+

WO1999064587A8 - Polypeptides possedant une activite de type beta-secretase - Google Patents

Polypeptides possedant une activite de type beta-secretase

Info

Publication number
WO1999064587A8
WO1999064587A8 PCT/FR1999/001326 FR9901326W WO9964587A8 WO 1999064587 A8 WO1999064587 A8 WO 1999064587A8 FR 9901326 W FR9901326 W FR 9901326W WO 9964587 A8 WO9964587 A8 WO 9964587A8
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
type activity
beta
secretase
secretase type
Prior art date
Application number
PCT/FR1999/001326
Other languages
English (en)
Other versions
WO1999064587A1 (fr
Inventor
Mohamed Rholam
Noeli Munoz-Gimenez
Mohamed Moutaouakil
Paul Cohen
Philippe Bertrand
Original Assignee
Aventis Pharma Sa
Univ Paris Curie
Mohamed Rholam
Munoz Gimenez Noeli
Mohamed Moutaouakil
Paul Cohen
Philippe Bertrand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9807068A external-priority patent/FR2779444A1/fr
Application filed by Aventis Pharma Sa, Univ Paris Curie, Mohamed Rholam, Munoz Gimenez Noeli, Mohamed Moutaouakil, Paul Cohen, Philippe Bertrand filed Critical Aventis Pharma Sa
Priority to JP2000553577A priority Critical patent/JP2002517239A/ja
Priority to KR1020007013630A priority patent/KR20010052499A/ko
Priority to IL13973999A priority patent/IL139739A0/xx
Priority to CA002330242A priority patent/CA2330242A1/fr
Priority to HU0104022A priority patent/HUP0104022A2/hu
Priority to EP99923674A priority patent/EP1084240A1/fr
Priority to AU40455/99A priority patent/AU4045599A/en
Publication of WO1999064587A1 publication Critical patent/WO1999064587A1/fr
Publication of WO1999064587A8 publication Critical patent/WO1999064587A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne de nouveaux polypeptides et leur utilisation pharmaceutique. Plus particulièrement, la présente invention concerne de nouveaux polypeptides possédant une activité de type β-secrétase caractérisés en ce qu'ils sont capables de cliver de manière spécifique le précurseur naturel du peptide β-amyloïde (APP).
PCT/FR1999/001326 1998-06-05 1999-06-04 Polypeptides possedant une activite de type beta-secretase WO1999064587A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2000553577A JP2002517239A (ja) 1998-06-05 1999-06-04 ベータセクレターゼ型活性をもつポリペプチド
KR1020007013630A KR20010052499A (ko) 1998-06-05 1999-06-04 베타-시크리타제형 활성을 지닌 폴리펩타이드
IL13973999A IL139739A0 (en) 1998-06-05 1999-06-04 Polypeptides with beta-secretase type activity
CA002330242A CA2330242A1 (fr) 1998-06-05 1999-06-04 Polypeptides possedant une activite de type beta-secretase
HU0104022A HUP0104022A2 (hu) 1998-06-05 1999-06-04 Béta-szekretáz típusú aktivitással rendelkező polipeptidek
EP99923674A EP1084240A1 (fr) 1998-06-05 1999-06-04 Polypeptides possedant une activite de type beta-secretase
AU40455/99A AU4045599A (en) 1998-06-05 1999-06-04 Polypeptides with beta-secretase type activity

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9807068A FR2779444A1 (fr) 1998-06-05 1998-06-05 Polypeptides possedant une activite de type beta-secretase et capables de cliver le precurseur naturel du peptide beta-amyloide (app)
FR98/07068 1998-06-05
US12259999P 1999-03-03 1999-03-03
US60/122,599 1999-03-03

Publications (2)

Publication Number Publication Date
WO1999064587A1 WO1999064587A1 (fr) 1999-12-16
WO1999064587A8 true WO1999064587A8 (fr) 2001-08-02

Family

ID=26234362

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1999/001326 WO1999064587A1 (fr) 1998-06-05 1999-06-04 Polypeptides possedant une activite de type beta-secretase

Country Status (7)

