to give a modified cyclosporin synthetase WO1999002659A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU86311/98A AU8631198A (en) 1997-07-09 1998-07-09 Method of altering the domains of cyclosporin synthetase to give a modified cyclosporin synthetase
EP98937563A EP0994943A2 (en) 1997-07-09 1998-07-09 Method of altering the domains of cyclosporin synthetase to give a modified cyclosporin synthetase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9714475.2A GB9714475D0 (en) 1997-07-09 1997-07-09 Organic compounds
GB9714475.2 1997-07-09

Publications (2)

Publication Number Publication Date
WO1999002659A2 WO1999002659A2 (en) 1999-01-21
WO1999002659A3 true WO1999002659A3 (en) 1999-05-14

Family

ID=10815609

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/004265 WO1999002659A2 (en) 1997-07-09 1998-07-09 Method of altering the domains of cyclosporin synthetase to give a modified cyclosporin synthetase

Country Status (4)

Country Link
EP (1) EP0994943A2 (en)
AU (1) AU8631198A (en)
GB (1) GB9714475D0 (en)
WO (1) WO1999002659A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7378391B2 (en) 2004-09-29 2008-05-27 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
US7511013B2 (en) 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
US7538084B2 (en) 2003-03-17 2009-05-26 Amr Technology, Inc. Cyclosporins
US7632807B2 (en) 2004-10-06 2009-12-15 Albany Molecular Research, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19928313A1 (en) * 1999-06-16 2000-12-21 Ullrich Keller Processes for altering peptide synthesis so that they can N-methylate their substrate amino acids
US6603902B1 (en) 1999-10-26 2003-08-05 Bti Photonics Inc. Wavelength selective variable reflector

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0578616A2 (en) * 1992-07-09 1994-01-12 Sandoz Ltd. Cylosporin synthetase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0578616A2 (en) * 1992-07-09 1994-01-12 Sandoz Ltd. Cylosporin synthetase

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
A. LAWEN AND R. TRABER: "Substrates specificities of cyclosporin synthetase and peptolide SDZ 214-103 synthetase", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 27, 1993, pages 20452 - 20465, XP002094831 *
G. WEBER ET AL.,: "The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame", CURRENT GENETICS, vol. 26, no. 2, 1994, pages 120 - 125, XP002094832 *
H. HUSI ET AL.,: "Prediction of substrate-specific pockets in cyclosporin synthetase", FEBS LETTERS, vol. 414, no. 3, - 15 September 1997 (1997-09-15), pages 532 - 536, XP002094835 *
J. DITTMANN ET AL.,: "Mechanism of cyclosporin A biosynthesis", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 4, 1994, pages 2841 - 2846, XP002094833 *
T. STACHELHAUS AND M.A. MARAHIEL: "Modular structure of genes encoding multifunctional peptide synthetases required for non-ribosomal peptide synthesis", FEMS MICROBIOLOGY LETTERS, vol. 125, no. 1, 1995, pages 3 - 14, XP002094834 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7538084B2 (en) 2003-03-17 2009-05-26 Amr Technology, Inc. Cyclosporins
US7378391B2 (en) 2004-09-29 2008-05-27 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
US7511013B2 (en) 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
US7632807B2 (en) 2004-10-06 2009-12-15 Albany Molecular Research, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents

Also Published As

Publication number Publication date
EP0994943A2 (en) 2000-04-26
WO1999002659A2 (en) 1999-01-21
GB9714475D0 (en) 1997-09-17
AU8631198A (en) 1999-02-08

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