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WO1999053085A3 - Regulation selective de la production d'adenovirus - Google Patents

Regulation selective de la production d'adenovirus Download PDF

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Publication number
WO1999053085A3
WO1999053085A3 PCT/US1999/008294 US9908294W WO9953085A3 WO 1999053085 A3 WO1999053085 A3 WO 1999053085A3 US 9908294 W US9908294 W US 9908294W WO 9953085 A3 WO9953085 A3 WO 9953085A3
Authority
WO
WIPO (PCT)
Prior art keywords
vectors
complex
virus
packaging
production
Prior art date
Application number
PCT/US1999/008294
Other languages
English (en)
Other versions
WO1999053085A2 (fr
Inventor
Patrick Hearing
Susanne I Schmid
Philomena H Ostapchuk
Ece Erturk
Original Assignee
Univ New York State Res Found
Patrick Hearing
Susanne I Schmid
Philomena H Ostapchuk
Ece Erturk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York State Res Found, Patrick Hearing, Susanne I Schmid, Philomena H Ostapchuk, Ece Erturk filed Critical Univ New York State Res Found
Priority to JP55211099A priority Critical patent/JP2002506355A/ja
Priority to NZ502175A priority patent/NZ502175A/xx
Priority to EP99917543A priority patent/EP0994958A2/fr
Priority to AU35636/99A priority patent/AU770005B2/en
Priority to IL13351099A priority patent/IL133510A0/xx
Publication of WO1999053085A2 publication Critical patent/WO1999053085A2/fr
Publication of WO1999053085A3 publication Critical patent/WO1999053085A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Wrapping Of Specific Fragile Articles (AREA)

Abstract

La présente invention concerne des vecteurs d'adénovirus et leur utilisation dans des systèmes d'apport d'ADN. Ces vecteurs ont été conçus pour présenter une capacité améliorée à porter un ADN étranger et un potentiel minimisé de production de virus de réplication. Ces vecteurs contiennent par ailleurs une ou plusieurs copies d'une séquence d'encapsidation minimale, afin de diriger l'encapsidation virale. Ces vecteurs contiennent éventuellement un ou plusieurs sites de liaison de répresseurs, de sorte que la production de virions peut être sélectivement inhibée. L'invention concerne également des systèmes de répression spécifiques, comprenant les répresseurs COUP-TF et lac. L'invention concerne enfin un complexe cellulaire, ci-après dénommé complexe P, fonctionnant de manière positive dans l'encapsidation et la production virales.
PCT/US1999/008294 1998-04-15 1999-04-15 Regulation selective de la production d'adenovirus WO1999053085A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP55211099A JP2002506355A (ja) 1998-04-15 1999-04-15 アデノウィルス生産の選択的制御
NZ502175A NZ502175A (en) 1998-04-15 1999-04-15 Selective regulation of adenovirus packaging with COUP-TF or lac repressor
EP99917543A EP0994958A2 (fr) 1998-04-15 1999-04-15 Regulation selective de la production d'adenovirus
AU35636/99A AU770005B2 (en) 1998-04-15 1999-04-15 Selective regulation of adenovirus production
IL13351099A IL133510A0 (en) 1998-04-15 1999-04-15 Selective regulation of adenovirus production

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8186798P 1998-04-15 1998-04-15
US8832198P 1998-06-05 1998-06-05
US60/088,321 1998-06-05
US60/081,867 1998-06-05

Publications (2)

Publication Number Publication Date
WO1999053085A2 WO1999053085A2 (fr) 1999-10-21
WO1999053085A3 true WO1999053085A3 (fr) 2000-01-27

Family

ID=26766062

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/008294 WO1999053085A2 (fr) 1998-04-15 1999-04-15 Regulation selective de la production d'adenovirus

Country Status (6)

