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WO1999058962A8 - Improved apparatus and methods for carrying out electrochemiluminescence test measurements - Google Patents

Improved apparatus and methods for carrying out electrochemiluminescence test measurements

Info

Publication number
WO1999058962A8
WO1999058962A8 PCT/US1999/010279 US9910279W WO9958962A8 WO 1999058962 A8 WO1999058962 A8 WO 1999058962A8 US 9910279 W US9910279 W US 9910279W WO 9958962 A8 WO9958962 A8 WO 9958962A8
Authority
WO
WIPO (PCT)
Prior art keywords
carrying
methods
improved apparatus
test measurements
electrochemiluminescence test
Prior art date
Application number
PCT/US1999/010279
Other languages
French (fr)
Other versions
WO1999058962A1 (en
Inventor
Jacob N Wohlstadter
Jue Zhang
David R Gambrel
Sergey Ivanov
John Liljestrand
Charles Quentin Davis
Original Assignee
Igen Int Inc
Jacob N Wohlstadter
Jue Zhang
David R Gambrel
Sergey Ivanov
John Liljestrand
Charles Quentin Davis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Igen Int Inc, Jacob N Wohlstadter, Jue Zhang, David R Gambrel, Sergey Ivanov, John Liljestrand, Charles Quentin Davis filed Critical Igen Int Inc
Priority to EP99922921A priority Critical patent/EP1078247A4/en
Priority to CA002331490A priority patent/CA2331490A1/en
Priority to JP2000548715A priority patent/JP2002514759A/en
Priority to AU39810/99A priority patent/AU755542B2/en
Publication of WO1999058962A1 publication Critical patent/WO1999058962A1/en
Publication of WO1999058962A8 publication Critical patent/WO1999058962A8/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
    • G01N21/69Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence specially adapted for fluids, e.g. molten metal
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76Chemiluminescence; Bioluminescence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Apparatus for the conduct of electrochemiluminescence measurements includes an ECL chamber (130) having a transparent window (127) defining one wall of the chamber and a photodetector (122) mounted closely adjacent thereto. An assay fluid is subject to a magnetic field and is electrically energized. Electrochemiluminescence induced in the fluid is measured by the photodetector.
PCT/US1999/010279 1998-05-11 1999-05-11 Improved apparatus and methods for carrying out electrochemiluminescence test measurements WO1999058962A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99922921A EP1078247A4 (en) 1998-05-11 1999-05-11 Improved apparatus and methods for carrying out electrochemiluminescence test measurements
CA002331490A CA2331490A1 (en) 1998-05-11 1999-05-11 Improved apparatus and methods for carrying out electrochemiluminescence test measurements
JP2000548715A JP2002514759A (en) 1998-05-11 1999-05-11 Improved apparatus and method for performing electrochemiluminescence test measurements
AU39810/99A AU755542B2 (en) 1998-05-11 1999-05-11 Improved apparatus and methods for carrying out electrochemiluminescence test measurements

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/076,325 1998-05-11
US09/076,325 US6200531B1 (en) 1998-05-11 1998-05-11 Apparatus for carrying out electrochemiluminescence test measurements

Publications (2)

Publication Number Publication Date
WO1999058962A1 WO1999058962A1 (en) 1999-11-18
WO1999058962A8 true WO1999058962A8 (en) 2000-03-30

Family

ID=22131292

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/010279 WO1999058962A1 (en) 1998-05-11 1999-05-11 Improved apparatus and methods for carrying out electrochemiluminescence test measurements

Country Status (6)