Country Link
EP (1) EP1084240A1 (fr)
KR (1) KR20010052499A (fr)
AU (1) AU4045599A (fr)
CA (1) CA2330242A1 (fr)
HU (1) HUP0104022A2 (fr)
IL (1) IL139739A0 (fr)
WO (1) WO1999064587A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6844148B1 (en) 1998-09-24 2005-01-18 Pharmacia & Upjohn Company Alzheimer's disease secretase, APP substrates therefor, and uses therefor
US6699671B1 (en) 1998-09-24 2004-03-02 Pharmacia & Upjohn Company Alzheimer's disease secretase, APP substrates therefor, and uses therefor
KR20070013361A (ko) 1998-09-24 2007-01-30 파마시아 앤드 업존 캄파니 엘엘씨 알츠하이머병 세크레타제
US7456007B1 (en) 1998-12-31 2008-11-25 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
US7115410B1 (en) 1999-02-10 2006-10-03 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
CA2359785A1 (fr) 1999-02-10 2000-08-17 John P. Anderson Compositions a base d'enzyme .beta.-secretase et procedes
AU3770800A (en) 1999-03-26 2000-10-16 Amgen, Inc. Beta secretase genes and polypeptides
WO2001000663A2 (fr) 1999-06-28 2001-01-04 Oklahoma Medical Research Foundation Memapsine recombinante catalytiquement active et procedes d'utilisation
US7514408B1 (en) 1999-12-02 2009-04-07 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
EP1301604B1 (fr) * 2000-07-19 2008-05-28 Pharmacia & Upjohn Company LLC Substrats et dosages permettant de surveiller l'activite de la beta-secretase
US7138262B1 (en) * 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
US7196163B2 (en) 2001-05-22 2007-03-27 Merk & Co., Inc. Assays using amyloid precursor proteins with modified β-secretase cleavage sites to monitor β-secretase activity
AU2002359301B2 (en) 2001-10-23 2008-07-03 Comentis, Inc. Beta-secretase inhibitors and methods of use
PT1986612E (pt) 2006-02-07 2012-11-06 Shire Human Genetic Therapies Composição estável de glucocerebrosidase
MX344786B (es) 2009-07-28 2017-01-06 Shire Human Genetic Therapies Composiciones y metodos para tratar enfermedad de gaucher.
EP2595651B1 (fr) 2010-07-19 2017-03-29 Shire Human Genetic Therapies, Inc. Lignée cellulaire optimisée pour le codon de récepteur de mannose de type c 1 (mrc1) et ses utilisations
AU2012267241B2 (en) 2011-06-10 2017-04-06 Temasek Life Sciences Laboratory Limited Genetic manipulation and expression systems for Pucciniomycotina and Ustilaginomycotina subphyla
WO2013130963A1 (fr) 2012-03-02 2013-09-06 Shire Human Genetic Therapies, Inc. Composition et méthode de traitement de la maladie de gaucher de type iii

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE910713A1 (en) * 1990-03-05 1991-09-11 Cephalon Inc Chymotrypsin-like proteases
JPH06503948A (ja) * 1990-08-17 1994-05-12 ボストン・ユニヴァーシティー アミロイドβ―蛋白質のプレカーサーの異常分解をひき起こすプロテアーゼ
US5292652A (en) * 1990-10-05 1994-03-08 Athena Neurosciences, Inc. Amyloidin protease and uses thereof
AU679675B2 (en) * 1992-05-11 1997-07-10 Bayer Corporation Methods for detecting beta amyloid precursor protein processing enzymes
IL105793A0 (en) * 1992-05-28 1993-09-22 Lilly Co Eli Protease and related dna compounds
JPH11507538A (ja) * 1995-06-07 1999-07-06 アテナ ニューロサイエンシズ インコーポレイティド β−セクレターゼ、β−セクレターゼに対する抗体、及びβ−セクレターゼ阻害を検出するためのアッセイ

Also Published As

Publication number Publication date
KR20010052499A (ko) 2001-06-25
CA2330242A1 (fr) 1999-12-16
AU4045599A (en) 1999-12-30
HUP0104022A2 (hu) 2002-03-28
IL139739A0 (en) 2002-02-10
WO1999064587A1 (fr) 1999-12-16
EP1084240A1 (fr) 2001-03-21

