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WO1999066077A3 - Methods for the detection of nucleic acids - Google Patents

Methods for the detection of nucleic acids Download PDF

Info

Publication number
WO1999066077A3
WO1999066077A3 PCT/US1999/013630 US9913630W WO9966077A3 WO 1999066077 A3 WO1999066077 A3 WO 1999066077A3 US 9913630 W US9913630 W US 9913630W WO 9966077 A3 WO9966077 A3 WO 9966077A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
nucleic acids
detection
disease
identifying
Prior art date
Application number
PCT/US1999/013630
Other languages
French (fr)
Other versions
WO1999066077A2 (en
Inventor
Anthony P Shuber
Stanley N Lapidus
George Q Daley
Original Assignee
Exact Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exact Lab Inc filed Critical Exact Lab Inc
Priority to CA002331254A priority Critical patent/CA2331254A1/en
Priority to EP99930331A priority patent/EP1086247A2/en
Publication of WO1999066077A2 publication Critical patent/WO1999066077A2/en
Publication of WO1999066077A3 publication Critical patent/WO1999066077A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Methods are provided for identifying nucleic acids. Methods of the invention are useful for identifying and analyzing nucleic acids, especially variants of single nucleotide polymorphisms, that are indicative of disease or the predisposition for disease.
PCT/US1999/013630 1998-06-16 1999-06-16 Methods for the detection of nucleic acids WO1999066077A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002331254A CA2331254A1 (en) 1998-06-16 1999-06-16 Methods for the detection of nucleic acids
EP99930331A EP1086247A2 (en) 1998-06-16 1999-06-16 Methods for the detection of nucleic acids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9818098A 1998-06-16 1998-06-16
US09/098,180 1998-06-16

Publications (2)

Publication Number Publication Date
WO1999066077A2 WO1999066077A2 (en) 1999-12-23
WO1999066077A3 true WO1999066077A3 (en) 2000-02-24

Family

ID=22267796

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/013630 WO1999066077A2 (en) 1998-06-16 1999-06-16 Methods for the detection of nucleic acids

Country Status (3)

Country Link
EP (1) EP1086247A2 (en)
CA (1) CA2331254A1 (en)
WO (1) WO1999066077A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US6964846B1 (en) 1999-04-09 2005-11-15 Exact Sciences Corporation Methods for detecting nucleic acids indicative of cancer
US7368233B2 (en) 1999-12-07 2008-05-06 Exact Sciences Corporation Methods of screening for lung neoplasm based on stool samples containing a nucleic acid marker indicative of a neoplasm
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
WO2007044071A2 (en) 2005-04-21 2007-04-19 Exact Sciences Corporation Analysis of heterogeneous nucleic acid samples

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993024657A2 (en) * 1992-05-29 1993-12-09 The General Hospital Corporation Use of genetic markers to diagnose familial dysautonomia
WO1997023651A1 (en) * 1995-12-22 1997-07-03 Exact Laboratories, Inc. Methods for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
EP0785280A2 (en) * 1995-11-29 1997-07-23 Affymetrix, Inc. (a California Corporation) Polymorphism detection
WO1997038135A1 (en) * 1996-04-05 1997-10-16 Medical Science Systems, Inc. Detecting genetic predisposition for osteoporosis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993024657A2 (en) * 1992-05-29 1993-12-09 The General Hospital Corporation Use of genetic markers to diagnose familial dysautonomia
EP0785280A2 (en) * 1995-11-29 1997-07-23 Affymetrix, Inc. (a California Corporation) Polymorphism detection
WO1997023651A1 (en) * 1995-12-22 1997-07-03 Exact Laboratories, Inc. Methods for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
WO1997038135A1 (en) * 1996-04-05 1997-10-16 Medical Science Systems, Inc. Detecting genetic predisposition for osteoporosis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FAN J ET AL: "Genetic mapping: Finding and analyzing single-nucleotide polymorphisms with high-density DNA arrays", AMERICAN JOURNAL OF HUMAN GENETICS,US,NEW YORK, NY, vol. 61, no. 4, SUPPL, - October 1997 (1997-10-01), pages 1601, XP002089397, ISSN: 0002-9297 *
WANG D.G. ET AL.,: "Large-scale identification, mapping and genotyping of single-nucleotide polymorphisms in the human genome", SCIENCE, vol. 280, - 15 May 1998 (1998-05-15), pages 1077 - 1082, XP002089398 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6964846B1 (en) 1999-04-09 2005-11-15 Exact Sciences Corporation Methods for detecting nucleic acids indicative of cancer
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US7368233B2 (en) 1999-12-07 2008-05-06 Exact Sciences Corporation Methods of screening for lung neoplasm based on stool samples containing a nucleic acid marker indicative of a neoplasm
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence

Also Published As

Publication number Publication date
EP1086247A2 (en) 2001-03-28
WO1999066077A2 (en) 1999-12-23
CA2331254A1 (en) 1999-12-23

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