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WO1999051299A3 - Composition pouvant etre radioactivee convenant pour la fabrication de dispositifs medicaux implantables - Google Patents

Composition pouvant etre radioactivee convenant pour la fabrication de dispositifs medicaux implantables Download PDF

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Publication number
WO1999051299A3
WO1999051299A3 PCT/US1999/005036 US9905036W WO9951299A3 WO 1999051299 A3 WO1999051299 A3 WO 1999051299A3 US 9905036 W US9905036 W US 9905036W WO 9951299 A3 WO9951299 A3 WO 9951299A3
Authority
WO
WIPO (PCT)
Prior art keywords
radioactivable
isotope
composition
beneficiated
isotopic
Prior art date
Application number
PCT/US1999/005036
Other languages
English (en)
Other versions
WO1999051299A2 (fr
Inventor
Stanley Satz
Original Assignee
Bionucleonics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/038,560 external-priority patent/US6187037B1/en
Application filed by Bionucleonics Inc filed Critical Bionucleonics Inc
Priority to EP99935270A priority Critical patent/EP1284684A2/fr
Priority to AU50784/99A priority patent/AU5078499A/en
Priority to JP2000542068A priority patent/JP2003518392A/ja
Priority to CA002323440A priority patent/CA2323440A1/fr
Priority to KR1020007010154A priority patent/KR20010041861A/ko
Publication of WO1999051299A2 publication Critical patent/WO1999051299A2/fr
Publication of WO1999051299A3 publication Critical patent/WO1999051299A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1002—Intraluminal radiation therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Radiation-Therapy Devices (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne des compositions pouvant être radioactivées, de préférence des compositions d'alliages métalliques contenant un métal qui possède des caractéristiques de mémoire de forme, et au moins un isotope pouvant être radioactivé qui comporte un élément de la série des lanthanides ou des mélanges d'éléments de la série des lanthanides, ou un autre isotope approprié. L'isotope pouvant être radioactivé est présent selon une concentration suffisante (par rapport aux autres constituants de la composition) pour permettre l'administration d'une dose de rayonnement efficace à un tissu cible en vue d'atteindre un objectif thérapeutique spécifié. Une des applications les plus avantageuses et utiles de la composition est la formation de dispositifs médicaux utiles pour le traitement d'affections des artères coronaires et la réduction de la prolifération de cellules cancéreuses. Dans un des modes de réalisation préférés de l'invention, un isotope pouvant être radioactivé est incorporé, par une combinaison enrichie en isotopes, à une matière de matrice telle qu'un alliage de nickel/titane (p. ex. alliages de métaux du type nitinol), ou par une combinaison enrichie en isotopes à un polymère biodégradable organique naturel ou synthétique de manière à former une solution solide ; et l'alliage ou la solution solide obtenu(e) est ensuite façonné(e) en une endoprothèse ou en une autre forme appropriée pour l'administration sélective et ciblée de quantités thérapeutiques et efficaces de formes posologiques faibles de rayonnement (principalement de particules bêta) à un site ou à un tissu spécifique du corps humain.
PCT/US1999/005036 1998-03-11 1999-03-10 Composition pouvant etre radioactivee convenant pour la fabrication de dispositifs medicaux implantables WO1999051299A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP99935270A EP1284684A2 (fr) 1998-03-11 1999-03-10 Composition pouvant etre radioactivee convenant pour la fabrication de dispositifs medicaux implantables
AU50784/99A AU5078499A (en) 1998-03-11 1999-03-10 Radioactivable composition suitable for fabrication of implantable medical devices
JP2000542068A JP2003518392A (ja) 1998-03-11 1999-03-10 植え込み型医療用デバイスの製造に適した放射化可能組成物
CA002323440A CA2323440A1 (fr) 1998-03-11 1999-03-10 Composition pouvant etre radioactivee convenant pour la fabrication de dispositifs medicaux implantables
KR1020007010154A KR20010041861A (ko) 1998-03-11 1999-03-10 이식 가능한 의료 기기의 제조에 적합한 방사선 활성 조성물

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/038,560 1998-03-11
US09/038,560 US6187037B1 (en) 1998-03-11 1998-03-11 Metal stent containing radioactivatable isotope and method of making same
US13859498A 1998-08-22 1998-08-22
US09/138,594 1998-08-22

Publications (2)

Publication Number Publication Date
WO1999051299A2 WO1999051299A2 (fr) 1999-10-14
WO1999051299A3 true WO1999051299A3 (fr) 2002-11-14

Family

ID=26715320

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/005036 WO1999051299A2 (fr) 1998-03-11 1999-03-10 Composition pouvant etre radioactivee convenant pour la fabrication de dispositifs medicaux implantables