Country Link
US (3) US6200531B1 (en)
EP (1) EP1078247A4 (en)
JP (1) JP2002514759A (en)
AU (1) AU755542B2 (en)
CA (1) CA2331490A1 (en)
WO (1) WO1999058962A1 (en)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2764381A1 (en) * 1997-06-09 1998-12-11 Univ De Neuchatel ELECTROCHEMICOLUMINESCENT DETECTOR
US6200531B1 (en) * 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
US6381484B1 (en) * 1999-07-12 2002-04-30 Steve T Ayanruoh Palm sized medical examination device
US6487326B1 (en) 1999-11-29 2002-11-26 Board Of Regents, The University Of Texas System Thin film fiber optic electrode sensor array and apparatus
US6927851B2 (en) * 2000-03-31 2005-08-09 Neogen Corporation Methods and apparatus to improve the sensitivity and reproducibility of bioluminescent analytical methods
GB2368903A (en) * 2000-11-08 2002-05-15 Proimmune Ltd Analysis of biological and biochemical assays
DE10106138B4 (en) * 2001-02-10 2006-02-23 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Modular measuring and / or testing device
CA2440656A1 (en) * 2001-03-09 2002-09-19 Apollo Biotechnology, Inc. Conjugate probes and optical detection of analytes
EP1384266B1 (en) * 2001-04-30 2008-03-26 Mergeoptics GmbH Arrangement comprising at least two different electronic semiconductor circuits
US7842246B2 (en) 2001-06-29 2010-11-30 Meso Scale Technologies, Llc Assay plates, reader systems and methods for luminescence test measurements
DE60236732D1 (en) 2001-07-30 2010-07-29 Meso Scale Technologies Llc ASSAY ELECTRODES WITH REAL-ESTABLISHED LIPID / PROTEIN LAYERS AND PROCESS FOR THEIR PREPARATION AND USE
AU2002333526B2 (en) 2001-09-10 2008-01-17 Meso Scale Technologies, Llc. Methods and apparatus for conducting multiple measurements on a sample
US7030403B2 (en) * 2001-12-06 2006-04-18 Biocontrol Systems, Inc. Sample collection and bioluminescent sample testing system
US9429509B2 (en) * 2002-01-28 2016-08-30 Sysmex Corporation Particle analyzer and particle analysis method
US7186398B2 (en) 2002-02-22 2007-03-06 Purdue Research Foundation Fe/Au nanoparticles and methods
US8442689B2 (en) 2002-03-11 2013-05-14 Craig P. Lovell System for flexibly representing and processing assay plates
US20050123823A1 (en) * 2002-03-14 2005-06-09 Gust Jr. John D. Enzyme-based photoelectrochemical cell for electric current generation
JP2005530183A (en) * 2002-06-20 2005-10-06 バイオヴェリス コーポレイション Electrochemiluminescence flow cell and flow cell components
WO2004003219A2 (en) * 2002-06-28 2004-01-08 Igen International, Inc. Improved assay systems and components
JP4098008B2 (en) * 2002-07-03 2008-06-11 オリンパス株式会社 Optical gain correction filter and bar code reader having the same
KR100434690B1 (en) * 2002-07-19 2004-06-04 소광섭 Apparatus and method for detecting luminescence from biological systems in response to magnetic fields
RU2221236C1 (en) * 2002-09-16 2004-01-10 Калачев Алексей Александрович Process of analysis of physical and/or chemical properties of surface layer of solid body ( variants )
US6807062B2 (en) * 2002-11-07 2004-10-19 Hewlett-Packard Development Company, L.P. Employment of an over-bent ledge of a rack component to support an over-bent ledge of a drop-in chassis
EP1560930A4 (en) * 2002-11-15 2007-05-16 Applera Corp Nucleic acid sequence detection
AU2003302263A1 (en) * 2002-12-26 2004-07-29 Meso Scale Technologies, Llc. Assay cartridges and methods of using the same
US20040166520A1 (en) * 2003-01-03 2004-08-26 Connolly D. Michael Identifying items with nucleic acid taggants
WO2004083806A2 (en) * 2003-01-22 2004-09-30 University Of South Florida Autonomous genosensor apparatus and methods for use
US7173705B2 (en) * 2003-02-26 2007-02-06 Hamamatsu Photonics K.K. Measuring device for immunochromatography test piece
JP2005030847A (en) * 2003-07-10 2005-02-03 Sysmex Corp Electronic apparatus and analysis system
