WO1999058671A3 - Homologues du gene d'assurance de longevite des levures, lag1, d'origine humaine ou issus de nematodes - Google Patents
Homologues du gene d'assurance de longevite des levures, lag1, d'origine humaine ou issus de nematodes Download PDFInfo
- Publication number
- WO1999058671A3 WO1999058671A3 PCT/US1999/010160 US9910160W WO9958671A3 WO 1999058671 A3 WO1999058671 A3 WO 1999058671A3 US 9910160 W US9910160 W US 9910160W WO 9958671 A3 WO9958671 A3 WO 9958671A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lag1
- human
- nematode
- methods
- providing
- Prior art date
Links
- 241000244206 Nematoda Species 0.000 title abstract 3
- 101100074187 Caenorhabditis elegans lag-1 gene Proteins 0.000 title 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 title 1
- 101000777471 Homo sapiens C-C motif chemokine 4 Proteins 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 4
- 102100021984 C-C motif chemokine 4-like Human genes 0.000 abstract 2
- 101000737602 Homo sapiens Ceramide synthase 1 Proteins 0.000 abstract 2
- 108020004491 Antisense DNA Proteins 0.000 abstract 1
- 108020005544 Antisense RNA Proteins 0.000 abstract 1
- 108091026890 Coding region Proteins 0.000 abstract 1
- 239000003816 antisense DNA Substances 0.000 abstract 1
- 239000003184 complementary RNA Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
- 101150058356 lag-1 gene Proteins 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
- C07K14/4354—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes
- C07K14/43545—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes from Caenorhabditis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention se rapporte à des acides nucléiques de LAG1 d'origine humaine ou issus de nématodes et aux polypeptides codés et exprimés par ces acides nucléiques, ainsi qu'aux vecteurs et cellules hôtes associés. La présente invention concerne de l'ADN et de l'ARN antisens. Elle se rapporte également à des procédés permettant d'accroître la longévité et la tolérance au stress de cellules eucaryotes et consistant à fournir à ces cellules des polypeptides de LAG1 d'origine humaine ou issus de nématodes. Les procédés permettant de fournir à une cellule des polypeptides de LAG1 consistent à surexprimer le gène LAG1 endogène, ou à introduire dans la cellule un vecteur d'expression contenant la région appropriée de codage de LAG1. Il est possible de mettre en oeuvre ces procédés sur des cellules mammaliennes, et notamment sur des cellules humaines. La présente invention se rapporte également à des compositions pharmaceutiques permettant la mise en oeuvre de ces procédés.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7501498A | 1998-05-08 | 1998-05-08 | |
| US09/075,014 | 1998-05-08 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1999058671A2 WO1999058671A2 (fr) | 1999-11-18 |
| WO1999058671A9 WO1999058671A9 (fr) | 2000-03-09 |
| WO1999058671A3 true WO1999058671A3 (fr) | 2000-11-09 |
Family
ID=22123003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1999/010160 WO1999058671A2 (fr) | 1998-05-08 | 1999-05-10 | Homologues du gene d'assurance de longevite des levures, lag1, d'origine humaine ou issus de nematodes |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO1999058671A2 (fr) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992000382A1 (fr) * | 1990-06-15 | 1992-01-09 | Carnegie Institution Of Washington | Gdf-1 |
| WO1995033834A1 (fr) * | 1994-06-03 | 1995-12-14 | Research Corporation Technologies, Inc. | Lag1: un gene pour augmenter la longevite des cellules eucaryotiques |
| WO1998005761A1 (fr) * | 1996-08-07 | 1998-02-12 | The General Hospital Corporation | Polypeptides age-1 et molecules et methodes associees |
| WO1998017823A1 (fr) * | 1996-10-21 | 1998-04-30 | Mcgill University | CONSERVATION STRUCTURELLE ET FONCTIONNELLE DU GENE D'HORLOGE clk-1 CHEZ $i(C. ELEGANS) |
| WO1999006558A1 (fr) * | 1997-07-30 | 1999-02-11 | Incyte Pharmaceuticals, Inc. | Homologues proteiques d'assurance de longevite humaine |
-
1999
- 1999-05-10 WO PCT/US1999/010160 patent/WO1999058671A2/fr active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992000382A1 (fr) * | 1990-06-15 | 1992-01-09 | Carnegie Institution Of Washington | Gdf-1 |
| WO1995033834A1 (fr) * | 1994-06-03 | 1995-12-14 | Research Corporation Technologies, Inc. | Lag1: un gene pour augmenter la longevite des cellules eucaryotiques |
| WO1998005761A1 (fr) * | 1996-08-07 | 1998-02-12 | The General Hospital Corporation | Polypeptides age-1 et molecules et methodes associees |
| WO1998017823A1 (fr) * | 1996-10-21 | 1998-04-30 | Mcgill University | CONSERVATION STRUCTURELLE ET FONCTIONNELLE DU GENE D'HORLOGE clk-1 CHEZ $i(C. ELEGANS) |
| WO1999006558A1 (fr) * | 1997-07-30 | 1999-02-11 | Incyte Pharmaceuticals, Inc. | Homologues proteiques d'assurance de longevite humaine |
Non-Patent Citations (7)
| Title |
|---|
| D'MELLO, NOEL P. ET AL: "Cloning and characterization of LAG1, a longevity - assurance gene in yeast", J. BIOL. CHEM. (1994), 269(22), 15451-9, XP002127185 * |
| HEKIMI S ET AL: "Molecular genetics of life span in C. elegans: how much does it teach us?", TRENDS IN GENETICS,NL,ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, vol. 14, no. 1, January 1998 (1998-01-01), pages 14-20, XP004101479, ISSN: 0168-9525 * |
| HODES R ET AL: "Longevity assurance genes: how do they influence aging and life span?", JOURNAL OF THE AMERICAN GERIATRICS SOCIETY,US,ELSEVIER SCIENCE PUBLISHING, NEW YORK, NY, vol. 44, no. 8, 1996, pages 988-991, XP002084173, ISSN: 0002-8614 * |
| JIANG, JAMES C. ET AL: "Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human", GENOME RES. (1998), 8(12), 1259-1272, XP002127187 * |
| KIRCHMAN, PAUL A. ET AL: "LAG1 and LAC1 are homologous genes involved in determining the replicative life span of the budding yeast, Saccharomyces cerevisiae.", FASEB JOURNAL, (1996) VOL. 10, NO. 6, PP. A1517. MEETING INFO.: JOINT MEETING OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, THE AMERICAN SOCIETY FOR INVESTIGATIVE PATHOLOGY AND THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS NEW ORLEANS,, XP002127186 * |
| LEE S -J: "EXPRESSION OF GROWTH/DIFFERENTIATION FACTOR 1 IN THE NERVOUS SYSTEM: CONSERVATION OF A BICISTRONIC STRUCTURE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 88, no. 10, 1991, pages 4520-4524, XP000561931, ISSN: 0027-8424 * |
| WILSON R. ET AL.: "AC Q17870", EMBL DATABASE, 1 November 1996 (1996-11-01), Heidelberg, XP002127184 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999058671A9 (fr) | 2000-03-09 |
| WO1999058671A2 (fr) | 1999-11-18 |
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