Country Status (5)

Country Link
EP (1) EP1284684A2 (fr)
JP (1) JP2003518392A (fr)
KR (1) KR20010041861A (fr)
AU (1) AU5078499A (fr)
WO (1) WO1999051299A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7101391B2 (en) 2000-09-18 2006-09-05 Inflow Dynamics Inc. Primarily niobium stent
US7402173B2 (en) 2000-09-18 2008-07-22 Boston Scientific Scimed, Inc. Metal stent with surface layer of noble metal oxide and method of fabrication

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19953636A1 (de) * 1999-11-09 2001-05-23 Karlsruhe Forschzent Radioaktive Materialien
US6575887B1 (en) * 1999-11-18 2003-06-10 Epsilon Medical, Inc. Devices for the inhibition or suppression of cellular proliferation in tubular body structures
EP1232769A1 (fr) * 2001-02-15 2002-08-21 AEA Technology QSA GmbH Capsule fabriquée avec du Pd-103
EP1232770A1 (fr) * 2001-02-15 2002-08-21 AEA Technology QSA GmbH Capsule radioactive
US7041046B2 (en) 2001-05-07 2006-05-09 Xoft, Inc. Combination ionizing radiation and immunomodulator delivery devices and methods for inhibiting hyperplasia
US6537195B2 (en) 2001-05-07 2003-03-25 Xoft, Microtube, Inc. Combination x-ray radiation and drug delivery devices and methods for inhibiting hyperplasia
JP4886939B2 (ja) * 2001-07-19 2012-02-29 真也 岡崎 生体内留置用ヨウ素放出性治療材料およびステント
AU2010366132B2 (en) 2010-12-20 2015-05-21 Graftcraft I Goteborg Ab Removable stent and method of production
US8945207B2 (en) 2010-12-20 2015-02-03 Graftcraft I Göteborg Ab Removable stent and method of production
KR101550370B1 (ko) 2013-12-26 2015-09-07 한국원자력의학원 저선량 방사선을 이용한 손상된 연골세포의 복구방법
US10441686B2 (en) * 2015-03-12 2019-10-15 Utah-Inha Dds & Advanced Therapeutics Research Center Stent having functional material coated on cell space thereof
WO2019183724A1 (fr) 2018-03-26 2019-10-03 Triumf, A Joint Venture Of The Governors Of The University Of Alberta, The University Of British Columbia, The Governors Of The University Of Calgary, Carleton University, University Of Guelph, Mcmaster University, University Of Manitoba, Universite De Montreal, Queen's University, University Of Reg Systèmes, appareil et procédés pour séparer de l'actinium, du radium et du thorium

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795286A (en) * 1996-08-15 1998-08-18 Cathco, Inc. Radioisotope impregnated sheet of biocompatible material for preventing scar tissue formation
US5843163A (en) * 1996-06-06 1998-12-01 Wall; William H. Expandable stent having radioactive treatment means
US5865720A (en) * 1997-03-06 1999-02-02 Scimed Life Systems, Inc. Expandable and retrievable radiation delivery system
US5919126A (en) * 1997-07-07 1999-07-06 Implant Sciences Corporation Coronary stent with a radioactive, radiopaque coating

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843163A (en) * 1996-06-06 1998-12-01 Wall; William H. Expandable stent having radioactive treatment means
US5795286A (en) * 1996-08-15 1998-08-18 Cathco, Inc. Radioisotope impregnated sheet of biocompatible material for preventing scar tissue formation
US5865720A (en) * 1997-03-06 1999-02-02 Scimed Life Systems, Inc. Expandable and retrievable radiation delivery system
US5919126A (en) * 1997-07-07 1999-07-06 Implant Sciences Corporation Coronary stent with a radioactive, radiopaque coating

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7101391B2 (en) 2000-09-18 2006-09-05 Inflow Dynamics Inc. Primarily niobium stent
US7402173B2 (en) 2000-09-18 2008-07-22 Boston Scientific Scimed, Inc. Metal stent with surface layer of noble metal oxide and method of fabrication
US7604703B2 (en) 2000-09-18 2009-10-20 Boston Scientific Scimed, Inc. Primarily niobium stent
US7582112B2 (en) 2003-02-10 2009-09-01 Boston Scientific Scimed, Inc. Metal stent with surface layer of noble metal oxide and method of fabrication

Also Published As

Publication number Publication date
AU5078499A (en) 1999-10-25
WO1999051299A2 (fr) 1999-10-14
KR20010041861A (ko) 2001-05-25
EP1284684A2 (fr) 2003-02-26
JP2003518392A (ja) 2003-06-10

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