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WO1999065452A3 - Hydrogels de polymeres solubles dans l'eau reticules par des domaines proteiques - Google Patents

Hydrogels de polymeres solubles dans l'eau reticules par des domaines proteiques Download PDF

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Publication number
WO1999065452A3
WO1999065452A3 PCT/US1999/013843 US9913843W WO9965452A3 WO 1999065452 A3 WO1999065452 A3 WO 1999065452A3 US 9913843 W US9913843 W US 9913843W WO 9965452 A3 WO9965452 A3 WO 9965452A3
Authority
WO
WIPO (PCT)
Prior art keywords
water soluble
hydrogels
protein domains
soluble polymers
polymers crosslinked
Prior art date
Application number
PCT/US1999/013843
Other languages
English (en)
Other versions
WO1999065452B1 (fr
WO1999065452A9 (fr
WO1999065452A2 (fr
Inventor
Jindrich Kopecek
Russell Stewart
Karin Caldwell
Chung Wang
Chih-Hu Ho
Original Assignee
Univ Utah Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Utah Res Found filed Critical Univ Utah Res Found
Priority to AU46966/99A priority Critical patent/AU4696699A/en
Publication of WO1999065452A2 publication Critical patent/WO1999065452A2/fr
Publication of WO1999065452A3 publication Critical patent/WO1999065452A3/fr
Publication of WO1999065452A9 publication Critical patent/WO1999065452A9/fr
Publication of WO1999065452B1 publication Critical patent/WO1999065452B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2063—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Colloid Chemistry (AREA)

Abstract

L'invention concerne un hydrogel hybride réceptif aux stimuli dans lequel la masse du polymère est formée de brins de polymères solubles dans l'eau relativement bon marché, réticulés par des domaines protéiques. La réceptivité du gel est régulée ou modulée par le composant protéique. Les propriétés physiques et biologiques de l'hydrogel sont déterminées par des domaines protéiques spécifiquement conçus ou mis au point. La réticulation des domaines protéiques avec les polymères solubles dans l'eau se fait par une liaison non covalente telle qu'une liaison par chélation ou coordination, une liaison biotine-avidine, une interaction protéine-protéine et une interaction protéine-ligand; ou par une liaison covalente. L'invention concerne également des procédés de production et d'utilisation des hydrogels polymère-protéine.
PCT/US1999/013843 1998-06-19 1999-06-18 Hydrogels de polymeres solubles dans l'eau reticules par des domaines proteiques WO1999065452A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU46966/99A AU4696699A (en) 1998-06-19 1999-06-18 Hydrogels of water soluble polymers crosslinked by protein domains

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8986298P 1998-06-19 1998-06-19
US60/089,862 1998-06-19

Publications (4)

Publication Number Publication Date
WO1999065452A2 WO1999065452A2 (fr) 1999-12-23
WO1999065452A3 true WO1999065452A3 (fr) 2000-04-06
WO1999065452A9 WO1999065452A9 (fr) 2000-05-04
WO1999065452B1 WO1999065452B1 (fr) 2000-06-08

Family

ID=22219949

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/013843 WO1999065452A2 (fr) 1998-06-19 1999-06-18 Hydrogels de polymeres solubles dans l'eau reticules par des domaines proteiques

Country Status (2)

Country Link
AU (1) AU4696699A (fr)
WO (1) WO1999065452A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017126149A1 (de) 2017-11-08 2019-05-09 Johannes Gutenberg-Universität Mainz Wirkstoffhaltiger Schichtverbund sowie Verfahren zu dessen Herstellung

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925677A (en) * 1988-08-31 1990-05-15 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US5750585A (en) * 1995-04-04 1998-05-12 Purdue Research Foundation Super absorbent hydrogel foams
US6004583A (en) * 1995-03-22 1999-12-21 Orex Pharmaceutical Development Corp. Protein-containing polymer composition for oral administration

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925677A (en) * 1988-08-31 1990-05-15 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US6004583A (en) * 1995-03-22 1999-12-21 Orex Pharmaceutical Development Corp. Protein-containing polymer composition for oral administration
US5750585A (en) * 1995-04-04 1998-05-12 Purdue Research Foundation Super absorbent hydrogel foams

Also Published As

Publication number Publication date
WO1999065452B1 (fr) 2000-06-08
AU4696699A (en) 2000-01-05
WO1999065452A9 (fr) 2000-05-04
WO1999065452A2 (fr) 1999-12-23

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