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WO1999061598A3 - Lentiviral vector compositions and methods of use - Google Patents

Lentiviral vector compositions and methods of use Download PDF

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Publication number
WO1999061598A3
WO1999061598A3 PCT/US1999/011634 US9911634W WO9961598A3 WO 1999061598 A3 WO1999061598 A3 WO 1999061598A3 US 9911634 W US9911634 W US 9911634W WO 9961598 A3 WO9961598 A3 WO 9961598A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
lentiviral vector
vector compositions
compositions
lentiviral
Prior art date
Application number
PCT/US1999/011634
Other languages
French (fr)
Other versions
WO1999061598A2 (en
Inventor
Lung-Ji Chang
Yan Cui
Tomoo Iwakuma
Original Assignee
Univ Florida
Chang Lung Ji
Yan Cui
Tomoo Iwakuma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida, Chang Lung Ji, Yan Cui, Tomoo Iwakuma filed Critical Univ Florida
Priority to AU42078/99A priority Critical patent/AU4207899A/en
Publication of WO1999061598A2 publication Critical patent/WO1999061598A2/en
Publication of WO1999061598A3 publication Critical patent/WO1999061598A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • C12N2840/206—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES having multiple IRES

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed are lentiviral vector compositions and methods of use.
PCT/US1999/011634 1998-05-26 1999-05-26 Lentiviral vector compositions and methods of use WO1999061598A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU42078/99A AU4207899A (en) 1998-05-26 1999-05-26 Lentiviral vector compositions and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8663598P 1998-05-26 1998-05-26
US60/086,635 1998-05-26

Publications (2)

Publication Number Publication Date
WO1999061598A2 WO1999061598A2 (en) 1999-12-02
WO1999061598A3 true WO1999061598A3 (en) 2000-04-13

Family

ID=22199866

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/011634 WO1999061598A2 (en) 1998-05-26 1999-05-26 Lentiviral vector compositions and methods of use

Country Status (4)

Country Link
EP (1) EP1082447A2 (en)
AU (2) AU4207899A (en)
CA (1) CA2333481A1 (en)
WO (1) WO1999061598A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2495300A (en) * 1999-01-07 2000-07-24 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Lentivirus vector system
US6790657B1 (en) 1999-01-07 2004-09-14 The United States Of America As Represented By The Department Of Health And Human Services Lentivirus vector system
AU2001253728A1 (en) * 2000-04-28 2001-11-12 The Trustees Of The University Of Pennsylvania Recombinant lentiviral vectors pseudotyped in envelopes containing filovirus binding domains
EP1468094A4 (en) * 2001-12-24 2005-01-26 Es Cell Int Pte Ltd Method of transducing es cells
US7399278B1 (en) 2003-05-05 2008-07-15 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Method and system for measuring amniotic fluid volume and/or assessing fetal weight
US20240052366A1 (en) * 2020-02-13 2024-02-15 Oxford Biomedica (Uk) Limited Production of Lentiviral Vectors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007943A1 (en) * 1990-10-31 1992-05-14 Somatix Therapy Corporation Retroviral vectors useful for gene therapy
US5436146A (en) * 1989-09-07 1995-07-25 The Trustees Of Princeton University Helper-free stocks of recombinant adeno-associated virus vectors
WO1997007225A2 (en) * 1995-08-21 1997-02-27 Cell Genesys, Inc. High efficiency retroviral packaging system
WO1997036481A1 (en) * 1996-04-02 1997-10-09 The Regents Of The University Of California Design of novel highly efficient hiv based packaging systems for gene therapy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2066053C (en) * 1989-08-18 2001-12-11 Harry E. Gruber Recombinant retroviruses delivering vector constructs to target cells

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436146A (en) * 1989-09-07 1995-07-25 The Trustees Of Princeton University Helper-free stocks of recombinant adeno-associated virus vectors
WO1992007943A1 (en) * 1990-10-31 1992-05-14 Somatix Therapy Corporation Retroviral vectors useful for gene therapy
WO1997007225A2 (en) * 1995-08-21 1997-02-27 Cell Genesys, Inc. High efficiency retroviral packaging system
WO1997036481A1 (en) * 1996-04-02 1997-10-09 The Regents Of The University Of California Design of novel highly efficient hiv based packaging systems for gene therapy

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
L. NALDINI ET AL.: "Efficient tranfer, intergration and sustained long-term expression of the transgene in adult rat brain injected with a lentiviral vector", PNAS, vol. 93, 1996, pages 11382 - 11388, XP002130632 *
L. NALDINI ET AL.: "In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector", SCIENCE, vol. 272, no. 5259, 1996, pages 263 - 267, XP000583652 *
P. CORBEAU ET AL.: "Efficient gene transfer by a HIV-1-derived vector utilizing a stable packaging cell line", PNAS, vol. 93, 1996, pages 14070 - 14075, XP000872865 *
R. CARROLL ET AL.: "A HIV-1-based retroviral vector system utilizing stable HIV-1 packaging cell lines", JOURNAL OF VIROLOGY, vol. 68, no. 9, 1994, pages 6047 - 6051, XP002063697 *
V. NARRY KIM ET AL.: "Minimal requirement for a lentivirus vector based on human HIV-1", JOURNAL OF VIROLOGY, vol. 72, no. 1, 1998, pages 811 - 816, XP000872453 *

Also Published As

Publication number Publication date
AU4312699A (en) 2000-01-17
AU773015B2 (en) 2004-05-13
CA2333481A1 (en) 2000-01-06
AU4207899A (en) 1999-12-13
WO1999061598A2 (en) 1999-12-02
EP1082447A2 (en) 2001-03-14

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