US20070051626A1 (en) * 2003-09-26 2007-03-08 Chiho Itou Cataphoresis apparatus cataphoresis method, and detection method for organism-related material using the apparatus and the method
US7393504B2 (en) * 2003-10-09 2008-07-01 Jyh-Myng Zen Flow injection electrochemical detecting device
US7438853B2 (en) * 2004-05-19 2008-10-21 Jyh-Myng Zen Photoelectrocatalytic method and photoelectrochemical detector for electrochemical analysis
JP5118964B2 (en) 2004-06-23 2013-01-16 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム Methods and compositions for detection of biological molecules using two-particle complexes
US20060275841A1 (en) * 2004-12-20 2006-12-07 Martin Blankfard Assay method and apparatus with reduced sample matrix effects
RU2377571C2 (en) * 2005-01-07 2009-12-27 Секисуй Кемикал Ко., Лтд. Detector device with cartridge
CA2842402C (en) * 2005-03-10 2016-02-23 Gen-Probe Incorporated Systems and methods to perform assays for detecting or quantifying analytes within samples
DE20190164T1 (en) 2005-05-09 2024-01-18 Labrador Diagnostics Llc FLUID SYSTEMS POC DEVICES AND THEIR USE
US8206974B2 (en) 2005-05-19 2012-06-26 Netbio, Inc. Ruggedized apparatus for analysis of nucleic acid and proteins
AU2011203525B8 (en) * 2005-05-19 2014-03-06 Ande Corporation An apparatus for analyzing/processing a sample of biomolecular analyte, device and method
AU2006309289B2 (en) * 2005-06-03 2011-12-08 Board Of Regents Of The University Of Texas System Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode
WO2007002580A2 (en) * 2005-06-23 2007-01-04 Bioveris Corporation Diagnostic as say system with multi -well reagent container
US7630849B2 (en) 2005-09-01 2009-12-08 Applied Biosystems, Llc Method of automated calibration and diagnosis of laboratory instruments
US20090001294A1 (en) * 2005-10-07 2009-01-01 Korea Atomic Energy Research Institute Neutron Coincidence Counter for Non-Destructive Accounting for Nuclear Material and the Handling Thereof
US7537934B2 (en) * 2005-12-30 2009-05-26 Intel Corporation Chemiluminescence sensor array
US20070170056A1 (en) * 2006-01-26 2007-07-26 Arnold Don W Microscale electrochemical cell and methods incorporating the cell
US8496879B2 (en) 2006-02-08 2013-07-30 Molecular Devices, Llc Optical detection utilizing cartridge with tunable filter assembly
US8968658B2 (en) 2006-02-08 2015-03-03 Molecular Devices, Llc Luminescence measurement utilizing cartridge with integrated detector
US8119066B2 (en) * 2006-02-08 2012-02-21 Molecular Devices, Llc Multimode reader
US7515259B2 (en) * 2006-03-10 2009-04-07 Dionex Corporation Flow cell for optical detector and method of forming same
JP2008109864A (en) * 2006-10-30 2008-05-15 Hitachi Ltd Genetic sequence analysis system
US20080182136A1 (en) * 2007-01-26 2008-07-31 Arnold Don W Microscale Electrochemical Cell And Methods Incorporating The Cell
WO2009011942A2 (en) 2007-04-04 2009-01-22 Network Biosystems, Inc. Methods for rapid multiplexed amplification of target nucleic acids
JP5026851B2 (en) * 2007-04-23 2012-09-19 株式会社日立製作所 Chemiluminescence detector
MX2010003578A (en) 2007-10-02 2010-06-09 Theranos Inc Modular point-of-care devices and uses thereof.
ES2457541T3 (en) * 2008-04-11 2014-04-28 Board Of Regents Of The University Of Texas System Method and apparatus for amplification of electrogenerated chemiluminescence by nanoparticles
US8372652B2 (en) 2008-05-08 2013-02-12 Board Of Regents Of The University Of Texas System Luminescent nanostructured materials for use in electrogenerated chemiluminescence
US20100261292A1 (en) 2009-04-10 2010-10-14 Meso Scale Technologies, Llc Methods for Conducting Assays
WO2010147654A2 (en) 2009-06-15 2010-12-23 Netbio Inc. Improved methods for forensic dna quantitation
US20110143947A1 (en) 2009-07-27 2011-06-16 Meso Scale Technologies, Llc Assay Apparatuses, Consumables and Methods
