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WO1999056698A3 - Treatment of celiac disease - Google Patents

Treatment of celiac disease Download PDF

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Publication number
WO1999056698A3
WO1999056698A3 PCT/DK1999/000255 DK9900255W WO9956698A3 WO 1999056698 A3 WO1999056698 A3 WO 1999056698A3 DK 9900255 W DK9900255 W DK 9900255W WO 9956698 A3 WO9956698 A3 WO 9956698A3
Authority
WO
WIPO (PCT)
Prior art keywords
interfering
deamidation
celiac disease
glutamine residue
gliadin
Prior art date
Application number
PCT/DK1999/000255
Other languages
French (fr)
Other versions
WO1999056698A2 (en
Inventor
Hans Sjoestroem
Ove Noren
Original Assignee
Univ Koebenhavn
Hans Sjoestroem
Ove Noren
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Koebenhavn, Hans Sjoestroem, Ove Noren filed Critical Univ Koebenhavn
Priority to EP99917810A priority Critical patent/EP1075267A2/en
Priority to AU35961/99A priority patent/AU3596199A/en
Publication of WO1999056698A2 publication Critical patent/WO1999056698A2/en
Publication of WO1999056698A3 publication Critical patent/WO1999056698A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/08—Oxides; Hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/12—Magnesium silicate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to a method of treating celiac disease comprising interfering with the deamidation of at least one glutamine residue in a gliadin or glutenin molecule. This may be provided by prohibiting or interfering with the deamidation of at least one glutamine residue by derivation of at least one glutamine residue in a gliadin or glutenine molecule in wheat flour by a chemical or enzymatic deamidation of gluten followed by chemical or enzymatic derivation of the generated carboxyl group(s). In a further aspect, the invention relates to a method of interfering with the deamidation of at least one glutamine residue in a gliadin or glutenin molecule and thereby treating celiac disease, the method comprising administering, to a patient having or suspected of having celiac disease, at least one of the following substances: (a) a substance which is capable of increasing the pH in the gastroduodenal tract of a subject, e.g. an antacidum, an anticholinergic agent, H2-receptor antagonists or a proton pump inhibitor, (b) a substance which is capable of eliminating deamidating bacteria in the gastroduodenal tract of a subject, e.g. an antibiotic or antimicrobial agent, and/or (c) a substance which is capable of interfering with the effect of at least one deamidating enzyme in the gastroduodenal tract of a subject.
PCT/DK1999/000255 1998-05-06 1999-05-06 Treatment of celiac disease WO1999056698A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99917810A EP1075267A2 (en) 1998-05-06 1999-05-06 Treatment of celiac disease
AU35961/99A AU3596199A (en) 1998-05-06 1999-05-06 Treatment of celiac disease

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK0621/98 1998-05-06
DK62198 1998-05-06
US9154598P 1998-07-01 1998-07-01
US60/091,545 1998-07-01

Publications (2)

Publication Number Publication Date
WO1999056698A2 WO1999056698A2 (en) 1999-11-11
WO1999056698A3 true WO1999056698A3 (en) 1999-12-29

Family

ID=26064330

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1999/000255 WO1999056698A2 (en) 1998-05-06 1999-05-06 Treatment of celiac disease

Country Status (3)

