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WO1999000346A8 - Synthese de compositions de dihydrohonokiol - Google Patents

Synthese de compositions de dihydrohonokiol

Info

Publication number
WO1999000346A8
WO1999000346A8 PCT/US1998/013265 US9813265W WO9900346A8 WO 1999000346 A8 WO1999000346 A8 WO 1999000346A8 US 9813265 W US9813265 W US 9813265W WO 9900346 A8 WO9900346 A8 WO 9900346A8
Authority
WO
WIPO (PCT)
Prior art keywords
dihydrohonokiol
synthesis
compositions
disclosed
homologs
Prior art date
Application number
PCT/US1998/013265
Other languages
English (en)
Other versions
WO1999000346A1 (fr
Inventor
William B Stavinoha
Neera Satsangi
Rajiv K Satsangi
Original Assignee
Univ Texas
William B Stavinoha
Neera Satsangi
Rajiv K Satsangi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, William B Stavinoha, Neera Satsangi, Rajiv K Satsangi filed Critical Univ Texas
Priority to AU81689/98A priority Critical patent/AU8168998A/en
Priority to CA002297723A priority patent/CA2297723A1/fr
Priority to EP98931609A priority patent/EP0991614A1/fr
Priority to JP50574599A priority patent/JP2002507211A/ja
Publication of WO1999000346A1 publication Critical patent/WO1999000346A1/fr
Publication of WO1999000346A8 publication Critical patent/WO1999000346A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
    • C07C39/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne la synthèse et l'utilisation du composé anxiolytique dihydrohonokiol, ses dérivés, ses analogues et ses homologues. L'invention concerne également un procédé anxiolytique destiné à un mammifère.
PCT/US1998/013265 1997-06-26 1998-06-26 Synthese de compositions de dihydrohonokiol WO1999000346A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU81689/98A AU8168998A (en) 1997-06-26 1998-06-26 Synthesis of dihydrohonokiol compositions
CA002297723A CA2297723A1 (fr) 1997-06-26 1998-06-26 Synthese de compositions de dihydrohonokiol
EP98931609A EP0991614A1 (fr) 1997-06-26 1998-06-26 Synthese de compositions de dihydrohonokiol
JP50574599A JP2002507211A (ja) 1997-06-26 1998-06-26 ジヒドロホノキオール組成物の合成

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5084597P 1997-06-26 1997-06-26
US60/050,845 1997-06-26

Publications (2)

Publication Number Publication Date
WO1999000346A1 WO1999000346A1 (fr) 1999-01-07
WO1999000346A8 true WO1999000346A8 (fr) 2000-02-17

Family

ID=21967834

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/013265 WO1999000346A1 (fr) 1997-06-26 1998-06-26 Synthese de compositions de dihydrohonokiol

Country Status (5)

Country Link
EP (1) EP0991614A1 (fr)
JP (1) JP2002507211A (fr)
AU (1) AU8168998A (fr)
CA (1) CA2297723A1 (fr)
WO (1) WO1999000346A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1140756A2 (fr) * 1998-12-31 2001-10-10 The Board Of Regents, The University Of Texas System Synthese de compositions a base de dihydrohonokiol
US20050070537A1 (en) 2002-10-10 2005-03-31 Chris Rundfeldt Use of dihydroimidazolones for the treatment of dogs
WO2006107451A2 (fr) * 2005-02-23 2006-10-12 Univ Emory Derives d'honokiol pour traiter les maladies proliferantes
CN101279901B (zh) * 2007-12-25 2011-08-17 四川大学 和厚朴酚系列衍生物及其制备方法和用途
EP2423181A1 (fr) 2010-07-28 2012-02-29 Prous Institute For Biomedical Research S.A. Dérivés de biphényldiol substitués à cible multiple
US9486419B2 (en) 2013-04-17 2016-11-08 Ariel-University Research And Development Company CB2 receptor ligands for the treatment of psychiatric disorders
US9820988B2 (en) 2014-03-24 2017-11-21 Boehringer Ingelheim Vetmedica Gmbh Treatment of epileptic disorders in feline animals
US11897910B2 (en) 2015-06-11 2024-02-13 The Medical College Of Wisconsin, Inc. Mito-honokiol compounds and methods of synthesis and use thereof
WO2016201188A1 (fr) * 2015-06-11 2016-12-15 The Medical College Of Wisconsin, Inc. Composés mito-honokiol et leurs procédés de synthèse et d'utilisation
MX389172B (es) * 2015-10-23 2025-03-20 Colgate Palmolive Co Sintesis mejorada de honokiol.
WO2021026285A1 (fr) * 2019-08-06 2021-02-11 Kirkland Justin Formulations comprenant du dihydrohonokiol
CN112125805B (zh) 2020-09-11 2022-10-18 北京红惠新医药科技有限公司 水溶性厚朴酚衍生物及和厚朴酚衍生物和其中间体的制备方法、和相关的单羟基保护中间体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5995229A (ja) * 1982-11-24 1984-06-01 Tsumura Juntendo Inc 新規ハイドロオキシビフエニル化合物
CN1029227C (zh) * 1989-02-08 1995-07-05 大制药株式会社 苯衍生物的制备方法
US5449682A (en) * 1990-02-13 1995-09-12 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted benzyl element

Also Published As

Publication number Publication date
JP2002507211A (ja) 2002-03-05
CA2297723A1 (fr) 1999-01-07
EP0991614A1 (fr) 2000-04-12
AU8168998A (en) 1999-01-19
WO1999000346A1 (fr) 1999-01-07

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