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WO1999061626A3 - Human hydrolase homologs: n-terminal asparagine amidohydrolase, glycosyl hydrolase, glucohydrolase, biotinidase, and n-acetylglucosamine 6-p deacetylase - Google Patents

Human hydrolase homologs: n-terminal asparagine amidohydrolase, glycosyl hydrolase, glucohydrolase, biotinidase, and n-acetylglucosamine 6-p deacetylase Download PDF

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Publication number
WO1999061626A3
WO1999061626A3 PCT/US1999/012021 US9912021W WO9961626A3 WO 1999061626 A3 WO1999061626 A3 WO 1999061626A3 US 9912021 W US9912021 W US 9912021W WO 9961626 A3 WO9961626 A3 WO 9961626A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrolase
biotinidase
glucohydrolase
acetylglucosamine
deacetylase
Prior art date
Application number
PCT/US1999/012021
Other languages
French (fr)
Other versions
WO1999061626A2 (en
Inventor
Olga Bandman
Jennifer L Hillman
Henry Yue
Preeti Lal
Neil C Corley
Karl J Guegler
Chandra Patterson
Mariah R Baughn
Original Assignee
Incyte Pharma Inc
Olga Bandman
Jennifer L Hillman
Henry Yue
Preeti Lal
Neil C Corley
Karl J Guegler
Chandra Patterson
Mariah R Baughn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharma Inc, Olga Bandman, Jennifer L Hillman, Henry Yue, Preeti Lal, Neil C Corley, Karl J Guegler, Chandra Patterson, Mariah R Baughn filed Critical Incyte Pharma Inc
Priority to CA002329076A priority Critical patent/CA2329076A1/en
Priority to EP99953359A priority patent/EP1080203A2/en
Priority to JP2000551010A priority patent/JP2003500002A/en
Priority to AU43222/99A priority patent/AU4322299A/en
Publication of WO1999061626A2 publication Critical patent/WO1999061626A2/en
Publication of WO1999061626A3 publication Critical patent/WO1999061626A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/82—Asparaginase (3.5.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The invention provides human hydrolase homologs (HHH) and polynucleotides which identify and encode HHH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HHH.
PCT/US1999/012021 1998-05-29 1999-05-28 Human hydrolase homologs: n-terminal asparagine amidohydrolase, glycosyl hydrolase, glucohydrolase, biotinidase, and n-acetylglucosamine 6-p deacetylase WO1999061626A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002329076A CA2329076A1 (en) 1998-05-29 1999-05-28 Human hydrolase homologs: n-terminal asparagine amidohydrolase, glycosyl hydrolase, glucohydrolase, biotinidase, and n-acetylglucosamine 6-p deacetylase
EP99953359A EP1080203A2 (en) 1998-05-29 1999-05-28 Human hydrolase homologs: n-terminal asparagine amidohydrolase, glycosyl hydrolase, glucohydrolase, biotinidase, and n-acetylglucosamine 6-p deacetylase
JP2000551010A JP2003500002A (en) 1998-05-29 1999-05-28 Human hydrolase homologs: N-terminal asparagine amide hydrolase, glycosyl hydrolase, glucohydrolase, biotinidase and N-acetylglucosamine 6-P deacetylase
AU43222/99A AU4322299A (en) 1998-05-29 1999-05-28 Human hydrolase homologs: n-terminal asparagine amidohydrolase, glycosyl hydrolase, glucohydrolase, biotinidase, and n-acetylglucosamine 6-p deacetylase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8723698P 1998-05-29 1998-05-29
US60/087,236 1998-05-29

Publications (2)

Publication Number Publication Date
WO1999061626A2 WO1999061626A2 (en) 1999-12-02
WO1999061626A3 true WO1999061626A3 (en) 2000-04-06

Family

ID=22203944

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/012021 WO1999061626A2 (en) 1998-05-29 1999-05-28 Human hydrolase homologs: n-terminal asparagine amidohydrolase, glycosyl hydrolase, glucohydrolase, biotinidase, and n-acetylglucosamine 6-p deacetylase

Country Status (5)

Country Link
EP (1) EP1080203A2 (en)
JP (1) JP2003500002A (en)
AU (1) AU4322299A (en)
CA (1) CA2329076A1 (en)
WO (1) WO1999061626A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4843799A (en) * 1998-06-30 2000-01-17 Incyte Pharmaceuticals, Inc. Human oxidoreductase proteins
IL178921A0 (en) * 1998-12-24 2007-03-08 Yeda Res & Dev Caspase-8 interacting proteins
CN1301854A (en) * 1999-12-29 2001-07-04 复旦大学 New polypeptide-glycosylhydoxlase 12 and polynucleotide coding such polypeptide
AU2002357163A1 (en) * 2001-12-12 2003-07-09 University Of Cincinnati Apyrase polypeptides and nucleic acids encoding same
AU2003231245A1 (en) * 2002-04-30 2003-11-17 Incyte Corporation Molecules for disease detection and treatment

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0811687A2 (en) * 1996-06-07 1997-12-10 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Polypeptides having l-asparaginase activity
WO1998000553A1 (en) * 1996-07-03 1998-01-08 Incyte Pharmaceuticals, Inc. Human hyaluronidase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0811687A2 (en) * 1996-06-07 1997-12-10 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Polypeptides having l-asparaginase activity
WO1998000553A1 (en) * 1996-07-03 1998-01-08 Incyte Pharmaceuticals, Inc. Human hyaluronidase

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EMEST EMBL 16 February 1998 (1998-02-16), STRAUSBERG ET AL.: "ob82d08.s1 NCI_CGAP_GCB1 Homo sapiens cDNA clone IMAGE:1337871 similar to SW:PNAD_MOUSE Q64311 PROTEIN N-TERMINAL ASPARAGINE AMIDOHYDROLASE", XP002116477 *
GRIGORYEV ET AL.: "A mouse amidase specific for N-terminal asparaginase - the gene, the enzyme, and their function in the N-end rule pathway", J. BIOL. CHEM., vol. 271, no. 45, 8 November 1996 (1996-11-08), pages 28521 - 28532, XP002116471 *
STEWART ET AL: "The sequence of porcine protein NH2-terminal asparagine amidohydrolase - a new component of the N-end rule pathway", J. BIOL. CHEM., vol. 270, no. 1, 6 January 1995 (1995-01-06), pages 25 - 28, XP002116472 *

Also Published As

Publication number Publication date
JP2003500002A (en) 2003-01-07
EP1080203A2 (en) 2001-03-07
AU4322299A (en) 1999-12-13
CA2329076A1 (en) 1999-12-02
WO1999061626A2 (en) 1999-12-02

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