Similar Documents

Publication Publication Date Title
WO1999064587A8 (fr) Polypeptides possedant une activite de type beta-secretase
AU3519299A (en) Human casb12 polypeptide, a serine protease
ZA988070B (en) Insulin-like polypeptide and uses therefor.
AU2002210340A1 (en) A novel polypeptide- human cbp20 protein 47.74 and the polynucleotide encoding said polypeptide
AU4824801A (en) A novel polypeptide, a human glucose transport like protein 18 and the polynucleotide encoding the polypeptide
AU7043801A (en) A novel polypeptide, human insulin-like growth factor-binding protein 9 and the polynucleotide encoding thereof
AU8948801A (en) A novel polypeptide, a human transformer-2-beta protein 29.15 and the polynucleotide encoding the polypeptide
AU2002214916A1 (en) A novel polypeptide, a human garp protein 12.98 and the polynucleotide encoding the polypeptide
AU2002210321A1 (en) A novel polypeptide, a human myotube protein 10.56 and the polynucleotide encoding the polypeptide
AU4632401A (en) A novel polypeptide, cytochrome human constitution protein 10 and the polynucleotide encoding the polypeptide
AU2002210334A1 (en) A novel polypeptide- human notch protein 24.64 and the polynucleotide encoding said polypeptide
AU8376301A (en) A novel polypeptide, a kringle protein 14 and the polynucleotide encoding the polypeptide
AU1378701A (en) A novel polypeptide, a human apoptosis associated protein 12 and the polynucleotide encoding the polypeptide
AU2002210341A1 (en) A novel polypeptide- human plp protein 40.15 and the polynucleotide encoding said polypeptide
AU4823901A (en) A novel polypeptide, glucose transport-associated human protein 10 and the polynucleotide encoding the polypeptide
AU5815301A (en) A novel polypeptide, a human serine protease 8 and the polynucleotide encoding the polypeptide
AU1378601A (en) A novel polypeptide, a human s4 ribosome protein 20 and the polynucleotide encoding the polypeptide
AU6890901A (en) A novel polypeptide, a human atp dependent serine protein hydrolase 9.1 and the polynucleotide encoding the polypeptide
AU6201001A (en) A novel polypeptide-human proteolytic enzyme regulatory protein 12 and the polynucleotide encoding said polypeptide
AU9364501A (en) A novel polypeptide, a human protein plp39 and the polynucleotide encoding the polypeptide
AU2002210319A1 (en) A novel polypeptide- zinc finger protein 8.8 and the polynucleotide encoding said polypeptide
AU8952701A (en) A novel polypeptide, a enzymatic activation protein ras gtp 9.57 and the polynucleotide encoding the polypeptide
AU7624201A (en) A novel polypeptide, a human atp dependent-uncoiling enzyme protein 10 and the polynucleotide encoding the polypeptide
AU2002212051A1 (en) A novel polypeptide, a human big protein 9.24 and the polynucleotide encoding the polypeptide
AU2002221502A1 (en) A novel polypeptide, a human big protein 0767-19.36 and the polynucleotide encoding the polypeptide

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AL AU BA BB BG BR CA CN CU CZ EE GD GE HR HU ID IL IN IS JP KP KR LC LK LR LT LV MG MK MN MX NO NZ PL RO RU SG SI SK SL TR TT UA US UZ VN YU ZA

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 139739

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 40455/99

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: PV2000-4495

Country of ref document: CZ

Ref document number: 2000/07118

Country of ref document: ZA

Ref document number: 200007118

Country of ref document: ZA

Ref document number: 1020007013630

Country of ref document: KR

ENP Entry into the national phase

Ref document number: 2330242

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 1999923674

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1999923674

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: PV2000-4495

Country of ref document: CZ

WWP Wipo information: published in national office

Ref document number: 1020007013630

Country of ref document: KR

AK Designated states

Kind code of ref document: C1

Designated state(s): AE AL AU BA BB BG BR CA CN CU CZ EE GD GE HR HU ID IL IN IS JP KP KR LC LK LR LT LV MG MK MN MX NO NZ PL RO RU SG SI SK SL TR TT UA US UZ VN YU ZA

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: PAT. BUL. 50/99 UNDER (30) REPLACE "31.03.99" BY "03.03.99"

WWE Wipo information: entry into national phase

Ref document number: 09701945

Country of ref document: US

WWR Wipo information: refused in national office

Ref document number: PV2000-4495

Country of ref document: CZ

WWW Wipo information: withdrawn in national office

Ref document number: 1020007013630

Country of ref document: KR

WWW Wipo information: withdrawn in national office

Ref document number: 1999923674

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载