Country Link
EP (1) EP0994958A2 (fr)
JP (1) JP2002506355A (fr)
AU (1) AU770005B2 (fr)
IL (1) IL133510A0 (fr)
NZ (1) NZ502175A (fr)
WO (1) WO1999053085A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020136708A1 (en) 1993-06-24 2002-09-26 Graham Frank L. System for production of helper dependent adenovirus vectors based on use of endonucleases
AU769735B2 (en) * 1999-02-18 2004-02-05 Advec, Inc. A system for production of helper dependent adenovirus vectors based on use of endonucleases
EP1234048A2 (fr) * 1999-12-03 2002-08-28 The Trustees Of The University Of Pennsylvania Compositions et procedes servant a augmenter l'encapsidation et la production d'adenovirus de recombinaison au moyen de signaux multiples d'encapsidation
US6821512B1 (en) 1999-12-03 2004-11-23 The Trustees Of The University Of Pennsylvania Compositions and methods for increasing packaging and yield of recombinant adenoviruses using multiple packaging signals
US6867022B1 (en) 2000-01-21 2005-03-15 Regents Of The University Of Michigan Replication deficient adenovirus vectors and methods of making and using them
US6916635B2 (en) 2000-10-02 2005-07-12 The Research Foundation Of State University Of New York Hybrid adenovirus/adeno-associated virus vectors and methods of use thereof
WO2003027271A2 (fr) * 2001-09-25 2003-04-03 The Research Foundation Of The State University Of New York Regulation de l'encapsidation de l'adn adenovirual par iptg
US20070207124A1 (en) 2004-10-28 2007-09-06 University Of Pittsburgh Of The Commonwealth System Of Higher Education Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain
JP7105866B2 (ja) 2017-07-25 2022-07-25 オックスフォード ジェネティクス リミテッド アデノウイルスベクター
WO2023069926A1 (fr) 2021-10-18 2023-04-27 Regeneron Pharmaceuticals, Inc. Cellules eucaryotes comprenant des polynucléotides viraux associés à l'adénovirus

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
D'HALLUIN J.C. ET AL.: "Effects of novobiocin on adenovirus DNA synthesis and encapsidation", NUCLEIC ACID RESEARCH, vol. 8, no. 7, 1980, OXFORD, GB, pages 1625 - 1641, XP002117831 *
DULL T. ET AL.: "A third-gneration lentivirus vector with a conditional packaging system", JOURNAL OF VIROLOGY, vol. 72, no. 11, October 1998 (1998-10-01), BALTIMORE, US, pages 8463 - 8471, XP002117829 *
HUANG M.M., HEARING P.: "The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor, E2F, through a direct complex", GENES AND DEVELOPMENT, vol. 3, 1989, pages 1699 - 1710, XP002119862 *
O'CONNOR R J ET AL: "THE C-TERMINAL 70 AMINO ACIDS OF THE ADENOVIRUS E4-ORF6/7 PROTEIN ARE ESSENTIAL AND SUFFICIENT FOR E2F COMPLEX FORMATION", NUCLEIC ACIDS RESEARCH, vol. 19, no. 23, 11 December 1991 (1991-12-11), pages 6579 - 6586, XP000604601, ISSN: 0305-1048 *
SCHMID S I AND HEARING P: "Bipartite structure and functional independence of adenovirus 5 packaging elements", JOURNAL OF VIROLOGY, vol. 71, no. 5, May 1997 (1997-05-01), pages 3375 - 3384 3384, XP002108134, ISSN: 0022-538X *
SCHMID S.I., HEARING P.: "Cellular components interact with adenovirus type 5 minimal DNA packaging domains", JURNAL OF VIROLOGY, vol. 72, no. 8, August 1998 (1998-08-01), pages 6339 - 6347, XP002117828 *
SCHMID S.I., HEARING P.: "Selective encapsidation of adenovirus DNA", CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 199, no. 1, 1995, pages 67 - 80, XP002117827 *
TAGGART A. ET AL.: "The TATA-bimnding protein and associated factors are components of Pol III transcription factor TFIIIB", CELL, vol. 71, no. 6, 1992, pages 1015 - 1028, XP002117830 *

Also Published As

Publication number Publication date
WO1999053085A2 (fr) 1999-10-21
IL133510A0 (en) 2001-04-30
NZ502175A (en) 2002-12-20
AU770005B2 (en) 2004-02-12
EP0994958A2 (fr) 2000-04-26
AU3563699A (en) 1999-11-01
JP2002506355A (ja) 2002-02-26

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