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WO1999055875A3 - VACCINS CONTENANT DE LA PILINE DE RECOMBINAISON UTILISES CONTRE LES MALADIES PROVOQUEES PAR NEISSERIA GONORRHOEAE OU $i(NEISSERIA MENINGITIDIS) - Google Patents

VACCINS CONTENANT DE LA PILINE DE RECOMBINAISON UTILISES CONTRE LES MALADIES PROVOQUEES PAR NEISSERIA GONORRHOEAE OU $i(NEISSERIA MENINGITIDIS) Download PDF

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Publication number
WO1999055875A3
WO1999055875A3 PCT/US1999/009486 US9909486W WO9955875A3 WO 1999055875 A3 WO1999055875 A3 WO 1999055875A3 US 9909486 W US9909486 W US 9909486W WO 9955875 A3 WO9955875 A3 WO 9955875A3
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WO
WIPO (PCT)
Prior art keywords
neisseria
neisseria meningitidis
pile
pilin
region
Prior art date
Application number
PCT/US1999/009486
Other languages
English (en)
Other versions
WO1999055875A2 (fr
Inventor
Thomas N Metcalf Iii
Robert J Zagursky
Peggy Ooi
Original Assignee
American Cyanamid Co
Thomas N Metcalf Iii
Robert J Zagursky
Peggy Ooi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co, Thomas N Metcalf Iii, Robert J Zagursky, Peggy Ooi filed Critical American Cyanamid Co
Priority to JP2000546019A priority Critical patent/JP2002527041A/ja
Priority to AU39685/99A priority patent/AU3968599A/en
Priority to CA002325055A priority patent/CA2325055A1/fr
Priority to EP99922760A priority patent/EP1073748A2/fr
Priority to KR1020007011991A priority patent/KR20010043105A/ko
Priority to IL13931199A priority patent/IL139311A0/xx
Priority to BR9910005-3A priority patent/BR9910005A/pt
Publication of WO1999055875A2 publication Critical patent/WO1999055875A2/fr
Publication of WO1999055875A3 publication Critical patent/WO1999055875A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Les gènes pilE de chacun de Neisseria gonorrhoeae et de Neisseria meningitidis sont clonés et leurs protéines piline de recombinaison correspondantes sont exprimées. En outre, un gène chimère pilE est construit dans lequel la région du gène pilE de Neisseria meningitidis de classe I codant la région N-terminale de la protéine piline est remplacée par la région correspondante du gène pilE de Neisseria gonorrhoeae. La protéine piline de classe I chimère méningococcique de recombinaison est exprimée à des taux supérieurs à la protéine piline exprimée par le gène pilE complet de Neisseria meningitidis. De surcroît un gène chimère pilE est construit dans lequel la région du gène pilE de Neisseria meningitidis de classe II codant la région C-terminale de la protéine piline est remplacée par la région correspondante du gène pilE de Neisseria gonorrhoeae. Les protéines piline de recombinaison sont utilisées dans des vaccins destinés à protéger contre les maladies provoquées par Neisseria gonorrhoeae ou Neisseria meningitidis.
PCT/US1999/009486 1998-04-29 1999-04-29 VACCINS CONTENANT DE LA PILINE DE RECOMBINAISON UTILISES CONTRE LES MALADIES PROVOQUEES PAR NEISSERIA GONORRHOEAE OU $i(NEISSERIA MENINGITIDIS) WO1999055875A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2000546019A JP2002527041A (ja) 1998-04-29 1999-04-29 淋菌（Ｎｅｉｓｓｅｒｉａｇｏｎｏｒｒｈｏｅａｅ）または髄膜炎菌（Ｎｅｉｓｓｅｒｉａｍｅｎｉｎｇｉｔｉｄｉｓ）に対する組換えピリンを含有するワクチン
AU39685/99A AU3968599A (en) 1998-04-29 1999-04-29 Vaccines containing recombinant pilin against Neisseria Gonorrhoeae or Neisseria Meningitidis
CA002325055A CA2325055A1 (fr) 1998-04-29 1999-04-29 Vaccins contenant de la piline de recombinaison utilises contre les maladies provoquees par neisseria gonorrhoeae ou neisseria meningitidis
EP99922760A EP1073748A2 (fr) 1998-04-29 1999-04-29 VACCINS CONTENANT DE LA PILINE DE RECOMBINAISON UTILISES CONTRE LES MALADIES PROVOQUEES PAR $i(NEISSERIA GONORRHOEAE) OU $i(NEISSERIA MENINGITIDIS)
KR1020007011991A KR20010043105A (ko) 1998-04-29 1999-04-29 나이제리아 고노리아 또는 나이제리아 메닌지티디스에대한 재조합 필린을 함유한 백신
IL13931199A IL139311A0 (en) 1998-04-29 1999-04-29 Vaccines containing recombinant pilin against neisseria gonorrhoeae or neisseria meningitidis
BR9910005-3A BR9910005A (pt) 1998-04-29 1999-04-29 Composição de vacina, processos para imunização contra neisseria gonorrhoeae e para preparar uma composição de vacina, sequência de dna isolada e purificada, plasmìdeo, célula hospedeira, processo para produção de uma proteìna pilina recombinante quimérica de neisseria gonorrhoeae e neisseria meningitidis, proteìna pilina recombinante quimérica isolada e purificada de neisseria gonorhoeae e neisseria meningitidis, e, processo para imunização contra neisseria muningitidis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8340598P 1998-04-29 1998-04-29
US60/083,405 1998-04-29