US8203118B2 (en) * 2009-12-11 2012-06-19 Honeywell International, Inc. Ion-trap mass spectrometer driven by a monolithic photodiode array
JP5286299B2 (en) * 2010-01-28 2013-09-11 株式会社日立ハイテクノロジーズ Analysis equipment
US20110312557A1 (en) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Loc device for pathogen detection with dialysis, lysis and parallel nucleic acid amplification
US9046507B2 (en) 2010-07-29 2015-06-02 Gen-Probe Incorporated Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure
CA2814680C (en) 2010-10-14 2021-11-16 Meso Scale Technologies, Llc Reagent storage in an assay device
HUE029030T2 (en) 2010-10-25 2017-01-30 Hoffmann La Roche Use of signal enhancing compounds in electrochemiluminescence detection
MX349288B (en) 2011-01-21 2017-07-21 Theranos Inc Systems and methods for sample use maximization.
AU2012222178B2 (en) 2011-02-24 2014-12-18 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
US9219836B2 (en) 2011-05-23 2015-12-22 Datamax-O'neil Corporation Sensing apparatus for detecting and determining the width of media along a feed path
WO2012170525A1 (en) 2011-06-06 2012-12-13 Source Technologies, Llc Printing ribbon security apparatus and method
EP2723574B1 (en) 2011-06-23 2019-08-07 Datamax-O'Neil Corporation Print station
EP2723575A4 (en) 2011-06-24 2015-05-06 Datamax O Neil Corp Ribbon drive assembly
WO2012177978A1 (en) 2011-06-24 2012-12-27 Source Technologies, Llc Apparatus and method for determining and adjusting printhead pressure
US9481186B2 (en) 2011-07-14 2016-11-01 Datamax-O'neil Corporation Automatically adjusting printing parameters using media identification
EP2739480A4 (en) 2011-08-05 2016-02-24 Datamax O Neil Corp Print station system
WO2013023227A1 (en) 2011-08-05 2013-02-14 Source Technologies, Llc Printing system
EP2768672B1 (en) 2011-10-20 2018-07-11 Datamax-O'Neil Corporation Top of form sensor
EP2776833B1 (en) 2011-11-11 2018-09-05 Eli N. Glezer Co-binder assisted assay methods
CA2856420A1 (en) 2011-11-22 2013-05-30 Datamax-O'neil Corporation Synchronized media hanger/guide
US9024988B2 (en) 2011-12-22 2015-05-05 Datamax-O'neil Corporation Media detection apparatus and method
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9081001B2 (en) * 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
US9061527B2 (en) 2012-12-07 2015-06-23 Datamax-O'neil Corporation Thermal printer with single latch, adjustable media storage and centering assemblies and print assembly
CN105209886B (en) 2013-01-04 2019-04-02 梅索磅秤技术有限公司 Apparatus and method adapted to interrogate a sample
JP6239243B2 (en) 2013-02-08 2017-11-29 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Automatic analyzer
AU2014249190C1 (en) 2013-03-11 2021-11-18 Meso Scale Technologies, Llc. Improved methods for conducting multiplexed assays
DE102013102440B3 (en) 2013-03-12 2014-05-15 Dionex Softron Gmbh Positioning unit for flow cell for optical detection in HPLC field, has front end facing away from flow cell formed by outer surface of flange of cell, and terminal piece whose front end is connected with light conductor and sample supply
DE102013102439B4 (en) 2013-03-12 2021-09-02 Dionex Softron Gmbh Process for the production of a fluidic connection component for chromatography
DE102013102438B3 (en) 2013-03-12 2014-03-20 Dionex Softron Gmbh Flow cell for measuring e.g. permittivity of sample fluid in HPLC application, has capillary tubes arranged within protective tube to obviate unwanted mechanical application on side of capillary tubes surrounded along longitudinal direction
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
KR20220038550A (en) 2013-03-13 2022-03-28 메소 스케일 테크놀러지즈, 엘엘시 Improved assay methods
US10202500B2 (en) 2013-03-15 2019-02-12 Lubrizol Advanced Materials, Inc. Heavy metal free CPVC compounds
