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WO1999064065A3 - Tumour therapy and imaging - Google Patents

Tumour therapy and imaging Download PDF

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Publication number
WO1999064065A3
WO1999064065A3 PCT/GB1999/001870 GB9901870W WO9964065A3 WO 1999064065 A3 WO1999064065 A3 WO 1999064065A3 GB 9901870 W GB9901870 W GB 9901870W WO 9964065 A3 WO9964065 A3 WO 9964065A3
Authority
WO
WIPO (PCT)
Prior art keywords
agent
imaging
tumour
tumour therapy
patient
Prior art date
Application number
PCT/GB1999/001870
Other languages
French (fr)
Other versions
WO1999064065A2 (en
Inventor
Kenneth Dawson Bagshawe
Original Assignee
Enzacta R & D Ltd
Kenneth Dawson Bagshawe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzacta R & D Ltd, Kenneth Dawson Bagshawe filed Critical Enzacta R & D Ltd
Priority to AU59469/99A priority Critical patent/AU5946999A/en
Publication of WO1999064065A2 publication Critical patent/WO1999064065A2/en
Publication of WO1999064065A3 publication Critical patent/WO1999064065A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

A method of combating a tumour in a patient, the method comprising administering to the patient a) an agent which tolerizes the patient to a said tumour selective agent or to an agent which interacts selectively with the said tumour selective agent; b) a tumour selective agent which comprises a polypeptide; and c) at least one further agent which interacts selectively with the said tumour selective agent.
PCT/GB1999/001870 1998-06-11 1999-06-11 Tumour therapy and imaging WO1999064065A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU59469/99A AU5946999A (en) 1998-06-11 1999-06-11 Tumour therapy and imaging

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9812550.3 1998-06-11
GBGB9812550.3A GB9812550D0 (en) 1998-06-11 1998-06-11 Tumour therapy and imaging

Publications (2)

Publication Number Publication Date
WO1999064065A2 WO1999064065A2 (en) 1999-12-16
WO1999064065A3 true WO1999064065A3 (en) 2000-06-29

Family

ID=10833545

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/001870 WO1999064065A2 (en) 1998-06-11 1999-06-11 Tumour therapy and imaging

Country Status (3)

Country Link
AU (1) AU5946999A (en)
GB (1) GB9812550D0 (en)
WO (1) WO1999064065A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201308363D0 (en) * 2013-05-09 2013-06-19 Bagshawe Kenneth D Tumour therapy
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
BR112018013407A2 (en) 2015-12-30 2018-12-18 Kodiak Sciences Inc antibodies and conjugates thereof
WO2018071434A1 (en) 2016-10-11 2018-04-19 Microdose Therapeutx, Inc. Inhaler and methods of use thereof
JP2021514656A (en) 2018-03-02 2021-06-17 コディアック サイエンシーズ インコーポレイテッドＫｏｄｉａｋ Ｓｃｉｅｎｃｅｓ Ｉｎｃ． IL-6 antibody and its fusion constructs and conjugates
US20220251206A1 (en) * 2019-06-11 2022-08-11 Bristol-Myers Squibb Company Anti-ctla4 antibody prodruggable (probody) at a cdr position
US11912784B2 (en) 2019-10-10 2024-02-27 Kodiak Sciences Inc. Methods of treating an eye disorder

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63219374A (en) * 1987-03-09 1988-09-13 Takara Shuzo Co Ltd Chemically modified carboxypeptidase and use thereof
WO1989010140A1 (en) * 1988-04-22 1989-11-02 Cancer Research Campaign Technology Limited Further improvements relating to drug delivery systems
WO1991001758A1 (en) * 1989-08-07 1991-02-21 Debiopharm S.A. Biologically active drug polymer derivatives
WO1998024478A2 (en) * 1996-11-30 1998-06-11 Enzacta R & D Limited Tumour therapy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63219374A (en) * 1987-03-09 1988-09-13 Takara Shuzo Co Ltd Chemically modified carboxypeptidase and use thereof
WO1989010140A1 (en) * 1988-04-22 1989-11-02 Cancer Research Campaign Technology Limited Further improvements relating to drug delivery systems
WO1991001758A1 (en) * 1989-08-07 1991-02-21 Debiopharm S.A. Biologically active drug polymer derivatives
WO1998024478A2 (en) * 1996-11-30 1998-06-11 Enzacta R & D Limited Tumour therapy

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ABUCHOWSKI A ET AL: "CANCER THERAPY WITH CHEMICALLY MODIFIED ENZYMES.I. ANTITUMOR PROPERTIES OF POLYETHYLENE GLYCOL-ASPARAGINASE CONJUGATES", CANCER BIOCHEMISTRY BIOPHYSICS, vol. 7, 1 January 1984 (1984-01-01), pages 175 - 186, XP002055709 *
BRYGIER, JEANNE ET AL: "Preparation and preliminary characterization of poly ( ethylene glycol )-pepstatin conjugate", APPL. BIOCHEM. BIOTECHNOL. 1994, VOL. 47, NO. 1, PAGE(S) 1-10, XP002121730 *
C DELGADO ET AL: "Enhanced tumour specificity of an anti-carcinoembryonic antigen Fab' fragment by poly(ethylene glycol) (PEG) modification", BRITISH JOURNAL OF CANCER, vol. 73, no. 2, 1 January 1996 (1996-01-01), pages 175 - 182, XP002084719 *
E ENOAMOOQUAYE ET AL: "Altered biodistribution of an antibody-enzyme conjugate modified with polyethylene-glycol", BRITISH JOURNAL OF CANCER, vol. 73, no. 11, 1 June 1996 (1996-06-01), pages 1323 - 1327, XP002084718 *
NUCCI M L ET AL: "THE THERAPEUTIC VALUE OF POLY(ETHYLENE GLYCOL)-MODIFIED PROTEINS", ADVANCED DRUG DELIVERY REVIEWS, vol. 6, no. 2, 1 March 1991 (1991-03-01), pages 133 - 151, XP002064123 *
PATENT ABSTRACTS OF JAPAN vol. 013, no. 011 (C - 558) 11 January 1989 (1989-01-11) *
PEDLEY R B ET AL: "THE POTENTIAL FOR ENHANCED TUMOUR LOCALISATION BY POLY(ETHYLENE GLYCOL) MODIFICATION OF ANTI-CEA ANTIBODY", BRITISH JOURNAL OF CANCER, vol. 70, 1994, pages 1126 - 1130, XP000575990 *
PERRON MJ ET AL: "Activation of methotrexate-phenylalanine by monoclonal antibody-- carboxypeptidase A conjugate for the specific treatment of ovarian cancer in vitro.", BR J CANCER, FEB 1996, VOL. 73, NO. 3, PAGE(S) 281-287, XP002121729 *
POOL R: "PEG-TREATED ENZYMES ARE NEARLY INVISIBLE TO THE IMMUNE SYSTEM", SCIENCE, vol. 248, no. 4953, 20 April 1990 (1990-04-20), pages 305, XP000128555 *
SHARMA S K: "ACCELERATED CLEARANCE SYSTEMS", ADVANCED DRUG DELIVERY REVIEWS, vol. 22, 1 January 1996 (1996-01-01), pages 315 - 324, XP002064129 *

Also Published As

Publication number Publication date
WO1999064065A2 (en) 1999-12-16
GB9812550D0 (en) 1998-08-05
AU5946999A (en) 1999-12-30

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