Publications (2)

Publication Number Publication Date
WO1999055875A2 WO1999055875A2 (fr) 1999-11-04
WO1999055875A3 true WO1999055875A3 (fr) 2000-04-13

Family

ID=22178094

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/009486 WO1999055875A2 (fr) 1998-04-29 1999-04-29 VACCINS CONTENANT DE LA PILINE DE RECOMBINAISON UTILISES CONTRE LES MALADIES PROVOQUEES PAR NEISSERIA GONORRHOEAE OU $i(NEISSERIA MENINGITIDIS)

Country Status (9)

Country Link
EP (1) EP1073748A2 (fr)
JP (1) JP2002527041A (fr)
KR (4) KR20060118629A (fr)
CN (1) CN1245512C (fr)
AU (2) AU3968599A (fr)
BR (1) BR9910005A (fr)
CA (1) CA2325055A1 (fr)
IL (1) IL139311A0 (fr)
WO (1) WO1999055875A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0011108D0 (en) * 2000-05-08 2000-06-28 Microscience Ltd Virulence gene and protein and their use
GB0118249D0 (en) * 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
WO2005098028A1 (fr) * 2004-04-08 2005-10-20 The State Of Queensland Acting Through Its Department Of Health Détection de neisseria gonorrhoeae
US20110182981A1 (en) * 2008-08-25 2011-07-28 Peixuan Zhu Gonococcal vaccines
US9802988B2 (en) * 2009-05-20 2017-10-31 University Of Maryland, Baltimore Engineered type IV pilin of Clostridium difficile
WO2012059592A1 (fr) * 2010-11-05 2012-05-10 Institut National De La Sante Et De La Recherche Medicale (Inserm) Composés pour l'administration au cerveau d'un agent thérapeutique ou d'imagerie
JP5991740B2 (ja) * 2012-06-21 2016-09-14 キヤノン株式会社 ライセンス管理装置、ライセンス管理方法、およびプログラム
US10000545B2 (en) 2012-07-27 2018-06-19 Institut National De La Sante Et De La Recherche Medicale CD147 as receptor for pilus-mediated adhesion of Meningococci to vascular endothelia
CN103405760A (zh) * 2013-06-19 2013-11-27 中国科学院海洋研究所 迟缓爱德华氏菌菌毛蛋白FimA的应用
CN106290849A (zh) * 2015-05-13 2017-01-04 上海凯创生物技术有限公司 一种脑膜炎菌胶体金检测试剂盒
CN118994336B (zh) * 2024-10-22 2025-01-24 四川大学华西医院 鲍曼不动杆菌菌毛重组蛋白抗原、制备方法及其应用