US20140270080A1 (en) * 2013-03-15 2014-09-18 Lawrence Livermore National Security, Llc Electrochemical Test Cell For Enabling In-Situ X-Ray Diffraction and Scattering Studies of Scale Formation and Microstructural Changes in Materials with Flow Through Solution
TWD165449S (en) * 2013-11-25 2015-01-11 日立化成股份有限公司 Cell-collecting cartridge
US9676216B2 (en) 2014-03-27 2017-06-13 Datamax-O'neil Corporation Systems and methods for automatic printer configuration
CA2947747C (en) 2014-05-09 2024-03-05 Meso Scale Technologies, Llc. Graphene-modified electrodes
CA2948547A1 (en) 2014-05-15 2015-11-19 Meso Scale Technologies, Llc. Assay methods and kits for detecting an analyte of interest
CN107003305B (en) 2014-12-08 2021-04-02 豪夫迈·罗氏有限公司 Method for measuring vitamin D
GB2541743B (en) * 2015-08-28 2019-05-22 Chelsea Tech Group Ltd Ballast water monitoring device
EP3352892A4 (en) * 2015-09-22 2019-06-05 Wyatt Technology Corporation Method and apparatus to measure multiple signals from a liquid sample
CN105806828B (en) * 2015-10-29 2019-05-14 北京联众泰克科技有限公司 A kind of Electrogenerated chemiluminescent immunoassay system and its flow cell component
CN108698047B (en) 2016-03-11 2022-04-01 豪夫迈·罗氏有限公司 Branched amines in electrochemiluminescence detection
CN106052561B (en) * 2016-08-05 2019-07-09 京东方科技集团股份有限公司 Position sensor and including its conveyer and utilize its carry out position correction method
FI127861B (en) 2017-06-29 2019-04-15 Labmaster Oy A method and a device for dynamic generation of hot electrons into aqueous solutions
JP7110320B2 (en) * 2017-08-01 2022-08-01 エフ.ホフマン-ラ ロシュ アーゲー Method for monitoring the operation of detecting an analyte in a liquid sample
CN108152210B (en) * 2017-11-24 2020-03-31 东南大学 A special electrochemiluminescence detection cell for screen printing electrodes
EP4310184A3 (en) 2018-02-23 2024-05-01 Meso Scale Technologies, LLC. Methods of screening antigen-binding molecules by normalizing for the concentration of antigen-binding molecule
CN109030468B (en) * 2018-08-14 2024-03-22 四川理工学院 Electric enhancement gas-liquid phase chemiluminescence detection device and detection method
JP6757079B2 (en) * 2018-08-24 2020-09-16 国立大学法人東北大学 Electrochemical sensor and manufacturing method of electrochemical sensor
KR20250037585A (en) 2019-01-03 2025-03-17 메소 스케일 테크놀러지즈, 엘엘시 Compositions and methods for carrying out assay measurements
KR20220010471A (en) 2019-03-01 2022-01-25 메소 스케일 테크놀러지즈, 엘엘시 Electrochemiluminescent labeled probes for use in immunoassay methods, methods of use thereof, and kits comprising same
KR20220005571A (en) 2019-06-07 2022-01-13 에프. 호프만-라 로슈 아게 All LNA oligonucleotide hybridization
JP2021120621A (en) * 2020-01-30 2021-08-19 株式会社日立ハイテク Flow cell and automatic analyzer
CN111693516B (en) * 2020-05-07 2023-04-21 四川轻化工大学 Gas-liquid phase electrochemical luminescence detection device and detection method
CN111693515B (en) * 2020-05-07 2022-06-17 四川轻化工大学 A kind of flow electrochemiluminescence real-time detection device and detection method
US20240018571A1 (en) 2020-05-19 2024-01-18 Meso Scale Technologies, Llc. Methods, compositions, and kits for nucleic acid detection
AU2021299536A1 (en) 2020-07-01 2023-02-16 Meso Scale Technologies, Llc. Compositions and methods for assay measurements
EP4267961A1 (en) 2020-12-22 2023-11-01 F. Hoffmann-La Roche AG Method for detecting an analyte of interest in a sample
US11808146B2 (en) * 2021-01-25 2023-11-07 Saudi Arabian Oil Company Apparatus and method for observing performance of a treatment fluid in a core sample
US20230279290A1 (en) 2021-12-30 2023-09-07 Meso Scale Technologies, Llc. Compositions and methods for assay measurements
EP4479748A1 (en) 2022-02-18 2024-12-25 F. Hoffmann-La Roche AG Method for detecting an analyte of interest in a sample