Country Link
EP (1) EP1075267A2 (en)
AU (1) AU3596199A (en)
WO (1) WO1999056698A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6348495B1 (en) 1996-06-06 2002-02-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Method for treating celiac disease
TWI275587B (en) 1999-06-17 2007-03-11 Takeda Chemical Industries Ltd A crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
CA2375091A1 (en) 1999-06-30 2001-01-11 Takeda Chemical Industries, Ltd. Crystals of benzimidazole compounds
ES2361993T5 (en) 2002-02-14 2014-12-09 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of food products for celiac disease
US8143210B2 (en) 2002-02-14 2012-03-27 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
WO2004035052A1 (en) 2002-10-16 2004-04-29 Takeda Pharmaceutical Company Limited Stable solid preparations
ES2383595T3 (en) * 2002-11-20 2012-06-22 The Board Of Trustees Of The Leland Stanford Junior University Celiac disease diagnostic procedure
US7579313B2 (en) 2003-11-18 2009-08-25 The Board Of Trustees Of The Leland Stanford Junior University Transglutaminase inhibitors and methods of use thereof
AU2011247868B2 (en) * 2004-04-28 2014-05-22 Btg International Limited Epitopes related to coeliac disease
ITMI20062080A1 (en) * 2006-10-30 2008-04-30 Consiglio Nazionale Ricerche TREATMENT OF CEREAL FLOURS FOR FOOD CONSUMPTION BY CELIAC PATIENTS
JP2010521469A (en) 2007-03-16 2010-06-24 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ Enzyme combination therapy to digest dietary gluten
UY31695A (en) 2008-03-10 2009-11-10 Takeda Pharmaceutical BENCIMIDAZOL COMPOSITE CRYSTAL
MX374971B (en) * 2011-01-20 2025-03-06 Cyrex Laboratories Llc Methods and apparatus for detecting gluten sensitivity and differentiating it from celiac disease
JP2014508517A (en) * 2011-02-08 2014-04-10 ファディア・アクチボラゲット Wheat antigens and peptides for diagnosis of wheat-induced hypersensitivity
ITSR20130002A1 (en) * 2013-10-08 2015-04-08 Danilo Ciciulla NEW INDUSTRIAL PROCESS OF PROCESSING FOR THE PRODUCTION OF FARINACEOUS FOODS, INTENDED FOR SUBJECTS WITH CELIAC DISEASE CLINICALLY MANIFESTED, BASED ON COMMON FLOURS.
WO2017089961A1 (en) * 2015-11-24 2017-06-01 Universidade De Trás-Os-Montes E Alto Douro Process for preparing cereal flours enriched with l-theanine and corresponding products
CN105434459A (en) * 2015-12-25 2016-03-30 南阳医学高等专科学校 Formula of western medicine for treating ulcer and preparation process for western medicine
IT201800010305A1 (en) 2018-11-13 2020-05-13 Danilo Ciciulla PROCEDURE FOR THE PREPARATION OF WHEAT-BASED FOODS INTENDED FOR CELIACS OR SUBJECTS WITH GLUTEN SENSITIVITY

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4338334A (en) * 1977-12-29 1982-07-06 Merck & Co., Inc. 1-[4-(4-Sulfanilyl)phenyl] urea and derivatives in compositions and methods of treating rheumatoid arthritis and immune complex diseases
EP0278174A2 (en) * 1986-12-24 1988-08-17 Glaxo Group Limited Use of fluticasone propionate in the preparation of a pharmaceutical composition for the treatment of bowel diseases
DD262999A1 (en) * 1987-07-27 1988-12-21 Adw Ddr METHOD FOR PRODUCING A DIETETIC FOR ZOELIAKIE AND SPRUCE BARRIER
SU1581315A1 (en) * 1987-12-07 1990-07-30 Пятигорский научно-исследовательский институт курортологии и физиотерапии Method of treating celiac disease of children
EP0444829A2 (en) * 1990-02-27 1991-09-04 FISONS plc Immunosuppressive compounds
WO1992018524A1 (en) * 1991-04-17 1992-10-29 Prodotti Chimici E Alimentari S.P.A. N-alkyl-tauroursodeoxycholic acids and their therapeutically active derivatives, a process for their preparation and pharmaceutical compositions containing them
WO1998003872A2 (en) * 1996-07-18 1998-01-29 Detlef Schuppan Immunological process for detecting antibodies directed towards tissue transglutaminase (ttg), use of ttg for diagnostic purposes and therapy control, and oral pharmaceutical agent containing ttg

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4338334A (en) * 1977-12-29 1982-07-06 Merck & Co., Inc. 1-[4-(4-Sulfanilyl)phenyl] urea and derivatives in compositions and methods of treating rheumatoid arthritis and immune complex diseases
EP0278174A2 (en) * 1986-12-24 1988-08-17 Glaxo Group Limited Use of fluticasone propionate in the preparation of a pharmaceutical composition for the treatment of bowel diseases
DD262999A1 (en) * 1987-07-27 1988-12-21 Adw Ddr METHOD FOR PRODUCING A DIETETIC FOR ZOELIAKIE AND SPRUCE BARRIER
SU1581315A1 (en) * 1987-12-07 1990-07-30 Пятигорский научно-исследовательский институт курортологии и физиотерапии Method of treating celiac disease of children
EP0444829A2 (en) * 1990-02-27 1991-09-04 FISONS plc Immunosuppressive compounds
WO1992018524A1 (en) * 1991-04-17 1992-10-29 Prodotti Chimici E Alimentari S.P.A. N-alkyl-tauroursodeoxycholic acids and their therapeutically active derivatives, a process for their preparation and pharmaceutical compositions containing them
WO1998003872A2 (en) * 1996-07-18 1998-01-29 Detlef Schuppan Immunological process for detecting antibodies directed towards tissue transglutaminase (ttg), use of ttg for diagnostic purposes and therapy control, and oral pharmaceutical agent containing ttg