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EP0049945A2 (fr) * 1980-09-15 1982-04-21 Bactex Incorporated Méthode pour la détermination de la hiérarchie des organismes piliés et vaccin préparé à partir de ces organismes
US4443431A (en) * 1981-05-27 1984-04-17 The United States Of America As Represented By The Department Of Health And Human Services Neisseria gonorrhoeae vaccine
WO1985004654A1 (fr) * 1984-04-06 1985-10-24 Scripps Clinic And Research Foundation Vaccin ou procede de diagnostic utilisant un peptide et polypeptide indique pour cette utilisation
EP0474313A2 (fr) * 1990-09-07 1992-03-11 Centro De Ingenieria Genetica Y Biotecnologia Séquence nucléotidique codant pour une protéine de la membrane externe de Neisseria meningitidis, et utilisation de cette protéine dans la préparation de vaccins
WO1992013871A1 (fr) * 1991-01-31 1992-08-20 Washington University Polypeptides et polynucleotides utiles pour le diagnostic et le traitement de neisseria pathogene
WO1993011791A1 (fr) * 1991-12-18 1993-06-24 The State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University Preparations antigeniques destinees a stimuler la production d'anticorps se liant au poils des bacteries a poils
WO1994000153A1 (fr) * 1992-06-25 1994-01-06 Smithkline Beecham Biologicals (S.A.) Composition vaccinale contenant des adjuvants
WO1994008013A1 (fr) * 1992-10-07 1994-04-14 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University Variantes de piline et leurs utilisations
WO1996031618A1 (fr) * 1995-04-07 1996-10-10 The University Of North Carolina At Chapel Hill MOLECULE ISOLEE D'ACIDE NUCLEIQUE DE PROTEINE B REGULEE PAR Fe (FrpB) ET VACCIN UTILISANT CETTE MOLECULE

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Publication number Priority date Publication date Assignee Title
EP0049945A2 (fr) * 1980-09-15 1982-04-21 Bactex Incorporated Méthode pour la détermination de la hiérarchie des organismes piliés et vaccin préparé à partir de ces organismes
US4443431A (en) * 1981-05-27 1984-04-17 The United States Of America As Represented By The Department Of Health And Human Services Neisseria gonorrhoeae vaccine
WO1985004654A1 (fr) * 1984-04-06 1985-10-24 Scripps Clinic And Research Foundation Vaccin ou procede de diagnostic utilisant un peptide et polypeptide indique pour cette utilisation
EP0474313A2 (fr) * 1990-09-07 1992-03-11 Centro De Ingenieria Genetica Y Biotecnologia Séquence nucléotidique codant pour une protéine de la membrane externe de Neisseria meningitidis, et utilisation de cette protéine dans la préparation de vaccins
WO1992013871A1 (fr) * 1991-01-31 1992-08-20 Washington University Polypeptides et polynucleotides utiles pour le diagnostic et le traitement de neisseria pathogene
WO1993011791A1 (fr) * 1991-12-18 1993-06-24 The State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University Preparations antigeniques destinees a stimuler la production d'anticorps se liant au poils des bacteries a poils
WO1994000153A1 (fr) * 1992-06-25 1994-01-06 Smithkline Beecham Biologicals (S.A.) Composition vaccinale contenant des adjuvants
WO1994008013A1 (fr) * 1992-10-07 1994-04-14 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University Variantes de piline et leurs utilisations
WO1996031618A1 (fr) * 1995-04-07 1996-10-10 The University Of North Carolina At Chapel Hill MOLECULE ISOLEE D'ACIDE NUCLEIQUE DE PROTEINE B REGULEE PAR Fe (FrpB) ET VACCIN UTILISANT CETTE MOLECULE

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Also Published As

Publication number Publication date
WO1999055875A2 (fr) 1999-11-04
KR20060118630A (ko) 2006-11-23
KR20060118629A (ko) 2006-11-23
JP2002527041A (ja) 2002-08-27
EP1073748A2 (fr) 2001-02-07
CA2325055A1 (fr) 1999-11-04
IL139311A0 (en) 2001-11-25
BR9910005A (pt) 2001-01-16
KR20060118628A (ko) 2006-11-23
KR20010043105A (ko) 2001-05-25
CN1245512C (zh) 2006-03-15
AU3968599A (en) 1999-11-16
CN1298446A (zh) 2001-06-06
AU2003204738B2 (en) 2006-09-14

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