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WO1999064040A8 - Novel polyene macrolide compounds and uses - Google Patents

Novel polyene macrolide compounds and uses

Info

Publication number
WO1999064040A8
WO1999064040A8 PCT/US1999/012699 US9912699W WO9964040A8 WO 1999064040 A8 WO1999064040 A8 WO 1999064040A8 US 9912699 W US9912699 W US 9912699W WO 9964040 A8 WO9964040 A8 WO 9964040A8
Authority
WO
WIPO (PCT)
Prior art keywords
polyene macrolide
macrolide compounds
compounds
novel polyene
novel
Prior art date
Application number
PCT/US1999/012699
Other languages
French (fr)
Other versions
WO1999064040A1 (en
Inventor
John H Griffin
J Kevin Judice
Original Assignee
Advanced Medicine Inc
John H Griffin
J Kevin Judice
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Medicine Inc, John H Griffin, J Kevin Judice filed Critical Advanced Medicine Inc
Priority to AU45499/99A priority Critical patent/AU4549999A/en
Publication of WO1999064040A1 publication Critical patent/WO1999064040A1/en
Publication of WO1999064040A8 publication Critical patent/WO1999064040A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Novel multibinding compounds are disclosed. The compounds of the invention comprise 2-10 polyene macrolide antibiotic ligands covalently connected, each of said ligands being capable of binding to a ligand binding site in a cellular or viral membrane, thereby modulating the biological processes/functions thereof.
PCT/US1999/012699 1998-06-08 1999-06-07 Novel polyene macrolide compounds and uses WO1999064040A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU45499/99A AU4549999A (en) 1998-06-08 1999-06-07 Novel polyene macrolide compounds and uses

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US8846498P 1998-06-08 1998-06-08
US60/088,464 1998-06-08
US9294198P 1998-07-15 1998-07-15
US60/092,941 1998-07-15
US9769898P 1998-08-25 1998-08-25
US60/097,698 1998-08-25

Publications (2)

Publication Number Publication Date
WO1999064040A1 WO1999064040A1 (en) 1999-12-16
WO1999064040A8 true WO1999064040A8 (en) 2001-07-26

Family

ID=27375967

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/012699 WO1999064040A1 (en) 1998-06-08 1999-06-07 Novel polyene macrolide compounds and uses

Country Status (4)

Country Link
AR (1) AR019629A1 (en)
AU (1) AU4549999A (en)
SG (1) SG83724A1 (en)
WO (1) WO1999064040A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20010018A2 (en) 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
EP1483277A4 (en) 2002-02-15 2007-10-03 Merckle Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
US7271154B2 (en) 2002-02-15 2007-09-18 Merckle Gmbh Antibiotic conjugates
AU2003215245A1 (en) 2002-02-15 2003-09-09 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
RS20050007A (en) * 2002-07-08 2007-09-21 Glaxo Smith Kline Istraživački Centar Zagreb D.O.O., Novel nonsteroidal anti- inflammatory substances, compositions and methods for their use
EP1521764A2 (en) * 2002-07-08 2005-04-13 PLIVA-ISTRAZIVACKI INSTITUT d.o.o. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
DE60327341D1 (en) * 2002-07-08 2009-06-04 Glaxosmithkline Zagreb HYBRID MOLECULES OF MAKROLIDES WITH STEROIDAL / NON-STEROIDAL ANTI-STARTING ACTIVE MOLECULES
WO2004007709A2 (en) * 2002-07-16 2004-01-22 Biotica Technology Limited Production of polyketides
CN105594715B (en) * 2016-03-24 2017-12-26 重庆大学 TOR protein inhibitors suppress the new application of plant of Solanaceae late disease bacteria
CN106905342B (en) * 2017-02-21 2019-05-03 河北农业大学 Structure of two active metabolites of streptomyces roseoflavus and preparation thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196351A (en) * 1987-09-30 1993-03-23 Beckman Instruments, Inc. Bidentate conjugate and method of use thereof
US5824483A (en) * 1994-05-18 1998-10-20 Pence Inc. Conformationally-restricted combinatiorial library composition and method
EP0799182A4 (en) * 1994-12-23 1998-03-25 Smithkline Beecham Corp 3,3-(disubstituted)cyclohexan-1-ol dimers and related compounds
CA2251086C (en) * 1996-04-12 2007-02-20 Eli Lilly And Company Glycopeptide compounds
WO1998011436A1 (en) * 1996-09-13 1998-03-19 Whitehead Institute For Biomedical Research Non-specific affinity enhancement to identify combinatorial library members

Also Published As

Publication number Publication date
WO1999064040A1 (en) 1999-12-16
SG83724A1 (en) 2001-10-16
AR019629A1 (en) 2002-02-27
AU4549999A (en) 1999-12-30

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