Non-Patent Citations (14)

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Title
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DATABASE WPI Section Ch Week 199113, Derwent World Patents Index; Class B06, AN 1991-092939, XP002118955 *
DE MAGALHAES A.F.N. ET AL: "[The use of antibiotics in digestive tract diseases]. USO DE ANTIBIOTICOS EM DOENCAS DO APARELHO DIGESTIVO.", REVISTA BRASILEIRA DE CLINICA E TERAPEUTICA, (1979) 8/11 (505-516). CODEN: RBCTAP, XP002118952 *
FREEMAN H.J.: "Ranitidine -associated interstitial nephritis in a patient with celiac sprue.", CAN. J. GASTROENTEROL., (1988) 2/1 (35-36). ISSN: 0835-7900 CODEN: CJGAEJ, Canada, XP002085955 *
FRIIS S U: "COELIAC DISEASE. PATHOGENESIS AND CLINICAL ASPECTS", APMIS, vol. 104, no. SUPPL. 61, 1 January 1996 (1996-01-01), pages 5 - 48, XP000605982, ISSN: 0903-4641 *
GRAHAM D Y ET AL: "Mechanism of increase in steatorrhea with calcium and magnesium in exocrine pancreatic insufficiency: an animal model.", GASTROENTEROLOGY, (1982 SEP) 83 (3) 638-44. JOURNAL CODE: FH3. ISSN: 0016-5085., United States, XP002085956 *
GRAHAM D Y: "Pancreatic enzyme replacement: the effect of antacids or cimetidine.", DIGESTIVE DISEASES AND SCIENCES, (1982 JUN) 27 (6) 485-90. JOURNAL CODE: EAD. ISSN: 0163-2116., United States, XP002085957 *
JOURET A. ET AL: "[Digestive pathologies and intraepithelial lymphocytes]. PATHOLOGIE DIGESTIVE ET LYMPHOCYTES INTRA-EPITHELIAUX.", ACTA ENDOSCOPICA, (1995) 25/5 SUPPL. (563-569). ISSN: 0240-642X CODEN: AENDD5, France, XP002085954 *
KASPER H ET AL: "[Therapy of diseases of the small intestine]. Die Therapie von Dunndarmerkrankungen.", MEDIZINISCHE WELT, (1969 DEC 20) 51 2777-9. JOURNAL CODE: MIM. ISSN: 0025-8512., GERMANY, WEST: Germany, Federal Republic of, XP002085953 *
MEHTA D.I. ET AL: "Chronic diarrhea: Causes, presentation, and management.", INDIAN JOURNAL OF PEDIATRICS, (1996) 63/4 (459-471). ISSN: 0019-5456 CODEN: IJPEA2, India, XP002085951 *
MOLBERG, OYBIND ET AL: "Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease", NAT. MED. (N. Y.) (1998), 4(6), 713-717 CODEN: NAMEFI;ISSN: 1078-8956, XP002085952 *
SOLLID L M ET AL: "Autoantibodies in coeliac disease: tissue transglutaminase --guilt by association?.", GUT, (1997 DEC) 41 (6) 851-2., XP002118953 *
UHLIG, H. ET AL: "Role of tissue transglutaminase in gliadin binding to reticular extracellular matrix and relation to coeliac disease autoantibodies", AUTOIMMUNITY (1998), 28(4), 185-195, XP002118954 *
UNSWORTH J ET AL: "Flat small intestinal mucosa and autoantibodies against the gut epithelium.", JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, (1982) 1 (4) 503-13. JOURNAL CODE: JL6. ISSN: 0277-2116., United States, XP002085950 *

Also Published As

Publication number Publication date
AU3596199A (en) 1999-11-23
EP1075267A2 (en) 2001-02-14
WO1999056698A2 (en) 1999-11-11

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