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WO1999001470A3 - Peptidomimetic derivatives suicidal inhibitors of the hiv proliferation - Google Patents

Peptidomimetic derivatives suicidal inhibitors of the hiv proliferation Download PDF

Info

Publication number
WO1999001470A3
WO1999001470A3 PCT/EP1998/003970 EP9803970W WO9901470A3 WO 1999001470 A3 WO1999001470 A3 WO 1999001470A3 EP 9803970 W EP9803970 W EP 9803970W WO 9901470 A3 WO9901470 A3 WO 9901470A3
Authority
WO
WIPO (PCT)
Prior art keywords
hiv proliferation
suicidal
inhibitors
peptidomimetic derivatives
suicidal inhibitors
Prior art date
Application number
PCT/EP1998/003970
Other languages
French (fr)
Other versions
WO1999001470A2 (en
Inventor
Domenico Ungheri
Franco Pellacini
Stefano Romagnano
Jean-Louis Kraus
Jean-Claude Chermann
Original Assignee
Zambon Spa
Inst Nat Sante Rech Med
Domenico Ungheri
Franco Pellacini
Stefano Romagnano
Kraus Jean Louis
Chermann Jean Claude
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa, Inst Nat Sante Rech Med, Domenico Ungheri, Franco Pellacini, Stefano Romagnano, Kraus Jean Louis, Chermann Jean Claude filed Critical Zambon Spa
Priority to AU88025/98A priority Critical patent/AU8802598A/en
Priority to EP98939556A priority patent/EP1001969A1/en
Publication of WO1999001470A2 publication Critical patent/WO1999001470A2/en
Publication of WO1999001470A3 publication Critical patent/WO1999001470A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Dipeptides of formula (I) wherein X is oxygen or a group SO2 and R is hydrogen or a protecting group, are suicidal inhibitors of HIV.
PCT/EP1998/003970 1997-06-30 1998-06-29 Peptidomimetic derivatives suicidal inhibitors of the hiv proliferation WO1999001470A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU88025/98A AU8802598A (en) 1997-06-30 1998-06-29 Peptidomimetic derivatives suicidal inhibitors of the hiv proliferation
EP98939556A EP1001969A1 (en) 1997-06-30 1998-06-29 Peptidomimetic derivatives suicidal inhibitors of the hiv proliferation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI97A001545 1997-06-30
IT97MI001545A IT1292438B1 (en) 1997-06-30 1997-06-30 PEPTIDOMIMETIC DERIVATIVES SUICIDE INHIBITORS OF HIV PROLIFERATION

Publications (2)

Publication Number Publication Date
WO1999001470A2 WO1999001470A2 (en) 1999-01-14
WO1999001470A3 true WO1999001470A3 (en) 1999-03-25

Family

ID=11377465

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/003970 WO1999001470A2 (en) 1997-06-30 1998-06-29 Peptidomimetic derivatives suicidal inhibitors of the hiv proliferation

Country Status (4)

Country Link
EP (1) EP1001969A1 (en)
AU (1) AU8802598A (en)
IT (1) IT1292438B1 (en)
WO (1) WO1999001470A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0094815A2 (en) * 1982-05-18 1983-11-23 Smithkline Beckman Corporation Oligopeptide prodrugs
WO1991010679A2 (en) * 1990-01-22 1991-07-25 Warner Lambert Co RENIN INHIBITING PEPTIDES HAVING AN 'alpha'-HETEROATOM AMINO ACID AT THE P3 POSITION
WO1997001576A2 (en) * 1995-06-29 1997-01-16 Laboratoire Laphal Phenyl peptides, method for preparing same, and pharmaceutical compositions containing said peptides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0094815A2 (en) * 1982-05-18 1983-11-23 Smithkline Beckman Corporation Oligopeptide prodrugs
WO1991010679A2 (en) * 1990-01-22 1991-07-25 Warner Lambert Co RENIN INHIBITING PEPTIDES HAVING AN 'alpha'-HETEROATOM AMINO ACID AT THE P3 POSITION
WO1997001576A2 (en) * 1995-06-29 1997-01-16 Laboratoire Laphal Phenyl peptides, method for preparing same, and pharmaceutical compositions containing said peptides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NIDDAM V ET AL: "THIOPHENOXY PEPTIDES: A NEW CLASS OF HIV REPLICATION INHIBITORS", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 6, 1996, pages 609 - 614, XP000647604 *

Also Published As

Publication number Publication date
ITMI971545A1 (en) 1998-12-30
WO1999001470A2 (en) 1999-01-14
ITMI971545A0 (en) 1997-06-30
IT1292438B1 (en) 1999-02-08
AU8802598A (en) 1999-01-25
EP1001969A1 (en) 2000-05-24

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