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3816795A (en) 1965-10-23 1974-06-11 American Cyanamid Co Method for providing electroluminescent light from a polycyclic heterocyclic compound in an aprotic solvent under electric current
US3583230A (en) * 1968-06-12 1971-06-08 Sondell Research Dev Co Sample injection method and apparatus
NL7001235A (en) 1970-01-29 1971-08-02
GB1509186A (en) 1974-05-08 1978-05-04 Secr Social Service Brit Specimen agitation apparatus
US3900418A (en) * 1973-04-12 1975-08-19 Bell Northern Research Ltd Electrochemical luminescent solutions and devices incorporating such solutions
FR2247732A1 (en) 1973-10-16 1975-05-09 Accumulateurs Fixes
US3984688A (en) 1975-04-21 1976-10-05 Source Gas Analyzers, Inc. Monitor for detection of chemiluminescent reactions
US4132605A (en) * 1976-12-27 1979-01-02 Rockwell International Corporation Method for evaluating the quality of electroplating baths
US4210724A (en) 1977-03-28 1980-07-01 Olympus Optical Co., Ltd. Apparatus for liquid disposal and distribution in automatic culture system
US4213703A (en) 1978-05-30 1980-07-22 Beckman Instruments, Inc. Photometer with stationary sample holder and rotatable shutter
US4443713A (en) 1978-10-30 1984-04-17 Phillips Petroleum Company Waveform generator
US4280815A (en) 1979-06-18 1981-07-28 Technicon Instruments Corporation Electrochemiluminescent immunoassay and apparatus therefor
DE3013765A1 (en) 1980-04-10 1981-10-15 Philips Patentverwaltung Gmbh, 2000 Hamburg DETECTOR ARRANGEMENT, ESPECIALLY FOR LIQUID CHROMATOGRAPHY
US4297105A (en) 1980-06-27 1981-10-27 Alcan Research And Development Limited Automatic photometric titrator
US4303410A (en) 1980-11-03 1981-12-01 The United States Of America As Represented By The Secretary Of The Navy Light burst activity analyzer
US4537861A (en) 1983-02-03 1985-08-27 Elings Virgil B Apparatus and method for homogeneous immunoassay
EP0141780A1 (en) * 1983-10-11 1985-05-15 Battelle Memorial Institute Electrochemical water purification method
JPS60117503A (en) * 1983-11-29 1985-06-25 松下電器産業株式会社 Transparent conductive film forming coating liquid and forming method thereof
US5500188A (en) * 1984-03-01 1996-03-19 Molecular Devices Corporation Device for photoresponsive detection and discrimination
US5238808A (en) 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US5310687A (en) 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
JPS6235326A (en) 1985-08-09 1987-02-16 Canon Inc Display element
US5147806A (en) 1988-04-29 1992-09-15 Igen, Inc. Method and apparatus for conducting electrochemiluminescence measurements
JPH01500059A (en) 1986-05-22 1989-01-12 ユニリーバー・ナームローゼ・ベンノートシヤープ assay
US4849340A (en) 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
JPS6443745A (en) 1987-08-12 1989-02-16 Hitachi Ltd Instrument for measuring light emitted by organism
JPH01247962A (en) 1988-03-29 1989-10-03 Hisaka Works Ltd heat pump
US5093268A (en) 1988-04-28 1992-03-03 Igen, Inc. Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena
US5247243A (en) 1988-11-03 1993-09-21 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
US5779976A (en) 1988-11-03 1998-07-14 Igen International, Inc. Apparatus for improved luminescence assays
US5061445A (en) 1988-11-03 1991-10-29 Igen, Inc. Apparatus for conducting measurements of electrochemiluminescent phenomena
US5068088A (en) 1988-11-03 1991-11-26 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
US5705402A (en) 1988-11-03 1998-01-06 Igen International, Inc. Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
US5746974A (en) * 1988-11-03 1998-05-05 Igen International, Inc. Apparatus for improved luminescence assays using particle concentration, electrochemical generation of chemiluminescence and chemiluminescence detection
US5296191A (en) 1988-11-03 1994-03-22 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
JPH02137275A (en) * 1988-11-17 1990-05-25 Nec Corp Photo coupler
US5324457A (en) 1989-10-02 1994-06-28 Board Of Regents, The University Of Tx System Devices and methods for generating electrogenerated chemiluminescence
US5189549A (en) * 1990-02-26 1993-02-23 Molecular Displays, Inc. Electrochromic, electroluminescent and electrochemiluminescent displays
US5298427A (en) 1990-04-24 1994-03-29 The Board Of Trustees Of The University Of Arkansas Chemiluminescent detection of amino acids
US5132227A (en) 1990-05-02 1992-07-21 Batelle Memorial Institute Monitoring formaldehyde
IL100867A (en) 1991-02-06 1995-12-08 Igen Inc Method and apparatus for improved luminescence assays
US7462322B2 (en) * 1991-02-06 2008-12-09 Bioveris Corporation Methods and apparatus for improved luminescence assays
JPH0534345A (en) 1991-02-19 1993-02-09 Tdk Corp Measuring method of antigen-antibody utilizing chemiluminescence
US5376313A (en) 1992-03-27 1994-12-27 Abbott Laboratories Injection molding a plastic assay cuvette having low birefringence
JPH0634548A (en) * 1992-07-16 1994-02-08 Omron Corp Device for measuring electrochemical emission
US5466416A (en) * 1993-05-14 1995-11-14 Ghaed; Ali Apparatus and methods for carrying out electrochemiluminescence test measurements
US5541113A (en) * 1993-09-22 1996-07-30 Beckman Instruments, Inc. Method for detecting an analyte using an electrochemical luminescent transition metal label
US5965452A (en) * 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US5429893A (en) * 1994-02-04 1995-07-04 Motorola, Inc. Electrochemical capacitors having dissimilar electrodes
JP3559998B2 (en) * 1994-06-28 2004-09-02 株式会社堀場製作所 Chemiluminescence analyzer
DE4429857C2 (en) * 1994-08-23 2000-06-29 Balluff Gebhard Feinmech Magnetic position detector
US5786141A (en) * 1994-08-26 1998-07-28 Bard; Allen J. Electrogenerated chemiluminescence labels for analysis and/or referencing
JP3302186B2 (en) * 1994-09-01 2002-07-15 触媒化成工業株式会社 Substrate with transparent conductive film, method for producing the same, and display device provided with the substrate
DE4435107C1 (en) 1994-09-30 1996-04-04 Biometra Biomedizinische Analy Miniaturized flow thermal cycler
US5744367A (en) 1994-11-10 1998-04-28 Igen International, Inc. Magnetic particle based electrochemiluminescent detection apparatus and method
US5538687A (en) * 1994-12-16 1996-07-23 Behringer Mannheim Gmbh Apparatus for generating optically detectable signals by applying electrical potentials to sample liquids
US5993740A (en) * 1995-01-20 1999-11-30 Hitachi, Ltd. Immunoassay method and analyzer using magnetic particles
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
KR100449615B1 (en) * 1995-03-10 2004-12-08 메소 스케일 테크놀러지즈, 엘엘시 Multi-array, multi-specific electrochemiluminescence test
AU5854396A (en) * 1995-05-08 1996-11-29 Igen, Inc. Electrochemiluminescent metal chelate labels and means for d etection
US5589136A (en) * 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
WO1997010498A1 (en) * 1995-09-12 1997-03-20 Eisai Co., Ltd. Method and apparatus for detecting electrochemiluminescence
EP0914203B1 (en) * 1996-05-20 2001-03-21 Dinex A/S A method and a reactor for electrochemical conversion of a material e.g. soot particles being insoluble in a fluid
US5833925A (en) * 1996-11-13 1998-11-10 Beckman Instruments, Inc. Automatic chemistry analyzer with improved ion selective electrode assembly
JP4088721B2 (en) * 1997-03-13 2008-05-21 日産化学工業株式会社 Conductive tin oxide fine powder and method for producing conductive tin oxide sol
US6200531B1 (en) * 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
US6136268A (en) * 1999-08-17 2000-10-24 Orion Diagnostica Method for luminescence measurements
JP2005530183A (en) * 2002-06-20 2005-10-06 バイオヴェリス コーポレイション Electrochemiluminescence flow cell and flow cell components
AU2006309289B2 (en) * 2005-06-03 2011-12-08 Board Of Regents Of The University Of Texas System Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode

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US20010008612A1 (en) 2001-07-19
EP1078247A1 (en) 2001-02-28
JP2002514759A (en) 2002-05-21
WO1999058962A1 (en) 1999-11-18
US6517777B2 (en) 2003-02-11
US20030118477A1 (en) 2003-06-26
AU755542B2 (en) 2002-12-12
EP1078247A4 (en) 2002-12-04
CA2331490A1 (en) 1999-11-18
AU3981099A (en) 1999-11-29
US6200531B1 (en) 2001-03-13

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